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2024

Development and translation of a method of clinical utility for LC-MS/MS analysis to detect SARS-CoV-2 antigens from ONP swabs and saliva

DOI
10.26434/chemrxiv-2024-4t52c
Preprint

2023

2022

Lagovirus Non-structural Protein p23: A Putative Viroporin That Interacts With Heat Shock Proteins and Uses a Disulfide Bond for Dimerization.

Smertina, E., Carroll, A. J., Boileau, J., Emmott, E., Jenckel, M., Vohra, H., . . . Frese, M. (2022). Lagovirus Non-structural Protein p23: A Putative Viroporin That Interacts With Heat Shock Proteins and Uses a Disulfide Bond for Dimerization.. Frontiers in microbiology, 13, 923256. doi:10.3389/fmicb.2022.923256

DOI
10.3389/fmicb.2022.923256
Journal article

Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages

DOI
10.1101/2022.03.16.484655
Preprint

2021

Multiplexed single-cell proteomics using SCoPE2

Petelski, A., Emmott, E., Leduc, A., Huffman, G., Specht, H., Perlman, D., & Slavov, N. (2021). Multiplexed single-cell proteomics using SCoPE2. doi:10.1101/2021.03.12.435034

DOI
10.1101/2021.03.12.435034
Journal article

The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the Vesivirus genus

Sutherland, H., Conley, M., Emmott, E., Streetley, J., Goodfellow, I., & Bhella, D. (2021). The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the Vesivirus genus. doi:10.1101/2021.02.05.429895

DOI
10.1101/2021.02.05.429895
Journal article

2020

2019

Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity

Emmott, E., de Rougemont, A., Hosmillo, M., Lu, J., Fitzmaurice, T., Haas, J., & Goodfellow, I. (2019). Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(11), 4259-4271. doi:10.1074/jbc.RA118.006780

DOI
10.1074/jbc.RA118.006780
Journal article

Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation

Hosmillo, M., Lu, J., McAllaster, M., Eaglesham, J., Wang, X., Emmott, E., . . . Goodfellow, I. (2019). Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation. doi:10.1101/571455

DOI
10.1101/571455
Journal article

On the value of preprints: An early career researcher perspective

Sarabipour, S., Debat, H. J., Emmott, E., Burgess, S. J., Schwessinger, B., & Hensel, Z. (2019). On the value of preprints: An early career researcher perspective. PLOS BIOLOGY, 17(2). doi:10.1371/journal.pbio.3000151

DOI
10.1371/journal.pbio.3000151
Journal article

Ribosome Stoichiometry: From Form to Function

Emmott, E., Jovanovic, M., & Slavov, N. (2019). Ribosome Stoichiometry: From Form to Function. TRENDS IN BIOCHEMICAL SCIENCES, 44(2), 95-109. doi:10.1016/j.tibs.2018.10.009

DOI
10.1016/j.tibs.2018.10.009
Journal article

Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells

Mears, H., Emmott, E., Chaudhry, Y., Hosmillo, M., Goodfellow, I., & Sweeney, T. (2019). Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells. doi:10.12688/wellcomeopenres.15223.1

DOI
10.12688/wellcomeopenres.15223.1
Journal article

2018

UK circulating strains of human parainfluenza 3: an amplicon based next generation sequencing method and phylogenetic analysis

Smielewska, A., Emmott, E., Ranellou, K., Popay, A., Goodfellow, I., & Jalal, H. (n.d.). UK circulating strains of human parainfluenza 3: an amplicon based next generation sequencing method and phylogenetic analysis. Wellcome Open Research, 3, 118. doi:10.12688/wellcomeopenres.14730.1

DOI
10.12688/wellcomeopenres.14730.1
Journal article

Automated sample preparation for high-throughput single-cell proteomics

Specht, H., Harmange, G., Perlman, D., Emmott, E., Niziolek, Z., Budnik, B., & Slavov, N. (2018). Automated sample preparation for high-throughput single-cell proteomics. doi:10.1101/399774

DOI
10.1101/399774
Journal article

Maintaining confidence in the reporting of scientific outputs

Sarabipour, S., Wissink, E., Burgess, S., Hensel, Z., Debat, H., Emmott, E., . . . Schwessinger, B. (2018). Maintaining confidence in the reporting of scientific outputs. doi:10.7287/peerj.preprints.27098v1

DOI
10.7287/peerj.preprints.27098v1
Journal article

Ribosome stoichiometry: from form to function.

Emmott, E., Jovanovic, M., & Slavov, N. (2018). Ribosome stoichiometry: from form to function.. doi:10.7287/peerj.preprints.26991v1

DOI
10.7287/peerj.preprints.26991v1
Journal article

UK circulating strains of human parainfluenza 3: an amplicon based next generation sequencing method and phylogenetic analysis

Smielewska, A., Emmott, E., Ranellou, K., Popay, A., Goodfellow, I., & Jalal, H. (2018). UK circulating strains of human parainfluenza 3: an amplicon based next generation sequencing method and phylogenetic analysis. doi:10.12688/wellcomeopenres.14730.2

DOI
10.12688/wellcomeopenres.14730.2
Journal article

Unrecognised Outbreak: Human parainfluenza virus infections in a pediatric oncology unit.  A new diagnostic PCR and virus monitoring system may allow early detection of future outbreaks.

Smielewska, A., Pearson, C., Popay, A., Roddick, I., Reacher, M., Emmott, E., . . . Jalal, H. (2018). Unrecognised Outbreak: Human parainfluenza virus infections in a pediatric oncology unit.  A new diagnostic PCR and virus monitoring system may allow early detection of future outbreaks.. Wellcome open research, 3, 119. doi:10.12688/wellcomeopenres.14732.1

DOI
10.12688/wellcomeopenres.14732.1
Journal article

2017

Phosphoproteomic Analysis Reveals the Importance of Kinase Regulation During Orbivirus Infection

Mohl, B. -P., Emmott, E., & Roy, P. (2017). Phosphoproteomic Analysis Reveals the Importance of Kinase Regulation During Orbivirus Infection. MOLECULAR & CELLULAR PROTEOMICS, 16(11), 1990-2005. doi:10.1074/mcp.M117.067355

DOI
10.1074/mcp.M117.067355
Journal article

VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction

Hunter, M. R., Scourfield, E. J., Emmott, E., & Graham, S. C. (2017). VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction. BIOCHEMICAL JOURNAL, 474, 3615-3626. doi:10.1042/BCJ20170588

DOI
10.1042/BCJ20170588
Journal article

Spatial and temporal control of norovirus protease activity is determined by polyprotein processing and intermolecular interactions within the viral replication complex

Emmott, E., de Rougemont, A., Haas, J., & Goodfellow, I. (2017). Spatial and temporal control of norovirus protease activity is determined by polyprotein processing and intermolecular interactions within the viral replication complex. doi:10.1101/175463

DOI
10.1101/175463
Journal article

VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction

Hunter, M., Scourfield, E., Emmott, E., & Graham, S. (2017). VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction. doi:10.1101/169185

DOI
10.1101/169185
Journal article

Norovirus-Mediated Modification of the Translational Landscape via Virus and Host-Induced Cleavage of Translation Initiation Factors

Emmott, E., Sorgeloos, F., Caddy, S. L., Vashist, S., Sosnovtsev, S., Lloyd, R., . . . Goodfellow, I. (2017). Norovirus-Mediated Modification of the Translational Landscape via Virus and Host-Induced Cleavage of Translation Initiation Factors. MOLECULAR & CELLULAR PROTEOMICS, 16(4), S215-S229. doi:10.1074/mcp.M116.062448

DOI
10.1074/mcp.M116.062448
Journal article

Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures

Conley, M., Emmott, E., Orton, R., Taylor, D., Carneiro, D. G., Murata, K., . . . Bhella, D. (2017). Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures. JOURNAL OF GENERAL VIROLOGY, 98(1), 68-76. doi:10.1099/jgv.0.000658

DOI
10.1099/jgv.0.000658
Journal article

2016

Norovirus-mediated modification of the translational landscape via virus and host-induced cleavage of translation initiation factors

Emmott, E., Sorgeloos, F., Caddy, S., Vashist, S., Sosnovtsev, S., Lloyd, R., . . . Goodfellow, I. (2016). Norovirus-mediated modification of the translational landscape via virus and host-induced cleavage of translation initiation factors. doi:10.1101/060772

DOI
10.1101/060772
Journal article

2015

A Cell-based Fluorescence Resonance Energy Transfer (FRET) Sensor Reveals Inter-and Intragenogroup Variations in Norovirus Protease Activity and Polyprotein Cleavage

Emmott, E., Sweeney, T. R., & Goodfellow, I. (2015). A Cell-based Fluorescence Resonance Energy Transfer (FRET) Sensor Reveals Inter-and Intragenogroup Variations in Norovirus Protease Activity and Polyprotein Cleavage. JOURNAL OF BIOLOGICAL CHEMISTRY, 290(46), 27841-27853. doi:10.1074/jbc.M115.688234

DOI
10.1074/jbc.M115.688234
Journal article

Evidence for Human Norovirus Infection of Dogs in the United Kingdom

Caddy, S. L., de Rougemont, A., Emmott, E., El-Attar, L., Mitchell, J. A., Hollinshead, M., . . . Goodfellow, I. (2015). Evidence for Human Norovirus Infection of Dogs in the United Kingdom. JOURNAL OF CLINICAL MICROBIOLOGY, 53(6), 1873-1883. doi:10.1128/JCM.02778-14

DOI
10.1128/JCM.02778-14
Journal article

Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection

Royall, E., Doyle, N., Abdul-Wahab, A., Emmott, E., Morley, S. J., Goodfellow, I., . . . Locker, N. (2015). Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection. JOURNAL OF BIOLOGICAL CHEMISTRY, 290(8), 4748-4758. doi:10.1074/jbc.M114.602649

DOI
10.1074/jbc.M114.602649
Journal article

2014

Norovirus Translation Requires an Interaction between the C Terminus of the Genome-linked Viral Protein VPg and Eukaryotic Translation Initiation Factor 4G

Chung, L., Bailey, D., Leen, E. N., Emmott, E. P., Chaudhry, Y., Roberts, L. O., . . . Goodfellow, I. G. (2014). Norovirus Translation Requires an Interaction between the C Terminus of the Genome-linked Viral Protein VPg and Eukaryotic Translation Initiation Factor 4G. Journal of Biological Chemistry, 289(31), 21738-21750. doi:10.1074/jbc.M114.550657

DOI
10.1074/jbc.M114.550657
Journal article

Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics

Emmott, E., & Goodfellow, L. (2014). Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (89). doi:10.3791/51656

DOI
10.3791/51656
Journal article

2013

Progress towards the prevention and treatment of norovirus infections

Arias, A., Emmott, E., Vashist, S., & Goodfellow, I. (2013). Progress towards the prevention and treatment of norovirus infections. FUTURE MICROBIOLOGY, 8(11), 1475-1487. doi:10.2217/fmb.13.109

DOI
10.2217/fmb.13.109
Journal article

The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology

Emmott, E., Munday, D., Bickerton, E., Britton, P., Rodgers, M. A., Whitehouse, A., . . . Hiscox, J. A. (2013). The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology. JOURNAL OF VIROLOGY, 87(17), 9486-9500. doi:10.1128/JVI.00321-13

DOI
10.1128/JVI.00321-13
Journal article

Serological Evidence for Multiple Strains of Canine Norovirus in the UK Dog Population

Caddy, S., Emmott, E., El-Attar, L., Mitchell, J., de Rougemont, A., Brownlie, J., & Goodfellow, I. (2013). Serological Evidence for Multiple Strains of Canine Norovirus in the UK Dog Population. PLOS ONE, 8(12). doi:10.1371/journal.pone.0081596

DOI
10.1371/journal.pone.0081596
Journal article

2012

Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes

Munday, D. C., Surtees, R., Emmott, E., Dove, B. K., Digard, P., Barr, J. N., . . . Hiscox, J. A. (2012). Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes. PROTEOMICS, 12(4-5), 666-672. doi:10.1002/pmic.201100488

DOI
10.1002/pmic.201100488
Journal article

2011

Viruses and the Nucleolus

Matthews, D., Emmott, E., & Hiscox, J. (2011). Viruses and the Nucleolus. NUCLEOLUS, 15, 321-345. doi:10.1007/978-1-4614-0514-6_14

DOI
10.1007/978-1-4614-0514-6_14
Journal article

2010

Quantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus

Munday, D. C., Emmott, E., Surtees, R., Lardeau, C. -H., Wu, W., Duprex, W. P., . . . Hiscox, J. A. (2010). Quantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus. MOLECULAR & CELLULAR PROTEOMICS, 9(11), 2438-2459. doi:10.1074/mcp.M110.001859

DOI
10.1074/mcp.M110.001859
Journal article

Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus

Emmott, E., Smith, C., Emmett, S. R., Dove, B. K., & Hiscox, J. A. (2010). Elucidation of the avian nucleolar proteome by quantitative proteomics using SILAC and changes in cells infected with the coronavirus infectious bronchitis virus. PROTEOMICS, 10(19), 3558-3562. doi:10.1002/pmic.201000139

DOI
10.1002/pmic.201000139
Journal article

Quantitative Proteomics Using SILAC Coupled to LC-MS/MS Reveals Changes in the Nucleolar Proteome in Influenza A Virus-Infected Cells

Emmott, E., Wise, H., Loucaides, E. M., Matthews, D. A., Digard, P., & Hiscox, J. A. (2010). Quantitative Proteomics Using SILAC Coupled to LC-MS/MS Reveals Changes in the Nucleolar Proteome in Influenza A Virus-Infected Cells. JOURNAL OF PROTEOME RESEARCH, 9(10), 5335-5345. doi:10.1021/pr100593g

DOI
10.1021/pr100593g
Journal article

Quantitative Proteomics Using Stable Isotope Labeling with Amino Acids in Cell Culture Reveals Changes in the Cytoplasmic, Nuclear, and Nucleolar Proteomes in Vero Cells Infected with the Coronavirus Infectious Bronchitis Virus

Emmott, E., Rodgers, M. A., Macdonald, A., McCrory, S., Ajuh, P., & Hiscox, J. A. (2010). Quantitative Proteomics Using Stable Isotope Labeling with Amino Acids in Cell Culture Reveals Changes in the Cytoplasmic, Nuclear, and Nucleolar Proteomes in Vero Cells Infected with the Coronavirus Infectious Bronchitis Virus. MOLECULAR & CELLULAR PROTEOMICS, 9(9), 1920-1936. doi:10.1074/mcp.M900345-MCP200

DOI
10.1074/mcp.M900345-MCP200
Journal article

2009

Nucleolar targeting: the hub of the matter

Emmott, E., & Hiscox, J. A. (2009). Nucleolar targeting: the hub of the matter. EMBO REPORTS, 10(3), 231-238. doi:10.1038/embor.2009.14

DOI
10.1038/embor.2009.14
Journal article

Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis

Leppard, K. N., Emmott, E., Cortese, M. S., & Rich, T. (2009). Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis. JOURNAL OF GENERAL VIROLOGY, 90, 95-104. doi:10.1099/vir.0.005512-0

DOI
10.1099/vir.0.005512-0
Journal article

2008

Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus

Emmott, E., Dove, B. K., Howell, G., Chappell, L. A., Reed, M. L., Boyne, J. R., . . . Hiscox, J. A. (2008). Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus. VIROLOGY, 380(2), 191-202. doi:10.1016/j.virol.2008.05.032

DOI
10.1016/j.virol.2008.05.032
Journal article