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A new expert report published in The Lancet Infectious Diseases outlines a research and policy road map to tackle four neglected tropical diseases (NTDs) affecting millions in sub-Saharan Africa.
Led by Professor Louise Kelly-Hope and an international team of researchers, the report focuses on onchocerciasis, lymphatic filariasis, loiasis, and mansonellosis.
Onchocerciasis (river blindness) and lymphatic filariasis (a cause of lymphoedema) are already recognised by the World Health Organization as disabling and disfiguring NTDs. However, loiasis and mansonellosis remain overlooked, lacking official recognition and large-scale control efforts. The report highlights this gap and calls for more attention and action.
Over the next 5 to 10 years, the team recommends priorities such as mapping disease risk, expanding treatment coverage, improving surveillance, and strengthening clinical care. Broader themes include using data modelling to guide decisions, applying a One Health approach (linking human, animal, and environmental health), addressing complex challenges and emergencies, and building long-term sustainability.
These research priorities align with global health goals, including the WHO’s NTD road map and the UN Sustainable Development Goals.
Published as part of a Lancet Infectious Diseases Commission, an initiative that convenes experts to tackle urgent health challenges, the report reflects the work of a multidisciplinary team from Africa, Europe, and North America. These Commissions provide in-depth analysis and practical recommendations to guide policy, research, and global health action.
Read the full Lancet Infectious Diseases Commission: Vector-borne helminthiases: a road map for current and future research to support control and elimination in sub-Saharan Africa [DOI: 10.1016/S1473-3099(25)00084-2].
The Lancet Infectious Diseases has also published an accompanying profile on Professor Kelly-Hope, highlighting her leadership and long-standing contributions to global health and disease control and elimination.