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About

The labs goal is the use and development of proteomic methods to study RNA virus replication and virus-host interactions, and in particular the use and development of single-cell proteomic methods to aid in this research. The lab primarily works on (murine) norovirus and SARS-CoV-2. We are particularly interested in the role (viral and cellular) substrates of viral proteases play in the viral life cycle, for example cellular substrates of the SARS-CoV-2 proteases Meyer et al. 2021, and the role of precursor forms of the norovirus protease during infection (Emmott et al. 2019).

We also apply our proteomics expertise to support other groups working on different questions, currently on clinical samples from people living with cystic fibrosis, and snake venom proteomics.

Current lab members:
PhD Students:
Stephen Holmes
Charlotte Duncan
Jessica Coomber
Patchara Sittishivapark

PDRAs:
Leandro Neves
Frazer Buchanan
Rebee Penrice-Randal
Max Erdmann
I’ah Donovan-Banfield

Consulting:
Ed can consult on:
- single-cell proteomics
- mass spectrometry-based proteomics
- virology, especially calicivirus (e.g. norovirus)/coronavirus biology

Recruiting:
Currently the lab is in the happy position we are full and not looking to recruit! We are not expecting to take on further lab members prior to ~Oct 2025.

Prior history:
Prior to establishing his research group, Ed was a Postdoc in Nikolai Slavov’s lab, part of the Department of Bioengineering and the Barnett Institute for Chemical and Biological Analysis at Northeastern University. His postdoctoral research with Nikolai involved the study of ribosome heterogeneity and the immune response, as well as the development and application of single cell proteomic methods (SCoPE-MS/SCoPE2). Prior to joining Nikolai’s lab, Ed was a postdoc in Ian Goodfellow’s lab in the Department of Pathology at the University of Cambridge and Imperial College London where he studied norovirus replication and virus-host interactions, becoming particularly interested in the role of the viral protease, and polyprotein processing. His PhD was at the University of Leeds under the supervision of Julian Hiscox with his thesis on ‘High-throughput proteomic analysis of the interactions of avian coronavirus and its nucleocapsid with the host cell’. His Bachelors was from the University of Warwick in Medical Microbiology & Virology where his undergraduate research on Adenovirus interactions with PML bodies was supervised by Keith Leppard.

Prizes or Honours

  • Deans Excellence - Research Award (University of Liverpool/ISMIB, 2023)
  • Tandem Mass Tag Research Award (Thermo Scientific, 2018)

Funded Fellowships

  • Wellcome Career Development Award (Wellcome Trust, 2024 - 2031)