Publications
2024
Revealing the structural microenvironment of high metastatic risk uveal melanomas following decellularisation.
Aughton, K., Hattersley, J., Coupland, S. E., & Kalirai, H. (2024). Revealing the structural microenvironment of high metastatic risk uveal melanomas following decellularisation.. Scientific reports, 14(1), 26811. doi:10.1038/s41598-024-78171-2
Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6.
Howie, J., Tulloch, L. B., Brown, E., Reilly, L., Ashford, F. B., Kennedy, J., . . . Fuller, W. (2024). Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6.. Cell reports, 43(2), 113679. doi:10.1016/j.celrep.2024.113679
2023
K-Ras independence due to N-Ras expression in cancer cell lines giving resistance to K-Ras specific inhibitors
Ferguson, R., Aughton, K., Evans, A., Shaw, V., Costello, E., & Greenhalf, W. (2023). K-Ras independence due to N-Ras expression in cancer cell lines giving resistance to K-Ras specific inhibitors. Pancreatology, 23, e149. doi:10.1016/j.pan.2023.06.783
Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cellson Tumor Growth and Metastasis (vol 48, pg 408, 2023)
Draper, J., Alexander, J., Nair, R. M., Scullion, N., Narayana, R. V. L., Aughton, K., . . . Coupland, S. E. (2023). Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cellson Tumor Growth and Metastasis (vol 48, pg 408, 2023). CURRENT EYE RESEARCH. doi:10.1080/02713683.2023.2192394
Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation
Ferguson, R., Aughton, K., Evans, A., Shaw, V., Armstrong, J., Ware, A., . . . Greenhalf, W. (2023). Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation. CURRENT ISSUES IN MOLECULAR BIOLOGY, 45(3), 2505-2520. doi:10.3390/cimb45030164
Wild-type N-Ras Complements Mutant K-Ras in Pancreatic Cancer Cell Lines but K-Ras has a Specific Role in Cell Cycle Independent Regulation of G2 Cyclins
2022
Investigating the Role of DUSP4 in Uveal Melanoma.
Aughton, K., Sabat-Pospiech, D., Barlow, S., Coupland, S. E., & Kalirai, H. (2022). Investigating the Role of DUSP4 in Uveal Melanoma.. Translational vision science & technology, 11(12), 13. doi:10.1167/tvst.11.12.13
Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cells on Tumor Growth and Metastasis
Draper, J., Alexander, J., Nair, R. M. M., Scullion, N., Narayana, R. V. L., Aughton, K., . . . Coupland, S. E. E. (2022). Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cells on Tumor Growth and Metastasis. CURRENT EYE RESEARCH. doi:10.1080/02713683.2022.2152055
Wild-type N-Ras Complements Mutant K-Ras in Pancreatic Cancer Cell Lines but K-Ras has a Specific Role in Cell Cycle Independent Regulation of G2 Cyclins
2021
hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA
Aughton, K., Elander, N. O., Evans, A., Jackson, R., Campbell, F., Costello, E., . . . Greenhalf, W. (2021). hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA. CANCERS, 13(22). doi:10.3390/cancers13225758
2020
MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators.
Aughton, K., Kalirai, H., & Coupland, S. E. (2020). MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators.. International Journal of Molecular Sciences, 21(16). doi:10.3390/ijms21165648
Unpacking the genetic etiology of uveal melanoma
Thornton, S., Kalirai, H., Aughton, K., & Coupland, S. E. (2020). Unpacking the genetic etiology of uveal melanoma. Expert Review of Ophthalmology. doi:10.1080/17469899.2020.1785872
Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture
Aughton, K., Shahidipour, H., Djirackor, L., Coupland, S. E., & Kalirai, H. (2020). Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture. Translational Vision Science and Technology, 9(7). doi:10.1167/tvst.9.7.39
2018
Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy
Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., . . . Canc, E. S. G. P. (2018). Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy. British Journal of Cancer, 118, 1084-1088. doi:10.1038/s41416-018-0005-1
Development of Novel Therapeutic Response Biomarkers
Elander, N., Aughton, K., & Greenhalf, W. (2018). Development of Novel Therapeutic Response Biomarkers. In Pancreatic Cancer (pp. 1273-1304). Springer New York. doi:10.1007/978-1-4939-7193-0_59
Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predict survival in pancreatic cancer.
Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., . . . Greenhalf, W. (2018). Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predict survival in pancreatic cancer.. British Journal of Cancer, 118(7), 947-954. doi:10.1038/s41416-018-0004-2
2017
Development of Novel Therapeutic Response Biomarkers
Elander, N., Aughton, K., & Greenhalf, W. (2017). Development of Novel Therapeutic Response Biomarkers. In Pancreatic Cancer (pp. 1-32). Springer New York. doi:10.1007/978-1-4939-6631-8_59-1
2016
Combined analysis of cytidine deaminase mRNA transcript expression with hENT1 protein expression on tissue microarrays from the ESPAC-3 trial helps predict patient survival with gemcitabine treatment
Aughton, K., Elander, N., Palmer, D., Cox, T., Campbell, F., Garner, E., . . . Greenhalf, W. (2016). Combined analysis of cytidine deaminase mRNA transcript expression with hENT1 protein expression on tissue microarrays from the ESPAC-3 trial helps predict patient survival with gemcitabine treatment. Pancreatology, 16(3), S30. doi:10.1016/j.pan.2016.05.104
Identification of novel signalling pathways dysregulated in pancreatic cancer-associated fibroblasts
Barrera, L., Lane, B., Brumskill, S., Oldfield, F., Lamond, R., Wilkinson, L., . . . Costello, E. (2016). Identification of novel signalling pathways dysregulated in pancreatic cancer-associated fibroblasts. Pancreatology, 16(3), S31. doi:10.1016/j.pan.2016.05.106
2015
Multiple quantum filtered <SUP>23</SUP>Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]<sub>i</sub>
Eykyn, T. R., Aksentijevic, D., Aughton, K. L., Southworth, R., Fuller, W., & Shattock, M. J. (2015). Multiple quantum filtered <SUP>23</SUP>Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]<sub>i</sub>. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 86, 95-101. doi:10.1016/j.yjmcc.2015.07.009
2014
Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman.
Boguslavskyi, A., Pavlovic, D., Aughton, K., Clark, J. E., Howie, J., Fuller, W., & Shattock, M. J. (2014). Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman.. Cardiovascular research, 104(1), 72-82. doi:10.1093/cvr/cvu182
2013
Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism.
Pavlovic, D., Hall, A. R., Kennington, E. J., Aughton, K., Boguslavskyi, A., Fuller, W., . . . Shattock, M. J. (2013). Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism.. Journal of molecular and cellular cardiology, 61, 164-171. doi:10.1016/j.yjmcc.2013.04.013
A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle.
Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., . . . Fuller, W. (2013). A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle.. The Journal of biological chemistry, 288(19), 13808-13820. doi:10.1074/jbc.m113.460956
2011
In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist.
af Forselles, K. J., Root, J., Clarke, T., Davey, D., Aughton, K., Dack, K., & Pullen, N. (2011). In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist.. British journal of pharmacology, 164(7), 1847-1856. doi:10.1111/j.1476-5381.2011.01495.x
2008
Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro.
Aughton, K. L., Hamilton-Smith, K., Gupta, J., Morton, J. S., Wayman, C. P., & Jackson, V. M. (2008). Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro.. British journal of pharmacology, 155(2), 236-243. doi:10.1038/bjp.2008.253
2002
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma
Lovat, P. E., Oliverio, S., Ranalli, M., Corazzi, M., Rodolfo, C., Bernassola, F., . . . Redfern, C. P. (2002). GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Research.