Aïssa Group

Publications

Livesley, S.; Sterling, A. J.; Robertson, C. M.; Goundry, W. R. F.; Morris, J. A.; Duarte, F.; Aïssa, C. Electrophilic Activation of [1.1.1]Propellane for the Synthesis of Nitrogen-Substituted Bicyclo[1.1.1]pentanesAngew. Chen. Int. Ed. 2022, 61, e202111291.

Barday, M.; Nicolas, E.; Higginson, B.; Delmotte, F.; Appelmans, M.; Aïssa, C. Tandem Nickel-Catalyzed Dimerization/(4+2) Cycloaddition of Terminal Alkynes with Four-Membered Ring Ketones. Synthesis 2021. doi: 10.1055/a-1671-8497.

 

Janot, C.; Chagnoleau, J.-B.; Halcovitch, N. R.; Muir, J.; Aïssa, C. Palladium-Catalyzed Synthesis of α-Carbonyl-α’-(Hetero)aryl Sulfoxonium Ylides: Scope and Insight into the MechanismJ. Org. Chem. 202085, 1126–1137.

 

Clare, D.; Dobson, B. C.; Inglesby, P. A.; Aïssa, C. Chemospecific Cyclizations of α-Carbonyl Sulfoxonium Ylides on Aryls and HeteroarylsAngew. Chen. Int. Ed. 2019, 58, 16198–16202.

Janot, C.; Palamini, P.; Dobson, B. C.; Muir, J.; Aïssa, C. Palladium-catalyzed synthesis of bis-substituted sulfoxonium ylidesOrg. Lett. 2019, 21, 296–299.

Synthesis of sulfoxonium ylides by palladium-catalyzed cross-coupling

Elwrfalli, F.; Esvan, Y. J.; Robertson, C. M.; Aïssa, C. Regioselective cycloaddition of potassium alkynyltrifluoroborates with 3-azetidinones and 3-oxetanone by nickel-catalysed C–C bond activationChem. Commun. 2019, 55, 497–500.

Regioselective cycloaddition of potassium alkynyltrifluoroborates with 3-azetidinones and 3-oxetanone by nickel-catalysed C–C bond activation

Barday, M.; Janot, C.; Halcovitch, N. R.; Muir, J.; Aïssa, C. Cross-Coupling of a-Carbonyl Sulfoxonium Ylides with C–H Bonds. Angew. Chem. Int. Ed. 201756, 13117–13121.

Cross-Coupling of α-Carbonyl Sulfoxonium Ylides with C–H Bonds

Barday, M.; Janot, C.; Clare, D.; Carr-Knox, C.; Higginson, B.; Aïssa, C. On the Regioselectivity of the Nickel-Catalyzed Insertion of Alkynes into the Carbon–Carbon Bond of Oxetan-3-one. Synthesis 201749, 3582–3589.

On the Regioselectivity of the Nickel-Catalyzed Insertion of Alkynes into the Carbon–Carbon Bond of Oxetan-3-one

Tetlow, D. J.; Winder, S. J.; Aïssa, C. The synthesis and biological evaluation of a kabiramide C fragment modified with a WH2 consensus actin-binding motif as a potential disruptor of the actin cytoskeleton. Chem. Commun. 2016, 52, 807–810.

The synthesis and biological evaluation of a kabiramide C fragment modified with a WH2 consensus actin-binding motif as a potential disruptor of the actin cytoskeleton

Barday, M.; Ho, K. Y. T.; Halsall, C. T.; Aïssa, C. Regioselective Synthesis of 3‑Hydroxy-4,5-alkyl-Substituted Pyridines Using 1,3-Enynes as Alkynes Surrogates. Org. Lett. 2016, 18, 1756–1759.

Regioselective Synthesis of 3‑Hydroxy-4,5-alkyl-Substituted Pyridines Using 1,3-Enynes as Alkynes Surrogates

Yip, S. Y. Y.; Aïssa, C. Isomerization of Olefins Triggered by Rhodium-Catalyzed C-H Bond Activation: Control of Endocyclic beta-Hydrogen Elimination. Angew. Chem. Int. Ed. 201554, 6870–6873.

Control of endocyclic beta-elimination by rhodium catalyst

Aïssa, C.; Ho, K. Y. T.; Tetlow, D. J.; Pin-No, M. Diastereoselective Carbocyclization of 1,6-Heptadienes Triggered by Rhodium-Catalyzed Activation of an Olefinic C-H BondAngew. Chem. Int. Ed. 2014, 53, 4209–4212.

Diastereoselective Carbocyclization of 1,6-Heptadienes Triggered by Rhodium-Catalyzed Activation of an Olefinic C–H Bond

Aïssa, C. Transition-Metal-Catalyzed Cycloaddition of Small Ring Compounds (5.35) in Comprehensive Organic Synthesis 2nd Edition. Eds Knochel, P.; Molander G. A.; 2014, 1738–1771. [Book chapter]

Aïssa, C. Stereoselectivity of Metal-Catalyzed Cyclizations of 1,6-DienesSynlett 201425, 2379–2384. [Review]

Aïssa, C.; Crépin, D.; Tetlow, D. J.; Ho, K. Y. T. Multiple Rhodium-Catalyzed Cleavages of Single C-C BondsOrg. Lett. 2013, 15, 1322–1325.

Multiple Rhodium-Catalyzed Cleavages of Single C–C bonds

Ho, K. Y .T.; Aïssa, C. Regioselective Cycloaddition of 3-Azetidinones and 3-Oxetanones with Alkynes through Nickel-Catalysed Carbon-Carbon Bond ActivationChem - Eur. J. 2012, 18, 3486–3489.

Nickel-catalyzed activation of carbon-carbon bond

Aïssa, C. Transition-Metal-Catalyzed Rearrangements of Small Cycloalkanes: Regioselectivity Trends in β-Carbon Elimination Reactions. Synthesis 2011, 21, 3389–3407. [Review]

Crépin, D.; Tugny, C.; Murray, J.; Aïssa, C. Facile and chemoselective rhodium-catalysed intramolecular hydroacylation of alpha,alpha-disubtituted 4-alkylidenecyclopropanalsChem. Commun. 2011, 47, 10957–10959.

Facile and chemoselective rhodium-catalysed intramolecular hydroacylation of α,α-disubstituted 4-alkylidenecyclopropanals

Crépin, D.; Dawick, J.; Aïssa, C Combined Rhodium-Catalyzed Carbon-Hydrogen Activation and Beta-Carbon Elimination to access Eight-Membered RingsAngew. Chem. Int. Ed. 2010, 49, 620–623.

Rh-catalyzed C–H and C–C activation

Aïssa, C. Mechanistic Manifold and New Developments of the Julia-Kocienski ReactionEur. J. Org. Chem. 2009, 1831–1844. [Review]