Photo of Professor Ian Prior

Professor Ian Prior

NWCR Professor of Molecular Oncology Molecular & Physiology Cell Signalling

    Research

    Mechanisms underpinning adaptive and acquired resistance to direct KRAS inhibitors

    The role of codon bias in KRAS oncogenicity

    Analysis of endogenous Ras isoform and mutation-specific signalling

    Research Grants

    Four year PhD Programme (2007)

    WELLCOME TRUST (UK)

    October 2007 - September 2011

    North West Cancer Research Bid

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    January 2018 - September 2023

    Improved Digital Imaging for Liverpool Biomedical Electron Microscopy

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    March 2019 - March 2020

    Kinomic reprogramming during clonal evolution and therapy resistance in chronic lymphocytic leukaemia

    LEUKA (UK)

    September 2018 - December 2020

    Wellcome Trust Four-Year PhD Studentship Programme

    WELLCOME TRUST (UK)

    October 2017 - March 2022

    Absolute quantitation of endogenous Ras isoform protein abundance: Does codon bias explain the predominance of KRAS mutations in cancer?

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    June 2018 - November 2020

    Translating discovery science: DUBs that regulate centrosome clustering, an Achilles' heel of cancer

    BREAST CANCER NOW (UK)

    October 2019 - September 2023

    Kinome profiling and mass cytometry as tools to detect rewiring of B cell receptor signalling in the malignant cells of chronic lymphocytic leukaemia patients taking ibrutinib

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    March 2019 - February 2022

    Wellcome Trust Four-year PhD Studentship 2016

    WELLCOME TRUST (UK)

    October 2016 - April 2021

    Development of novel multiplex single-colour Ras GTPase sensor to compare spatio-temporal features of ras signalling cascades with subcellular resolution.

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    August 2016 - August 2019

    The North West Cancer Bioinformatics Fellowship

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    October 2015 - September 2018

    Kinome reprogramming in response to activating KRAS mutations and Ras pathway therapeutics CASE

    ASTRAZENECA LIMITED (UK)

    October 2015 - September 2019

    Wellcome Trust Four-Year PhD Studentship with the Cellular and Molecular Physiology PhD Programme

    WELLCOME TRUST (UK)

    October 2015 - September 2019

    Liverpool 3View: a national hub for 3D-EM bioscience research

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2014 - December 2014

    Why are Ras isoforms not redundant? Characterising isoform-specific oncogenic Ras signalling networks

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    January 2015 - December 2017

    YEAR 1 (part2) Wellcome Trust ISSF Non-Clinical Fellowships

    WELLCOME TRUST (UK)

    October 2012 - December 2021

    Analysis of Ras isoform-specific signalling using RNAi.

    ROYAL SOCIETY (CHARITABLE)

    August 2005 - April 2006

    Analysis of endogenous isoform-specific Ras signalling: summer vacation studentship grant for Rebecca Lea

    BIOCHEMICAL SOCIETY (UK)

    June 2014 - August 2014

    Wellcome Trust Four Year PhD Studentship with the PhD Programme in Cellular and Molecular Physiology - 2009

    WELLCOME TRUST (UK)

    October 2009 - March 2014

    Analysis of Ras isoform-specific signalling.

    CANCER RESEARCH UK (CRUK) (UK)

    June 2006 - May 2008

    Establishment of an advanced electron microscopy unit.

    WELLCOME TRUST (UK)

    August 2004 - October 2009

    miRNA profiling in isogenic cell lines and contingencies on deubiquitinase activity

    CANCER RESEARCH UK (CRUK) (UK)

    April 2012 - March 2013

    Spatial regulation of signalling networks: analysis of Ras compartment-specific signalling

    WELLCOME TRUST (UK)

    March 2009 - March 2012

    Wellcome Trust four year PhD studentship with the Cellular and Molecular Physiology Programme

    WELLCOME TRUST (UK)

    October 2013 - September 2017

    Wellcome Trust Four Year PhD Studentship with the PhD Programme in Cellular and Molecular Physiology - 2010

    WELLCOME TRUST (UK)

    October 2010 - March 2015

    Liverpool Imaging Partnership: Molecular physiology and drug response

    MEDICAL RESEARCH COUNCIL (MRC)

    February 2013 - February 2017

    Characterising isoform-specific oncogenic KRAS4A and KRAS4B signalling

    NORTH WEST CANCER RESEARCH FUND

    January 2013 - December 2014

    Biomedical vacation scholarship for Alexandra Sheardown

    WELLCOME TRUST (UK)

    July 2012 - August 2012

    Analysis of cell cycle and signaling pathways by quantitative mass spectroscopy.

    CANCER RESEARCH UK (CRUK) (UK)

    September 2008 - August 2009

    Stretching the supply routes: ErbB2 gene amplification and endocytic recycling in metastatic breast cancer

    BREAST CANCER NOW (UK)

    January 2015 - January 2019

    Nanoscale analysis of signalling domains regulating Ras activity.

    NORTH WEST CANCER RESEARCH FUND

    February 2005 - February 2008

    Nanoscale characterisation of cell surface signalling domains.

    ROYAL SOCIETY

    October 2003 - September 2008

    Characterising the Bruton's kinase signaling nexus in leukaemia

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    September 2015 - September 2018

    SILAC analysis of compartment-specific Ras signalling

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    November 2009 - November 2012

    University of Liverpool Institutional Discipline Bridging.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2003 - October 2006

    Identifying and characterising negative regulators of oncogenic Ras signalling

    NORTH WEST CANCER RESEARCH FUND

    September 2008 - August 2011

    Characterising compartmentalised Ras isoform signalling.

    ROYAL SOCIETY

    October 2008 - September 2011

    Securing and enhancing Liverpool Biomedical EM cryo-preparation facilities

    WELLCOME TRUST (UK)

    July 2007 - June 2010

    Inter-microtubule bridges in kinetochore fibres of the mitotic spindle

    NORTH WEST CANCER RESEARCH FUND

    January 2013 - December 2015