2024
Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (n.d.). Patients with <scp>naproxen‐induced</scp> liver injury display T‐cell memory responses toward an oxidative (S)‐<scp>O‐Desmethyl</scp> Naproxen metabolite but not the acyl glucuronide. Allergy. doi:10.1111/all.15830DOI: 10.1111/all.15830
Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide (Conference Paper)
Thomson, P., Fragkas, N., Kafu, L. M., Aithal, G. P., Lucena, M. I., Terracciano, L., . . . Naisbitt, D. J. (2023). Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronide. In ALLERGY. doi:10.1111/all.15830DOI: 10.1111/all.15830
2023
Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism (Journal article)
Cai, W., Chvanov, M., Awais, M., Meng, X., Latawiec, D., Brown, J., . . . Sutton, R. (2023). Sodium valproate causes pancreatic injury in vitro and in vivo via dysregulation of one carbon metabolism. Pancreatology, 23, e20-e21. doi:10.1016/j.pan.2023.06.453DOI: 10.1016/j.pan.2023.06.453
Zhang, Y., Grice, S., Wang, N., Liu, Y., Zhao, Q., Liu, T., . . . Zhang, F. (2023). HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp. CLINICAL AND EXPERIMENTAL DERMATOLOGY. doi:10.1093/ced/llad282DOI: 10.1093/ced/llad282
Ogese, M. O., Lister, A., Farrell, L., Gardner, J., Kafu, L., Ali, S. -E., . . . Naisbitt, D. J. (2023). A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment. TOXICOLOGICAL SCIENCES. doi:10.1093/toxsci/kfad101DOI: 10.1093/toxsci/kfad101
Line, J., Saville, E., Meng, X., & Naisbitt, D. (2023). Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions. FRONTIERS IN TOXICOLOGY, 5. doi:10.3389/ftox.2023.1268107DOI: 10.3389/ftox.2023.1268107
Thomson, P., Hammond, S., Meng, X., & Naisbitt, D. J. (n.d.). What’s been Hapten-ing over the last 88 years?. Medicinal Chemistry Research. doi:10.1007/s00044-023-03091-1DOI: 10.1007/s00044-023-03091-1
Almutairi, M., Lister, A., Zhao, Q., Line, J., Adair, K., Tailor, A., . . . Naisbitt, D. J. (2023). Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides.. Journal of immunology (Baltimore, Md. : 1950), 210(8), 1031-1042. doi:10.4049/jimmunol.2200531DOI: 10.4049/jimmunol.2200531
Ali, S. -E., Meng, X., Kafu, L., Hammond, S., Zhao, Q., Ogese, M., . . . Naisbitt, D. J. (2023). Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System. CHEMICAL RESEARCH IN TOXICOLOGY, 36(3), 390-401. doi:10.1021/acs.chemrestox.2c00343DOI: 10.1021/acs.chemrestox.2c00343
Ali, S. -E., Waddington, J. C., Lister, A., Sison-Young, R., Jones, R. P., Rehman, A. H., . . . Meng, X. (2023). Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. TOXICOLOGICAL SCIENCES, 192(1), 106-116. doi:10.1093/toxsci/kfad015DOI: 10.1093/toxsci/kfad015
Hammond, S., Meng, X., Mosedale, M., & Naisbitt, D. J. (2023). Activation of tolvaptan-responsive T-cell clones with the structurally-related mozavaptan. Toxicology Letters, 373, 148-151. doi:10.1016/j.toxlet.2022.11.017DOI: 10.1016/j.toxlet.2022.11.017
2022
Ariza, A., Jaruthamsophon, K., Meng, X., Labella, M., Adair, K., Tailor, A., . . . Naisbitt, D. J. (2022). Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 35(11), 2122-2132. doi:10.1021/acs.chemrestox.2c00231DOI: 10.1021/acs.chemrestox.2c00231
Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144DOI: 10.1093/toxsci/kfab144
2021
Zhao, Q., Almutairi, M., Tailor, A., Lister, A., Harper, N., Line, J., . . . Naisbitt, D. J. (2021). HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2412-+. doi:10.1016/j.jid.2021.03.014DOI: 10.1016/j.jid.2021.03.014
Adair, K., Meng, X., & Naisbitt, D. J. (2021). Drug hapten-specific T-cell activation: Current status and unanswered questions. PROTEOMICS, 21(17-18). doi:10.1002/pmic.202000267DOI: 10.1002/pmic.202000267
Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: <i>In Vitro</i> Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084DOI: 10.1093/toxsci/kfab084
Thomson, P. J., Kafu, L., Meng, X., Snoeys, J., De Bondt, A., De Maeyer, D., . . . Naisbitt, D. J. (2021). Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat. ALLERGY, 76(6), 1825-1835. doi:10.1111/all.14652DOI: 10.1111/all.14652
Yip, V. L. M., Pertinez, H., Meng, X., Maggs, J. L., Carr, D. F., Park, B. K., . . . Pirmohamed, M. (2021). Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2572-2588. doi:10.1111/bcp.14667DOI: 10.1111/bcp.14667
Amporndanai, K., Meng, X., Shang, W., Jin, Z., Zhao, Y., Rao, Z., . . . Rogers, M. (2021). Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23313-7DOI: 10.1038/s41467-021-23313-7
In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs (Journal article)
Naisbitt, D. (2021). In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Frontiers in Immunology. doi:10.3389/fimmu.2021.630530DOI: 10.3389/fimmu.2021.630530
2020
Waddington, J. C., Ali, S. -E., Penman, S. L., Whitaker, P., Hamlett, J., Chadwick, A., . . . Meng, X. (2020). Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(12), 2939-2943. doi:10.1021/acs.chemrestox.0c00400DOI: 10.1021/acs.chemrestox.0c00400
Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646DOI: 10.4049/jimmunol.2000646
Tailor, A., Meng, X., Adair, K., Farrell, J., Waddington, J. C., Daly, A., . . . Naisbitt, D. J. (2020). HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts. TOXICOLOGICAL SCIENCES, 178(1), 115-126. doi:10.1093/toxsci/kfaa128DOI: 10.1093/toxsci/kfaa128
Ariza, A., Fernandez-Santamaria, R., Meng, X., Salas, M., Ogese, M. O., Tailor, A., . . . Naisbitt, D. J. (2020). Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity. ALLERGY, 75(10), 2562-2573. doi:10.1111/all.14298DOI: 10.1111/all.14298
Waddington, J. C., Meng, X., Illing, P. T., Tailor, A., Adair, K., Whitaker, P., . . . Park, B. K. (2020). Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation. TOXICOLOGICAL SCIENCES, 177(2), 454-465. doi:10.1093/toxsci/kfaa124DOI: 10.1093/toxsci/kfaa124
Safety perspectives on presently considered drugs for the treatment of COVID‐19 (Journal article)
Penman, S. L., Kiy, R. T., Jensen, R. L., Beoku‐Betts, C., Alfirevic, A., Back, D., . . . Chadwick, A. E. (n.d.). Safety perspectives on presently considered drugs for the treatment of COVID‐19. British Journal of Pharmacology. doi:10.1111/bph.15204DOI: 10.1111/bph.15204
Meng, X., Waddington, J. C., Tailor, A., Lister, A., Hamlett, J., Berry, N., . . . Sporn, M. B. (2020). CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1. JOURNAL OF MEDICINAL CHEMISTRY, 63(17), 9965-9976. doi:10.1021/acs.jmedchem.0c01088DOI: 10.1021/acs.jmedchem.0c01088
Naisbitt, D. J., Olsson-Brown, A., Gibson, A., Meng, X., Ogese, M. O., Tailor, A., & Thomson, P. (2020). Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions. ALLERGY, 75(4), 781-797. doi:10.1111/all.14127DOI: 10.1111/all.14127
Ali, S. -E., Waddington, J. C., Park, B. K., & Meng, X. (2020). Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 33(1), 61-76. doi:10.1021/acs.chemrestox.9b00275DOI: 10.1021/acs.chemrestox.9b00275
2019
Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology, 70(5), 1732-1749. doi:10.1002/hep.30701DOI: 10.1002/hep.30701
Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo (Journal article)
Tailor, A., Waddington, J. C., Hamlett, J., Maggs, J., Kafu, L., Farrell, J., . . . Meng, X. (2019). Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 32(10), 2095-2106. doi:10.1021/acs.chemrestox.9b00282DOI: 10.1021/acs.chemrestox.9b00282
Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01 (Journal article)
Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01. Allergy, 74(8), 1533-1548. doi:10.1111/all.13769DOI: 10.1111/all.13769
Alhilali, K. A., Al-Attar, Z., Gibson, A., Tailor, A., Meng, X., Monshouwer, M., . . . Naisbitt, D. J. (2019). Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers. TOXICOLOGICAL SCIENCES, 168(2), 597-609. doi:10.1093/toxsci/kfz007DOI: 10.1093/toxsci/kfz007
Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions (Conference Paper)
Waddington, J., Meng, X., Illing, P., Tailor, A., Jenkins, R., Purcell, A., . . . Park, B. (2019). Beta-lactam protein binding leads to the presentation of novel MHC peptides, generating a potential immunogen for drug-hypersensitive reactions. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 176 (pp. 3004-3005). Retrieved from https://www.webofscience.com/
2018
HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors (Journal article)
Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163DOI: 10.1021/acs.chemrestox.8b00163
Waddington, J. C., Meng, X., Naisbitt, D. J., & Park, B. K. (2018). Immune drug-induced liver disease and drugs. Current Opinion in Toxicology, 10, 46-53. doi:10.1016/j.cotox.2017.12.006DOI: 10.1016/j.cotox.2017.12.006
Mechanisms leading to T-cell activation in drug hypersensitivity (Journal article)
Meng, X., Yerly, D., & Naisbitt, D. J. (2018). Mechanisms leading to T-cell activation in drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 317-324. doi:10.1097/ACI.0000000000000458DOI: 10.1097/ACI.0000000000000458
Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017) (Journal article)
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020DOI: 10.4049/jimmunol.1800020
2017
Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. doi:10.1021/acs.chemrestox.7b00291DOI: 10.1021/acs.chemrestox.7b00291
Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors. (Journal article)
Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263DOI: 10.1021/acs.chemrestox.7b00263
Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R., Marlot, P., Marson, A., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. Chemical Research in Toxicology, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063DOI: 10.1021/acs.chemrestox.7b00063
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.. Journal of Immunology, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209DOI: 10.4049/jimmunol.1700209
Amali, M. O., Sullivan, A., Jenkins, R. E., Farrell, J., Meng, X., Faulkner, L., . . . Naisbitt, D. J. (2017). Detection of drug-responsive B lymphocytes and antidrug IgG in patients with β-lactam hypersensitivity. ALLERGY, 72(6), 896-907. doi:10.1111/all.13087DOI: 10.1111/all.13087
Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218DOI: 10.1093/toxsci/kfw218
Meng, X., Ariza, A., Waddington, J., Park, K., & Naisbitt, D. (2016). Immunological Mechanisms of Drug Hypersensitivity. CURRENT PHARMACEUTICAL DESIGN, 22(45), 6734-6747. doi:10.2174/1381612822666161003115103DOI: 10.2174/1381612822666161003115103
Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333DOI: 10.1021/acs.chemrestox.6b00333
2016
Tailor, A., Waddington, J. C., Meng, X., & Park, B. K. (2016). Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 1912-1935. doi:10.1021/acs.chemrestox.6b00147DOI: 10.1021/acs.chemrestox.6b00147
Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with <i>HLA</i>-<i>DRB1</i>*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400DOI: 10.1021/acs.chemrestox.6b00400
A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity (Presentation material)
Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.
Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393DOI: 10.1021/acs.chemrestox.6b00393
Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253DOI: 10.1021/acs.chemrestox.6b00253
7th drug hypersensitivity meeting: part one (Journal article)
Carr, D. F., Chung, W. -H., Jenkiins, R. E., Chaponda, M., Nwikue, G., Cornejo Castro, E. M., . . . Ruano, F. J. (2016). 7th drug hypersensitivity meeting: part one. Clinical and Translational Allergy, 6(S3). doi:10.1186/s13601-016-0121-zDOI: 10.1186/s13601-016-0121-z
2015
Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036DOI: 10.1016/j.jaci.2015.02.036
Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin (Journal article)
Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. Chemical Research in Toxicology, 28(1), 51-58. doi:10.1021/tx500285kDOI: 10.1021/tx500285k
Ogese, M. O., Jenkins,, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase. Chemical Research in Toxicology, 28(1), 144-154. doi:10.1021/tx500458kDOI: 10.1021/tx500458k
2014
Abacavir forms novel cross-linking abacavir protein adducts in patients (Journal article)
Meng, X., Lawrenson, A., Berry, N., Maggs, J., French, N., Back, D., . . . Park, K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Clinical and translational allergy, 4(Suppl 3), P38. doi:10.1186/2045-7022-4-s3-p38DOI: 10.1186/2045-7022-4-s3-p38
Antigen exposure required for T cell activation (Journal article)
Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-s3-p115DOI: 10.1186/2045-7022-4-s3-p115
Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis (Journal article)
Amali, M., Sullivan, A., Farrell, J., Meng, X., Jenkins, R., Whitaker, P., . . . Naisbitt, D. J. (2014). Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis. Clinical and translational allergy, 4(Suppl 3), P113. doi:10.1186/2045-7022-4-s3-p113DOI: 10.1186/2045-7022-4-s3-p113
Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury (Journal article)
Usui, T., Saide, K., Meng, X., Whitaker, P., Peckham, D., French, N., . . . Park, K. (2014). Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury. Clinical and translational allergy, 4(Suppl 3), P116. doi:10.1186/2045-7022-4-s3-p116DOI: 10.1186/2045-7022-4-s3-p116
Abacavir forms novel cross-linking abacavir protein adducts in patients (Journal article)
Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Chemical Research in Toxicology, 27(04), 524-535. doi:10.1021/tx400406pDOI: 10.1021/tx400406p
Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity (Journal article)
Yip, V., Maggs, J., Meng, X., Marson, A., Park, K., & Pirmohamed, M. (2014). Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity. LANCET, 383, 114. Retrieved from https://www.webofscience.com/
Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein (Journal article)
Monrad, R. N., Errey, J. C., Barry, C. S., Iqbal, M., Meng, X., Iddon, L., . . . Davis, B. G. (2014). Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein. CHEMICAL SCIENCE, 5(10), 3789-3794. doi:10.1039/c4sc01329hDOI: 10.1039/c4sc01329h
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients (Journal article)
Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079DOI: 10.1124/jpet.114.215079
The importance of hapten - protein complex formation in the development of drug allergy (Journal article)
Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078DOI: 10.1097/ACI.0000000000000078
2013
β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)
Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124mDOI: 10.1021/tx400124m
Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides. (Journal article)
Stachulski, A. V., & Meng, X. (2013). Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.. Natural product reports, 30(6), 806-848. doi:10.1039/c3np70003hDOI: 10.1039/c3np70003h
Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)
Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107DOI: 10.1021/tx4000107
2012
Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)
El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900DOI: 10.1124/jpet.111.190900
2011
In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin (Journal article)
Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, J. G., . . . Park, B. K. (2011). In vitro assessment of the interactions between diclofenac and tolmetin acyl glucuronide drug metabolites and human serum albumin. Toxicology, 290(2-3), 142-143. doi:10.1016/j.tox.2011.09.072DOI: 10.1016/j.tox.2011.09.072
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871DOI: 10.1124/jpet.111.183871
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871DOI: 10.1124/jpet.111.183871
Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis (Journal article)
Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis. J Immunol, 187(1), 200-211.
2010
Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites (Journal article)
Hammond, T. G., Regan, S. L., Meng, X., Maggs, J. L., Jenkins, R. E., Kenna, G. L., . . . Park, B. K. (2010). Protein binding and pharmacokinetics of reactive acyl glucuronide drug metabolites. Toxicology, 278(3), 357-358. doi:10.1016/j.tox.2010.08.108DOI: 10.1016/j.tox.2010.08.108
High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma. (Journal article)
Karlsson, E. S., Johnson, C. H., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.. Rapid communications in mass spectrometry : RCM, 24(20), 3043-3051. doi:10.1002/rcm.4740DOI: 10.1002/rcm.4740
Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides. (Journal article)
Johnson, C. H., Karlsson, E., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.. Xenobiotica; the fate of foreign compounds in biological systems, 40(1), 9-23. doi:10.3109/00498250903348720DOI: 10.3109/00498250903348720
2009
Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i> (Journal article)
Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222DOI: 10.1002/prca.200800222
Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide (Journal article)
Jones, A. E., Wilson, H. K., Meath, P., Meng, X., Holt, D. W., Johnston, A., . . . Stachulski, A. V. (2009). Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide. Tetrahedron Letters, 50(35), 4973-4977. doi:10.1016/j.tetlet.2009.06.060DOI: 10.1016/j.tetlet.2009.06.060
Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-<i>O</i>-acyl glucuronides (Journal article)
Berry, N. G., Iddon, L., Iqbal, M., Meng, X., Jayapal, P., Johnson, C. H., . . . Stachulski, A. V. (2009). Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-<i>O</i>-acyl glucuronides. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2525-2533. doi:10.1039/b822777bDOI: 10.1039/b822777b
2008
Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions. (Journal article)
Johnson, C. H., Athersuch, T. J., Wilson, I. D., Iddon, L., Meng, X., Stachulski, A. V., . . . Nicholson, J. K. (2008). Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.. Analytical chemistry, 80(13), 4886-4895. doi:10.1021/ac702614tDOI: 10.1021/ac702614t
2007
Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis. (Journal article)
Meng, X., Maggs, J. L., Pryde, D. C., Planken, S., Jenkins, R. E., Peakman, T. M., . . . Stachulski, A. V. (2007). Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.. Journal of medicinal chemistry, 50(24), 6165-6176. doi:10.1021/jm0706766DOI: 10.1021/jm0706766
Investigation of the immunogenicity of diclofenac and diclofenac metabolites (Journal article)
Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014DOI: 10.1016/j.toxlet.2006.10.014
2004
Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac. (Journal article)
Kenny, J. R., Maggs, J. L., Meng, X., Sinnott, D., Clarke, S. E., Park, B. K., & Stachulski, A. V. (2004). Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.. Journal of medicinal chemistry, 47(11), 2816-2825. doi:10.1021/jm030891wDOI: 10.1021/jm030891w
