NMR Centre for Structural Biology

The NMR is a purpose built facility with particular strengths in structural Biology, screening of small molecule libraries and metabolomics and biomarker identification

The facility

The Centre houses a 800 MHz, 700MHz, and 600 MHz solution-state spectrometer equipped with cryogenic probeheads and autosample changers. There is also an associated computing laboratory in the Centre dedicated to data processing and analysis.

The Centre has an array of biophysical techniques that support the NMR methodology. These include:

  • Isothermal titration calorimetry
  • Surface plasmon resonance
  • Fluorimetry (plate reader and cuvette modes).

We also have considerable expertise in the production of highly purified recombinant proteins.

Our wide biological scope

Research in the Centre is supported by Biotechnology and Biological Sciences Research Council (BBSRC)British Heart FoundationNational Institute for Health ResearchWellcome Trust, and North-West Cancer Research. Particular strengths of the Centre are in:

  • Structural Biology
  • Metabolomics and biomarker identification
  • Screening of small molecule libraries

We focus on:

  • Structural biology of the extracellular matrix
  • Focal adhesion
  • Mitochondrial proteins involved in ageing
  • Neuronal calcium-binding and scaffold proteins
  • Amyloidogenic proteins and peptides.

There is a strong commitment in these projects to combine the structural studies with biological, chemical, and computational approaches. This will help understand molecular mechanisms and, where appropriate, develop small molecule inhibitors.

Collaborations

The Centre supports the extensive cross-disciplinary research at the University of Liverpool and also operates as a shared research facility under the Technology Directorate. Our projects are driven by colleagues from the University with interests in areas such as personalised medicine, parasite metabolism and tropical diseases, antibiotics and insecticide resistance, drug safety science, animal diseases and animal feed development.

Take a tour

Take a virtual tour of the facility

Visit the Centre website

For more information, visit the NMR website