2024
Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction. (Journal article)
Kalizang'oma, A., Swarthout, T. D., Mwalukomo, T. S., Kamng'ona, A., Brown, C., Msefula, J., . . . Heyderman, R. S. (2024). Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction.. The Journal of infectious diseases, jiae040. doi:10.1093/infdis/jiae040DOI: 10.1093/infdis/jiae040
Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017. (Journal article)
Kovacs, D., Mambule, I., Read, J. M., Kiran, A., Chilombe, M., Bvumbwe, T., . . . Ho, A. (2024). Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017.. The Journal of infectious diseases, jiad587. doi:10.1093/infdis/jiad587DOI: 10.1093/infdis/jiad587
2023
Rollinson, V., French, N., Turner, R., & Pirmohamed, M. (2023). A Survey of the UK Pharmacy Profession's Educational Needs on Pharmacogenomics. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2023. doi:10.1155/2023/2388845DOI: 10.1155/2023/2388845
2021
Korver, S., Bowen, J., Pearson, K., Gonzalez, R. J., French, N., Park, K., . . . Goldring, C. (2021). The application of cytokeratin-18 as a biomarker for drug-induced liver injury. ARCHIVES OF TOXICOLOGY, 95(11), 3435-3448. doi:10.1007/s00204-021-03121-0DOI: 10.1007/s00204-021-03121-0
Jones, S. W., Penman, S. L., French, N. S., Park, B. K., & Chadwick, A. E. (2021). Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models. Toxicology in Vitro, 105096. doi:10.1016/j.tiv.2021.105096DOI: 10.1016/j.tiv.2021.105096
2018
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity (Journal article)
Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030DOI: 10.1021/acs.chemrestox.8b00030
Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017) (Journal article)
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. doi:10.4049/jimmunol.1800020DOI: 10.4049/jimmunol.1800020
2017
Scarfe, L., Brillant, N., Kumar, J. D., Ali, N., Alrumayh, A., Amali, M., . . . Park, B. K. (2017). Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. NPJ REGENERATIVE MEDICINE, 2. doi:10.1038/s41536-017-0029-9DOI: 10.1038/s41536-017-0029-9
Ogese, M. O., Faulkner, L., Jenkins, R. E., French, N. S., Copple, I. M., Antoine, D. J., . . . Naisbitt, D. J. (2017). Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. TOXICOLOGICAL SCIENCES, 158(1), 76-89. doi:10.1093/toxsci/kfx069DOI: 10.1093/toxsci/kfx069
Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development (Chapter)
Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4DOI: 10.1016/B978-0-12-409547-2.12384-4
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.. Journal of Immunology, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209DOI: 10.4049/jimmunol.1700209
Usui, T., Meng, X., Saide, K., Farrell, J., Thomson, P., Whitaker, P., . . . Naisbitt, D. J. (2017). Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury. TOXICOLOGICAL SCIENCES, 155(2), 420-431. doi:10.1093/toxsci/kfw218DOI: 10.1093/toxsci/kfw218
Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333DOI: 10.1021/acs.chemrestox.6b00333
2016
Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393DOI: 10.1021/acs.chemrestox.6b00393
Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253DOI: 10.1021/acs.chemrestox.6b00253
2015
Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation (Journal article)
Naisbitt, D., Yang, E. L., Alhaidari, M., Berry, N., Lawrenson, A. S., Farrell, J., . . . Park, B. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867DOI: 10.1097/QAD.0000000000000867
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409DOI: 10.18632/oncotarget.4409
Kamalian, L., Chadwick, A., Bayliss, M., French, N., Monshouwer, M., Snoeys, J., & Park, B. K. (2015). The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death.. Toxicology in Vitro, 29(4), 732-740. doi:10.1016/j.tiv.2015.02.011DOI: 10.1016/j.tiv.2015.02.011
Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis (Journal article)
Garner, R. C., Park, K. B., French, N. S., Earnshaw, C., Schipani, A., Selby, A. M., . . . Turner, M. A. (2015). Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis. British Journal Of Clinical Pharmacology, 80(1), 157-167. doi:10.1111/bcp.12597DOI: 10.1111/bcp.12597
Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin (Journal article)
Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. Chemical Research in Toxicology, 28(1), 51-58. doi:10.1021/tx500285kDOI: 10.1021/tx500285k
2014
Abacavir forms novel cross-linking abacavir protein adducts in patients (Journal article)
Meng, X., Lawrenson, A., Berry, N., Maggs, J., French, N., Back, D., . . . Park, K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Clinical and translational allergy, 4(Suppl 3), P38. doi:10.1186/2045-7022-4-s3-p38DOI: 10.1186/2045-7022-4-s3-p38
Antigen exposure required for T cell activation (Journal article)
Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-s3-p115DOI: 10.1186/2045-7022-4-s3-p115
Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury (Journal article)
Usui, T., Saide, K., Meng, X., Whitaker, P., Peckham, D., French, N., . . . Park, K. (2014). Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury. Clinical and translational allergy, 4(Suppl 3), P116. doi:10.1186/2045-7022-4-s3-p116DOI: 10.1186/2045-7022-4-s3-p116
Abacavir forms novel cross-linking abacavir protein adducts in patients (Journal article)
Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients. Chemical Research in Toxicology, 27(04), 524-535. doi:10.1021/tx400406pDOI: 10.1021/tx400406p
2013
Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)
Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107DOI: 10.1021/tx4000107
Challenges and approaches for the development of safer immunomodulatory biologics (Journal article)
Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974DOI: 10.1038/nrd3974
Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)
Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B<SUP>☆</SUP>57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077DOI: 10.1002/hep.26077
2012
<i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers (Journal article)
Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). <i>In silico</i> analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350DOI: 10.1186/gm350
Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)
El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900DOI: 10.1124/jpet.111.190900
HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)
Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.
2011
Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury (Journal article)
Lewis, P. J. S., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury. HEPATOLOGY, 54(5), 1767-1776. doi:10.1002/hep.24538DOI: 10.1002/hep.24538
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871DOI: 10.1124/jpet.111.183871
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871DOI: 10.1124/jpet.111.183871
Assessing the Safety of Stem Cell Therapeutics (Journal article)
Goldring, C. E. P., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, B. K. (2011). Assessing the Safety of Stem Cell Therapeutics. Cell Stem Cell, 9(2), 176. doi:10.1016/j.stem.2011.06.006DOI: 10.1016/j.stem.2011.06.006
Assessing the Safety of Stem Cell Therapeutics (Journal article)
Goldring, C. E. P., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, B. K. (2011). Assessing the Safety of Stem Cell Therapeutics. CELL STEM CELL, 8(6), 618-628. doi:10.1016/j.stem.2011.05.012DOI: 10.1016/j.stem.2011.05.012
2001
Context-dependent Pax-5 repression of a PU.1/NF-κB regulated reporter gene in B lineage cells (Journal article)
Linderson, Y., French, N. S., Neurath, M. F., & Pettersson, S. (2001). Context-dependent Pax-5 repression of a PU.1/NF-κB regulated reporter gene in B lineage cells. GENE, 262(1-2), 107-114. doi:10.1016/S0378-1119(00)00546-1DOI: 10.1016/S0378-1119(00)00546-1
2000
Microbe-host interactions in the alimentary tract: the gateway to understanding inflammatory bowel disease (Journal article)
French, N., & Pettersson, S. (2000). Microbe-host interactions in the alimentary tract: the gateway to understanding inflammatory bowel disease. GUT, 47(2), 162-163. doi:10.1136/gut.47.2.162DOI: 10.1136/gut.47.2.162
1999
Novel <i>Salmonella typhimurium</i> properties in host-parasite interactions (Journal article)
Borg, S., Björkman, J., Eriksson, S., Syk, A., Andersson, D. I., Schesser, K., . . . French, N. S. (1999). Novel <i>Salmonella typhimurium</i> properties in host-parasite interactions. IMMUNOLOGY LETTERS, 68(2-3), 247-249. doi:10.1016/S0165-2478(99)00073-5DOI: 10.1016/S0165-2478(99)00073-5
1997
Structure and functional properties of mouse VL30 retrotransposons (Journal article)
French, N. S., & Norton, J. D. (1997). Structure and functional properties of mouse VL30 retrotransposons. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1352(1), 33-47. doi:10.1016/S0167-4781(97)00009-2DOI: 10.1016/S0167-4781(97)00009-2
1996
Suppression of tumorigenicity in Ras-transformed fibroblasts by alpha 2(1) collagen (Journal article)
Travers, H., French, N. S., & Norton, J. D. (1996). Suppression of tumorigenicity in Ras-transformed fibroblasts by alpha 2(1) collagen. CELL GROWTH & DIFFERENTIATION, 7(10), 1353-1360. Retrieved from https://www.webofscience.com/
1995
CONSTRUCTION OF A RETROVIRAL VECTOR INCORPORATING MOUSE VL30 RETROTRANSPOSON-DERIVED, TRANSCRIPTIONAL REGULATORY SEQUENCES (Journal article)
FRENCH, N. S., & NORTON, J. D. (1995). CONSTRUCTION OF A RETROVIRAL VECTOR INCORPORATING MOUSE VL30 RETROTRANSPOSON-DERIVED, TRANSCRIPTIONAL REGULATORY SEQUENCES. ANALYTICAL BIOCHEMISTRY, 228(2), 354-355. doi:10.1006/abio.1995.1364DOI: 10.1006/abio.1995.1364
1994
ANALYSIS OF RETROTRANSPOSON FAMILIES IN GENOMIC DNA BY 2-DIMENSIONAL RESTRICTION MAPPING - DETECTION OF VL30 INSERTIONS IN MOUSE THYMIC LYMPHOMA (Journal article)
FRENCH, N. S., & NORTON, J. D. (1994). ANALYSIS OF RETROTRANSPOSON FAMILIES IN GENOMIC DNA BY 2-DIMENSIONAL RESTRICTION MAPPING - DETECTION OF VL30 INSERTIONS IN MOUSE THYMIC LYMPHOMA. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1219(2), 484-492. doi:10.1016/0167-4781(94)90075-2DOI: 10.1016/0167-4781(94)90075-2
