Dr Joseph Sacco

Molecular & Clinical Cancer Medicine

    Publications

    2021

    Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles (Journal article)

    Ye, W., Olsson-Brown, A., Watson, R. A., Cheung, V. T. F., Morgan, R. D., Nassiri, I., . . . Fairfax, B. P. (2021). Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles. BRITISH JOURNAL OF CANCER, 124(10), 1661-1669. doi:10.1038/s41416-021-01310-3

    DOI: 10.1038/s41416-021-01310-3

    Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB-IVM1c melanoma (Journal article)

    Malvehy, J., Samoylenko, I., Schadendorf, D., Gutzmer, R., Grob, J. -J., Sacco, J. J., . . . Gogas, H. (2021). Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB-IVM1c melanoma. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(3). doi:10.1136/jitc-2020-001621

    DOI: 10.1136/jitc-2020-001621

    Cost-utility analysis of a decade of liver screening for metastases using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) (Journal article)

    Eleuteri, A., Rola, A. C., Kalirai, H., Hussain, R., Sacco, J., Damato, B. E., . . . Taktak, A. F. G. (2021). Cost-utility analysis of a decade of liver screening for metastases using the Liverpool Uveal Melanoma Prognosticator Online (LUMPO). COMPUTERS IN BIOLOGY AND MEDICINE, 130. doi:10.1016/j.compbiomed.2021.104221

    DOI: 10.1016/j.compbiomed.2021.104221

    2020

    Adjuvant management of locally advanced oral squamous cell carcinoma – real world challenges and opportunities (Journal article)

    Brooker, R. C., Hobkirk, A., Cashman, H., Sato, T., Broderick, D., Wong, H., . . . Schache, A. G. (n.d.). Adjuvant management of locally advanced oral squamous cell carcinoma – real world challenges and opportunities. British Journal of Oral and Maxillofacial Surgery. doi:10.1016/j.bjoms.2020.08.034

    DOI: 10.1016/j.bjoms.2020.08.034

    Vitiligo and other clinical melanocyte-related adverse events following tebentafusp (IMCgp100) exposure in patients with uveal melanoma (Conference Paper)

    Orloff, M., Sacco, J. J., Nathan, P., Holland, C., Cohen, C., Harper, J., . . . Carvajal, R. D. (2020). Vitiligo and other clinical melanocyte-related adverse events following tebentafusp (IMCgp100) exposure in patients with uveal melanoma. In CANCER RESEARCH Vol. 80. doi:10.1158/1538-7445.AM2020-3295

    DOI: 10.1158/1538-7445.AM2020-3295

    Looking a Gift Horse in the Mouth: Observations on NHS England's Interim Guidance on Pembrolizumab in Head and Neck Squamous Cell Cancer (Journal article)

    Harrington, K. J., Bhide, S. A., Forster, M. D., Good, J. S., Gunn, L., Kong, A., . . . Wong, K. H. (2020). Looking a Gift Horse in the Mouth: Observations on NHS England's Interim Guidance on Pembrolizumab in Head and Neck Squamous Cell Cancer. Clinical Oncology, 32(8), 490-492. doi:10.1016/j.clon.2020.05.016

    DOI: 10.1016/j.clon.2020.05.016

    Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way? (Journal article)

    Cheung, V. T. F., Gupta, T., Olsson-Brown, A., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?. BRITISH JOURNAL OF CANCER, 123(2), 207-215. doi:10.1038/s41416-020-0882-y

    DOI: 10.1038/s41416-020-0882-y

    Immune checkpoint inhibitor-related colitis assessment and prognosis: can inflammatory bowel disease scoring point the way? (Conference Paper)

    Cheung, V. T. F., Gupta, T., Olsson-Brown, A., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). Immune checkpoint inhibitor-related colitis assessment and prognosis: can inflammatory bowel disease scoring point the way?. In JOURNAL OF CROHNS & COLITIS Vol. 14 (pp. S286-S288). Retrieved from http://gateway.webofknowledge.com/

    IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY? (Conference Paper)

    Cheung, V. T., Gupta, T., Olsson-Brown, A. C., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?. In GASTROENTEROLOGY Vol. 158 (pp. S535-S536). Retrieved from http://gateway.webofknowledge.com/

    Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development. (Journal article)

    Figueiredo, C. R., Kalirai, H., Sacco, J. J., Azevedo, R. A., Duckworth, A., Slupsky, J. R., . . . Coupland, S. E. (2020). Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.. The Journal of Pathology, 250(4), 420-439. doi:10.1002/path.5384

    DOI: 10.1002/path.5384

    Two distinct clinical patterns of checkpoint inhibitor-induced thyroid dysfunction (Journal article)

    Olsson-Brown, A., Lord, R., Sacco, J., Wagg, J., Coles, M., & Pirmohamed, M. (2020). Two distinct clinical patterns of checkpoint inhibitor-induced thyroid dysfunction. ENDOCRINE CONNECTIONS, 9(4), 318-325. doi:10.1530/EC-19-0473

    DOI: 10.1530/EC-19-0473

    2019

    Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck (Journal article)

    Carter, R. J., Milani, M., Butterworth, M., Alotibi, A., Harper, N., Yedida, G., . . . Varadarajan, S. (2019). Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Cell Death and Disease, 10(12). doi:10.1038/s41419-019-2150-8

    DOI: 10.1038/s41419-019-2150-8

    Implementation of a dedicated immuno-oncology toxicity service reduces the acute impact of immune-related adverse events (Conference Paper)

    Olsson-Brown, A. C., Guinan, T., Mckay, M., Thurston, K., Chow, S., Lord, R., & Sacco, J. J. (2019). Implementation of a dedicated immuno-oncology toxicity service reduces the acute impact of immune-related adverse events. In ANNALS OF ONCOLOGY Vol. 30. Retrieved from http://gateway.webofknowledge.com/

    SELPAC: A 3 arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel (PT) in metastatic uveal melanoma (UM) (Conference Paper)

    Nathan, P., Needham, A., Corrie, P. G., Danson, S., Evans, J., Ochsenreither, S., . . . Sacco, J. J. (2019). SELPAC: A 3 arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel (PT) in metastatic uveal melanoma (UM). In ANNALS OF ONCOLOGY Vol. 30. Retrieved from http://gateway.webofknowledge.com/

    Integration of Checkpoint Inhibitors into the Management of Locally Advanced Head and Neck Cancer - Future Perspectives (Journal article)

    Brooker, R. C., Sacco, J. J., & Schache, A. G. (2019). Integration of Checkpoint Inhibitors into the Management of Locally Advanced Head and Neck Cancer - Future Perspectives. Clinical Oncology, 31(7), 424-431. doi:10.1016/j.clon.2019.04.011

    DOI: 10.1016/j.clon.2019.04.011

    An open label, multicenter, phase I/II study of RP1 as a single agent and in combination with PD1 blockade in patients with solid tumors. (Conference Paper)

    Middleton, M. R., Sacco, J. J., Merchan, J. R., Curti, B. D., Vanderwalde, A. M., Olsson-Brown, A. C., . . . Harrington, K. J. (2019). An open label, multicenter, phase I/II study of RP1 as a single agent and in combination with PD1 blockade in patients with solid tumors.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 37. doi:10.1200/JCO.2019.37.15_suppl.TPS2671

    DOI: 10.1200/JCO.2019.37.15_suppl.TPS2671

    Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features and clinical outcome. (Journal article)

    Kenawy, N., Kalirai, H., Sacco, J. J., Lake, S. L., Heegaard, S., Larsen, A. -C., . . . Coupland, S. E. (2019). Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features and clinical outcome.. Pigment cell & melanoma research, 32(4), 564-575. doi:10.1111/pcmr.12767

    DOI: 10.1111/pcmr.12767

    2018

    The unexpected challenges of immunotherapy (Conference Paper)

    Olsson-Brown, A. C., Guinan, T. J., Mckay, M., Chow, S., Lord, R., Pirmohamed, M., & Sacco, J. J. (2018). The unexpected challenges of immunotherapy. In ANNALS OF ONCOLOGY Vol. 29 (pp. 20). Retrieved from http://gateway.webofknowledge.com/

    Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma (Journal article)

    Jama, N., Farquhar, N., Butt, Z., Coupland, S. E., Sacco, J. J., Scase, T., . . . Killick, D. R. (2018). Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma. Journal of Comparative Pathology, 162, 50-58. doi:10.1016/j.jcpa.2018.06.007

    DOI: 10.1016/j.jcpa.2018.06.007

    Recent breakthroughs in metastatic uveal melanoma: a cause for optimism? (Journal article)

    Sacco, J. J., Kalirai, H., Kenyani, J., Figueiredo, C. R., Coulson, J. M., & Coupland, S. E. (2018). Recent breakthroughs in metastatic uveal melanoma: a cause for optimism?. FUTURE ONCOLOGY, 14(14), 1335-1338. doi:10.2217/fon-2018-0116

    DOI: 10.2217/fon-2018-0116

    A randomised, double-blind, placebo-controlled phase IIa trial of AMG319 given orally as neoadjuvant therapy in patients with human papillomavirus (HPV) positive and negative head and neck squamous cell carcinoma (HNSCC). (Conference Paper)

    Ottensmeier, C. H. H., Jones, T., Sacco, J. J., McCaul, J. A., Brennan, P., Paterson, C., . . . King, E. (2018). A randomised, double-blind, placebo-controlled phase IIa trial of AMG319 given orally as neoadjuvant therapy in patients with human papillomavirus (HPV) positive and negative head and neck squamous cell carcinoma (HNSCC).. In JOURNAL OF CLINICAL ONCOLOGY Vol. 36. doi:10.1200/JCO.2018.36.15_suppl.6068

    DOI: 10.1200/JCO.2018.36.15_suppl.6068

    The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity (Journal article)

    Fielding, A. B., Concannon, M., Darling, S., Rusilowicz, E., Sacco, J., Prior, I. A., . . . Coulson, J. M. (2018). The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity. Oncogene, 37(17), 2326-2342. doi:10.1038/s41388-017-0092-0

    DOI: 10.1038/s41388-017-0092-0

    Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics (Journal article)

    Bailey, F. P., Clarke, K., Kalirai, H., Kenyani, J., Shahidipour, H., Falciani, F., . . . Eyers, P. A. (2018). Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics. Pigment Cell and Melanoma Research, 31(2), 253-266. doi:10.1111/pcmr.12650

    DOI: 10.1111/pcmr.12650

    Two distinct clinical trajectories of inflammatory thyroiditis evoked by checkpoint blockade in malignant melanoma. (Conference Paper)

    Olsson-Brown, A. C., Lord, R., Sacco, J. J., Coles, M. C., Wagg, J., & Pirmohamed, M. (2018). Two distinct clinical trajectories of inflammatory thyroiditis evoked by checkpoint blockade in malignant melanoma.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 36. doi:10.1200/JCO.2018.36.5_suppl.131

    DOI: 10.1200/JCO.2018.36.5_suppl.131

    Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma (Journal article)

    Farquhar, N., Thornton, S., Coupland, S. E., Coulson, J., Sacco, J. J., Krishna, Y., . . . Kalirai, H. (2018). Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma. The Journal of Pathology: Clinical Research, 4(1), 26-38. doi:10.1002/cjp2.86

    DOI: 10.1002/cjp2.86

    2017

    Modulating the DNA Damage Response to Improve Treatment Response in Cervical Cancer (Journal article)

    Cossar, L. H., Schache, A. G., Risk, J. M., Sacco, J. J., Jones, N. J., & Lord, R. (2017). Modulating the DNA Damage Response to Improve Treatment Response in Cervical Cancer. Clinical Oncology, 29(9), 626-634. doi:10.1016/j.clon.2017.03.002

    DOI: 10.1016/j.clon.2017.03.002

    Gene expression profiling in bladder cancer identifies potential therapeutic targets (Journal article)

    Hussain, S. A., Palmeri, D. H., Syn, W. -K., Sacco, J. J., Greensmith, R. M. D., Elmetwali, T., . . . James, N. D. (2017). Gene expression profiling in bladder cancer identifies potential therapeutic targets. INTERNATIONAL JOURNAL OF ONCOLOGY, 50(4), 1147-1159. doi:10.3892/ijo.2017.3893

    DOI: 10.3892/ijo.2017.3893

    2016

    Challenges and Strategies in Precision Medicine for Non-Small-Cell Lung Cancer (Journal article)

    Sacco, J. J., Al-Akhrass, H., & Wilson, C. M. (2016). Challenges and Strategies in Precision Medicine for Non-Small-Cell Lung Cancer. CURRENT PHARMACEUTICAL DESIGN, 22(28), 4374-4385. doi:10.2174/1381612822666160603014932

    DOI: 10.2174/1381612822666160603014932

    Systemic listeriosis following vaccination with the attenuated Listeria monocytogenes therapeutic vaccine, ADXS11-001 (Journal article)

    Sacco, J. J., Evans, M., Harrington, K. J., Man, S., Powell, N., Shaw, R. J., & Jones, T. M. (2016). Systemic listeriosis following vaccination with the attenuated Listeria monocytogenes therapeutic vaccine, ADXS11-001. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 12(4), 1085-1086. doi:10.1080/21645515.2015.1121338

    DOI: 10.1080/21645515.2015.1121338

    2015

    Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors (Journal article)

    Sacco, J., Kenyani, J., Butt, Z., Carter, R., Chew, H. Y., Cheeseman, L. P., . . . Coulson, J. (2015). Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. Oncotarget, 6(15), 13757-13771. doi:10.18632/oncotarget.3765

    DOI: 10.18632/oncotarget.3765

    Dysregulation of the Met pathway in non-small cell lung cancer: implications for drug targeting and resistance (Journal article)

    Sacco, J., & Clague, M. (2015). Dysregulation of the Met pathway in non-small cell lung cancer: implications for drug targeting and resistance. Translational Lung Cancer Research, 4(3), 242-252. doi:10.3978/j.issn.2218-6751.2015.03.05

    DOI: 10.3978/j.issn.2218-6751.2015.03.05

    2014

    The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells (Journal article)

    Sacco, J., Yau, T. Y., Darling, S., Patel, V., Liu, H., Urbe, S., . . . Coulson, J. (2014). The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells. Oncogene, 33(33), 4265-4272. doi:10.1038/onc.2013.512

    DOI: 10.1038/onc.2013.512

    2010

    Emerging Roles of Deubiquitinases in Cancer-Associated Pathways (Journal article)

    Sacco, J. J., Coulson, J. M., Clague, M. J., & Urbe, S. (2010). Emerging Roles of Deubiquitinases in Cancer-Associated Pathways. IUBMB LIFE, 62(2), 140-157. doi:10.1002/iub.300

    DOI: 10.1002/iub.300

    The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. (Journal article)

    Sacco, J. J., Botten, J., Macbeth, F., Bagust, A., & Clark, P. (2010). The average body surface area of adult cancer patients in the UK: a multicentre retrospective study.. PloS one, 5(1), e8933. doi:10.1371/journal.pone.0008933

    DOI: 10.1371/journal.pone.0008933