Dr Neil French Ph.D.

Senior Scientific Operations Manager, CDSS Molecular and Clinical Pharmacology

    Publications

    2017

    Definition of the Nature and Hapten Threshold of the beta-Lactam Antigen Required for T Cell Activation In Vitro and in Patients (Journal article)

    Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2017). Definition of the Nature and Hapten Threshold of the beta-Lactam Antigen Required for T Cell Activation In Vitro and in Patients. JOURNAL OF IMMUNOLOGY, 198(11), 4217-4227. doi:10.4049/jimmunol.1700209

    DOI: 10.4049/jimmunol.1700209

    New Approaches to Investigate Drug-Induced Hypersensitivity (Journal article)

    Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333

    DOI: 10.1021/acs.chemrestox.6b00333

    2015

    Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin (Journal article)

    Meng, X., Maggs, J. L., Usui, T., Whitaker, P., French, N. S., Naisbitt, D. J., & Park, B. K. (2015). Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin. CHEMICAL RESEARCH IN TOXICOLOGY, 28(1), 51-58. doi:10.1021/tx500285k

    DOI: 10.1021/tx500285k

    Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis (Journal article)

    Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409

    DOI: 10.18632/oncotarget.4409

    Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis (Journal article)

    Garner, C. R., Park, K. B., French, N. S., Earnshaw, C., Schipani, A., Selby, A. M., . . . Turner, M. A. (2015). Observational infant exploratory [C-14]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(1), 157-167. doi:10.1111/bcp.12597

    DOI: 10.1111/bcp.12597

    The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death (Journal article)

    Kamalian, L., Chadwick, A. E., Bayliss, M., French, N. S., Monshouwer, M., Snoeys, J., & Park, B. K. (2015). The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death. TOXICOLOGY IN VITRO, 29(4), 732-740. doi:10.1016/j.tiv.2015.02.011

    DOI: 10.1016/j.tiv.2015.02.011

    Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57:01-restricted CD8(+) T-cell activation (Journal article)

    Naisbitt, D. J., Yang, E. L., Alhaidari, M., Berry, N. G., Lawrenson, A. S., Farrell, J., . . . Park, B. K. (2015). Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57:01-restricted CD8(+) T-cell activation. AIDS, 29(18), 2385-2395. doi:10.1097/QAD.0000000000000867

    DOI: 10.1097/QAD.0000000000000867

    2014

    Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients (Journal article)

    Meng, X., Lawrenson, A. S., Berry, N. G., Maggs, J. L., French, N. S., Back, D. J., . . . Park, B. K. (2014). Abacavir Forms Novel Cross-Linking Abacavir Protein Adducts in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 27(4), 524-535. doi:10.1021/tx400406p

    DOI: 10.1021/tx400406p

    Abacavir forms novel cross-linking abacavir protein adducts in patients. (Journal article)

    Meng, X., Lawrenson, A., Berry, N., Maggs, J., French, N., Back, D., . . . Park, K. (2014). Abacavir forms novel cross-linking abacavir protein adducts in patients.. Clinical and translational allergy, 4(Suppl 3), P38. doi:10.1186/2045-7022-4-S3-P38

    DOI: 10.1186/2045-7022-4-S3-P38

    Antigen exposure required for T cell activation. (Journal article)

    Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation.. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-S3-P115

    DOI: 10.1186/2045-7022-4-S3-P115

    Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury. (Journal article)

    Usui, T., Saide, K., Meng, X., Whitaker, P., Peckham, D., French, N., . . . Park, K. (2014). Isoniazid-specific T-cell Responses in patients with anti-tuberculosis drug related liver injury.. Clinical and translational allergy, 4(Suppl 3), P116. doi:10.1186/2045-7022-4-S3-P116

    DOI: 10.1186/2045-7022-4-S3-P116

    2013

    Challenges and approaches for the development of safer immunomodulatory biologics (Journal article)

    Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974

    DOI: 10.1038/nrd3974

    Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients (Journal article)

    Meng, X., Howarth, A., Earnshaw, C. J., Jenkins, R. E., French, N. S., Back, D. J., . . . Park, B. K. (2013). Detection of Drug Bioactivation in Vivo: Mechanism of Nevirapine-Albumin Conjugate Formation in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 26(4), 575-583. doi:10.1021/tx4000107

    DOI: 10.1021/tx4000107

    Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)

    Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

    DOI: 10.1002/hep.26077

    2012

    Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)

    El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

    DOI: 10.1124/jpet.111.190900

    HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)

    Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.

    In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers (Journal article)

    Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350

    DOI: 10.1186/gm350

    2011

    Assessing the Safety of Stem Cell Therapeutics (Journal article)

    Goldring, C. E. P., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, B. K. (2011). Assessing the Safety of Stem Cell Therapeutics. CELL STEM CELL, 8(6), 618-628. doi:10.1016/j.stem.2011.05.012

    DOI: 10.1016/j.stem.2011.05.012

    Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury (Journal article)

    Lewis, P. J. S., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury. HEPATOLOGY, 54(5), 1767-1776. doi:10.1002/hep.24538

    DOI: 10.1002/hep.24538

    Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

    Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871

    DOI: 10.1124/jpet.111.183871

    Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

    Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

    DOI: 10.1124/jpet.111.183871

    2001

    Context-dependent Pax-5 repression of a PU.1/NF-kappa B regulated reporter gene in B lineage cells (Journal article)

    Linderson, Y., French, N. S., Neurath, M. F., & Pettersson, S. (2001). Context-dependent Pax-5 repression of a PU.1/NF-kappa B regulated reporter gene in B lineage cells. GENE, 262(1-2), 107-114. doi:10.1016/S0378-1119(00)00546-1

    DOI: 10.1016/S0378-1119(00)00546-1

    2000

    Microbe-host interactions in the alimentary tract: the gateway to understanding inflammatory bowel disease (Journal article)

    French, N., & Pettersson, S. (2000). Microbe-host interactions in the alimentary tract: the gateway to understanding inflammatory bowel disease. GUT, 47(2), 162-163. doi:10.1136/gut.47.2.162

    DOI: 10.1136/gut.47.2.162

    1999

    Novel Salmonella typhimurium properties in host-parasite interactions (Journal article)

    Borg, S., Bjorkman, J., Eriksson, S., Syk, A., Andersson, D. I., Schesser, K., . . . French, N. S. (1999). Novel Salmonella typhimurium properties in host-parasite interactions. IMMUNOLOGY LETTERS, 68(2-3), 247-249. doi:10.1016/S0165-2478(99)00073-5

    DOI: 10.1016/S0165-2478(99)00073-5

    1997

    Structure and functional properties of mouse VL30 retrotransposons (Journal article)

    French, N. S., & Norton, J. D. (1997). Structure and functional properties of mouse VL30 retrotransposons. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1352(1), 33-47. doi:10.1016/S0167-4781(97)00009-2

    DOI: 10.1016/S0167-4781(97)00009-2

    1996

    Suppression of tumorigenicity in Ras-transformed fibroblasts by alpha 2(1) collagen (Journal article)

    Travers, H., French, N. S., & Norton, J. D. (1996). Suppression of tumorigenicity in Ras-transformed fibroblasts by alpha 2(1) collagen. CELL GROWTH & DIFFERENTIATION, 7(10), 1353-1360. Retrieved from http://gateway.webofknowledge.com/

    1995

    CONSTRUCTION OF A RETROVIRAL VECTOR INCORPORATING MOUSE VL30 RETROTRANSPOSON-DERIVED, TRANSCRIPTIONAL REGULATORY SEQUENCES (Journal article)

    FRENCH, N. S., & NORTON, J. D. (1995). CONSTRUCTION OF A RETROVIRAL VECTOR INCORPORATING MOUSE VL30 RETROTRANSPOSON-DERIVED, TRANSCRIPTIONAL REGULATORY SEQUENCES. ANALYTICAL BIOCHEMISTRY, 228(2), 354-355. doi:10.1006/abio.1995.1364

    DOI: 10.1006/abio.1995.1364

    1994

    ANALYSIS OF RETROTRANSPOSON FAMILIES IN GENOMIC DNA BY 2-DIMENSIONAL RESTRICTION MAPPING - DETECTION OF VL30 INSERTIONS IN MOUSE THYMIC LYMPHOMA (Journal article)

    FRENCH, N. S., & NORTON, J. D. (1994). ANALYSIS OF RETROTRANSPOSON FAMILIES IN GENOMIC DNA BY 2-DIMENSIONAL RESTRICTION MAPPING - DETECTION OF VL30 INSERTIONS IN MOUSE THYMIC LYMPHOMA. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1219(2), 484-492. doi:10.1016/0167-4781(94)90075-2

    DOI: 10.1016/0167-4781(94)90075-2