Publications
2025
Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes.
O'Neill, K. M., Edgar, K. S., Pun, S. H., Campbell, D. C., Toh, T., Wong, X. N., . . . Grieve, D. J. (2025). Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes.. Stem cell research & therapy, 16(1), 275. doi:10.1186/s13287-025-04393-4
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity.
Chambers, S. E. J., Guduric-Fuchs, J., Pedrini, E., Bertelli, P. M., Charoensuk, C., Peixoto, E., . . . Medina, R. J. (2025). Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity.. Angiogenesis, 28(3), 30. doi:10.1007/s10456-025-09982-8
From Bench to Bedside: Unraveling Cerebral Malaria and Malarial Retinopathy by Combining Clinical and Pre-Clinical Perspectives
McDonnell, S., MacCormick, I. J., Harkin, K., Medina, R. J., Rodriguez, A., & Stitt, A. W. (2025). From Bench to Bedside: Unraveling Cerebral Malaria and Malarial Retinopathy by Combining Clinical and Pre-Clinical Perspectives. Current Eye Research, 1-15. doi:10.1080/02713683.2025.2463142
Atovaquone-induced activation of the PERK/eIF2α signaling axis mitigates metabolic radiosensitisation.
Feng, J., Pathak, V., Byrne, N. M., Chambers, S., Wang, T., Islam, R., . . . Coulter, J. A. (2025). Atovaquone-induced activation of the PERK/eIF2α signaling axis mitigates metabolic radiosensitisation.. Cell communication and signaling : CCS, 23(1), 164. doi:10.1186/s12964-025-02160-9
International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus.
Short, E., Huckstepp, R. T. R., Alavian, K., Amoaku, W. M. K., Barber, T. M., van Beek, E. J. R., . . . Bentley, B. L. (2025). International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus.. GeroScience. doi:10.1007/s11357-025-01509-9
2024
Modulation of diabetes-related retinal pathophysiology by PTX3
Pathak, V., Bertelli, P. M., Pedrini, E., Harkin, K., Peixoto, E., Allen, L. -D., . . . Medina, R. J. (2024). Modulation of diabetes-related retinal pathophysiology by PTX3.. Proceedings of the National Academy of Sciences of the United States of America, 121(41), e2320034121. doi:10.1073/pnas.2320034121
Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.
Short, E., ICCARP., Calimport, S., & Bentley, B. (2024). Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.. GeroScience. doi:10.1007/s11357-024-01315-9
A new gene signature for endothelial senescence identifies self‐<scp>RNA</scp> sensing by retinoic acid‐inducible gene I as a molecular facilitator of vascular aging
Guduric-Fuchs, J., Pedrini, E., Bertelli, P. M., McDonnell, S., Pathak, V., McLoughlin, K., . . . Medina, R. J. (2024). A new gene signature for endothelial senescence identifies self-RNA sensing by retinoic acid-inducible gene I as a molecular facilitator of vascular aging.. Aging cell, 23(9), e14240. doi:10.1111/acel.14240
Retinal vascular regeneration
Pathak, V., Bertelli, P. M., Guduric-Fuchs, J., Eyre, J., Reid, E., Lois, N., . . . Medina, R. J. (2024). Retinal vascular regeneration. In Retinal and Choroidal Vascular Diseases of the Eye (pp. 581-588). Elsevier. doi:10.1016/b978-0-443-15583-3.00044-5
2023
Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer
Feng, J., Pathak, V., Byrne, N. M., Wang, T., Yin, C., Medina, R. J., & Coulter, J. A. (2023). Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer. Cancer Nanotechnology, 14(1). doi:10.1186/s12645-023-00185-8
Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity.
Romeo, S. G., Secco, I., Schneider, E., Reumiller, C. M., Santos, C. X. C., Zoccarato, A., . . . Zampetaki, A. (2023). Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity.. Nature communications, 14(1), 5552. doi:10.1038/s41467-023-41326-2
PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia.
Pun, S. H., O'Neill, K. M., Edgar, K. S., Gill, E. K., Moez, A., Naderi-Meshkin, H., . . . Grieve, D. J. (2023). PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia.. Cells, 12(18), 2220. doi:10.3390/cells12182220
Ocular application of electrospun materials for drug delivery and cellular therapies.
Mishra, D., Gade, S., Pathak, V., Vora, L. K., Mcloughlin, K., Medina, R., . . . Raghu Raj Singh, T. (2023). Ocular application of electrospun materials for drug delivery and cellular therapies.. Drug discovery today, 28(9), 103676. doi:10.1016/j.drudis.2023.103676
2022
Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina.
Kurzawa-Akanbi, M., Whitfield, P., Burté, F., Bertelli, P. M., Pathak, V., Doherty, M., . . . Lako, M. (2022). Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina.. Journal of extracellular vesicles, 11(12), e12295. doi:10.1002/jev2.12295
Long term high glucose exposure induces premature senescence in retinal endothelial cells.
Bertelli, P. M., Pedrini, E., Hughes, D., McDonnell, S., Pathak, V., Peixoto, E., . . . Medina, R. J. (2022). Long term high glucose exposure induces premature senescence in retinal endothelial cells.. Frontiers in physiology, 13, 929118. doi:10.3389/fphys.2022.929118
Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina.
Lechner, J., Medina, R. J., Lois, N., & Stitt, A. W. (2022). Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina.. Stem cell research & therapy, 13(1), 388. doi:10.1186/s13287-022-03073-x
The Long Pentraxin PTX3 as a New Biomarker and Pharmacological Target in Age-Related Macular Degeneration and Diabetic Retinopathy.
Stravalaci, M., Ferrara, M., Pathak, V., Davi, F., Bottazzi, B., Mantovani, A., . . . Inforzato, A. (2021). The Long Pentraxin PTX3 as a New Biomarker and Pharmacological Target in Age-Related Macular Degeneration and Diabetic Retinopathy.. Frontiers in pharmacology, 12, 811344. doi:10.3389/fphar.2021.811344
2021
Current concepts on endothelial stem cells definition, location, and markers.
Chambers, S. E. J., Pathak, V., Pedrini, E., Soret, L., Gendron, N., Guerin, C. L., . . . Medina, R. J. (2021). Current concepts on endothelial stem cells definition, location, and markers.. Stem cells translational medicine, 10 Suppl 2, S54-S61. doi:10.1002/sctm.21-0022
miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia.
Guduric-Fuchs, J., Pedrini, E., Lechner, J., Chambers, S. E. J., O'Neill, C. L., Mendes Lopes de Melo, J., . . . Medina, R. J. (2021). miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia.. Molecular therapy. Nucleic acids, 23, 968-981. doi:10.1016/j.omtn.2021.01.015
2020
Tibetan <i>PHD2</i>, an allele with loss-of-function properties.
Song, D., Navalsky, B. E., Guan, W., Ingersoll, C., Wang, T., Loro, E., . . . Lee, F. S. (2020). Tibetan <i>PHD2</i>, an allele with loss-of-function properties.. Proceedings of the National Academy of Sciences of the United States of America, 117(22), 12230-12238. doi:10.1073/pnas.1920546117
Vascular Regeneration for Ischemic Retinopathies: Hope from Cell Therapies.
Bertelli, P. M., Pedrini, E., Guduric-Fuchs, J., Peixoto, E., Pathak, V., Stitt, A. W., & Medina, R. J. (2020). Vascular Regeneration for Ischemic Retinopathies: Hope from Cell Therapies.. Current eye research, 45(3), 372-384. doi:10.1080/02713683.2019.1681004
NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes post-ischaemic revascularization.
O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., . . . Grieve, D. J. (2020). NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes post-ischaemic revascularization.. Cardiovascular research, 116(2), 393-405. doi:10.1093/cvr/cvz090
Editorial: Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation.
Medina, R. J., & Smadja, D. M. (2019). Editorial: Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation.. Frontiers in medicine, 6, 290. doi:10.3389/fmed.2019.00290
2019
No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells.
Dutton, L. R., O'Neill, C. L., Medina, R. J., & Brazil, D. P. (2019). No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells.. The Journal of biological chemistry, 294(48), 18041-18045. doi:10.1074/jbc.ac119.010148
The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic.
O'Leary, O. E., Canning, P., Reid, E., Bertelli, P. M., McKeown, S., Brines, M., . . . Stitt, A. W. (2019). The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic.. Experimental eye research, 182, 144-155. doi:10.1016/j.exer.2019.03.001
Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives.
Pathak, V., Pathak, N. M., O'Neill, C. L., Guduric-Fuchs, J., & Medina, R. J. (2019). Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives.. Clinical medicine insights. Endocrinology and diabetes, 12, 1179551419844521. doi:10.1177/1179551419844521
Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies.
McLoughlin, K. J., Pedrini, E., MacMahon, M., Guduric-Fuchs, J., & Medina, R. J. (2019). Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies.. Frontiers in medicine, 6, 33. doi:10.3389/fmed.2019.00033
Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling.
Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., . . . Margariti, A. (2019). Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling.. Stem cells (Dayton, Ohio), 37(2), 226-239. doi:10.1002/stem.2936
2018
The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β.
Chambers, S. E. J., O'Neill, C. L., Guduric-Fuchs, J., McLoughlin, K. J., Liew, A., Egan, A. M., . . . Medina, R. J. (2018). The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β.. Stem cells (Dayton, Ohio), 36(6), 834-843. doi:10.1002/stem.2810
Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors.
Dittmer, M., Young, A., O'Hagan, T., Eleftheriadis, G., Bankhead, P., Dombrowski, Y., . . . Fitzgerald, D. C. (2018). Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors.. Molecular brain, 11(1), 25. doi:10.1186/s13041-018-0367-6
Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood-Derived Endothelial Colony-Forming Cells for Ischemic Retinopathies.
Reid, E., Guduric-Fuchs, J., O'Neill, C. L., Allen, L. -D., Chambers, S. E. J., Stitt, A. W., & Medina, R. J. (2018). Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood-Derived Endothelial Colony-Forming Cells for Ischemic Retinopathies.. Stem cells translational medicine, 7(1), 59-67. doi:10.1002/sctm.17-0187
The Vasoreparative Potential of Endothelial Colony Forming Cells: A Journey Through Pre-clinical Studies.
O'Neill, C. L., McLoughlin, K. J., Chambers, S. E. J., Guduric-Fuchs, J., Stitt, A. W., & Medina, R. J. (2018). The Vasoreparative Potential of Endothelial Colony Forming Cells: A Journey Through Pre-clinical Studies.. Frontiers in medicine, 5, 273. doi:10.3389/fmed.2018.00273
2017
MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy.
Dellett, M., Brown, E. D., Guduric-Fuchs, J., O'Connor, A., Stitt, A. W., Medina, R. J., & Simpson, D. A. (2017). MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy.. Journal of cellular and molecular medicine, 21(12), 3405-3419. doi:10.1111/jcmm.13251
Endothelial Progenitors: A Consensus Statement on Nomenclature.
Medina, R. J., Barber, C. L., Sabatier, F., Dignat-George, F., Melero-Martin, J. M., Khosrotehrani, K., . . . Stitt, A. W. (2017). Endothelial Progenitors: A Consensus Statement on Nomenclature.. Stem cells translational medicine, 6(5), 1316-1320. doi:10.1002/sctm.16-0360
2016
Endothelial cell-derived pentraxin 3 limits the vasoreparative therapeutic potential of circulating angiogenic cells.
O'Neill, C. L., Guduric-Fuchs, J., Chambers, S. E. J., O'Doherty, M., Bottazzi, B., Stitt, A. W., & Medina, R. J. (2016). Endothelial cell-derived pentraxin 3 limits the vasoreparative therapeutic potential of circulating angiogenic cells.. Cardiovascular research, 112(3), 677-688. doi:10.1093/cvr/cvw209
Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor.
Hookham, M. B., Ali, I. H. A., O'Neill, C. L., Hackett, E., Lambe, M. H., Schmidt, T., . . . Brazil, D. P. (2016). Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor.. Stem cell research & therapy, 7(1), 173. doi:10.1186/s13287-016-0430-0
The progress in understanding and treatment of diabetic retinopathy.
Stitt, A. W., Curtis, T. M., Chen, M., Medina, R. J., McKay, G. J., Jenkins, A., . . . Lois, N. (2016). The progress in understanding and treatment of diabetic retinopathy.. Progress in retinal and eye research, 51, 156-186. doi:10.1016/j.preteyeres.2015.08.001
2015
Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy.
Cahoon, J. M., Rai, R. R., Carroll, L. S., Uehara, H., Zhang, X., O'Neil, C. L., . . . Ambati, B. K. (2015). Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy.. Diabetes, 64(12), 4247-4259. doi:10.2337/db14-1030
Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications.
Rajasekar, P., O'Neill, C. L., Eeles, L., Stitt, A. W., & Medina, R. J. (2015). Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications.. Journal of diabetes research, 2015, 436879. doi:10.1155/2015/436879
2014
Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells.
Prasain, N., Lee, M. R., Vemula, S., Meador, J. L., Yoshimoto, M., Ferkowicz, M. J., . . . Yoder, M. C. (2014). Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells.. Nature biotechnology, 32(11), 1151-1157. doi:10.1038/nbt.3048
Endothelial progenitor cells in diabetic retinopathy.
Lois, N., McCarter, R. V., O'Neill, C., Medina, R. J., & Stitt, A. W. (2014). Endothelial progenitor cells in diabetic retinopathy.. Frontiers in endocrinology, 5, 44. doi:10.3389/fendo.2014.00044
2013
The role of immune-related myeloid cells in angiogenesis.
Chambers, S. E. J., O'Neill, C. L., O'Doherty, T. M., Medina, R. J., & Stitt, A. W. (2013). The role of immune-related myeloid cells in angiogenesis.. Immunobiology, 218(11), 1370-1375. doi:10.1016/j.imbio.2013.06.010
Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.
Medina, R. J., O'Neill, C. L., O'Doherty, T. M., Chambers, S. E. J., Guduric-Fuchs, J., Neisen, J., . . . Stitt, A. W. (2013). Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.. Stem cells (Dayton, Ohio), 31(8), 1657-1668. doi:10.1002/stem.1414
Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors.
Jarajapu, Y. P. R., Bhatwadekar, A. D., Caballero, S., Hazra, S., Shenoy, V., Medina, R., . . . Grant, M. B. (2013). Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors.. Diabetes, 62(4), 1258-1269. doi:10.2337/db12-0808
Advances in our understanding of diabetic retinopathy.
Stitt, A. W., Lois, N., Medina, R. J., Adamson, P., & Curtis, T. M. (2013). Advances in our understanding of diabetic retinopathy.. Clinical science (London, England : 1979), 125(1), 1-17. doi:10.1042/cs20120588
Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis
Stitt, A. W., & Medina, R. J. (2013). Harnessing Endothelial Progenitor Cells for Therapeutic Angiogenesis. In Biochemical Basis and Therapeutic Implications of Angiogenesis (pp. 445-458). Springer New York. doi:10.1007/978-1-4614-5857-9_23
2012
A Review of Patents Relating to Therapeutic Angiogenesis Using Endothelial Progenitors and Other Vasculogenesis-Related Cell Types
J. Medina, R., L. O’Neill, C., M. O’Doherty, T., E.J. Wilson, S., & W. Stitt., A. (2012). A Review of Patents Relating to Therapeutic Angiogenesis Using Endothelial Progenitors and Other Vasculogenesis-Related Cell Types. Recent Patents on Regenerative Medicinee, 3(1), 63-73. doi:10.2174/2210296511303010063
Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells.
Liu, Y., Teoh, S. -H., Chong, M. S. K., Lee, E. S. M., Mattar, C. N. Z., Randhawa, N. K., . . . Chan, J. K. Y. (2012). Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells.. Stem cells (Dayton, Ohio), 30(9), 1911-1924. doi:10.1002/stem.1164
Therapeutic revascularisation of ischaemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells.
O'Neill, C. L., O'Doherty, M. T., Wilson, S. E., Rana, A. A., Hirst, C. E., Stitt, A. W., & Medina, R. J. (2012). Therapeutic revascularisation of ischaemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells.. Stem cell research & therapy, 3(4), 31. doi:10.1186/scrt122
Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types.
Guduric-Fuchs, J., O'Connor, A., Camp, B., O'Neill, C. L., Medina, R. J., & Simpson, D. A. (2012). Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types.. BMC genomics, 13, 357. doi:10.1186/1471-2164-13-357
Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.
Guduric-Fuchs, J., O'Connor, A., Cullen, A., Harwood, L., Medina, R. J., O'Neill, C. L., . . . Simpson, D. A. (2012). Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.. Journal of cellular biochemistry, 113(6), 2098-2111. doi:10.1002/jcb.24084
Endothelial progenitors as tools to study vascular disease.
Medina, R. J., O'Neill, C. L., O'Doherty, T. M., Wilson, S. E. J., & Stitt, A. W. (2012). Endothelial progenitors as tools to study vascular disease.. Stem cells international, 2012, 346735. doi:10.1155/2012/346735
Endothelial progenitor therapy: Innately beneficial, innately complicated
Neu, M., Bhatwadekar, A., Medina, R., Stitt, A., & Grant, M. (2012). Endothelial progenitor therapy: Innately beneficial, innately complicated. In Therapy for Ocular Angiogenesis Principles and Practice.
2011
Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients.
Medina, R. J., Archer, D. B., & Stitt, A. W. (2011). Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients.. Stem cell research & therapy, 2(6), 47. doi:10.1186/scrt88
Vascular stem cells and ischaemic retinopathies.
Stitt, A. W., O'Neill, C. L., O'Doherty, M. T., Archer, D. B., Gardiner, T. A., & Medina, R. J. (2011). Vascular stem cells and ischaemic retinopathies.. Progress in retinal and eye research, 30(3), 149-166. doi:10.1016/j.preteyeres.2011.02.001
Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8.
Medina, R. J., O'Neill, C. L., O'Doherty, T. M., Knott, H., Guduric-Fuchs, J., Gardiner, T. A., & Stitt, A. W. (2011). Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8.. Molecular medicine (Cambridge, Mass.), 17(9-10), 1045-1055. doi:10.2119/molmed.2011.00129
2010
Evidence supporting a role for N-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Müller glia dysfunction and death in diabetic retinopathy.
Yong, P. H., Zong, H., Medina, R. J., Limb, G. A., Uchida, K., Stitt, A. W., & Curtis, T. M. (2010). Evidence supporting a role for N-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Müller glia dysfunction and death in diabetic retinopathy.. Molecular vision, 16, 2524-2538.
Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy.
Medina, R. J., O'Neill, C. L., Humphreys, M. W., Gardiner, T. A., & Stitt, A. W. (2010). Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy.. Investigative ophthalmology & visual science, 51(11), 5906-5913. doi:10.1167/iovs.09-4951
Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.
Yamamoto, K. -I., Sakaguchi, M., Medina, R. J., Niida, A., Sakaguchi, Y., Miyazaki, M., . . . Huh, N. -H. (2010). Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.. Biochemical and biophysical research communications, 400(1), 175-180. doi:10.1016/j.bbrc.2010.08.039
Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy.
McVicar, C. M., Colhoun, L. M., Abrahams, J. L., Kitson, C. L., Hamilton, R., Medina, R. J., . . . Stitt, A. W. (2010). Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy.. PloS one, 5(7), e11870. doi:10.1371/journal.pone.0011870
Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.
Medina, R. J., O'Neill, C. L., Sweeney, M., Guduric-Fuchs, J., Gardiner, T. A., Simpson, D. A., & Stitt, A. W. (2010). Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.. BMC medical genomics, 3, 18. doi:10.1186/1755-8794-3-18
2009
A novel three-dimensional culture system for isolation and clonal propagation of neural stem cells using a thermo-reversible gelation polymer.
Yang, X. -Z., Kataoka, K., Medina, R., Yamamoto, K. -I., Than, S. S., Miyazaki, M., & Huh, N. -H. (2009). A novel three-dimensional culture system for isolation and clonal propagation of neural stem cells using a thermo-reversible gelation polymer.. Tissue engineering. Part C, Methods, 15(4), 615-623. doi:10.1089/ten.tec.2008.0516
2008
The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies.
Medina, R. J., O'Neill, C. L., Devine, A. B., Gardiner, T. A., & Stitt, A. W. (2008). The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies.. PloS one, 3(7), e2584. doi:10.1371/journal.pone.0002584
2007
Isolation of a bone marrow-derived stem cell line with high proliferation potential and its application for preventing acute fatal liver failure.
Miyazaki, M., Hardjo, M., Masaka, T., Tomiyama, K., Mahmut, N., Medina, R. J., . . . Huh, N. -H. (2007). Isolation of a bone marrow-derived stem cell line with high proliferation potential and its application for preventing acute fatal liver failure.. Stem cells (Dayton, Ohio), 25(11), 2855-2863. doi:10.1634/stemcells.2007-0078
2006
Isolation of epithelial stem cells from dermis by a three-dimensional culture system.
Medina, R. J., Kataoka, K., Takaishi, M., Miyazaki, M., & Huh, N. -H. (2006). Isolation of epithelial stem cells from dermis by a three-dimensional culture system.. Journal of cellular biochemistry, 98(1), 174-184. doi:10.1002/jcb.20757
Efficient differentiation into skin cells of bone marrow cells recovered in a pellet after density gradient fractionation.
Medina, R. J., Kataoka, K., Miyazaki, M., & Huh, N. -H. (2006). Efficient differentiation into skin cells of bone marrow cells recovered in a pellet after density gradient fractionation.. International journal of molecular medicine, 17(5), 721-727.
2003
Participation of adult mouse bone marrow cells in reconstitution of skin.
Kataoka, K., Medina, R. J., Kageyama, T., Miyazaki, M., Yoshino, T., Makino, T., & Huh, N. -H. (2003). Participation of adult mouse bone marrow cells in reconstitution of skin.. The American journal of pathology, 163(4), 1227-1231. doi:10.1016/s0002-9440(10)63482-7
Differentiation of bone marrow cells in culture and in vivo
Miyazaki, M., Kataoka, K., Medina, R. J., Kageyama, T., & Huh, N. -H. (2003). Differentiation of bone marrow cells in culture and in vivo. International Congress Series, 1252, 461-464. doi:10.1016/s0531-5131(03)00005-0