Research
Our research focuses on understanding the mechanisms that drive cellular stress responses and how these influence both beneficial and adverse effects of medicines. These responses include oxidative stress, the endoplasmic reticulum stress (unfolded protein) response, the DNA damage response, and autophagy.
Our goal is to harness the increasing understanding of these pathways to enhance the treatment of patients in several disease settings by improving the effectiveness of drugs while reducing their toxic side effects.
We aim to address the following questions:
- How do cells sense and respond to stress?
- Can we target stress responses therapeutically?
- Can cell stress responses warn us about unsafe medicines?
- Can we monitor the activity of stress response patients?
We have a particular interest in liver disease and drug-induced liver injury, and we work closely with the Human Liver Research Facility here in Liverpool. We welcome collaboration in other organ and disease areas.
Funders
Our key funders include: