Research
Mechanisms underpinning adaptive and acquired resistance to direct KRAS inhibitors
The role of codon bias in KRAS oncogenicity
Analysis of endogenous Ras isoform and mutation-specific signalling
Research grants
Creating an optimised toolkit for Ras network quantitation
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
August 2025 - January 2027
Liverpool array tomography: revitalising and strengthening the capabilities of a national hub for biomedical volume EM research (Liverpool AT: vEM)
MEDICAL RESEARCH COUNCIL
July 2024 - March 2025
A novel in vivo model for studying Ras-driven cancer
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
January 2022 - July 2025
A cellenONE BSC to enhance UK capability for single-cell proteomics
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
July 2022 - July 2023
Four year PhD Programme (2007)
WELLCOME TRUST (UK)
October 2007 - September 2011
North West Cancer Research Bid
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
January 2018 - September 2023
Improved Digital Imaging for Liverpool Biomedical Electron Microscopy
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
March 2019 - March 2020
Kinomic reprogramming during clonal evolution and therapy resistance in chronic lymphocytic leukaemia
LEUKA (UK)
September 2018 - December 2020
Wellcome Trust Four-Year PhD Studentship Programme
WELLCOME TRUST (UK)
October 2017 - March 2022
Absolute quantitation of endogenous Ras isoform protein abundance: Does codon bias explain the predominance of KRAS mutations in cancer?
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
June 2018 - November 2020
Translating discovery science: DUBs that regulate centrosome clustering, an Achilles' heel of cancer
BREAST CANCER NOW (UK)
October 2019 - March 2024
Kinome profiling and mass cytometry as tools to detect rewiring of B cell receptor signalling in the malignant cells of chronic lymphocytic leukaemia patients taking ibrutinib
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
March 2019 - September 2022
Wellcome Trust Four-year PhD Studentship 2016
WELLCOME TRUST (UK)
October 2016 - April 2021
Development of novel multiplex single-colour Ras GTPase sensor to compare spatio-temporal features of ras signalling cascades with subcellular resolution.
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
August 2016 - August 2019
The North West Cancer Bioinformatics Fellowship
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
October 2015 - September 2018
Kinome reprogramming in response to activating KRAS mutations and Ras pathway therapeutics CASE
ASTRAZENECA LIMITED (UK)
October 2015 - September 2019
Wellcome Trust Four-Year PhD Studentship with the Cellular and Molecular Physiology PhD Programme
WELLCOME TRUST (UK)
October 2015 - September 2019
Liverpool 3View: a national hub for 3D-EM bioscience research
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
January 2014 - December 2014
Why are Ras isoforms not redundant? Characterising isoform-specific oncogenic Ras signalling networks
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
January 2015 - December 2017
YEAR 1 (part2) Wellcome Trust ISSF Non-Clinical Fellowships
WELLCOME TRUST (UK)
October 2012 - March 2023
Analysis of Ras isoform-specific signalling using RNAi.
ROYAL SOCIETY (CHARITABLE)
August 2005 - April 2006
Analysis of endogenous isoform-specific Ras signalling: summer vacation studentship grant for Rebecca Lea
BIOCHEMICAL SOCIETY (UK)
June 2014 - August 2014
Wellcome Trust Four Year PhD Studentship with the PhD Programme in Cellular and Molecular Physiology - 2009
WELLCOME TRUST (UK)
October 2009 - March 2014
Analysis of Ras isoform-specific signalling.
CANCER RESEARCH UK (UK)
June 2006 - May 2008
Establishment of an advanced electron microscopy unit.
WELLCOME TRUST (UK)
August 2004 - October 2009
miRNA profiling in isogenic cell lines and contingencies on deubiquitinase activity
CANCER RESEARCH UK (UK)
April 2012 - March 2013
Spatial regulation of signalling networks: analysis of Ras compartment-specific signalling
WELLCOME TRUST (UK)
March 2009 - March 2012
Wellcome Trust four year PhD studentship with the Cellular and Molecular Physiology Programme
WELLCOME TRUST (UK)
October 2013 - September 2017
Wellcome Trust Four Year PhD Studentship with the PhD Programme in Cellular and Molecular Physiology - 2010
WELLCOME TRUST (UK)
October 2010 - March 2015
Liverpool Imaging Partnership: Molecular physiology and drug response
MEDICAL RESEARCH COUNCIL
February 2013 - February 2017
Characterising isoform-specific oncogenic KRAS4A and KRAS4B signalling
NORTH WEST CANCER RESEARCH FUND
January 2013 - December 2014
Biomedical vacation scholarship for Alexandra Sheardown
WELLCOME TRUST (UK)
July 2012 - August 2012
Analysis of cell cycle and signaling pathways by quantitative mass spectroscopy.
CANCER RESEARCH UK (UK)
September 2008 - August 2009
Stretching the supply routes: ErbB2 gene amplification and endocytic recycling in metastatic breast cancer
BREAST CANCER NOW (UK)
January 2015 - January 2019
Nanoscale analysis of signalling domains regulating Ras activity.
NORTH WEST CANCER RESEARCH FUND
February 2005 - February 2008
Nanoscale characterisation of cell surface signalling domains.
ROYAL SOCIETY
October 2003 - September 2008
Characterising the Bruton's kinase signaling nexus in leukaemia
NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)
September 2015 - September 2018
SILAC analysis of compartment-specific Ras signalling
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
November 2009 - November 2012
University of Liverpool Institutional Discipline Bridging.
MEDICAL RESEARCH COUNCIL
October 2003 - October 2006
Identifying and characterising negative regulators of oncogenic Ras signalling
NORTH WEST CANCER RESEARCH FUND
September 2008 - August 2011
Characterising compartmentalised Ras isoform signalling.
ROYAL SOCIETY
October 2008 - September 2011
Securing and enhancing Liverpool Biomedical EM cryo-preparation facilities
WELLCOME TRUST (UK)
July 2007 - June 2010
Inter-microtubule bridges in kinetochore fibres of the mitotic spindle
NORTH WEST CANCER RESEARCH FUND
January 2013 - December 2015