Later phase trial design and analysis
Theme leaders: Professor Carrol Gamble and Dr Catrin Tudur Smith
HTMR Trial Conduct Working Group webinar June 2014
Theme 2 Projects:
Methodological challenges remain for the design, conduct, analysis and reporting of later phase trials, and appropriately disseminated and accessible advancements are required to facilitate the rapid application of research findings. Our group will build on existing combined strengths focussing on specific areas of interest and expertise which include the following:
Using systematic reviews and meta-analysis to inform trial design
The group’s track record in systematic reviews and meta-analysis is evidenced by a number of publications across specific areas...
Longitudinal data arise when individuals are followed over time and may simultaneously include two components: event times and repeated measurements.
Clinical Trial Management
In addition to appropriate and well informed trial design, the effective management and appropriate analysis of a clinical trial is essential to ensure quality and integrity.
Non-compliance is known to be common with an estimated thirty to forty percent of the treated population being non-compliant to some extent.
Non-adherence to prescribed medications leads to therapeutic non-response and economic inefficiencies.
In the statistical literature, the situation where there are several reasons why an event can occur is known as ‘competing risks’.