CELT Pharmacology

The CELT pharmacology group bring to bear cutting-edge preclinical expertise to a diverse portfolio of projects. The team work closely with local, national, and international partners to better understand mechanisms that underpin clinical phenotypes and to translate new interventions through the preclinical and clinical challenges. The teams’ expertise spans in vitro, in vivo, bioanalytical and pharmacokinetic modelling capability that is harmonised to achieve maximum value for their projects.

Dr Emad Anaam

After graduating with MSc in laboratory diagnosis for studying the significance of in-vitro serum biomarkers in early diagnosis of ovarian cancer, Emad was awarded a PhD scholarship from the University of Liverpool to work on the in-vitro metabolic profiling of head and neck cancer cells. Emad joined CELT as a postdoctoral research associate in 2022 to work on a project that aims to develop methods for in-vitro release testing of Long-Acting injectables (LAIs) and seeks to progress a new approach combining LAIs and microarray patches (MAPS) to simplify the therapy of various chronic diseases.

Dr Usman Arshad

Usman obtained an MSc in Drug Discovery Skills from King’s College London and a BSc in Physiology and Pharmacology with Honours from UCLAN before He undertook his CRUK funded PhD at the University of Liverpool which focused on developing nanomedicines for metastatic cancers. In his role as a post-doctoral research associate within CELT, Usman conducted research on the LONGEVITY project and various COVID-19 projects.

Dr Jennifer Blaylock

Jen completed her PhD at the University of Aberdeen and has extensive experience conducting and managing biological research and clinical trials before undertaking a role as project manager for the LONGEVITY project - a multinational collaboration aiming to develop long-acting injectable medicines for malaria prophylaxis, TB prevention and HCV therapy that forms part of the CELT project portfolio. Jen’s previous experience includes biobanking, research governance, research quality management and overseeing large research study portfolios.

Helen Cox

Helen Cox has joined CELT as a full time Research Technician following a secondment with the group since October 2021. She has worked for the University of Liverpool since graduating with a BSc (Hons) in Anatomy & Human Biology in 1989, apart from a period of time in the late 1990s at Liverpool John Moores University where she completed a MPhil in muscle physiology under the supervision of Professor Dave Goldspink. Helen has gained experience, particularly in histology labs, in a wide variety of research settings including breast cancer, orthopaedics, herpes virology, lung cancer, anti-coagulant therapeutics, pancreatitis and women’s health.

Ian Crook

Ian joined CELT as a Project Officer, providing comprehensive support to senior members of the team, across a large portfolio of research projects and related activity. Prior to this role Ian had worked with a number of other areas across the University including the School of Medicine and Institute of Population Health.

Dr Paul Curley

Paul took up a role as a Research Fellow in the Department Pharmacology and Therapeutics to focus on the development and pharmacological assessment of novel long-acting therapeutics. He developed substantial experience with multiple in vitro, in vivo and in silico methods for the assessment of nanoparticle and small molecule drug delivery and became the lead researcher for bioanalysis and in vitro testing of long-acting therapeutics within CELT. This included the development and validation of bioanalytical methods for the quantitation of therapeutics, investigating drug uptake and toxicity utilising in vitro cell systems, and in vivo disposition of small molecule and nanoformulated antiretrovirals. Paul also gained expertise in physiologically-based pharmacokinetic (PBPK) modelling and utilised this skill to predict plasma and tissue distribution of standard and long-acting antiretroviral formulations prior to preclinical and ultimately clinical in vivo studies.

Joanne Herriott

Jo joined the CELT Pharmacology group to conduct work as a research technician. She previously worked for the Biomedical Services Unit for 21 years where she specialised in Containment Level 3 laboratory work.


Edyta Kijak

Edyta graduated in Animal Production at University of Technology and Agriculture in Bydgoszcz, Poland before working as a scientist at Aptuit (an Evotec company) in the Department of Pharmacology. Edyta previously worked as an animal technician at University of Liverpool and at Cancer Research UK before taking up a role as a research technician for CELT.

Julie Kivlin

Julie joined CELT as a Senior Finance Officer supporting the LONGEVITY project to provide comprehensive budget support to all LONGEVITY partners as well as detailed monitoring and reconciliation of complex budgets.  Prior to joining the University, Julie worked within a number of public and private sector companies assisting with the financial management of externally funded projects.

Dr Henry Pertinez

In his role as a pharmacometrician (specialist in analysis and mathematical modelling of quantitative pharmacological data), both pharmacokinetic and pharmacodynamic, Henry has conducted quantitative data analysis using various techniques such as compartmental and non-compartmental pharmacokinetic analysis, physiologically-based pharmacokinetic modelling (PBPK), deconvolution and population mixed effects analysis to provide insight into the meaning and interpretation of data, and for simulation and extrapolation of drug use scenarios. 

Dr Rajith Rajoli

Rajith obtained his PhD in Pharmacology from the University of Liverpool in 2017 before undertaking a role as a Research Fellow at CELT. As a pharmacometrician, he worked on design, validation, simulation, and dose optimisation of various chemical entities using physiologically-based pharmacokinetic (PBPK) models for various routes of administration. This work has been primarily in the therapeutic areas of HIV, TB, HCV, malaria and SARS-CoV-2. His research interests focus on improving the estimation capabilities of PBPK models to better inform drug pharmacokinetics. Rajith has authored over 30 peer reviewed publication in various journals, books and review manuscripts.

Dr Jo Sharp

Jo completed her PhD at The University of Manchester in 2010 focused on the virulence and gene expression of Aspergillus fumigatus and efficacy of antifungal drugs. She has managed a number of complex projects in her role as programme manager for CELT Pharmacology, and has over 10 years’ experience of preclinical models of infection. Jo has led the preclinical evaluation team investigating antiviral candidates against SARS-CoV2 and HIV as well as novel long-acting medicines for diseases such as malaria, TB and HCV.

Dr Lee Tatham

Lee completed his BSc in Microbiology before undertaking a PhD, investigating the antimicrobial efficacy and mode of action of solid drug nanoparticles. He held various postdoctoral positions focusing on the pharmacological assessment of novel nanoscale drug delivery systems and their application to HIV therapy. Lee has expertise in the development and application of pre-clinical models to assess the pharmacology and bio-distribution of drug-loaded nanoparticles for both oral and parenteral delivery. His research activities primarily focus on delivering the objectives of Tandem Nano Ltd. He has published a number of research articles and is co-inventor of patents relating to the application of nanotechnology to drug delivery.

Anthony Valentijn

After graduating from Monash University, Australia with a BSc (Hons) in Immunology, Anthony spent eight years working on hypertension, specifically the renin-angiotensin system. Anthony moved to the UK to work on the biology of the epithelia, covering development, apoptosis, stem cells and cancer. Anthony has over 25 years of experience in medical research and is an expert in 3D culture systems. He began working for CELT as a research technician to manage the day-to-day running of the CELT labs and provide technical support for his colleagues.

Shirl Wedgwood

Shirl was appointed as Senior Research Administrator at CELT to work on the LONGEVITY Project and provides administrative support to the management team and researchers. Prior to this, she was the senior clerical officer in the Biomedical Services Unit supporting the day to day Administration of the central office and the animal unit as well as providing administrative support to the Technical Staff and Researchers.

Lorraine is turned to the side bu smiling into the camera

Dr Lorraine Ralph

Lorraine obtained a BSc in Pharmacology from the University of Liverpool before completing a PhD in Population Pharmacokinetics using NONMEM at the University of Glasgow. After gaining over 20 years’ experience in industry, she returned to the University of Liverpool to work as a Pharmacometrician. Lorraine performs modelling and simulation using ‘R’ and Julia to support decision making and dose optimisation using a variety of techniques including compartmental analysis and physiologically-based pharmacokinetic modelling (PBPK).

Eduardo is smiling into the camera

Dr Eduardo Gallardo Toledo

Eduardo obtained his BSc in Biochemistry and an MSc in Biochemistry and Toxicology from Universidad de Chile before he was awarded a PhD scholarship from the Chilean Agencia Nacional de Investigación y Desarrollo to work on the development of nanomedicines for Alzheimer’s disease. He joined CELT as a post-doctoral research associate in 2021 to evaluate in situ forming implants (ISFIs) for the treatment of chronic disease. Currently, Eduardo conducts research on a project aiming to evaluate long-acting injectable (LAI) formulations to prevent and treat tuberculosis.

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