Photo of Prof Terry Jones

Prof Terry Jones BSc(Hons), MBBS, FRCSEd, FRCS(ORL-HNS), MD

Professor of Head and Neck Surgery Molecular and Clinical Cancer Medicine

    Research

    Research Interest 1

    My main clinical interests relate to function-sparing transoral laser techniques to remove cancers of the larynx (voice-box), oropharynx and hypopharynx (throat), thereby leaving patients with better speech and swallowing function after surgery.
    My research interests can be divided into 3 main themes:

    Basic/translational research: Much of this research is conducted in collaboration with Dr Mark Boyd, Reader in Molecular Oncology and focuses on the role of the p53 /MDM2/MTBP pathway in the development of metastasis and radioresistance and the therapeutic exploitation of the Unfolded Protein Response.

    Clinical Trials: I am the Chief Investigator for the following LCTU managed trials.
    REALISTIC: a CR-UK funded Phase I, dose escalation trial of recombinant Listeria monocytogenes (lm)-based vaccine encoding human papilloma virus serotype 16 target antigens (adxs11-001) in patients with Human Papilloma Virus 16 (HPV-16) associated oropharyngeal squamous cell carcinoma (OPSCC).
    HPVUK: A GSK funded multi-centre study designed to establish the prevalence of HPV-16 associated OPSCC in the United Kingdom over the last decade. I am also the Principal Investigator (PI) for
    TITAN: A CR-UK funded, multi-centre phase III feasibility study of induction chemotherapy in advanced Head & Neck Cancer. In addition, I am the PI for a further four ongoing multi-centre randomised clinical trials.(PET-NECK,DETERMINE, DETEQT & IoN)

    Clinical outcomes research:
    This inculudes the acoustic analysis of voice following TOLS for tumours of the larynx; the predictive role of cardio-pulmonary testing in patients undergoing major surgery for H&N cancer and the role of percutaneous tracheostomy in the development of adult tracheal stenosis.

    Research Group Membership
    Research Grants

    Functional investigation of novel biomarkers in head and neck cancers

    CANCER RESEARCH UK (UK)

    September 2011 - August 2013

    TITAN: Trial of induction TPF therapy in advance head and neck cancer

    CANCER RESEARCH UK (UK)

    October 2010 - September 2013

    IMCAT - Immunotherapy for squamous cell carcinoma of the head and neck by Transimmunization

    CANCER RESEARCH UK (UK)

    March 2010 - November 2011

    Evaluation of Metastasis-inducing Proteins as Biomarkers of Patient Outcome in Human Cancers

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2009 - February 2013

    Workshop on the design and analysis of clinical trials in Head and Neck Cancer

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2013 - April 2014

    Study on tumours of the oropharynx caused by the HPB virus

    WARRINGTON AND HALTON HOSPITALS NHS FOUNDATION TRUSTS (UK)

    July 2013 - December 2014

    REALISTIC: A Phase I, dose escalation of trial of recombinant listeria moncytogenes (Lm) based vaccine encloding human papilloma virus serotype 16 target antigens (ADXS11-001) in patients with HPV-16+ oropharyngeal SCC.

    CANCER RESEARCH UK (UK)

    October 2010 - September 2014

    Research Collaborations

    Professor Tony Ng

    External: King's College London

    Dr Lakis Liloglou

    Internal

    H&N basic research rpojects

    Dr Janet Risk

    Internal

    Dr Jacqueline James

    External: The University of Ulster

    UK HPV Prevalence in OPSCC Study.

    Dr Liz Junor

    External: The University of Edinburgh

    UK HPV Prevalence in OPSCC Study. Phase III RCT of induction TPF in patients with advanced SCCHN.

    Dr Stephen Man

    External: University of Wales, Cardiff

    Phase I trail of HPV therapeutic vaccine in patients with HPV positive Oropharyngeal Squamous Cell carcinoma. TILS in SCCHN

    Professor Alison Fiander

    External: The University of Wales, Cardiff

    Phase I trail of HPV therapeutic vaccine in patients with HPV positive Oropharyngeal Squamous Cell carcinoma. UK HPV Prevalence in OPSCC Study.

    Dr Chris Nutting

    External: Institute of Cancer Research

    Phase I trail of HPV therapeutic vaccine in patients with HPV positive Oropharyngeal Squamous Cell carcinoma. UK HPV Prevalence in OPSCC Study. Phase III RCT of induction TPF in patients with advanced SCCHN.

    Dr Mererid Evans

    External: University of Wales, Cardiff

    Phase I trail of HPV therapeutic vaccine in patients with HPV positive Oropharyngeal Squamous Cell carcinoma. UK HPV Prevalence in OPSCC Study. Phase III RCT of induction TPF in patients with advanced SCCHN.

    Professor Ross Sibson

    Internal

    Exon array analysis of SCCHN cell lines with a view to identifying differential expressed genes associated with increased cellular motility

    Dr Kevin Harrington

    External: Institute of Cancer Research

    Phase I trail of HPV therapeutic vaccine in patients with HPV positive Oropharyngeal Squamous Cell carcinoma. UK HPV Prevalence in OPSCC Study. Phase III RCT of induction TPF in patients with advanced SCCHN.

    Professor Hisham Mehanna

    External: The University of Warwick

    UK HPV Prevalence in OPSCC Study. Phase III RCT of induction TPF in patients with advanced SCCHN.

    Dr Ned Powell

    External: University of Wales, Cardiff

    Phase I trail of HPV therapeutic vaccine in patients with HPV positive Oropharyngeal Squamous Cell carcinoma. UK HPV Prevalence in OPSCC Study.

    Mr Richard Shaw

    Internal

    Ongoing collaboration to develop a strong academic department of H+N cancer medicine

    Professor Kevin Park

    Internal

    Proteomics of H+N cancer.
    Investigation of novel cytotoxic agents for HNSCC.

    Dr Neil Kitteringham

    Internal

    The role of novel therapeutic agents in the treatment of HNSCC.
    Proteomic analysis of HNSCC, in an attempt to identify biomarkers of metastatic potential.

    Professor Phillip Rudland

    Internal

    Identification of genes involved in metastasis of HNSCC

    Mr. Jean-Pierre Jeannon

    External: Guys and St Thomas` NHS Trust

    Randomised controlled trail of the effectiveness of Immune-enhanced feed for patients undergoing major head and neck surgery

    Dr Ged Dempsey and Professor Peter Calverley

    External: Aintree University Hospitals NHS Foundation Trust

    The role of pre-operative Anaerobic Threshold measurement in patients undergoing major head and neck surgery

    Dr Huw Lewis-Jones and Dr Rebecca Hanlon

    External: Aintree University Hospitals NHS Foundation Trust

    The role of CT and MR imaging in patients with head and neck cancer

    Dr Jon Sheard

    External: Aintree University Hospitals NHS Foundation Trust

    The role of fine-needle aspiration cytology (FNAC)in the diagnosis of patients with SCCHN.

    Professor Paul Carding

    External: The University of Newcastle-upon-Tyne

    The analysis of voice in patients with head and neck cancer,uncergoing voice-altering treatments.

    Mr Simon Rogers

    External: Aintree University Hospitals NHS Foundation Trust

    Quality of Life outcomes in Head and Neck Cancer patients

    Dr Tim Helliwell

    Internal

    The role of matrix metalloproteases in the development of metastasis of squamous cell carcinoma of the head and neck (SCCHN)

    Dr Mark Boyd

    Internal

    The role of the MDM2/p53 pathway in squamous cell carcinoma of the head and neck (SCCHN)

    Professor Andrew Jones

    Internal

    Clinical outcomes in patients with head and neck cancer.