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Research

My lab is interested in the study of virus-host interactions and virus replication for RNA viruses, especially where the replication of these viruses is governed by proteolytic cleavage and the impact of viral proteases on the host cell. These include the coronaviruses and noroviruses. We develop and apply mass spectrometry-based proteomic methods in support of this research. An example would be the development and application of single-cell proteomics by mass spectrometry methods, having helped develop the SCoPE2 carrier/reference approach being adopted internationally across different single-cell proteomics approaches. The ultimate goal of our research is to identify and characterize virus-host interactions and replication mechanisms that can be targeted to inhibit virus replication as an antiviral strategy.

RNA virus replication & Single-cell proteomics

Viral proteases and their targets

Proteomics methods development

Research grants

CF- TRAILFINDER (CF- TRAILFINDER)

CYSTIC FIBROSIS TRUST (UK)

November 2024 - October 2029

Enabling Population-Scale Genomics insights using high-throughput, robotic liquid handling at the Centre for Genomic Research

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

August 2024 - July 2025

Coronaviruses: linking polyprotein processing and replication complex function’

WELLCOME TRUST (UK)

December 2023 - March 2032

NovaseqX at Centre for Genomics Research

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

August 2023 - July 2024

Analysis of biomarkers to complement wearable technology

DEFENCE SCIENCE & TECHNOLOGY LABORATORY (UK)

February 2023 - September 2025

Uncovering cellular substrates of 3C-like proteases to identify conserved virus-host interactions as antiviral targets

MEDICAL RESEARCH COUNCIL

November 2022 - November 2025

A cellenONE BSC to enhance UK capability for single-cell proteomics

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2022 - July 2023

REIMS Proof of Concept - Age Grading Mosquitoes

INNOVATIVE VECTOR CONTROL CONSORTIUM (IVCC) - (UK)

April 2021 - December 2022

The utility of sputum proteomics to test response to CFTR modulator therapy

NORTH WEST LUNG CENTRE CHARITY (UK)

January 2022 - January 2024

Understanding proteolytic cleavage of host proteins during avian coronavirus infection

HOUGHTON TRUST (UK)

October 2021 - September 2022

COVID-19: Molecular mapping of SARS-Cov2 and the host response with multiomics mass spectrometry to stratify disease outcomes for therapeutic and diagnostic interventions.

UK RESEARCH AND INNOVATION

October 2020 - April 2022

Investigating the role of GOLGA3 cleavage during SARS-CoV-2 infection

ROYAL SOCIETY

March 2021 - March 2022

Exploiting and advancing single-cell proteomics to identify novel pathways to disrupt RNA virus infection.

THE ACADEMY OF MEDICAL SCIENCES (UK)

May 2021 - May 2024

Ultra-sensitive Proteomics Platform

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

August 2020 - August 2021