Publications
Selected publications
- Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons (Journal article - 2020)
- HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling (Journal article - 2020)
- Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage (Journal article - 2019)
- The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair (Journal article - 2019)
- Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response (Journal article - 2018)
- USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation (Journal article - 2021)
2025
Targeting Chk1 and Wee1 kinases enhances radiosensitivity of 2D and 3D head and neck cancer models to X-rays and low/high-LET protons.
Melia, E., Fisch, A. -S., Tinhofer, I., & Parsons, J. L. (2025). Targeting Chk1 and Wee1 kinases enhances radiosensitivity of 2D and 3D head and neck cancer models to X-rays and low/high-LET protons.. Cell death & disease, 16(1), 128. doi:10.1038/s41419-025-07435-0
2024
Current Insights into the Radiobiology of Boron Neutron Capture Therapy and the Potential for Further Improving Biological Effectiveness.
Punshon, L. D., Fabbrizi, M. R., Phoenix, B., Green, S., & Parsons, J. L. (2024). Current Insights into the Radiobiology of Boron Neutron Capture Therapy and the Potential for Further Improving Biological Effectiveness.. Cells, 13(24), 2065. doi:10.3390/cells13242065
HDAC Inhibitors Can Enhance Radiosensitivity of Head and Neck Cancer Cells Through Suppressing DNA Repair.
Antrobus, J., Mackinnon, B., Melia, E., Hughes, J. R., & Parsons, J. L. (2024). HDAC Inhibitors Can Enhance Radiosensitivity of Head and Neck Cancer Cells Through Suppressing DNA Repair.. Cancers, 16(23), 4108. doi:10.3390/cancers16234108
Myoferlin: A Potential Marker of Response to Radiation Therapy and Survival in Locally Advanced Rectal Cancer.
Fowler, H., Clifford, R. E., Bowden, D., Sutton, P. A., Govindarajah, N., Fok, M., . . . Vimalachandran, D. (2024). Myoferlin: A Potential Marker of Response to Radiation Therapy and Survival in Locally Advanced Rectal Cancer.. International journal of radiation oncology, biology, physics, S0360-3016(24)00696-5. doi:10.1016/j.ijrobp.2024.05.030
CIZ1 regulates G1 length and the CDK threshold for initiation of DNA replication to prevent DNA replication stress
The Potential for Targeting G<sub>2</sub>/M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy.
Melia, E., & Parsons, J. L. (2024). The Potential for Targeting G<sub>2</sub>/M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy.. Cancers, 16(17), 3016. doi:10.3390/cancers16173016
Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia.
Hill, R. M., Li, C., Hughes, J. R., Rocha, S., Grundy, G. J., & Parsons, J. L. (2024). Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia.. Journal of cellular and molecular medicine, 28(12), e18482. doi:10.1111/jcmm.18482
Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation.
Fabbrizi, M. R., Doggett, T. J., Hughes, J. R., Melia, E., Dufficy, E. R., Hill, R. M., . . . Parsons, J. L. (2024). Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation.. Cell death discovery, 10(1), 282. doi:10.1038/s41420-024-02059-3
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence.
Fabbrizi, M. R., Nickson, C. M., Hughes, J. R., Robinson, E. A., Vaidya, K., Rubbi, C. P., . . . Parsons, J. L. (2024). Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence.. Cell death & disease, 15(2), 150. doi:10.1038/s41419-024-06541-9
KH-like Domains in PARP9/DTX3L and PARP14 Coordinate Protein-Protein Interactions to Promote Cancer Cell Survival.
Saleh, H., Liloglou, T., Rigden, D. J., Parsons, J. L., & Grundy, G. J. (2024). KH-like Domains in PARP9/DTX3L and PARP14 Coordinate Protein-Protein Interactions to Promote Cancer Cell Survival.. Journal of molecular biology, 436(4), 168434. doi:10.1016/j.jmb.2023.168434
Most DNA repair defects do not modify the relationship between relative biological effectiveness and linear energy transfer in CRISPR-edited cells
Liberal, F. D. C. G., Parsons, J. L., & Mcmahon, S. J. (2023). Most DNA repair defects do not modify the relationship between relative biological effectiveness and linear energy transfer in CRISPR-edited cells. MEDICAL PHYSICS. doi:10.1002/mp.16764
2023
DNA damage and repair dependencies of ionising radiation modalities.
Melia, E., & Parsons, J. L. (2023). DNA damage and repair dependencies of ionising radiation modalities.. Bioscience reports, 43(10), BSR20222586. doi:10.1042/bsr20222586
The Cellular Response to Complex DNA Damage Induced by Ionising Radiation
Wilkinson, B., Hill, M. A. A., & Parsons, J. L. L. (2023). The Cellular Response to Complex DNA Damage Induced by Ionising Radiation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(5). doi:10.3390/ijms24054920
2022
ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
Mellone, M., Piotrowska, K., Venturi, G., James, L., Bzura, A., Lopez, M. A., . . . Thomas, G. J. (2022). ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance. CANCER RESEARCH, 82(24), 4571-4585. doi:10.1158/0008-5472.CAN-22-0435
TRIM26 Maintains Cell Survival in Response to Oxidative Stress through Regulating DNA Glycosylase Stability
Konis, S. M. R., Hughes, J. R., & Parsons, J. L. (2022). TRIM26 Maintains Cell Survival in Response to Oxidative Stress through Regulating DNA Glycosylase Stability. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(19). doi:10.3390/ijms231911613
Overcoming the Impact of Hypoxia in Driving Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma
Hill, R. M., Rocha, S., & Parsons, J. L. (n.d.). Overcoming the Impact of Hypoxia in Driving Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma. Cancers, 14(17), 4130. doi:10.3390/cancers14174130
Effectiveness of PARP inhibition in enhancing the radiosensitivity of 3D spheroids of head and neck squamous cell carcinoma.
Zhou, C., Fabbrizi, M. R., Hughes, J. R., Grundy, G. J., & Parsons, J. L. (2022). Effectiveness of PARP inhibition in enhancing the radiosensitivity of 3D spheroids of head and neck squamous cell carcinoma.. Frontiers in oncology, 12, 940377. doi:10.3389/fonc.2022.940377
Histone Deacetylases and Their Potential as Targets to Enhance Tumour Radiosensitisation
Antrobus, J., & Parsons, J. L. (n.d.). Histone Deacetylases and Their Potential as Targets to Enhance Tumour Radiosensitisation. Radiation, 2(1), 149-167. doi:10.3390/radiation2010011
Cell death mechanisms in head and neck cancer cells in response to low and high-LET radiation
Fabbrizi, M. R., & Parsons, J. L. (2022). Cell death mechanisms in head and neck cancer cells in response to low and high-LET radiation. EXPERT REVIEWS IN MOLECULAR MEDICINE, 24. doi:10.1017/erm.2021.31
Factors affecting the radiation response in glioblastoma.
Aiyappa-Maudsley, R., Chalmers, A. J., & Parsons, J. L. (2022). Factors affecting the radiation response in glioblastoma. NEURO-ONCOLOGY ADVANCES, 4(1). doi:10.1093/noajnl/vdac156
2021
Proton beam therapy in rectal cancer: A systematic review and meta-analysis
Fok, M., Toh, S., Easow, J., Fowler, H., Clifford, R., Parsons, J., & Vimalachandran, D. (2021). Proton beam therapy in rectal cancer: A systematic review and meta-analysis. SURGICAL ONCOLOGY-OXFORD, 38. doi:10.1016/j.suronc.2021.101638
USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation
Nickson, C. M., Fabbrizi, M. R., Carter, R. J., Hughes, J. R., Kacperek, A., Hill, M. A., & Parsons, J. L. (2021). USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation. FRONTIERS IN ONCOLOGY, 11. doi:10.3389/fonc.2021.671431
The Enzyme-Modified Comet (EMNC) Assay for Complex DNA Damage Detection
Fabbrizi, M. R., Hughes, J. R., & Parsons, J. L. (n.d.). The Enzyme-Modified Comet (EMNC) Assay for Complex DNA Damage Detection. Methods and Protocols, 4(1), 14. doi:10.3390/mps4010014
USP9X Inhibition Enhances Radiosensitisation of Head and Neck Cancer Cells in Response to High-LET Radiation by Destabilising Centrosome Proteins
Fabbrizi, M. R., Nickson, C. M., Carter, R. J., Hughes, J. R., Kacperek, A., Hill, M. A., & Parsons, J. L. (n.d.). USP9X Inhibition Enhances Radiosensitisation of Head and Neck Cancer Cells in Response to High-LET Radiation by Destabilising Centrosome Proteins. The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response, 2. doi:10.3390/iecc2021-09211
2020
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer
Clifford, R. E., Govindarajah, N., Bowden, D., Sutton, P., Glenn, M., Darvish-Damavandi, M., . . . Vimalachandran, D. (2020). Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer. Cells, 9(12). doi:10.3390/cells9122693
The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response
Hughes, J. R., & Parsons, J. L. (n.d.). The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response. Frontiers in Cell and Developmental Biology, 8. doi:10.3389/fcell.2020.607060
Base excision repair and its implications to cancer therapy
Grundy, G. J., & Parsons, J. L. (2020). Base excision repair and its implications to cancer therapy. GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR, 64(5), 831-843. doi:10.1042/EBC20200013
microRNA-184 is induced by store-operated calcium entry and regulates early keratinocyte differentiation
Richardson, A., Powell, A. K., Sexton, D. W., Parsons, J. L., Reynolds, N. J., & Ross, K. (2020). microRNA-184 is induced by store-operated calcium entry and regulates early keratinocyte differentiation. JOURNAL OF CELLULAR PHYSIOLOGY, 235(10), 6854-6861. doi:10.1002/jcp.29579
LhARA: The Laser-hybrid Accelerator for Radiobiological Applications
Aymar, G., Becker, T., Boogert, S., Borghesi, M., Bingham, R., Brenner, C., . . . Xiao, R. (2020). LhARA: The Laser-hybrid Accelerator for Radiobiological Applications. FRONTIERS IN PHYSICS, 8. doi:10.3389/fphy.2020.567738
FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy
Hughes, J. R., & Parsons, J. L. (n.d.). FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy. International Journal of Molecular Sciences, 21(18). doi:10.3390/ijms21186492
The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma
Zhou, C., & Parsons, J. L. (2020). The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma. Expert Reviews in Molecular Medicine, 22. doi:10.1017/erm.2020.4
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons
Vitti, E. T., Kacperek, A., & Parsons, J. L. (2020). Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons. CANCERS, 12(6). doi:10.3390/cancers12061490
The Laser-hybrid Accelerator for Radiobiological Applications
Aymar, G., Becker, T., Boogert, S., Borghesi, M., Bingham, R., Brenner, C., . . . Xiao, R. (2020). The Laser-hybrid Accelerator for Radiobiological Applications. Retrieved from http://arxiv.org/abs/2006.00493v1
Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons
Hussain, R. N., Coupland, S. E., Khzouz, J., Kalirai, H., & Parsons, J. L. (n.d.). Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons. Cancers, 12(6), 1388. doi:10.3390/cancers12061388
Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling.
Madders, E. C. E. T., & Parsons, J. L. (2020). Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling.. Advances in experimental medicine and biology, 1241, 59-75. doi:10.1007/978-3-030-41283-8_5
HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling
Bennett, L., Madders, E. C. E. T., & Parsons, J. L. (2020). HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling. Nucleic Acids Research, 48(03), 1301-1313. doi:10.1093/nar/gkz1129
Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment
Fabbrizi, M. R., & Parsons, J. L. (n.d.). Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment. Cancer Drug Resistance. doi:10.20517/cdr.2020.49
2019
The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.
Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., . . . Ramadan, K. (2019). The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.. The EMBO journal, 38(21). doi:10.15252/embj.2019102361
The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair
Vitti, E. T., & Parsons, J. L. (2019). The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair. Cancers, 11(7). doi:10.3390/cancers11070946
Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage
Carter, R. J., Nickson, C. M., Thompson, J. M., Kacperek, A., Hill, M. A., & Parsons, J. L. (2019). Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage. International Journal of Radiation: Oncology - Biology - Physics, 104(3), 656-665. doi:10.1016/j.ijrobp.2019.02.053
Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy
Govindarajah, N., Clifford, R., Bowden, D., Sutton, P. A., Parsons, J. L., & Vimalachandran, D. (2019). Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 138, 104-111. doi:10.1016/j.critrevonc.2019.03.018
The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks
Albelazi, M. S., Martin, P. R., Mohammed, S., Mutti, L., Parsons, J. L., & Elder, R. H. (2019). The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks. GENES, 10(4). doi:10.3390/genes10040315
2018
Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer
Clifford, R., Govindarajah, N., Parsons, J. L., Gollins, S., West, N. P., & Vimalachandran, D. (2018). Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer. British Journal of Surgery, 105(12), 1553-1572. doi:10.1002/bjs.10993
NTH1 is a new target for ubiquitylation-dependent regulation by TRIM26 required for the cellular response to oxidative stress
Williams, S. C., & Parsons, J. L. (2018). NTH1 is a new target for ubiquitylation-dependent regulation by TRIM26 required for the cellular response to oxidative stress. Molecular and cellular biology, 38(12), 15 pages. doi:10.1128/mcb.00616-17
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response
Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. doi:10.1016/j.jprot.2018.02.030
Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response
Carter, R. J., Nickson, C. M., Thompson, J. M., Kacperek, A., Hill, M. A., & Parsons, J. L. (2018). Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response. International Journal of Radiation: Oncology - Biology - Physics, 100(3), 776-784. doi:10.1016/j.ijrobp.2017.11.012
INVESTIGATING THE ROLE OF ACID CERAMIDASE IN THE RADIOTHERAPY RESPONSE OF AN IN VITRO MODEL OF COLORECTAL CANCER
Govindarajah, N., Sutton, P., Bowden, D., Parsons, J. L., & Vimalachandran, D. (2018). INVESTIGATING THE ROLE OF ACID CERAMIDASE IN THE RADIOTHERAPY RESPONSE OF AN IN VITRO MODEL OF COLORECTAL CANCER. In BRITISH JOURNAL OF SURGERY Vol. 105 (pp. 16). Retrieved from https://www.webofscience.com/
PARP-1 FRAGMENTS AND ACID CERAMIDASE (AC) EXPRESSION: A POTENTIAL MECHANISM OF RADIORESISTANCE IN COLORECTAL CANCER?
Govindarajah, N., Sutton, P., Bowden, D., Parsons, J. L., & Vimalachandran, D. (2018). PARP-1 FRAGMENTS AND ACID CERAMIDASE (AC) EXPRESSION: A POTENTIAL MECHANISM OF RADIORESISTANCE IN COLORECTAL CANCER?. In DISEASES OF THE COLON & RECTUM Vol. 61 (pp. E68). Retrieved from https://www.webofscience.com/
2017
The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure
Martin, P. R., Couve, S., Zutterling, C., Albelazi, M. S., Groisman, R., Matkarimov, B. T., . . . Saparbaev, M. K. (2017). The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-17693-4
Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity
Nickson, C. M., Moori, P., Carter, R. J., Rubbi, C. P., & Parsons, J. L. (2017). Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity. Oncotarget, 8(18), 29963-29975. doi:10.18632/oncotarget.16265
Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response
Edmonds, M. J., Carter, R. J., Nickson, C. M., Williams, S. C., & Parsons, J. L. (2017). Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response. Nucleic Acids Research, 45(2), 726-738. doi:10.1093/nar/gkw959
2016
Base Excision Repair, a Pathway Regulated by Posttranslational Modifications
Carter, R. J., & Parsons, J. L. (2016). Base Excision Repair, a Pathway Regulated by Posttranslational Modifications. Molecular and Cellular Biology, 36(10), 1426-1437. doi:10.1128/MCB.00030-16
The Base Excision Repair Pathway
Parsons, J. L., & Edmonds, M. J. (2016). The Base Excision Repair Pathway. In Encyclopedia of Cell Biology (pp. 442-450). Elsevier. doi:10.1016/b978-0-12-394447-4.10046-x
2014
Regulation of base excision repair proteins by ubiquitylation
Edmonds, M. J., & Parsons, J. L. (2014). Regulation of base excision repair proteins by ubiquitylation. EXPERIMENTAL CELL RESEARCH, 329(1), 132-138. doi:10.1016/j.yexcr.2014.07.031
ARF induction in response to DNA strand breaks is regulated by PARP1
Orlando, G., Khoronenkova, S. V., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2014). ARF induction in response to DNA strand breaks is regulated by PARP1. Nucleic Acids Research, 42(4), 2320-2329. doi:10.1093/nar/gkt1185
Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay
Nickson, C. M., & Parsons, J. L. (2014). Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay. FRONTIERS IN GENETICS, 5. doi:10.3389/fgene.2014.00232
2013
Co-ordination of base excision repair and genome stability
Parsons, J. L., & Dianov, G. L. (2013). Co-ordination of base excision repair and genome stability. DNA REPAIR, 12(5), 326-333. doi:10.1016/j.dnarep.2013.02.001
Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer
Parsons, J. L., Nicolay, N. H., & Sharma, R. A. (2013). Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer. ANTIOXIDANTS & REDOX SIGNALING, 18(8), 851-873. doi:10.1089/ars.2011.4203
2012
Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress
Parsons, J. L., Khoronenkova, S. V., Dianova, I. I., Ternette, N., Kessler, B. M., Datta, P. K., & Dianov, G. L. (2012). Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress. NUCLEIC ACIDS RESEARCH, 40(22), 11404-11415. doi:10.1093/nar/gks909
ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
Khoronenkova, S. V., Dianova, I. I., Ternette, N., Kessler, B. M., Parsons, J. L., & Dianov, G. L. (2012). ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage. MOLECULAR CELL, 45(6), 801-813. doi:10.1016/j.molcel.2012.01.021
Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination
Markkanen, E., van Loon, B., Ferrari, E., Parsons, J. L., Dianov, G. L., & Huebscher, U. (2012). Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(2), 437-442. doi:10.1073/pnas.1110449109
In vitro base excision repair using mammalian cell extracts.
Parsons, J. L., & Dianov, G. L. (2012). In vitro base excision repair using mammalian cell extracts.. Methods in molecular biology (Clifton, N.J.), 920, 245-262. doi:10.1007/978-1-61779-998-3_17
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability
Meisenberg, C., Tait, P. S., Dianova, I. I., Wright, K., Edelmann, M. J., Ternette, N., . . . Dianov, G. L. (2012). Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. NUCLEIC ACIDS RESEARCH, 40(2), 701-711. doi:10.1093/nar/gkr744
2011
Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
Altun, M., Kramer, H. B., Willems, L. I., McDermott, J. L., Leach, C. A., Goldenberg, S. J., . . . Kessler, B. M. (2011). Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes. CHEMISTRY & BIOLOGY, 18(11), 1401-1412. doi:10.1016/j.chembiol.2011.08.018
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair
Strom, C. E., Mortusewicz, O., Finch, D., Parsons, J. L., Lagerqvist, A., Johansson, F., . . . Helleday, T. (2011). CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair. DNA REPAIR, 10(9), 961-969. doi:10.1016/j.dnarep.2011.07.004
USP7/HAUSP stimulates repair of oxidative DNA lesions
Khoronenkova, S. V., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2011). USP7/HAUSP stimulates repair of oxidative DNA lesions. NUCLEIC ACIDS RESEARCH, 39(7), 2604-2609. doi:10.1093/nar/gkq1210
USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase β
Parsons, J. L., Dianova, I. I., Khoronenkova, S. V., Edelmann, M. J., Kessler, B. M., & Dianov, G. L. (2011). USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase β. MOLECULAR CELL, 41(5), 609-615. doi:10.1016/j.molcel.2011.02.016
Regulation of DNA repair by ubiquitylation
Dianov, G. L., Meisenberg, C., & Parsons, J. L. (2011). Regulation of DNA repair by ubiquitylation. BIOCHEMISTRY-MOSCOW, 76(1), 69-79. doi:10.1134/S0006297911010093
2010
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair
Parsons, J. L., Dianova, I. I., Finch, D., Tait, P. S., Strom, C. E., Helleday, T., & Dianov, G. L. (2010). XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair. DNA REPAIR, 9(7), 835-841. doi:10.1016/j.dnarep.2010.04.008
Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy
Yang, J., Parsons, J., Nicolay, N. H., Caporali, S., Harrington, C. F., Singh, R., . . . Sharma, R. A. (2010). Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy. ONCOGENE, 29(3), 463-468. doi:10.1038/onc.2009.327
2009
Ubiquitin ligase ARF-BP1/Mule modulates base excision repair
Parsons, J. L., Tait, P. S., Finch, D., Dianova, I. I., Edelmann, M. J., Khoronenkova, S. V., . . . Dianov, G. L. (2009). Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO JOURNAL, 28(20), 3207-3215. doi:10.1038/emboj.2009.243
2008
Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks
Woodhouse, B. C., Dianova, I. I., Parsons, J. L., & Dianov, G. L. (2008). Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks. DNA REPAIR, 7(6), 932-940. doi:10.1016/j.dnarep.2008.03.017
CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins
Parsons, J. L., Tait, P. S., Finch, D., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2008). CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. MOLECULAR CELL, 29(4), 477-487. doi:10.1016/j.molcel.2007.12.027
2007
NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break
Parsons, J. L., Kavli, B., Slupphaug, G., & Dianov, G. L. (2007). NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break. BIOCHEMISTRY, 46(13), 4158-4163. doi:10.1021/bi0622569
Co-ordination of DNA single strand break repair
Dianou, G. L., & Parsons, J. L. (2007). Co-ordination of DNA single strand break repair. DNA REPAIR, 6(4), 454-460. doi:10.1016/j.dnarep.2006.10.009
DNA polymerase δ-dependent repair of DNA single strand breaks containing 3′-end proximal lesions
Parsons, J. L., Preston, B. D., O'Connor, T. R., & Dianov, G. L. (2007). DNA polymerase δ-dependent repair of DNA single strand breaks containing 3′-end proximal lesions. NUCLEIC ACIDS RESEARCH, 35(4), 1054-1063. doi:10.1093/nar/gkl1115
Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity
Schwerdtle, T., Hamann, I., Jahnke, G., Walter, I., Richter, C., Parsons, J. L., . . . Hartwig, A. (2007). Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity. MOLECULAR NUTRITION & FOOD RESEARCH, 51(2), 201-210. doi:10.1002/mnfr.200600107
Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells
Walter, I., Schwerdtle, T., Thuy, C., Parsons, J. L., Dianov, G. L., & Hartwig, A. (2007). Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells. DNA REPAIR, 6(1), 61-70. doi:10.1016/j.dnarep.2006.08.008
2006
The multiple influences of glutathione on bromate genotoxicity: Implications for the dose-response relationship
Chipman, J. K., Parsons, J. L., & Beddowes, E. J. (2006). The multiple influences of glutathione on bromate genotoxicity: Implications for the dose-response relationship. TOXICOLOGY, 221(2-3), 187-189. doi:10.1016/j.tox.2005.12.006
2005
End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair
Parsons, J. L., Dianova, I. I., Boswell, E., Weinfeld, M., & Dianov, G. L. (2005). End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair. FEBS JOURNAL, 272(22), 5753-5763. doi:10.1111/j.1742-4658.2005.04962.x
NEIL1 excises 3′ end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1
Parsons, J. L., Zharkov, D. O., & Dianov, G. L. (2005). NEIL1 excises 3′ end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. NUCLEIC ACIDS RESEARCH, 33(15), 4849-4856. doi:10.1093/nar/gki816
Isolation of a small molecule inhibitor of DNA base excision repair
Madhusudan, S., Smart, F., Shrimpton, P., Parsons, J. L., Gardiner, L., Houlbrook, S., . . . Hickson, I. D. (2005). Isolation of a small molecule inhibitor of DNA base excision repair. NUCLEIC ACIDS RESEARCH, 33(15), 4711-4724. doi:10.1093/nar/gki781
DNA polymerase β promotes recruitment of DNA ligase IIIα-XRCC1 to sites of base excision repair
Parsons, J. L., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2005). DNA polymerase β promotes recruitment of DNA ligase IIIα-XRCC1 to sites of base excision repair. BIOCHEMISTRY, 44(31), 10613-10619. doi:10.1021/bi050085m
APE1-dependent repair of DNA single-strand breaks containing 3′-end 8-oxoguanine
Parsons, J. L., Dianova, I. I., & Dianov, G. L. (2005). APE1-dependent repair of DNA single-strand breaks containing 3′-end 8-oxoguanine. NUCLEIC ACIDS RESEARCH, 33(7), 2204-2209. doi:10.1093/nar/gki518
Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts
Parsons, J. L., Dianova, I. I., Allinson, S. L., & Dianov, G. L. (2005). Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts. FEBS JOURNAL, 272(8), 2012-2021. doi:10.1111/j.1742-4658.2005.04628.x
2004
Monitoring base excision repair proteins on damaged DNA using human cell extracts
Parsons, J. L., & Dianov, G. L. (2004). Monitoring base excision repair proteins on damaged DNA using human cell extracts. BIOCHEMICAL SOCIETY TRANSACTIONS, 32, 962-963. doi:10.1042/BST0320962
APE1 is the major 3′-phosphoglycolate activity in human cell extracts
Parsons, J. L., Dianova, I. I., & Dianov, G. L. (2004). APE1 is the major 3′-phosphoglycolate activity in human cell extracts. NUCLEIC ACIDS RESEARCH, 32(12), 3531-3536. doi:10.1093/nar/gkh676
XRCC1-DNA polymerase β interaction is required for efficient base excision repair
Dianova, I. I., Sleeth, K. M., Allinson, S. L., Parsons, J. L., Breslin, C., Caldecott, K. W., & Dianov, G. L. (2004). XRCC1-DNA polymerase β interaction is required for efficient base excision repair. NUCLEIC ACIDS RESEARCH, 32(8), 2550-2555. doi:10.1093/nar/gkh567
2003
DNA <i>N</i>-glycosylase deficient mice:: a tale of redundancy
Parsons, J. L., & Elder, R. H. (2003). DNA <i>N</i>-glycosylase deficient mice:: a tale of redundancy. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 531(1-2), 165-175. doi:10.1016/j.mrfmmm.2003.05.001
Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases
Karahalil, B., de Souza-Pinto, N. C., Parsons, J. L., Elder, R. H., & Bohr, V. A. (2003). Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(36), 33701-33707. doi:10.1074/jbc.M301617200
2000
The role of glutathione in DNA damage by potassium bromate <i>in vitro</i>
Parsons, J. L., & Chipman, J. K. (2000). The role of glutathione in DNA damage by potassium bromate <i>in vitro</i>. MUTAGENESIS, 15(4), 311-316. doi:10.1093/mutage/15.4.311
1998
DNA oxidation by potassium bromate; a direct mechanism or linked to lipid peroxidation?
Chipman, J. K., Davies, J. E., Parsons, J. L., Nair, J., O'Neill, G., & Fawell, J. K. (1998). DNA oxidation by potassium bromate; a direct mechanism or linked to lipid peroxidation?. TOXICOLOGY, 126(2), 93-102. doi:10.1016/S0300-483X(97)00174-1