GeneMill

Synthetic biology can be described as the construction of artificial biological devices, pathways, or networks; or the re-engineering of existing ones.

The Liverpool GeneMill provides end-to-end design, construction, and validation of gene constructs for academic and industrial applications.  Full details of our services are available on our website.

The facility

The GeneMill is located in a bespoke lab space in the Biosciences Building, between two floors of industrial incubator space.

Services include:

  • Construct design
  • DNA synthesis (sequence verified) from plasmid libraries to artificial chromosomes
  • Genome editing tools, eg CRISPR/Cas9 and TALENs
  • Protein design and expression systems (bacteria, yeast, plant, mammalian, and cell-free systems)
  • Protein expression and function prototyping
  • Scalable fermentation analysis
  • Metabolomic/proteomic analyses.

Our biological scope

Synthetic biology can be applied to:

  • Structure/function analysis
  • Directed evolution
  • de novo design
  • Dynthetic pathway creation and biosensors
  • Biological re-engineering.

These services are applicable to a variety of research topics, including:

  • Agri-chem
  • Bio-engineering
  • Biofuels
  • Plant sciences
  • Life sciences
  • Pharmaceuticals
  • Designer chemicals
  • Flavours and fragrances.

Collaborations

The Liverpool GeneMill has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC) with an initial investment of £4 million to establish a facility for the rapid high throughput construction and testing of synthetic DNA constructs.

GeneMill provides undergraduate and postgraduate teaching in synthetic biology. We also offer consultancy and training to academics and industrial partners.

Contact

Please visit our website or contact us for further details.