NMR Centre for Structural Biology

The NMR Centre for Structural Biology is located in purpose-built accommodation adjacent to the Biosciences Building.

The facility

The Centre houses a 800 MHz, 700MHz, and 600 MHz solution-state spectrometer equipped with cryogenic probeheads, and two with autosample changers. There is also an associated computing laboratory in the Centre dedicated to data processing and analysis.

The Centre has an array of biophysical techniques that support the NMR methodology. These include:

  • Isothermal titration calorimetry
  • Surface plasmon resonance
  • Fluorimetry (plate reader and cuvette modes).

We also have considerable expertise in the production of highly purified recombinant proteins.

Our wide biological scope

Research in the Centre is supported by Biotechnology and Biological Sciences Research Council (BBSRC), British Heart Foundation, National Institute for Health Research, Wellcome Trust, and North-West Cancer Research. Particular strengths of the Centre are in:

  • Structural Biology
  • Metabolomics and biomarker identification
  • Screening of small molecule libraries

We focus on:

  • Structural biology of the extracellular matrix
  • Focal adhesion
  • Mitochondrial proteins involved in ageing
  • Neuronal calcium-binding and scaffold proteins
  • Amyloidogenic proteins and peptides.

There is a strong commitment in these projects to combine the structural studies with biological, chemical, and computational approaches. This will help understand molecular mechanisms and, where appropriate, develop small molecule inhibitors.

Collaborations

The Centre supports the extensive cross-disciplinary research at the University of Liverpool. Our projects are driven by colleagues from the University with interests in areas, such as, personalised medicine, parasite metabolism and tropical diseases, antibiotics and insecticide resistance, drug safety science, animal diseases, and animal feed development.

Contact

We welcome collaborations; should you wish to access the facilities in the Centre, please contact Professor Lu-Yun Lian (lu-yun.lian@liverpool.ac.uk) or visit the facility website for more information.