Prof Andrea Varro M.D., PhD

Professor Molecular & Physiology Cell Signalling

    Publications

    2019

    A novel FTIR analysis method for rapid high-confidence discrimination of esophageal cancer (Journal article)

    Martin, D. S., Barrett, S., Weightman, P., & Smith, C. (2019). A novel FTIR analysis method for rapid high-confidence discrimination ofesophageal cancer. Infrared Physics and Technology, 102. doi:10.1016/j.infrared.2019.103007

    DOI: 10.1016/j.infrared.2019.103007

    Integrated Omics Profiling Reveals Novel Patterns of Epigenetic Programming in Cancer-Associated Myofibroblasts (Journal article)

    Najgebauer, H., Liloglou, T., Jithesh, P. V., Giger, O. T., Varro, A., & Sanderson, C. M. (2019). Integrated Omics Profiling Reveals Novel Patterns of Epigenetic Programming in Cancer-Associated Myofibroblasts. Carcinogenesis, 40(4), 500-512. doi:10.1093/carcin/bgz001

    DOI: 10.1093/carcin/bgz001

    Recharacterization data for a geriatric gastrin polycolonal antibody. (Journal article)

    Dodd, S., Varro, A., Pritchard, D. M., & Dockray, G. J. (2019). Recharacterization data for a geriatric gastrin polycolonal antibody.. Data in brief, 24, 103886. doi:10.1016/j.dib.2019.103886

    DOI: 10.1016/j.dib.2019.103886

    Bioelectrical impedance vector analysis (BIVA) as a method to compare body composition differences according to cancer stage and type (Journal article)

    Nwosu, A. C., Mayland, C., Mason, S., Cox, T., Varro, A., Stanley, S., & Ellershaw, J. (n.d.). Bioelectrical impedance vector analysis (BIVA) as a method to compare body composition differences according to cancer stage and type. Clinical Nutrition ESPEN. doi:10.1016/j.clnesp.2019.02.006

    DOI: 10.1016/j.clnesp.2019.02.006

    Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in PatientsWith Autoimmune Chronic Atrophic Gastritis (Conference Paper)

    Boyce, M., Moore, A. R., Parsons, B., Lloyd, K., Sagatun, L., Varro, A., . . . Pritchard, D. M. (2019). Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in PatientsWith Autoimmune Chronic Atrophic Gastritis. In PANCREAS Vol. 48 (pp. 429). Retrieved from http://gateway.webofknowledge.com/

    Integrative Omic Profiling Reveals Unique Hypoxia Induced Signatures in Gastric Cancer Associated Myofibroblasts (Journal article)

    Najgebauer, H., Jarnuczak, A. E., Varro, A., & Sanderson, C. M. (2019). Integrative Omic Profiling Reveals Unique Hypoxia Induced Signatures in Gastric Cancer Associated Myofibroblasts. CANCERS, 11(2). doi:10.3390/cancers11020263

    DOI: 10.3390/cancers11020263

    Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2 (Journal article)

    Kumar, J. D., Aolymat, I., Tiszlavicz, L., Reisz, Z., Garalla, H. M., Beynon, R., . . . Varro, A. (2019). Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2. Oncotarget, 10(02), 98-112. Retrieved from https://www.oncotarget.com/article/26414/text/

    2018

    Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell (Journal article)

    Smith, C. I., Siggel-King, M. R. F., Ingham, J., Harrison, P., Martin, D. S., Varro, A., . . . Weightman, P. (2018). Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell. ANALYST, 143(24), 5912-5917. doi:10.1039/c8an01183d

    DOI: 10.1039/c8an01183d

    Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL (Journal article)

    Ingham, J., Craig, T., Smith, C. I., Varro, A., Pritchard, D. M., Barrett, S. D., . . . Siggel-King, M. R. F. (2018). Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL. Biomedical Physics and Engineering Express, 5. doi:10.1088/2057-1976/aaea53

    DOI: 10.1088/2057-1976/aaea53

    Stable Isotope Dynamic Labeling of Secretomes (SIDLS) Identifies Authentic Secretory Proteins Released by Cancer and Stromal Cells (Journal article)

    Hammond, D. E., Kumar, J. D., Raymond, L., Simpson, D. M., Beynon, R. J., Dockray, G. J., & Varro, A. (2018). Stable Isotope Dynamic Labeling of Secretomes (SIDLS) Identifies Authentic Secretory Proteins Released by Cancer and Stromal Cells. MOLECULAR & CELLULAR PROTEOMICS, 17(9), 1837-1849. doi:10.1074/mcp.TIR117.000516

    DOI: 10.1074/mcp.TIR117.000516

    Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance. (Thesis / Dissertation)

    Garalla, H. M., Lertkowit, N., Tiszlavicz, L., Reisz, Z., Holmberg, C., Beynon, R., . . . Varro, A. (2018). Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance..

    DOI: 10.14814/phy2.13683

    SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus (Journal article)

    Craig, T., Smith, A. D., Holder, G. M., Ingham, J., Smith, C. I., Varro, A., . . . Siggel-King, M. R. F. (2018). SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus. PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS, 255(4). doi:10.1002/pssb.201700518

    DOI: 10.1002/pssb.201700518

    An evaluation of the application of the aperture infrared SNOM technique to biomedical imaging (Journal article)

    Ingham, J., Pilling, M. J., Craig, T., Siggel-King, M. R. F., Smith, C. I., Gardner, P., . . . Weightman, P. (2018). An evaluation of the application of the aperture infrared SNOM technique to biomedical imaging. Biomedical Physics & Engineering Express, 4(2). doi:10.1088/2057-1976/aaa0de

    DOI: 10.1088/2057-1976/aaa0de

    2017

    Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use (Journal article)

    parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use. PLoS Pathogens. doi:10.1101/144907

    DOI: 10.1101/144907

    Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use (Journal article)

    Parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. PLoS Pathogens, 13(11). doi:10.1371/journal.ppat.1006653

    DOI: 10.1371/journal.ppat.1006653

    Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration. (Journal article)

    Varga, A., Kumar, J. D., Simpson, A. W. M., Dodd, S., Hegyi, P., Dockray, G. J., & Varro, A. (2017). Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration.. Physiological reports, 5(19). doi:10.14814/phy2.13394

    DOI: 10.14814/phy2.13394

    Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway (Journal article)

    Shawe-Taylor, M., Kumar, J. D., Holden, W., Dodd, S., Varga, A., Giger, O., . . . Dockray, G. J. (2017). Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway. PEPTIDES, 91, 49-57. doi:10.1016/j.peptides.2017.03.008

    DOI: 10.1016/j.peptides.2017.03.008

    Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex (Journal article)

    Calvigioni, D., Mate, Z., Fuzik, J., Girach, F., Zhang, M. -D., Varro, A., . . . Harkany, T. (2017). Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex. CEREBRAL CORTEX, 27(4), 2453-2468. doi:10.1093/cercor/bhw094

    DOI: 10.1093/cercor/bhw094

    The development of a framework to personalise hydration management in cancer care: the use of non-invasive technology to evaluate fluid status and dehydration-related symptoms (Conference Paper)

    Nwosu, A. C., mayland, C., mason, S., Benze, G., Nauck, F., Armour, K., . . . Ellershaw, J. (2017). The development of a framework to personalise hydration management in cancer care: the use of non-invasive technology to evaluate fluid status and dehydration-related symptoms. In BMJ Supportive and Palliative Care Vol. Volume 7. Belfast Waterfront: BMJ Publishing Group.

    KCTD12 Auxiliary Proteins Modulate Kinetics of GABA(B) Receptor-Mediated Inhibition in CholecystokininContaining Interneurons (Journal article)

    Booker, S. A., Althof, D., Gross, A., Loreth, D., Mueller, J., Unger, A., . . . Kulik, A. (2017). KCTD12 Auxiliary Proteins Modulate Kinetics of GABA(B) Receptor-Mediated Inhibition in CholecystokininContaining Interneurons. Cerebral Cortex, 27(3), 2318-2334. doi:10.1093/cercor/bhw090

    DOI: 10.1093/cercor/bhw090

    Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus (Journal article)

    Lee, Y., Urbanska, A. M., Hayakawa, Y., Wang, H., Au, A. S., Luna, A. M., . . . Wang, T. C. (2017). Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus. ONCOTARGET, 8(1), 203-214. doi:10.18632/oncotarget.10667

    DOI: 10.18632/oncotarget.10667

    Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis (Journal article)

    Boyce, M., Moore, A. R., Sagatun, L., Parsons, B. N., Varro, A., Campbell, F., . . . Pritchard, D. M. (2017). Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis. British Journal of Clinical Pharmacology, 83(3), 466-475. doi:10.1111/bcp.13146

    DOI: 10.1111/bcp.13146

    2016

    Editorial overview: Gastrointestinal: Gut hormones - from bench to bedside (Journal article)

    Dockray, G. J., & Varro, A. (2016). Editorial overview: Gastrointestinal: Gut hormones - from bench to bedside. CURRENT OPINION IN PHARMACOLOGY, 31, V-VI. doi:10.1016/j.coph.2016.09.004

    DOI: 10.1016/j.coph.2016.09.004

    The Association of Hydration Status with Physical Signs, Symptoms and Survival in Advanced Cancer-The Use of Bioelectrical Impedance Vector Analysis (BIVA) Technology to Evaluate Fluid Volume in Palliative Care: An Observational Study (Journal article)

    Nwosu, A. C., Mayland, C. R., Mason, S., Cox, T. F., Varro, A., & Ellershaw, J. (2016). The Association of Hydration Status with Physical Signs, Symptoms and Survival in Advanced Cancer-The Use of Bioelectrical Impedance Vector Analysis (BIVA) Technology to Evaluate Fluid Volume in Palliative Care: An Observational Study. PLOS ONE, 11(9). doi:10.1371/journal.pone.0163114

    DOI: 10.1371/journal.pone.0163114

    A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies. (Journal article)

    Calvete, O., Varro, A., Pritchard, D. M., Barroso, A., Oteo, M., Morcillo, M., . . . Benitez, J. (2016). A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.. Disease models & mechanisms, 9(9), 975-984. doi:10.1242/dmm.025890

    DOI: 10.1242/dmm.025890

    Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion (Journal article)

    Bhandari, S., Bakke, I., Kumar, J., Beisvag, V., Sandvik, A. K., Thommesen, L., . . . Norsett, K. G. (2016). Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 475(1), 119-124. doi:10.1016/j.bbrc.2016.05.052

    DOI: 10.1016/j.bbrc.2016.05.052

    Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1) (Journal article)

    Lloyd, K. A., Moore, A. R., Parsons, B. N., O'Hara, A., Boyce, M., Dockray, G. J., . . . Pritchard, D. M. (2016). Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1). ONCOTARGET, 7(29), 45462-45478. doi:10.18632/oncotarget.9990

    DOI: 10.18632/oncotarget.9990

    REGULATION OF MMP-7 EXPRESSION IN THE PROGRESSION TO OESOPHAGEAL ADENOCARCINOMA (Conference Paper)

    Garalla, H. M., Lertkowit, N., Tiszlavicz, L., Reisz, Z., Dockray, G., & Varro, A. (2016). REGULATION OF MMP-7 EXPRESSION IN THE PROGRESSION TO OESOPHAGEAL ADENOCARCINOMA. In GUT Vol. 65 (pp. A130). doi:10.1136/gutjnl-2016-312388.232

    DOI: 10.1136/gutjnl-2016-312388.232

    The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells (Journal article)

    Kumar, J. D., Kandola, S., Tiszlavicz, L., Reisz, Z., Dockray, G. J., & Varro, A. (2016). The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells. BRITISH JOURNAL OF CANCER, 114(10), 1152-1159. doi:10.1038/bjc.2016.93

    DOI: 10.1038/bjc.2016.93

    Distinct miRNA profiles in normal and gastric cancer myofibroblasts and significance in Wnt signaling (Journal article)

    Wang, L., Steele, I., Kumar, J. D., Dimaline, R., Jithesh, P. V., Tiszlavicz, L., . . . Varro, A. (2016). Distinct miRNA profiles in normal and gastric cancer myofibroblasts and significance in Wnt signaling. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 310(9), G696-G704. doi:10.1152/ajpgi.00443.2015

    DOI: 10.1152/ajpgi.00443.2015

    PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa (Journal article)

    Fossmark, R., Rao, S., Mjones, P., Munkvold, B., Flatberg, A., Varro, A., . . . Norsett, K. G. (2016). PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa. PEPTIDES, 79, 83-94. doi:10.1016/j.peptides.2016.03.016

    DOI: 10.1016/j.peptides.2016.03.016

    A knockin mouse with a missense mutation in the H/K-ATPase ATP4a gene, mimics an aggressive familial form of gastric type I neuroendocrine tumors in humans. Assessment of new therapeutic strategies (Journal article)

    Calvete, O., Vargiu, P., Varro, A., Oteo, M., Morcillo, M. A., Barroso, A., . . . Ortega, S. (2016). A knockin mouse with a missense mutation in the H/K-ATPase ATP4a gene, mimics an aggressive familial form of gastric type I neuroendocrine tumors in humans. Assessment of new therapeutic strategies. TRANSGENIC RESEARCH, 25(2), 253-254. Retrieved from http://gateway.webofknowledge.com/

    Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in Patients with Autoimmune Chronic Atrophic Gastritis (Conference Paper)

    Boyce, M., Moore, A. R., Parsons, B. N., Lloyd, K. A., Sagatun, L., Thomsen, L., . . . Pritchard, D. M. (2016). Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in Patients with Autoimmune Chronic Atrophic Gastritis. In NEUROENDOCRINOLOGY Vol. 103 (pp. 78). Retrieved from http://gateway.webofknowledge.com/

    2015

    Mesenchymal Stem Cells Exhibit Regulated Exocytosis in Response to Chemerin and IGF (Journal article)

    Kumar, J., Holmberg, C., Balabanova, S., Borysova, L., Burdyga, T., Beynon, R., . . . Varro, A. (2015). Mesenchymal Stem Cells Exhibit Regulated Exocytosis in Response to Chemerin and IGF. PLOS ONE, 10(10). doi:10.1371/journal.pone.0141331

    DOI: 10.1371/journal.pone.0141331

    Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population (Journal article)

    Geraghty, J., Thumbs, A., Kankwatira, A., Andrews, T., Moore, A., Malamba, R., . . . Gordon, M. (2015). Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population. PloS One, 10(8). doi:10.1371/journal.pone.0132043

    DOI: 10.1371/journal.pone.0132043

    Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration (Journal article)

    Kumar, J. D., Steele, I., Moore, A. R., Murugesan, S. V., Rakonczay, Z., Venglovecz, V., . . . Dockray, G. J. (2015). Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(2), G78-G86. doi:10.1152/ajpgi.00084.2015

    DOI: 10.1152/ajpgi.00084.2015

    HELICOBACTER PYLORI, HIV AND GASTRIC HYPOCHLORHYDRIA IN THE MALAWIAN POPULATION (Conference Paper)

    Geraghty, J., Thumbs, A., Kankwatira, A., Andrews, T., Moore, A., Malamba, R., . . . Gordon, M. (2015). HELICOBACTER PYLORI, HIV AND GASTRIC HYPOCHLORHYDRIA IN THE MALAWIAN POPULATION. In GUT Vol. 64 (pp. A295). doi:10.1136/gutjnl-2015-309861.636

    DOI: 10.1136/gutjnl-2015-309861.636

    A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and Helicobacter pylori IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort (Conference Paper)

    Moore, A. R., Steele, I., Murugesan, S. V., Tiszlavicz, L., Dockray, G. J., Varro, A., & Pritchard, D. M. (2015). A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and Helicobacter pylori IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort. In GASTROENTEROLOGY Vol. 148 (pp. S54). Retrieved from http://gateway.webofknowledge.com/

    Gastrin Increases miR-222 Expression in AGS(GR) Cells In Vitro and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans In Vivo via Activation of the CCK2 Receptor (Conference Paper)

    Lloyd, K. A., Moore, A. R., O'Hara, A., Boyce, M. J., Varro, A., & Pritchard, D. M. (2015). Gastrin Increases miR-222 Expression in AGS(GR) Cells In Vitro and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans In Vivo via Activation of the CCK2 Receptor. In GASTROENTEROLOGY Vol. 148 (pp. S341). Retrieved from http://gateway.webofknowledge.com/

    Identification of Potential Biomarkers of Netazepide (YF476) Treatment of Type I Gastric Neuroendocrine Tumours (Conference Paper)

    Moore, A. R., Parsons, B. N., Boyce, M. J., Rainbow, L., Fang, Y., Varro, A., . . . Pritchard, D. M. (2015). Identification of Potential Biomarkers of Netazepide (YF476) Treatment of Type I Gastric Neuroendocrine Tumours. In GASTROENTEROLOGY Vol. 148 (pp. S342). Retrieved from http://gateway.webofknowledge.com/

    Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Conference Paper)

    O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from http://gateway.webofknowledge.com/

    Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Journal article)

    O'Hara, A., Burkitt, M., Carr, D., Alfirevic, A., Moore, A., Murugesan, S., . . . Pritchard, M. (2015). Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy.

    Global hypomethylation of esophageal myofibroblasts is associated with accelerated tumor growth. (Conference Paper)

    Giger, O. T., Brown, B., Liloglou, T., Jithesh, P. V., Dockray, J. G., & Varro, A. (2015). Global hypomethylation of esophageal myofibroblasts is associated with accelerated tumor growth.. In CANCER RESEARCH Vol. 75. doi:10.1158/1538-7445.CHTME14-B20

    DOI: 10.1158/1538-7445.CHTME14-B20

    2014

    Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance (Journal article)

    Rasheed, F., Campbell, B. J., Alfizah, H., Varro, A., Zahra, R., Yamaoka, Y., & Pritchard, D. M. (2014). Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance. Helicobacter, 19(5), 387-399. doi:10.1111/hel.12142

    DOI: 10.1111/hel.12142

    Increased expression of chemerin in squamous esophageal cancer myofibroblasts and role in recruitment of mesenchymal stromal cells (Journal article)

    Kumar, J. D., Holmberg, C., Kandola, S., Steele, I., Hegyi, P., Tiszlavicz, L., . . . Varro, A. (2014). Increased expression of chemerin in squamous esophageal cancer myofibroblasts and role in recruitment of mesenchymal stromal cells. PLoS One, 9(8). doi:10.1371/journal.pone.0104877

    DOI: 10.1371/journal.pone.0104877

    Novel roles of gastrin (Journal article)

    Dimaline, R., & Varro, A. (2014). Novel roles of gastrin. JOURNAL OF PHYSIOLOGY-LONDON, 592(14), 2951-2958. doi:10.1113/jphysiol.2014.272435

    DOI: 10.1113/jphysiol.2014.272435

    OC-018 Gastrin Increases Mir-222 Expression In Gastric Epithelial Cells in Vitro And Hypergastrinaemic Ins-gas Mice In Vivo (Journal article)

    Lloyd, K., O'Hara, A., Varro, A., & Pritchard, D. M. (2014). OC-018 Gastrin Increases Mir-222 Expression In Gastric Epithelial Cells in Vitro And Hypergastrinaemic Ins-gas Mice In Vivo. Gut, 63, A9. doi:10.1136/gutjnl-2014-307263.18

    DOI: 10.1136/gutjnl-2014-307263.18

    Indian Hedgehog Mediates Gastrin-Induced Proliferation in Stomach of Adult Mice (Journal article)

    Feng, R., Aihara, E., Kenny, S., Yang, L., Li, J., Varro, A., . . . Zavros, Y. (2014). Indian Hedgehog Mediates Gastrin-Induced Proliferation in Stomach of Adult Mice. Gastroenterology, 147(3), 655-666.e9. doi:10.1053/j.gastro.2014.05.006

    DOI: 10.1053/j.gastro.2014.05.006

    The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression (Journal article)

    Balabanova, S., Holmberg, C., Steele, I., Ebrahimi, B., Rainbow, L., Burdyga, T., . . . Varro, A. (2014). The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression. Carcinogenesis, 35(8), 1798-1806. doi:10.1093/carcin/bgu086

    DOI: 10.1093/carcin/bgu086

    2013

    Signaling mediated by the NF-kappa B sub-units NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice (Journal article)

    Burkitt, M. D., Williams, J. M., Duckworth, C. A., O'Hara, A., Hanedi, A., Varro, A., . . . Pritchard, D. M. (2013). Signaling mediated by the NF-kappa B sub-units NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. ONCOGENE, 32(50), 5563-5573. doi:10.1038/onc.2013.334

    DOI: 10.1038/onc.2013.334

    Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis (Journal article)

    Moore, A. R., Boyce, M., Steele, I. A., Campbell, F., Varro, A., & Pritchard, D. M. (2013). Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis. PLOS ONE, 8(10). doi:10.1371/journal.pone.0076462

    DOI: 10.1371/journal.pone.0076462

    Mapping Proteolytic Processing in the Secretome of Gastric Cancer-Associated Myofibroblasts Reveals Activation of MMP-1, MMP-2, and MMP-3 (Journal article)

    Holmberg, C., Ghesquière, B., Impens, F., Gevaert, K., Kumar, J. D., Cash, N., . . . Varro, A. (2013). Mapping Proteolytic Processing in the Secretome of Gastric Cancer-Associated Myofibroblasts Reveals Activation of MMP-1, MMP-2, and MMP-3. Journal of Proteome Research, 12(7), 3413-3422. doi:10.1021/pr400270q

    DOI: 10.1021/pr400270q

    Sa1735 Proteasome Beta Subunits Interact With the PAI-2 and Reg1 Promoters and Are Required for Gastrin-Stimulated Transcription (Journal article)

    O'Hara, A., Howarth, A., Varro, A., & Dimaline, R. (2013). Sa1735 Proteasome Beta Subunits Interact With the PAI-2 and Reg1 Promoters and Are Required for Gastrin-Stimulated Transcription.

    The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1. (Journal article)

    O'Hara, A., Howarth, A., Varro, A., & Dimaline, R. (2013). The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.. PloS one, 8(3), e59913. doi:10.1371/journal.pone.0059913

    DOI: 10.1371/journal.pone.0059913

    Gastric Expression of Plasminogen Activator Inhibitor (PAI)-1 Is Associated with Hyperphagia and Obesity in Mice (Journal article)

    Kenny, S., Gamble, J., Lyons, S., Vlatkovic, N., Dimaline, R., Varro, A., & Dockray, G. J. (2013). Gastric Expression of Plasminogen Activator Inhibitor (PAI)-1 Is Associated with Hyperphagia and Obesity in Mice. ENDOCRINOLOGY, 154(2), 718-726. doi:10.1210/en.2012-1913

    DOI: 10.1210/en.2012-1913

    Hydration in Advanced Cancer: Can Bioelectrical Impedance Analysis Improve the Evidence Base? A Systematic Review of the Literature (Journal article)

    Nwosu, A. C., Mayland, C. R., Mason, S. R., Khodabukus, A. F., Varro, A., & Ellershaw, J. E. (2013). Hydration in Advanced Cancer: Can Bioelectrical Impedance Analysis Improve the Evidence Base? A Systematic Review of the Literature. JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 46(3), 433-+. doi:10.1016/j.jpainsymman.2012.08.018

    DOI: 10.1016/j.jpainsymman.2012.08.018

    Patients want to be involved in end-of-life care research (Journal article)

    Nwosu, A. C., Mayland, C. R., Mason, S., Varro, A., & Ellershaw, J. E. (2013). Patients want to be involved in end-of-life care research. BMJ Support Palliat Care.

    Patients want to be involved in end-of-life care research. (Journal article)

    Nwosu, A. C., Mayland, C. R., Mason, S., Varro, A., & Ellershaw, J. E. (2013). Patients want to be involved in end-of-life care research.. BMJ supportive & palliative care, 3(4), 457. doi:10.1136/bmjspcare-2013-000537

    DOI: 10.1136/bmjspcare-2013-000537

    Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice (Journal article)

    Duckworth, C. A., Clyde, D., Worthley, D. L., Wang, T. C., Varro, A., & Pritchard, D. M. (2013). Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice. GASTROENTEROLOGY, 145(1), 197-+. doi:10.1053/j.gastro.2013.03.012

    DOI: 10.1053/j.gastro.2013.03.012

    2012

    Release of TGFßig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression. (Journal article)

    Holmberg, C., Quante, M., Steele, I., Kumar, J. D., Balabanova, S., Duval, C., . . . Varro, A. (2012). Release of TGFßig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.. Carcinogenesis, 33(8), 1553-1562. doi:10.1093/carcin/bgs180

    DOI: 10.1093/carcin/bgs180

    Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori (Journal article)

    Schumacher, M. A., Donnelly, J. M., Engevik, A. C., Xiao,, C., Yang, L., Kenny, S., . . . Zavros, Y. (2012). Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology, 142(5), 1150-1159.

    Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage (Journal article)

    Demitrack, E. S., Aihara, E., Kenny, S., Varro, A., & Montrose, M. H. (2012). Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage.

    NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts (Journal article)

    Czepan, M., Rakonczay Jr., Z., Varro, A., Steele, I., Dimaline, R., Lertkowit, N., . . . Hegyi, P. (2012). NHE1 activity contributes to migration and is necessary for proliferation of human gastric myofibroblasts. Pflugers Arch..

    2011

    CLASSICAL AND ALTERNATIVE PATHWAY NF-KB SIGNALLING REGULATE GASTRIC EPITHELIAL RESPONSES TO GAMMA-IRRADIATION (Journal article)

    Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J. H., & Pritchard, D. M. (2011). CLASSICAL AND ALTERNATIVE PATHWAY NF-KB SIGNALLING REGULATE GASTRIC EPITHELIAL RESPONSES TO GAMMA-IRRADIATION. GUT, 60, A9. doi:10.1136/gut.2011.239301.17

    DOI: 10.1136/gut.2011.239301.17

    Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth (Journal article)

    Quante, M., Tu, S. P., Tomita, H., Gonda, T., Wang, S. S. W., Takashi, S., . . . Wang, T. C. (2011). Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth. Cancer Cell, 19(2), 257-272. doi:10.1016/j.ccr.2011.01.020

    DOI: 10.1016/j.ccr.2011.01.020

    Classical and alternative pathway nuclear factor-?B signalling regulate gastric epithelial responses to ?-irradiation (Journal article)

    Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J. H., & Pritchard, D. M. (2011). Classical and alternative pathway nuclear factor-?B signalling regulate gastric epithelial responses to ?-irradiation. Gastroenterology, 140(5), S823.

    Gastrin stimulates expression of plasminogen activator inhibitor (PAI)-1 in gastric epithelial cells (Journal article)

    Norsett, K. G., Steele, I., Duval, C., Sammut, S. J., Murugesan, S. V., Kenny, S., . . . Varro, A. (2011). Gastrin stimulates expression of plasminogen activator inhibitor (PAI)-1 in gastric epithelial cells. American Journal of Physiology, Gastrointestinal Liver Physiology, 301, G446-G453.

    Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing (Journal article)

    Tomita, H., Takaishi, S., Menheniott, T. R., Yang, X., Shibata, W., Jin, G., . . . Wang, T. C. (2011). Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.

    Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia (Journal article)

    Lofgren, J. L., Whary, M. T., Ge, Z., Muthupalani, S., Taylor, N. S., Mobley, M., . . . Fox, J. G. (2011). Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.

    Progastrin stimulates colonic myofibroblast proliferation in vitro and its transgenic over-expression increases colonic myofibroblast abundance in vivo (Journal article)

    Clyde, D., Duckworth, C. A., Varro, A., Wang, T. C., & Pritchard, D. M. (2011). Progastrin stimulates colonic myofibroblast proliferation in vitro and its transgenic over-expression increases colonic myofibroblast abundance in vivo. Gastroenterology, 140(5), S106.

    2010

    EGR1 Is a Target for Cooperative Interactions between Cholecystokinin and Leptin, and Inhibition by Ghrelin, in Vagal Afferent Neurons (Journal article)

    de Lartigue, G., Lur, G., Dimaline, R., Varro, A., Raybould, H., & Dockray, G. J. (2010). EGR1 Is a Target for Cooperative Interactions between Cholecystokinin and Leptin, and Inhibition by Ghrelin, in Vagal Afferent Neurons. Endocrinology, 151(8), 3589-3599. doi:10.1210/en.2010-0106

    DOI: 10.1210/en.2010-0106

    Cocaine- and Amphetamine-Regulated Transcript Mediates the Actions of Cholecystokinin on Rat Vagal Afferent Neurons (Journal article)

    De Lartigue, G., Dimaline, R., Varro, A., Raybould, H., De La Serre, C. B., & Dockray, G. J. (2010). Cocaine- and Amphetamine-Regulated Transcript Mediates the Actions of Cholecystokinin on Rat Vagal Afferent Neurons. Gastroenterology, 138(4), 1479-1490. doi:10.1053/j.gastro.2009.10.034

    DOI: 10.1053/j.gastro.2009.10.034

    Defining the Role of Cholecystokinin in the Lipid-Induced Human Brain Activation Matrix (Journal article)

    Lassman, D. J., McKie, S., Gregory, L. J., Lal, S., D'Amato, M., Steele, I., . . . Thompson, D. G. (2010). Defining the Role of Cholecystokinin in the Lipid-Induced Human Brain Activation Matrix. Gastroenterology, 138(4), 1514-1524. doi:10.1053/j.gastro.2009.12.060

    DOI: 10.1053/j.gastro.2009.12.060

    Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons. (Journal article)

    De Lartigue, G., Dimaline, R., Varro, A., Raybould, H., De la Serre, C. B., & Dockray, G. J. (2010). Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons.. Gastroenterology, 138(4), 1479-1490.

    EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons. (Journal article)

    de Lartigue, G., Lur, G., Dimaline, R., Varro, A., Raybould, H., & Dockray, G. J. (2010). EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.. Endocrinology, 151(8), 3589-3599.

    Elevated serum gastrin is associated with a history of advanced neoplasia in Barrett's esophagus. (Journal article)

    Wang, J. S., Varro, A., Lightdale, C. J., Lertkowit, N., Slack, K. N., Fingerhood, M. L., . . . Abrams, J. A. (2010). Elevated serum gastrin is associated with a history of advanced neoplasia in Barrett's esophagus.. Am J Gastroenterol., 105(5), 1039-1045.

    Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics, and role in influencing neurochemical phenotype (Journal article)

    Burdyga, G., Varro, A., Dimaline, R., Thompson, D. G., & Dockray, G. J. (2010). Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics, and role in influencing neurochemical phenotype. American Journal of Physiology, 299, G63-G69.

    Gastrin stimulates expression of plasminogen activator inhibitor (PAI)-1 in gastric epithelial cells. (Journal article)

    Norsett, K. G., Steele, I., Duval, C., Sammut, S. J., Murugesan, S. V., Kenny, S., . . . Varro, A. (2010). Gastrin stimulates expression of plasminogen activator inhibitor (PAI)-1 in gastric epithelial cells.. Am J Physiol Gastrointest Liver Physiol..

    Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing. (Journal article)

    Tomita, H., Takaishi, S., Menheniott, T. R., Yang, X., Shibata, W., Jin, G., . . . Wang, T. C. (2010). Inhibition of Gastric Carcinogenesis by the Hormone Gastrin Is Mediated by Suppression of TFF1 Epigenetic Silencing.. Gastroenterology.

    Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. (Journal article)

    Lofgren, J. L., Whary, M. T., Ge, Z., Muthupalani, S., Taylor, N. S., Mobley, M., . . . Fox, J. G. (2010). Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.. Gastroenterology, 140(1), 210-220.

    Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells (Journal article)

    Xiao, C., Ogle, S. A., Schumacher, M. A., Orr-Asman, M. A., Miller, M. L., Lertkowit, N., . . . Zavros, Y. (2010). Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells.

    Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. (Journal article)

    Xiao, C., Ogle, S. A., Schumacher, M. A., Orr-Asman, M. A., Miller, M. L., Lertkowit, N., . . . Zavros, Y. (2010). Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells.. Gastroenterology, 138(2), 5500-5561.

    Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy? (Journal article)

    Gonda, T. A., Varro, A., Wang, T. C., & Tycko, B. (2010). Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?. Semin Cell Dev Biol., 21(1), 2-10.

    Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy? (Journal article)

    Gonda, T. A., Varro, A., Wang, T. C., & Tycko, B. (2010). Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?.

    2009

    Importance of gastrin in the pathogenesis and treatment of gastric tumors (Journal article)

    Burkitt, M. D., Varro, A., & Pritchard, D. M. (2009). Importance of gastrin in the pathogenesis and treatment of gastric tumors. WORLD JOURNAL OF GASTROENTEROLOGY, 15(1), 1-16. doi:10.3748/wjg.15.1

    DOI: 10.3748/wjg.15.1

    Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1 (Journal article)

    Almeida-Vega, S., Catlow, K., Kenny, S., Dimaline, R., & Varro, A. (2009). Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.

    2008

    Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts (Journal article)

    Jiang, L., Gonda, T. A., Gamble, M. V., Salas, M., Seshan, V., Tu, S., . . . Tycko, B. (2008). Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts. Cancer Research, 68(23), 9900-9908. doi:10.1158/0008-5472.can-08-1319

    DOI: 10.1158/0008-5472.can-08-1319

    Cholecystokinin Regulates Expression of Y2 Receptors in Vagal Afferent Neurons Serving the Stomach (Journal article)

    Burdyga, G., de Lartigue, G., Raybould, H. E., Morris, R., Dimaline, R., Varro, A., . . . Dockray, G. J. (2008). Cholecystokinin Regulates Expression of Y2 Receptors in Vagal Afferent Neurons Serving the Stomach. Journal of Neuroscience, 28(45), 11583-11592. doi:10.1523/jneurosci.2493-08.2008

    DOI: 10.1523/jneurosci.2493-08.2008

    Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells (Journal article)

    Pagliocca, A., Hegyi, P., Venglovecz, V., Rackstraw, S. A., Khan, Z., Burdyga, G., . . . Dockray, G. J. (2008). Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells. EXPERIMENTAL PHYSIOLOGY, 93(11), 1174-1189. doi:10.1113/expphysiol.2008.042648

    DOI: 10.1113/expphysiol.2008.042648

    Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor (Journal article)

    Pritchard, D. M., Berry, D., Przemeck, S. M. C., Campbell, F., Edwards, S. W., & Varro, A. (2008). Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 295(4), G798-G805. doi:10.1152/ajpgi.00015.2008

    DOI: 10.1152/ajpgi.00015.2008

    Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells (Journal article)

    Kenny, S., Duval, C., Sammut, S. J., Steele, I., Pritchard, D. M., Atherton, J. C., . . . Varro, A. (2008). Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 295(3), G431-G441. doi:10.1152/ajpgi.90283.2008

    DOI: 10.1152/ajpgi.90283.2008

    Hypergastrinemia increases gastric epithelial susceptibility to apoptosis (Journal article)

    Przemeck, S. M. C., Varro, A., Berry, D., Steele, I., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2008). Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. REGULATORY PEPTIDES, 146(1-3), 147-156. doi:10.1016/j.regpep.2007.09.002

    DOI: 10.1016/j.regpep.2007.09.002

    Hypergastrinemia increases gastric epithelial susceptibility to apoptosis (Journal article)

    Przemeck, S. M. C., Varro, A., Berry, D., Steele, I., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2008). Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. Regulatory Peptides, 146(1-3), 147-156. doi:10.1016/j.regpep.2007.09.002

    DOI: 10.1016/j.regpep.2007.09.002

    Regulation of mammalian gastrin/CCK receptor (CCK2R) expressionin vitroandin vivo (Journal article)

    Ashurst, H. L., Varro, A., & Dimaline, R. (2008). Regulation of mammalian gastrin/CCK receptor (CCK2R) expressionin vitroandin vivo. Experimental Physiology, 93(2), 223-236. doi:10.1113/expphysiol.2007.040683

    DOI: 10.1113/expphysiol.2007.040683

    Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection (Journal article)

    Bodger, K., Ahmed, S., Pazmany, L., Pritchard, D. M., Micheal, A., Khan, A. L., . . . Varro, A. (2008). Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection. JOURNAL OF CLINICAL PATHOLOGY, 61(1), 72-78. doi:10.1136/jcp.2007.048058

    DOI: 10.1136/jcp.2007.048058

    Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection (Journal article)

    Bodger, K., Ahmed, S., Pazmany, L., Pritchard, D. M., Micheal, A., Khan, A. L., . . . Varro, A. (n.d.). Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection. Journal of Clinical Pathology, 61(1), 72-78. doi:10.1136/jcp.2007.048058

    DOI: 10.1136/jcp.2007.048058

    2007

    Neurologic, Gastric, and Opthalmologic Pathologies in a Murine Model of Mucolipidosis Type IV (Journal article)

    Venugopal, B., Browning, M. F., Curcio-Morelli, C., Varro, A., Michaud, N., Nanthakumar, N., . . . Slaugenhaupt, S. A. (2007). Neurologic, Gastric, and Opthalmologic Pathologies in a Murine Model of Mucolipidosis Type IV. The American Journal of Human Genetics, 81(5), 1070-1083. doi:10.1086/521954

    DOI: 10.1086/521954

    Carcinogenic hypergastrinemia: Signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome (Journal article)

    Schott, M., Sagert, C., Willenberg, H. S., Schinner, S., Ramp, U., Varro, A., . . . Scherbaum, W. A. (2007). Carcinogenic hypergastrinemia: Signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome. Journal of Clinical Endocrinology and Metabolism, 92(9), 3378-3382. doi:10.1210/jc.2007.0283

    DOI: 10.1210/jc.2007.0283

    Attack and defence in the gastric epithelium - a delicate balance (Journal article)

    Dimaline, R., & Varro, A. (2007). Attack and defence in the gastric epithelium - a delicate balance. Experimental Physiology, 92(4), 591-601. doi:10.1113/expphysiol.2006.036483

    DOI: 10.1113/expphysiol.2006.036483

    Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements (Journal article)

    Steele, I. A., Dimaline, R., Pritchard, D. M., Jr, P. R. M., Wang, T. C., Dockray, G. J., & Varro, A. (2007). Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 293(1), G347-G354. doi:10.1152/ajpgi.00076.2007

    DOI: 10.1152/ajpgi.00076.2007

    Identification of a Gastrin Response Element in the Vesicular Monoamine Transporter Type 2 Promoter and Requirement of 20 S Proteasome Subunits for Transcriptional Activity (Journal article)

    Catlow, K., Ashurst, H. L., Varro, A., & Dimaline, R. (2007). Identification of a Gastrin Response Element in the Vesicular Monoamine Transporter Type 2 Promoter and Requirement of 20 S Proteasome Subunits for Transcriptional Activity. Journal of Biological Chemistry, 282(23), 17069-17077. doi:10.1074/jbc.m611421200

    DOI: 10.1074/jbc.m611421200

    Potentiation of Oxyntic Atrophy–Induced Gastric Metaplasia in Amphiregulin-Deficient Mice (Journal article)

    Nam, K. T., Varro, A., Coffey, R. J., & Goldenring, J. R. (2007). Potentiation of Oxyntic Atrophy–Induced Gastric Metaplasia in Amphiregulin-Deficient Mice. Gastroenterology, 132(5), 1804-1819. doi:10.1053/j.gastro.2007.03.040

    DOI: 10.1053/j.gastro.2007.03.040

    Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling (Journal article)

    Varro, A., Kenny, S., Hemers, E., McCaig, C., Przemeck, S., Wang, T. C., . . . Pritchard, D. M. (2007). Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 292(4), G1133-G1140. doi:10.1152/ajpgi.00526.2006

    DOI: 10.1152/ajpgi.00526.2006

    Cocaine- and Amphetamine-Regulated Transcript: Stimulation of Expression in Rat Vagal Afferent Neurons by Cholecystokinin and Suppression by Ghrelin (Journal article)

    de Lartigue, G., Dimaline, R., Varro, A., & Dockray, G. J. (2007). Cocaine- and Amphetamine-Regulated Transcript: Stimulation of Expression in Rat Vagal Afferent Neurons by Cholecystokinin and Suppression by Ghrelin. Journal of Neuroscience, 27(11), 2876-2882. doi:10.1523/jneurosci.5508-06.2007

    DOI: 10.1523/jneurosci.5508-06.2007

    'GAST gene expression is upregulated in non-small cell lung cancer (Conference Paper)

    Liloglou, T., Daskalos, A., Xinarianos, G., Nikolaidis, G., Varro, A., & Field, J. K. (2007). 'GAST gene expression is upregulated in non-small cell lung cancer. In National Cancer Research Institute Conference (pp. 86). Birmingham: National Cancer Research Institute.

    Functional Regulation of ECL cells (Chapter)

    Varro, A., Kenny, S., Pritchards, D. M., McCaig, C., & Dockray, G. J. (2007). Functional Regulation of ECL cells. In E. Modlin (Ed.), A Centery Advances in Neuroedocrine Disease:a Tribute to Siegfried Oberdorfen (pp. 172-177). Cambridge, UK: Cambridge University Press.

    Post-translational Processing: Peptide Hormones and Neuropeptide Transmitters (Chapter)

    Varro, A. (2007). Post-translational Processing: Peptide Hormones and Neuropeptide Transmitters. In Y. Zheng (Ed.), Encylopedia of Life Scieces (pp. 1-5). Hoboken: John Wiley &Sons.

    2006

    Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy (Journal article)

    Ogawa, M., Nomura, S., Varro, A., Wang, T. C., & Goldenring, J. R. (2006). Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am JPhysiol Gastrointest Liver Physiol.

    Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones (Journal article)

    Burdyga, G., Varro, A., Dimaline, R., Thompson, D. G., & Dockray, G. J. (2006). Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones. Neuroscience, 137(4), 1405-1415. doi:10.1016/j.neuroscience.2005.10.057

    DOI: 10.1016/j.neuroscience.2005.10.057

    Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo (Journal article)

    Przemeck, S., Duckworth, C. A., Varro, A., Pritchard, D., & Pritchard, M. (2006). Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo. Gut, 55, A61.

    Gastrin increases murine intestinal crypt regeneration following injury (Journal article)

    Ottewell, P. D., Duckworth, C. A., Varro, A., Dimaline, R., Wang, T. C., Watson, A. J. M., . . . Pritchard, D. M. (2006). Gastrin increases murine intestinal crypt regeneration following injury. GASTROENTEROLOGY, 130(4), 1169-1180. doi:10.1053/j.gastro.2005.12.033

    DOI: 10.1053/j.gastro.2005.12.033

    Ghrelin receptors in rat and human nodose ganglia: putative role in regulating cannabinoid (CB-1) and melanin concentrating hormone (MCH-1) receptor abundance (Journal article)

    Burdyga, G., Varro, A., Dimaline, R., Thompson, D. G., & Dockray, G. J. (2006). Ghrelin receptors in rat and human nodose ganglia: putative role in regulating cannabinoid (CB-1) and melanin concentrating hormone (MCH-1) receptor abundance. Am J Physiol Gastrointest Liver Physiol. Retrieved from http://www.ncbi.nlm.nih.gov/

    The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori (Journal article)

    McCaig, C., Duval, C., Hemers, E., Steele, I., Pritchard, D. M., Przemeck, S., . . . Varro, A. (2006). The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. GASTROENTEROLOGY, 130(6), 1754-1763. doi:10.1053/j.gastro.2006.02.031

    DOI: 10.1053/j.gastro.2006.02.031

    2005

    Insulin-Like Growth Factor Binding Protein-5 Is a Target of Matrix Metalloproteinase-7: Implications for Epithelial-Mesenchymal Signaling (Journal article)

    Hemers, E., Duval, C., McCaig, C., Handley, M., Dockray, G. J., & Varro, A. (2005). Insulin-Like Growth Factor Binding Protein-5 Is a Target of Matrix Metalloproteinase-7: Implications for Epithelial-Mesenchymal Signaling. Cancer Research, 65(16), 7363-7369. doi:10.1158/0008-5472.can-05-0157

    DOI: 10.1158/0008-5472.can-05-0157

    Synergistic Inhibitory Effects of Gastrin and Histamine Receptor Antagonists on Helicobacter-Induced Gastric Cancer (Journal article)

    Takaishi, S., Cui, G., Frederick, D. M., Carlson, J. E., Houghton, J., Varro, A., . . . Wang, T. C. (2005). Synergistic Inhibitory Effects of Gastrin and Histamine Receptor Antagonists on Helicobacter-Induced Gastric Cancer. Gastroenterology, 128(7), 1965-1983. doi:10.1053/j.gastro.2005.03.027

    DOI: 10.1053/j.gastro.2005.03.027

    Gastrin induces MDM-2 and suppresses p53 expression in AGS(GR) cells, resulting in resistance to DNA damage induced apoptosis (Journal article)

    Przemeck, S. M. C., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Gastrin induces MDM-2 and suppresses p53 expression in AGS(GR) cells, resulting in resistance to DNA damage induced apoptosis. GUT, 54, A87-A88. Retrieved from http://gateway.webofknowledge.com/

    Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice (Journal article)

    Duckworth, C. A., Ottewell, P. D., Dimaline, R., Varro, A., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, 54, A98. Retrieved from http://gateway.webofknowledge.com/

    Radiation induces gastrin-CCKB receptor expression in IEC-6 and IEC-18 intestinal epithelial cells (Journal article)

    Ottewell, P. D., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Radiation induces gastrin-CCKB receptor expression in IEC-6 and IEC-18 intestinal epithelial cells. GUT, 54, A88. Retrieved from http://gateway.webofknowledge.com/

    Th1 cytokines, but not gastrin increase Helicobacter pylori induced apoptosis in short term primary cultures of murine gastric glands (Journal article)

    Przemeck, M. C., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Th1 cytokines, but not gastrin increase Helicobacter pylori induced apoptosis in short term primary cultures of murine gastric glands. GUT, 54, A61. Retrieved from http://gateway.webofknowledge.com/

    COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo (Journal article)

    Ottewell, P. D., Varro, A., Dockray, G. J., Kirton, C. M., Watson, A. J. M., Wang, T. C., . . . Pritchard, D. M. (2005). COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 288(3), G541-G549. doi:10.1152/ajpgi.00268.2004

    DOI: 10.1152/ajpgi.00268.2004

    Gastrin induces mdm-2 and suppresses p53 protein expression in Ags-GR cells, resulting in resistance to DNA damage induced apoptosis (Journal article)

    Przemeck, S. M., Watson, A. J., Varro, A., & Pritichard, D. M. (2005). Gastrin induces mdm-2 and suppresses p53 protein expression in Ags-GR cells, resulting in resistance to DNA damage induced apoptosis. Gastroenterology, 128(4 Supp), A-141.

    Gastrin: old hormone, new functions (Journal article)

    Dockray, G., Dimaline, R., & Varro, A. (2005). Gastrin: old hormone, new functions. Pfl?gers Archiv - European Journal of Physiology, 449(4), 344-355. doi:10.1007/s00424-004-1347-5

    DOI: 10.1007/s00424-004-1347-5

    Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice. (Journal article)

    Duckworth, C. A., Ottewell, P. D., Varro, A., Dimaline, R., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. Gastroenterology, 128(4), A203.

    2004

    Overexpression of Glycine-Extended Gastrin Inhibits Parietal Cell Loss and Atrophy in the Mouse Stomach (Journal article)

    Cui, G., Koh, T. J., Chen, D., Zhao, C. -M., Takaishi, S., Dockray, G. J., . . . Wang, T. C. (2004). Overexpression of Glycine-Extended Gastrin Inhibits Parietal Cell Loss and Atrophy in the Mouse Stomach. Cancer Research, 64(22), 8160-8166. doi:10.1158/0008-5472.can-04-0876

    DOI: 10.1158/0008-5472.can-04-0876

    Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element (Journal article)

    ASHCROFT, F. J., VARRO, A., DIMALINE, R., & DOCKRAY, G. J. (2004). Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal, 381(2), 397-403. doi:10.1042/bj20031793

    DOI: 10.1042/bj20031793

    Expression of Cannabinoid CB1 Receptors by Vagal Afferent Neurons Is Inhibited by Cholecystokinin (Journal article)

    Burdyga, G. (2004). Expression of Cannabinoid CB1 Receptors by Vagal Afferent Neurons Is Inhibited by Cholecystokinin. Journal of Neuroscience, 24(11), 2708-2715. doi:10.1523/jneurosci.5404-03.2004

    DOI: 10.1523/jneurosci.5404-03.2004

    Glycine-extended gastrin promotes the growth of lung cancer (Journal article)

    Koh, T. J., Field, J. K., Varro, A., Liloglou, T., Fielding, P., Cui, G. L., . . . Wang, T. C. (2004). Glycine-extended gastrin promotes the growth of lung cancer. CANCER RESEARCH, 64(1), 196-201. doi:10.1158/0008-5472.CAN-03-2112

    DOI: 10.1158/0008-5472.CAN-03-2112

    Glycine-extended gastrin promotes the growth of lung cancer (Journal article)

    Koh, T. J., Field, J. K., Varro, A., Liloglou, L., Fielding, P., Cui, G., . . . Wang, T. C. (2004). Glycine-extended gastrin promotes the growth of lung cancer. Cancer Research, 64(1), 196-201. doi:10.1158/0008-5472.CAN-03-2112

    DOI: 10.1158/0008-5472.CAN-03-2112

    Glycine-extended gastrin promotes the growth of lung cancer (Journal article)

    Koh, T. J., Field, J. K., Varro, A., Liloglou, T., Fielding, P., Cui, G. L., . . . Wang, T. C. (2004). Glycine-extended gastrin promotes the growth of lung cancer. Cancer Research, 64(1), 196-201. Retrieved from http://cancerres.aacrjournals.org/cgi/reprint/64/1/196

    Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-κB and RhoA: implications for invasion and apoptosis (Journal article)

    Varro, A., Noble, P. J., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004). Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-κB and RhoA: implications for invasion and apoptosis. Cancer Res, 64(5), 1695-1702. Retrieved from http://cancerres.aacrjournals.org/cgi/reprint/64/5/1695

    2003

    Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration (Journal article)

    Wroblewski, L. E., Noble, P. J. M., Pagliocca, A., Pritchard, D. M., Hart, C. A., Campbell, F., . . . Varro, A. (2003). Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. JOURNAL OF CELL SCIENCE, 116(14), 3017-3026. doi:10.1242/jcs.00518

    DOI: 10.1242/jcs.00518

    Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration (Journal article)

    Wroblewski, L. E., Noble, P. J., Pagliocca, A., Pritchard, D. M., Hart, C. A., Campbell, F., . . . Varro, A. (2003). Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. J Cell Sci, 116(Pt 14), 3017-3026. doi:10.1242/10.1242/jcs.00518

    DOI: 10.1242/10.1242/jcs.00518

    Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways (Journal article)

    Noble, P. J. M., Wilde, G., White, M. R. H., Pennington, S. R., Dockray, G. J., & Varro, A. (2003). Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways. American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(1), G75-G84. doi:10.1152/ajpgi.00300.2002

    DOI: 10.1152/ajpgi.00300.2002

    2002

    Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression (Journal article)

    Wroblewski, L. E., Pritchard, D. M., Carter, S., & Varro, A. (2002). Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression. BIOCHEMICAL JOURNAL, 365, 873-879. doi:10.1042/BJ20020068

    DOI: 10.1042/BJ20020068

    Stimulation of the gastrin-cholecystokininBreceptor promotes branching morphogenesis in gastric AGS cells (Journal article)

    Pagliocca, A., Wroblewski, L. E., Ashcroft, F. J., Noble, P. J., Dockray, G. J., & Varro, A. (2002). Stimulation of the gastrin-cholecystokininBreceptor promotes branching morphogenesis in gastric AGS cells. American Journal of Physiology-Gastrointestinal and Liver Physiology, 283(2), G292-G299. doi:10.1152/ajpgi.00056.2002

    DOI: 10.1152/ajpgi.00056.2002

    Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin (Journal article)

    Varro, A., Hemers, E., Archer, D., Pagliocca, A., Haigh, C., Ahmed, S., . . . Dockray, G. J. (2002). Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin. Gastroenterology, 123(1), 271-280. doi:10.1053/gast.2002.34162

    DOI: 10.1053/gast.2002.34162

    Gastrin-cholecystokinin(B) receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor (Journal article)

    Varro, A., Noble, P. J., Wroblewski, L. E., Bishop, L., & Dockray, G. J. (2002). Gastrin-cholecystokinin(B) receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor. Gut, 50(6), 827-833.

    Expression of the leptin receptor in rat and human nodose ganglion neurones (Journal article)

    Burdyga, G., Spiller, D., Morris, R., Lal, S., Thompson, D. G., Saeed, S., . . . Dockray, G. J. (2002). Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience, 109(2), 339-347. doi:10.1016/s0306-4522(01)00474-2

    DOI: 10.1016/s0306-4522(01)00474-2

    Gastrin-cholecystokininB receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the EGF-receptor (Journal article)

    Varro, A., Noble, P. -J., Wroblewski, L., Bishop, L., & Dockray, G. J. (2002). Gastrin-cholecystokininB receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the EGF-receptor. Gut, 50(6), 827-833.

    2001

    Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage (Journal article)

    Blackmore, C. G., Varro, A., Dimaline, R., Bishop, L., Gallacher, D. V., & Dockray, G. J. (2001). Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage. The Journal of Physiology, 531(3), 605-617. doi:10.1111/j.1469-7793.2001.0605h.x

    DOI: 10.1111/j.1469-7793.2001.0605h.x