About
You can find the lab on bluesky at emmottlab@bsky.social.
The lab's goal is the use and development of proteomic methods to study RNA virus replication and virus-host interactions, and in particular, the use and development of single-cell and other proteomic methods to aid in this research. The lab primarily works on (murine) norovirus and coronaviruses including SARS-CoV-2. We are particularly interested in the role viral and cellular substrates of viral proteases play in the viral life cycle, for example cellular substrates of the SARS-CoV-2 proteases Meyer et al. 2021, and the role of precursor forms of the norovirus protease during infection (Emmott et al. 2019).
We also apply our proteomics expertise to support other groups working on different questions. Currently we are part of two LifeArc/CF Trust consortia working with clinical samples from people living with cystic fibrosis - a long-running collaboration with Manchester and Alder Hey, and a collaboration with Chulalongkorn/LSTM on snake venom proteomics.
We are very grateful to our funders. Since November 2019, the lab has been supported by ~£4m funding as PI and a further ~£16m of collaborative funding.
Current lab members:
PhD Students:
Charlotte Duncan
Jessica Coomber
Patchara Sittishivapark
Markella Loi
Henry Steele-Childe
Trinity Bakshi
PDRAs:
Leandro Neves
Frazer Buchanan
Rebee Penrice-Randal
Max Erdmann
Rosie Maher
Consulting:
Ed can consult on:
- single-cell proteomics
- mass spectrometry-based proteomics
- virology, especially calicivirus (e.g. norovirus)/coronavirus biology
Prizes or Honours
- Deans Excellence - Research Award (University of Liverpool/ISMIB, 2023)
- Tandem Mass Tag Research Award (Thermo Scientific, 2018)
Funded Fellowships
- Wellcome Career Development Award (Wellcome Trust, 2024 - 2031)