The EATC4Children supports the development of scientists and clinical trainees. Current PhD and MRes student projects include:
Investigating the role of stem cells in JIA
We are interested in understanding how stem cells behave in inflammatory diseases such as juvenile idiopathic arthritis. We are investigating if the stem cells contribute to the onset or progression of disease and how their ability to repair joint tissues are affected by it. The results from our research will provide insights into how stem cells can be used in the future to develop new treatment options.
(PhD project, Supervisors: A. Midgley and R. Oldershaw)
Investigation into the expression and function of S100 proteins and non-coring RNAs in the urine and serum of JSLE patients (as part of Masterplans)
There is an urgent need for biomarkers in chronic disease such as JSLE, as it is often difficult to diagnose and children can spend many years on medications with long-lasting side effects. The aim of this project is to assess the use of S100 proteins detected in JSLE patients and to evaluate the use of circulating ncRNAs as potential biomarkers and uncover previously unknown pathomechanisms which could reveal novel therapeutic targets.
(PhD student project, Supervisors: M. Beresford, C. Hedrich, A. Midgley)
Investigation into the effect of calprotectin on a model of lupus nephritis
Looking at the effects of calprotectin (a protein found increased in the urine of lupus nephritis patients) on native kidney cells. This will help us to understand how kidney cells are damaged in lupus nephritis and potentially identify new avenues for treatments.
(MRes student project, Supervisors: M. Beresford and R. Wright)