Marie Yang

Background

I completed a BSc degree with a major in Neurosciences, followed by an MSc in Immunology (Marseille, France). I graduated with a Ph.D. in Food Science (peptide-Immunotherapy in allergy) at the University of Guelph, Ontario, Canada, in the research group of Prof. Yoshinori Mine. I then worked in the laboratory of Dr Yihong Wan as a postdoctoral researcher in the Department of Pharmacology at the UT Southwestern Medical Center, Dallas, Texas on the topic of lipid-mediated inflammation. I was subsequently recruited to the research group of Dr Ed Lavelle, School of Biochemistry and Immunology, Trinity College Dublin, to explore the vaccine applications of nanoparticulate materials. In April 2012, my genuine interest in oral pathogens brought me to join the group of Prof. Aras Kadioglu. 

Current Research

My broad interest lies in advancing the current understanding of vertebrate immunology, whether in the context of metabolic or infectious disorders, with the ultimate goal of developing novel therapeutic strategies. As such, I have been fortunate enough to work in various institutions on diverse aspects of the immune response. Since I started my employment at the University of Liverpool, Institute of Infection and Global Health, I have been involved in multiple research projects with a particular focus on the innate immune recognition of S. pneumoniae, and the development of novel in vivo models for pneumococcal meningitis.

Publications

Jin Z, Wei W, Yang M, Du Y, Wan Y. Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab. 2014 Sep 2;20(3):483-98. doi: 10.1016/j.cmet.2014.07.011.

Meraz IM, Hearnden CH, Liu X, Yang M, Williams L, Savage DJ, Gu J, Rhudy JR, Yokoi K, Lavelle EC, Serda RE. Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes. PLoS One. 2014 Apr 15;9(4):e94703. doi: 10.1371/journal.pone.0094703.

Yang M, Flavin K, Kopf, Radics G, McManus GJ, Moran B, Villalta-Cerdas A, Hearnden CHA, Echegoyen LA, Giordani S, Lavelle EC.  Chemical surface functionalization of carbon nanoparticles modulates inflammatory cell recruitment and NLRP3 inflammasome activation. Small. 2013. doi: 10.1002/smll.201300481. 

Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A, Wan Y. Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. Nat Commun. 2012;3:1008. PMID: 22910354

Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y. Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes Dev. 2012 Jun 15;26(12):1306-11. PMID: 22713870

Wei W, Wang X, Yang M, Smith LC, Dechow PC, Sonoda J, Evans RM, Wan Y. PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab 2010 Jun 9;11(6):503-16. PMID: 20519122

Yang M and Mine Y. Administration of T-cell epitope cocktail of major food allergen coincide with upregulation of TGF-β and FOXp3 local expression. Clin Exp Allergy. 2010 Jun 9;11(6):503-16. PMID: 20082619

Yang M, Yang C, Nau F, Pasco M, Juneja LR, Okubo T, and Mine Y. Immunomodulatory effects of egg white enzymatic hydrolysates containing immunodominant epitopes in a BALB/c mouse model of egg allergy. J Agric Food Chem. 2009 Mar 25;57(6):2241-8. PMID: 19231857

Yang M and Mine Y. Identification of novel T-cell determinants of hen ovalbumin in BALB/c mice. Biochem Biophys Res Comm. 2009 Jan 9;378(2):203-8. PMID: 19022223

Mine Y. and Yang M. Recent advances in the understanding of egg allergens: basic, industrial, and clinical perspectives. J Agric Food Chem. 2008 Jul; 56(13): 4874-900. PMID: 18543935

HobsonD.J., Rupa P., Diaz G. J., Zhang H., YangM., MineY., Turner P.V. and Kirby G. M. Proteomic analysis of ovomucoid hypersensitivity in mice by two-dimensional difference gel electrophoresis (2D-DIGE). Food Chemical Toxicol. 2007 Dec;45(12): 2372-80. PMID: 17897766

Mine Y. and Yang M. Epitope characterization of ovalbumin in BALB/c mice using different entry routes. Biochim Biophys Acta. 2007 Feb; 1774(2): 200-12. PMID: 17236828

Blog series for Meningitis Now:

https://www.meningitisnow.org/support-us/news-centre/news-stories/meet-researcher/

https://www.meningitisnow.org/support-us/news-centre/news-stories/my-road-pneumococcus-and-meningitis/

https://www.meningitisnow.org/support-us/news-centre/news-stories/laboratory-life-dull-not-bit-it/

https://www.meningitisnow.org/support-us/news-centre/news-stories/why-our-research-important/