Dr Xiaoli Meng Ph.D.

Research associate Molecular and Clinical Pharmacology

    Publications

    2019

    Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers (Journal article)

    Alhilali, K. A., Al-Attar, Z., Gibson, A., Tailor, A., Meng, X., Monshouwer, M., . . . Naisbitt, D. J. (2019). Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers. TOXICOLOGICAL SCIENCES, 168(2), 597-609. doi:10.1093/toxsci/kfz007

    DOI: 10.1093/toxsci/kfz007

    Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01. (Journal article)

    Zhao, Q., Alhilali, K., Alzahrani, A., Almutairi, M., Amjad, J., Liu, H., . . . Naisbitt, D. J. (2019). Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01.. Allergy, 74(8), 1533-1548. doi:10.1111/all.13769

    DOI: 10.1111/all.13769

    Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system. (Journal article)

    Ogese, M. O., Jenkins, R. E., Adair, K., Tailor, A., Meng, X., Faulkner, L. L., . . . Betts, C. (2019). Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.. Hepatology (Baltimore, Md.). doi:10.1002/hep.30701

    DOI: 10.1002/hep.30701

    2018

    Analysis of drug-protein adducts and their role in drug hypersensitivity. (Thesis / Dissertation)

    Tailor, A. A. (2018, September 25). Analysis of drug-protein adducts and their role in drug hypersensitivity..

    Definition of the nature and hapten threshold of the beta-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017) (Journal article)

    Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the beta-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020

    DOI: 10.4049/jimmunol.1800020

    HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors (Journal article)

    Usui, T., Tailor, A., Faulkner, L., Meng, X., Farrell, J., Daly, A. K., . . . Naisbitt, D. J. (2018). HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 31(10), 1022-1024. doi:10.1021/acs.chemrestox.8b00163

    DOI: 10.1021/acs.chemrestox.8b00163

    Immune drug-induced liver disease and drugs (Journal article)

    Waddington, J. C., Meng, X., Naisbitt, D. J., & Park, B. K. (2018). Immune drug-induced liver disease and drugs. Current Opinion in Toxicology, 10, 46-53. doi:10.1016/j.cotox.2017.12.006

    DOI: 10.1016/j.cotox.2017.12.006

    Mechanisms leading to T-cell activation in drug hypersensitivity (Journal article)

    Meng, X., Yerly, D., & Naisbitt, D. J. (2018). Mechanisms leading to T-cell activation in drug hypersensitivity. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 317-324. doi:10.1097/ACI.0000000000000458

    DOI: 10.1097/ACI.0000000000000458

    2017

    Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts (Journal article)

    Amali, M. O., Jenkins, R. E., Meng, X., Faulkner, L., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2017). Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2097-2099. doi:10.1021/acs.chemrestox.7b00291

    DOI: 10.1021/acs.chemrestox.7b00291

    Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors. (Journal article)

    Alzahrani, A., Ogese, M., Meng, X., Waddington, J. C., Tailor, A., Farrell, J., . . . Naisbitt, D. (2017). Dapsone and Nitroso Dapsone Activation of Naive T-Cells from Healthy Donors. CHEMICAL RESEARCH IN TOXICOLOGY, 30(12), 2174-2186. doi:10.1021/acs.chemrestox.7b00263

    DOI: 10.1021/acs.chemrestox.7b00263

    Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. (Journal article)

    Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the beta-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. JOURNAL OF IMMUNOLOGY, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209

    DOI: 10.4049/jimmunol.1700209

    From the Cover: Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. (Journal article)

    Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218

    DOI: 10.1093/toxsci/kfw218

    Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients (Journal article)

    Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R. E., Marlot, P. T., Marson, A. G., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063

    DOI: 10.1021/acs.chemrestox.7b00063

    New Approaches to Investigate Drug-Induced Hypersensitivity (Journal article)

    Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333

    DOI: 10.1021/acs.chemrestox.6b00333

    2016

    A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity (Presentation material)

    Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.

    Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients (Journal article)

    Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253

    DOI: 10.1021/acs.chemrestox.6b00253

    Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury (Journal article)

    Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393

    DOI: 10.1021/acs.chemrestox.6b00393

    Detection of drug-responsive B lymphocytes and antidrug IgG in patients with beta-lactam hypersensitivity (Journal article)

    Amali, M. O., Sullivan, A., Jenkins, R. E., Farrell, J., Meng, X., Faulkner, L., . . . Naisbitt, D. J. (2017). Detection of drug-responsive B lymphocytes and antidrug IgG in patients with beta-lactam hypersensitivity. ALLERGY, 72(6), 896-907. doi:10.1111/all.13087

    DOI: 10.1111/all.13087

    Immunological Mechanisms of Drug Hypersensitivity (Journal article)

    Meng, X., Ariza, A., Waddington, J., Park, K., & Naisbitt, D. (2016). Immunological Mechanisms of Drug Hypersensitivity. CURRENT PHARMACEUTICAL DESIGN, 22(45), 6734-6747. doi:10.2174/1381612822666161003115103

    DOI: 10.2174/1381612822666161003115103

    Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation (Journal article)

    Tailor, A., Waddington, J. C., Meng, X., & Park, B. K. (2016). Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 1912-1935. doi:10.1021/acs.chemrestox.6b00147

    DOI: 10.1021/acs.chemrestox.6b00147

    No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury (Journal article)

    Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400

    DOI: 10.1021/acs.chemrestox.6b00400

    2015

    Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin (Journal article)

    Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. CHEMICAL RESEARCH IN TOXICOLOGY, 28(1), 51-58. doi:10.1021/tx500285k

    DOI: 10.1021/tx500285k

    Promiscuous T-cell responses to drugs and drug-haptens (Journal article)

    Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036

    DOI: 10.1016/j.jaci.2015.02.036

    2014

    Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients (Journal article)

    Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 27(4), 524-535. doi:10.1021/tx400406p

    DOI: 10.1021/tx400406p

    Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase (Journal article)

    Ogese, M. O., Jenkins, R. E., Maggs, J. L., Meng, X., Whitaker, P., Peckham, D., . . . Naisbitt, D. J. (2015). Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase. CHEMICAL RESEARCH IN TOXICOLOGY, 28(1), 144-154. doi:10.1021/tx500458k

    DOI: 10.1021/tx500458k

    Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity (Journal article)

    Yip, V., Maggs, J., Meng, X., Marson, A., Park, K., & Pirmohamed, M. (2014). Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity. LANCET, 383, 114. Retrieved from http://gateway.webofknowledge.com/

    Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein (Journal article)

    Monrad, R. N., Errey, J. C., Barry, C. S., Iqbal, M., Meng, X., Iddon, L., . . . Davis, B. G. (2014). Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein. CHEMICAL SCIENCE, 5(10), 3789-3794. doi:10.1039/c4sc01329h

    DOI: 10.1039/c4sc01329h

    Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients (Journal article)

    Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079

    DOI: 10.1124/jpet.114.215079

    The importance of hapten - protein complex formation in the development of drug allergy (Journal article)

    Faulkner, L., Meng, X., Park, B. K., & Naisbitt, D. J. (2014). The importance of hapten - protein complex formation in the development of drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14(4), 293-300. doi:10.1097/ACI.0000000000000078

    DOI: 10.1097/ACI.0000000000000078

    2013

    Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)

    Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107

    DOI: 10.1021/tx4000107

    Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides. (Journal article)

    Stachulski, A. V., & Meng, X. (2013). Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.. Natural product reports, 30(6), 806-848. doi:10.1039/c3np70003h

    DOI: 10.1039/c3np70003h

    beta-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)

    Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). beta-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

    DOI: 10.1021/tx400124m

    2012

    Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)

    El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

    DOI: 10.1124/jpet.111.190900

    2011

    Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

    Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871

    DOI: 10.1124/jpet.111.183871

    Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

    Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

    DOI: 10.1124/jpet.111.183871

    Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis (Journal article)

    Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis. J Immunol, 187(1), 200-211.

    2010

    High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma. (Journal article)

    Karlsson, E. S., Johnson, C. H., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.. Rapid communications in mass spectrometry : RCM, 24(20), 3043-3051. doi:10.1002/rcm.4740

    DOI: 10.1002/rcm.4740

    Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides. (Journal article)

    Johnson, C. H., Karlsson, E., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.. Xenobiotica; the fate of foreign compounds in biological systems, 40(1), 9-23. doi:10.3109/00498250903348720

    DOI: 10.3109/00498250903348720

    2009

    Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo (Journal article)

    Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222

    DOI: 10.1002/prca.200800222

    Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide (Journal article)

    Jones, A. E., Wilson, H. K., Meath, P., Meng, X., Holt, D. W., Johnston, A., . . . Stachulski, A. V. (2009). Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide. Tetrahedron Letters, 50(35), 4973-4977. doi:10.1016/j.tetlet.2009.06.060

    DOI: 10.1016/j.tetlet.2009.06.060

    Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1 beta-O-acyl glucuronides (Journal article)

    Berry, N. G., Iddon, L., Iqbal, M., Meng, X., Jayapal, P., Johnson, C. H., . . . Stachulski, A. V. (2009). Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1 beta-O-acyl glucuronides. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2525-2533. doi:10.1039/b822777b

    DOI: 10.1039/b822777b

    2008

    Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions. (Journal article)

    Johnson, C. H., Athersuch, T. J., Wilson, I. D., Iddon, L., Meng, X., Stachulski, A. V., . . . Nicholson, J. K. (2008). Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.. Analytical chemistry, 80(13), 4886-4895. doi:10.1021/ac702614t

    DOI: 10.1021/ac702614t

    2007

    Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide:  Synthesis, Reactivity, and Mechanistic Analysis (Journal article)

    Meng, X., Maggs, J. L., Pryde, D. C., Planken, S., Jenkins, R. E., Peakman, T. M., . . . Stachulski, A. V. (2007). Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide:  Synthesis, Reactivity, and Mechanistic Analysis. Journal of Medicinal Chemistry, 50(24), 6165-6176. doi:10.1021/jm0706766

    DOI: 10.1021/jm0706766

    Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis. (Journal article)

    Meng, X., Maggs, J. L., Pryde, D. C., Planken, S., Jenkins, R. E., Peakman, T. M., . . . Stachulski, A. V. (2007). Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.. Journal of medicinal chemistry, 50(24), 6165-6176. doi:10.1021/jm0706766

    DOI: 10.1021/jm0706766

    Investigation of the immunogenicity of diclofenac and diclofenac metabolites (Journal article)

    Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014

    DOI: 10.1016/j.toxlet.2006.10.014

    2004

    Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac. (Journal article)

    Kenny, J. R., Maggs, J. L., Meng, X., Sinnott, D., Clarke, S. E., Park, B. K., & Stachulski, A. V. (2004). Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.. Journal of medicinal chemistry, 47(11), 2816-2825. doi:10.1021/jm030891w

    DOI: 10.1021/jm030891w