Publications
2025
Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis.
Van Netten, C., Vallabhaneni, K., Hardwick, B., Anumba, D., Briley, A. L., Collins, P., . . . Weeks, A. (2025). Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis.. BMJ Open, 15(5), e101255. doi:10.1136/bmjopen-2025-101255
Influencing Factors for the Acceptability of Accessing HIV Pre-exposure Prophylaxis via Community Pharmacies in Wales.
Gillespie, D., Williams, A. D. N., Ma, R., Couzens, Z., Hood, K., Hughes, D. A., . . . Wood, F. (2025). Influencing Factors for the Acceptability of Accessing HIV Pre-exposure Prophylaxis via Community Pharmacies in Wales.. Health expectations : an international journal of public participation in health care and health policy, 28(2), e70247. doi:10.1111/hex.70247
Improving medication adherence in the community: a purposive umbrella review of effective patient-directed interventions that are readily implementable in the United Kingdom National Health Service.
Mackridge, A. J., Wood, E. M., & Hughes, D. A. (2025). Improving medication adherence in the community: a purposive umbrella review of effective patient-directed interventions that are readily implementable in the United Kingdom National Health Service.. International journal of clinical pharmacy. doi:10.1007/s11096-025-01885-4
Relative Forgiveness of Different Allopurinol Implementation Patterns in People with Gout and their Impact on Clinical Outcomes: a Simulation Study.
White-Koning, M., Wright, D. F. B., Hughes, D. A., Michael, T. J. F., Coleshill, M. J., Aslani, P., . . . Stocker, S. L. (2025). Relative Forgiveness of Different Allopurinol Implementation Patterns in People with Gout and their Impact on Clinical Outcomes: a Simulation Study.. Clinical pharmacokinetics, 64(1), 93-105. doi:10.1007/s40262-024-01467-z
Risk of bias tools for medication adherence research: RoBIAS and RoBOAS.
Sinnappah, K. A., Hughes, D. A., Stocker, S. L., Wright, D. F. B., & ESPACOMP the International Society for Medication Adherence. (2025). Risk of bias tools for medication adherence research: RoBIAS and RoBOAS.. British journal of clinical pharmacology, 91(5), 1457-1478. doi:10.1111/bcp.16382
2024
Evidence Following Conditional NICE Technology Appraisal Recommendations: A Critical Analysis of Methods, Quality and Risk of Bias.
Pijeira Perez, Y., & Hughes, D. A. (2024). Evidence Following Conditional NICE Technology Appraisal Recommendations: A Critical Analysis of Methods, Quality and Risk of Bias.. PharmacoEconomics, 42(12), 1373-1394. doi:10.1007/s40273-024-01418-3
Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK.
Opatola, A. V., Seaborne, M. J., Kennedy, J., Hughes, D., Laing, H., Owen, R. K., . . . Brophy, S. (2024). Association of child weight and adverse outcomes following antibiotic prescriptions in children: a national data study in Wales, UK.. BMJ paediatrics open, 8(1), e002831. doi:10.1136/bmjpo-2024-002831
Patient preferences for using remote care technology in heart failure: A discrete choice experiment (Preprint)
Pharmacoeconomics and drug utilization research
Usher, C., Bennett, K., Mantovani, L., & Hughes, D. (2024). Pharmacoeconomics and drug utilization research. In Unknown Book (pp. 456-463). Wiley. doi:10.1002/9781119911685.ch45
Developing feasible person-centred care alternatives to emergency department responses for adults with epilepsy: a discrete choice analysis mixed-methods study.
Noble, A. J., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., McKinlay, A., . . . Holmes, E. (2024). Developing feasible person-centred care alternatives to emergency department responses for adults with epilepsy: a discrete choice analysis mixed-methods study.. Health and social care delivery research, 12(24), 1-158. doi:10.3310/hkqw4129
Patient-Led Urate Self-Monitoring to Improve Clinical Outcomes in People With Gout: A Feasibility Study.
Michael, T. J. F., Wright, D. F. B., Chan, J. S., Coleshill, M. J., Aslani, P., Hughes, D. A., . . . Stocker, S. L. (2024). Patient-Led Urate Self-Monitoring to Improve Clinical Outcomes in People With Gout: A Feasibility Study.. ACR open rheumatology, 6(7), 403-411. doi:10.1002/acr2.11666
A proposal for using benefit-risk methods to improve the prominence of adverse event results when reporting trials.
Totton, N., Waddingham, E., Owen, R., Julious, S., Hughes, D., & Cook, J. (2024). A proposal for using benefit-risk methods to improve the prominence of adverse event results when reporting trials.. Trials, 25(1), 409. doi:10.1186/s13063-024-08228-0
The experiences and perspectives of people with gout on urate self-monitoring.
Michael, T. J. F., Chan, J. S., Hughes, S., Wright, D. F. B., Coleshill, M. J., Hughes, D. A., . . . Stocker, S. L. (2024). The experiences and perspectives of people with gout on urate self-monitoring.. Health expectations : an international journal of public participation in health care and health policy, 27(3), e14071. doi:10.1111/hex.14071
A model-based cost-utility analysis of an automated notification system for deteriorating patients on general wards.
Holmes, E., Lloyd Williams, H., Hughes, D., Naujokat, E., Duller, B., & Subbe, C. P. (2024). A model-based cost-utility analysis of an automated notification system for deteriorating patients on general wards.. PloS one, 19(5), e0301643. doi:10.1371/journal.pone.0301643
Developing an alternative care pathway for emergency ambulance responses for adults with epilepsy: A Discrete Choice Experiment to understand which configuration service users prefer. Part of the COLLABORATE project.
Holmes, E., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., McKinlay, A., . . . Noble, A. J. (2024). Developing an alternative care pathway for emergency ambulance responses for adults with epilepsy: A Discrete Choice Experiment to understand which configuration service users prefer. Part of the COLLABORATE project.. Seizure, 118, 28-37. doi:10.1016/j.seizure.2024.04.008
Service users' preferences and feasibility - which alternative care pathway for adult ambulance users achieves the optimal balance? Workshops for the COLLABORATE project.
Noble, A. J., Morris, B., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., . . . Holmes, E. (2024). Service users' preferences and feasibility - which alternative care pathway for adult ambulance users achieves the optimal balance? Workshops for the COLLABORATE project.. Seizure, 118, 17-27. doi:10.1016/j.seizure.2024.04.010
We need to talk about values: a proposed framework for the articulation of normative reasoning in health technology assessment
Charlton, V., Distefano, M., Mitchell, P., Morrell, L., Rand, L., Badano, G., . . . Wester, G. (2023). We need to talk about values: a proposed framework for the articulation of normative reasoning in health technology assessment. HEALTH ECONOMICS POLICY AND LAW. doi:10.1017/S1744133123000038
Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D pilot): results of a feasibility randomised trial.
SuMMiT-D Collaborative Group ., Farmer, A. J., Allen, J., Bartlett, Y. K., Bower, P., Chi, Y., . . . Yu, L. -M. (2024). Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D pilot): results of a feasibility randomised trial.. Pilot and feasibility studies, 10(1), 15. doi:10.1186/s40814-023-01429-5
2023
Superiority and cost-effectiveness of monthly extended-release buprenorphine versus daily standard of care medication: a pragmatic, parallel-group, open-label, multicentre, randomised, controlled, phase 3 trial.
Marsden, J., Kelleher, M., Gilvarry, E., Mitcheson, L., Bisla, J., Cape, A., . . . Hoare, Z. (2023). Superiority and cost-effectiveness of monthly extended-release buprenorphine versus daily standard of care medication: a pragmatic, parallel-group, open-label, multicentre, randomised, controlled, phase 3 trial.. EClinicalMedicine, 66, 102311. doi:10.1016/j.eclinm.2023.102311
Best step-up treatments for children with uncontrolled asthma: A systematic review and network meta-analysis of individual participant data.
Cividini, S., Sinha, I., Donegan, S., Maden, M., Rose, K., Fulton, O., . . . PhD on behalf of the EINSTEIN collaborative group. (2023). Best step-up treatments for children with uncontrolled asthma: A systematic review and network meta-analysis of individual participant data.. The European respiratory journal, 2301011. doi:10.1183/13993003.01011-2023
A framework for understanding sources of bias in medication adherence research
Sinnappah, K. A. A., Hughes, D. A. A., Stocker, S. L. L., Vrijens, B., Aronson, J. K. K., & Wright, D. F. B. (2023). A framework for understanding sources of bias in medication adherence research. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15863
Costs of orphan medicinal products: longitudinal analysis of expenditure in Wales.
Pijeira Perez, Y., Wood, E., & Hughes, D. A. (2023). Costs of orphan medicinal products: longitudinal analysis of expenditure in Wales.. Orphanet journal of rare diseases, 18(1), 342. doi:10.1186/s13023-023-02956-3
Effectiveness of out-patient based acute heart failure care: a pilot randomised controlled trial
Wong, K. Y. K., Hughes, D. A., Debski, M., Latt, N., Assaf, O., Abdelrahman, A., . . . Cleland, J. G. F. (2023). Effectiveness of out-patient based acute heart failure care: a pilot randomised controlled trial. ACTA CARDIOLOGICA, 78(7), 828-837. doi:10.1080/00015385.2023.2197834
Appropriate design and reporting of superiority, equivalence and non-inferiority clinical trials incorporating a benefit-risk assessment: the BRAINS study including expert workshop.
Totton, N., Julious, S. A., Coates, E., Hughes, D. A., Cook, J. A., Biggs, K., . . . Cook, A. (2023). Appropriate design and reporting of superiority, equivalence and non-inferiority clinical trials incorporating a benefit-risk assessment: the BRAINS study including expert workshop.. Health technology assessment (Winchester, England), 27(20), 1-58. doi:10.3310/bhqz7691
Spanish translation of the ABC taxonomy for medication adherence.
Garcia-Cardenas, V., Hughes, D., Aguilar-Palacio, I., Benrimoj, S. I., Rabanaque, M. J., Martinez-Martinez, F., & Malo, S. (2023). Spanish translation of the ABC taxonomy for medication adherence.. Research in social & administrative pharmacy : RSAP, 19(9), 1292-1297. doi:10.1016/j.sapharm.2023.05.012
Medication adherence research comes of ageY
Wright, D. F. B., Sinnappah, K. A., & Hughes, D. A. (2023). Medication adherence research comes of ageY. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 89(7), 1914-1917. doi:10.1111/bcp.15722
Methodological considerations on estimating medication adherence from self-report, electronic monitoring and electronic healthcare databases using the TEOS framework
Dima, A. L., Allemann, S. S., Dunbar-Jacob, J., Hughes, D. A., Vrijens, B., & Wilson, I. B. (2023). Methodological considerations on estimating medication adherence from self-report, electronic monitoring and electronic healthcare databases using the TEOS framework. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 89(7), 1918-1927. doi:10.1111/bcp.15375
Between- and Within-Individual Sociodemographic and Psychological Determinants of PrEP Adherence Among Men Who have Sex with Men Prescribed a Daily PrEP Regimen in Wales.
Gillespie, D., de Bruin, M., Hughes, D. A., Ma, R., Williams, A., Wood, F., . . . Hood, K. (2023). Between- and Within-Individual Sociodemographic and Psychological Determinants of PrEP Adherence Among Men Who have Sex with Men Prescribed a Daily PrEP Regimen in Wales.. AIDS and behavior, 27(5), 1564-1572. doi:10.1007/s10461-022-03890-4
Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial (vol 19, 458, 2021)
Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., . . . Goebel, A. (2023). Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial (vol 19, 458, 2021). JOURNAL OF TRANSLATIONAL MEDICINE, 21(1). doi:10.1186/s12967-023-04131-5
Value of improving patient safety: health economic considerations for rapid response systems-a rapid review of the literature and expert round table
Subbe, C., Hughes, D. A., Lewis, S., Holmes, E. A., Kalkman, C., So, R., . . . Welch, J. (2023). Value of improving patient safety: health economic considerations for rapid response systems-a rapid review of the literature and expert round table. BMJ OPEN, 13(4). doi:10.1136/bmjopen-2022-065819
Health utilities and quality-adjusted life years for patients with amyotrophic lateral sclerosis receiving <i>reldesemtiv</i> or placebo in FORTITUDE-ALS.
Gebrehiwet, P., Meng, L., Rudnicki, S. A., Sarocco, P., Wei, J., Wolff, A. A., . . . Shefner, J. M. (2023). Health utilities and quality-adjusted life years for patients with amyotrophic lateral sclerosis receiving <i>reldesemtiv</i> or placebo in FORTITUDE-ALS.. Journal of medical economics, 26(1), 488-493. doi:10.1080/13696998.2023.2192588
Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: a protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandic epilepsy
Al-Najjar, N., Bray, L., Carter, B., Castle, A. P., Collingwood, A., Cook, G., . . . Pal, D. K. (2023). Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: a protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandic epilepsy. BMJ OPEN, 13(3). doi:10.1136/bmjopen-2022-065769
A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study
Jorgensen, A. L., Orrell, C., Waitt, C., Toh, C. -H., Sekaggya-Wiltshire, C., Hughes, D. A., . . . Pirmohamed, M. (2023). A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study. JMIR RESEARCH PROTOCOLS, 12. doi:10.2196/46710
A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Preprint)
The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial
Carter, B., Bray, L., al-Najjar, N., Piella, A. T., Tudur-Smith, C., Spowart, C., . . . Pal, D. (2023). The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial. TRIALS, 24(1). doi:10.1186/s13063-023-07091-9
Psychometric Properties of an Adapted Stigma Scale and Experiences of Stigma Associated with HIV Pre-exposure Prophylaxis Use Among Men Who have Sex with Men: A Mixed Methods Study
Gillespie, D., Williams, A., Wood, F., Couzens, Z., Jones, A., Ma, R., . . . Hood, K. (2023). Psychometric Properties of an Adapted Stigma Scale and Experiences of Stigma Associated with HIV Pre-exposure Prophylaxis Use Among Men Who have Sex with Men: A Mixed Methods Study. AIDS and Behavior. doi:10.1007/s10461-022-03967-0
2022
Methods for Extrapolating Survival Analyses for the Economic Evaluation of Advanced Therapy Medicinal Products
Hardy, W. A. S., & Hughes, D. A. (2022). Methods for Extrapolating Survival Analyses for the Economic Evaluation of Advanced Therapy Medicinal Products. HUMAN GENE THERAPY, 33(17-18), 845-856. doi:10.1089/hum.2022.056
Supply-Side Cost-Effectiveness Thresholds: Questions for Evidence-Based Policy.
Sampson, C., Zamora, B., Watson, S., Cairns, J., Chalkidou, K., Cubi-Molla, P., . . . Towse, A. (2022). Supply-Side Cost-Effectiveness Thresholds: Questions for Evidence-Based Policy.. Applied health economics and health policy, 20(5), 651-667. doi:10.1007/s40258-022-00730-3
Extended-release pharmacotherapy for opioid use disorder (EXPO): protocol for an open-label randomised controlled trial of the effectiveness and cost-effectiveness of injectable buprenorphine versus sublingual tablet buprenorphine and oral liquid methadone
Marsden, J., Kelleher, M., Hoare, Z., Hughes, D., Bisla, J., Cape, A., . . . Mitcheson, L. (2022). Extended-release pharmacotherapy for opioid use disorder (EXPO): protocol for an open-label randomised controlled trial of the effectiveness and cost-effectiveness of injectable buprenorphine versus sublingual tablet buprenorphine and oral liquid methadone. TRIALS, 23(1). doi:10.1186/s13063-022-06595-0
Advanced therapy medicinal products: a comprehensive overview for pharmacy professionals
Advanced therapy medicinal products: a comprehensive overview for pharmacy professionals (2022). Pharmaceutical Journal. doi:10.1211/pj.2022.1.150934
PrEP Use, Sexual Behaviour, and PrEP Adherence Among Men who have Sex with Men Living in Wales Prior to and During the COVID-19 Pandemic.
Gillespie, D., Couzens, Z., de Bruin, M., Hughes, D. A., Jones, A., Ma, R., . . . Hood, K. (2022). PrEP Use, Sexual Behaviour, and PrEP Adherence Among Men who have Sex with Men Living in Wales Prior to and During the COVID-19 Pandemic.. AIDS and behavior, 26(8), 2746-2757. doi:10.1007/s10461-022-03618-4
Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions
Osanlou, R., Walker, L., Hughes, D. A., Burnside, G., & Pirmohamed, M. (2022). Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions. BMJ OPEN, 12(7). doi:10.1136/bmjopen-2021-055551
Have infection control and prevention measures resulted in any adverse outcomes for care home and domiciliary care residents and staff?
What innovations can address inequalities experienced by women and girls due to the COVID-19 pandemic across the different areas of life/domains: work, health, living standards, personal security, participation and education?
Experiences of men who have sex with men when initiating, implementing and persisting with HIV pre-exposure prophylaxis
Gillespie, D., Wood, F., Williams, A., Ma, R., de Bruin, M., Hughes, D. A., . . . Hood, K. (2022). Experiences of men who have sex with men when initiating, implementing and persisting with HIV pre-exposure prophylaxis. HEALTH EXPECTATIONS. doi:10.1111/hex.13446
Clinical interventions to improve adherence to urate-lowering therapy in patients with gout: a systematic review.
Sinnappah, K. A., Stocker, S. L., Chan, J. S., Hughes, D. A., & Wright, D. F. B. (2022). Clinical interventions to improve adherence to urate-lowering therapy in patients with gout: a systematic review.. The International journal of pharmacy practice, riac025. doi:10.1093/ijpp/riac025
Extended-release pharmacotherapy for opioid use disorder (EXPO): Protocol for an open-label randomised controlled trial of injectable maintenance buprenorphine with personalised psychosocial intervention.
Health utilities and costs for neuromyelitis optica spectrum disorder
Hughes, D. A., Bourke, S., Jones, A., Bhatt, R., Huda, S., Mutch, K., & Jacob, A. (2022). Health utilities and costs for neuromyelitis optica spectrum disorder. ORPHANET JOURNAL OF RARE DISEASES, 17(1). doi:10.1186/s13023-022-02310-z
Novel oral iron therapy for iron deficiency anaemia: How to value safety in a new drug?
Culeddu, G., Su, L., Cheng, Y., Pereira, D. I. A., Payne, R. A., Powell, J. J., & Hughes, D. A. (2022). Novel oral iron therapy for iron deficiency anaemia: How to value safety in a new drug?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(3), 1347-1357. doi:10.1111/bcp.15078
Supporting People With Type 2 Diabetes in the Effective Use of Their Medicine Through Mobile Health Technology Integrated With Clinical Care to Reduce Cardiovascular Risk: Protocol for an Effectiveness and Cost-effectiveness Randomized Controlled Trial.
Farmer, A., Jones, L., Newhouse, N., Kenning, C., Williams, N., Chi, Y., . . . French, D. (2022). Supporting People With Type 2 Diabetes in the Effective Use of Their Medicine Through Mobile Health Technology Integrated With Clinical Care to Reduce Cardiovascular Risk: Protocol for an Effectiveness and Cost-effectiveness Randomized Controlled Trial.. JMIR research protocols, 11(2), e32918. doi:10.2196/32918
Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations
Husereau, D., Drummond, M., Augustovski, F., De Bekker-Grob, E., Briggs, A. H., Carswell, C., . . . Staniszewska, S. (2022). Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations. CLINICAL THERAPEUTICS, 44(2), 158-168. doi:10.1016/j.clinthera.2022.01.011
Choice of oral anticoagulant prescribed by general practices in Wales: Application of Dirichlet regression and linked data
Hill-McManus, D., & Hughes, D. A. (2022). Choice of oral anticoagulant prescribed by general practices in Wales: Application of Dirichlet regression and linked data. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15183
2021
Liothyronine for hypothyroidism: a candidate for disinvestment or in need of further research? A value of information analysis
Hughes, D. A., Skiadas, K., Fitzsimmons, D., Anderson, P., & Heald, A. (2021). Liothyronine for hypothyroidism: a candidate for disinvestment or in need of further research? A value of information analysis. BMJ OPEN, 11(12). doi:10.1136/bmjopen-2021-051702
Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial
Carter, B., Zenasni, Z., Moat, S. J., Hudson, P. R., Russell, I. T., & McCaddon, A. (2021). Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial. JOURNAL OF NUTRITION, 151(12), 3738-3745. doi:10.1093/jn/nxab280
Is there a role for natural desiccated thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a consecutive case series
Heald, A. H., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., . . . Hughes, D. A. (2021). Is there a role for natural desiccated thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a consecutive case series. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 75(12). doi:10.1111/ijcp.14967
Pharmacogenomics spotlight commentary: From the United Kingdom to global populations
Magavern, E. F., Daly, A. K., Gilchrist, A., & Hughes, D. A. (2021). Pharmacogenomics spotlight commentary: From the United Kingdom to global populations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4546-4548. doi:10.1111/bcp.14917
Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial
Johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., . . . Goebel, A. (2021). Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial. JOURNAL OF TRANSLATIONAL MEDICINE, 19(1). doi:10.1186/s12967-021-03128-2
Supporting People With Type 2 Diabetes in the Effective Use of Their Medicine Through Mobile Health Technology Integrated With Clinical Care to Reduce Cardiovascular Risk: Protocol for an Effectiveness and Cost-effectiveness Randomized Controlled Trial (Preprint)
Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series
Heald, A., Premawardhana, L., Taylor, P., Okosieme, O., Bangi, T., Devine, H., . . . Hughes, D. (2021). Is there a role for Natural Desiccated Thyroid in the treatment of levothyroxine unresponsive hypothyroidism? Results from a Consecutive Case Series. doi:10.22541/au.163251250.02145771/v1
Mechanistically Informed Non-invasive Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: a Randomised Double-blind Sham-controlled Trial.
johnson, S., Marshall, A., Hughes, D., Holmes, E., Henrich, F., Nurmikko, T., . . . Goebel, A. (2021). Mechanistically Informed Non-invasive Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: a Randomised Double-blind Sham-controlled Trial.. doi:10.21203/rs.3.rs-809958/v1
Using routinely recorded data in a UK RCT: a comparison to standard prospective data collection methods
Powell, G. A., Bonnett, L. J., Smith, C. T., Hughes, D. A., Williamson, P. R., & Marson, A. G. (2021). Using routinely recorded data in a UK RCT: a comparison to standard prospective data collection methods. TRIALS, 22(1). doi:10.1186/s13063-021-05294-6
Linked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development
Hill-McManus, D., Marshall, S., Liu, J., Willke, R. J., & Hughes, D. A. (2021). Linked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development. CLINICAL PHARMACOLOGY & THERAPEUTICS, 110(1), 49-63. doi:10.1002/cpt.2051
A systematic review of economic evaluations of advanced therapy medicinal products
Lloyd-Williams, H., & Hughes, D. A. (2021). A systematic review of economic evaluations of advanced therapy medicinal products. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2428-2443. doi:10.1111/bcp.14275
Managing access to advanced therapy medicinal products: Challenges for NHS Wales
Champion, A. R., Lewis, S., Davies, S., & Hughes, D. A. (2021). Managing access to advanced therapy medicinal products: Challenges for NHS Wales. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2444-2449. doi:10.1111/bcp.14286
TEOS: A framework for constructing operational definitions of medication adherence based on Timelines-Events-Objectives-Sources
Dima, A. L., Allemann, S. S., Dunbar-Jacob, J., Hughes, D. A., Vrijens, B., & Wilson, I. B. (2021). TEOS: A framework for constructing operational definitions of medication adherence based on Timelines-Events-Objectives-Sources. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2521-2533. doi:10.1111/bcp.14659
Cost-effectiveness of home versus hospital management of children at onset of type 1 diabetes: the DECIDE randomised controlled trial
McCarroll, Z., Townson, J., Pickles, T., Gregory, J. W., Playle, R., Robling, M., & Hughes, D. A. (2021). Cost-effectiveness of home versus hospital management of children at onset of type 1 diabetes: the DECIDE randomised controlled trial. BMJ OPEN, 11(5). doi:10.1136/bmjopen-2020-043523
Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation
Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., . . . Williamson, P. R. (2021). Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation. LANCET RHEUMATOLOGY, 3(5), E347-E356. doi:10.1016/S2665-9913(21)00036-9
The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)
Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J. -D., . . . Wang-Steverding, X. (2021). The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE). MEDICINA-LITHUANIA, 57(4). doi:10.3390/medicina57040388
The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., . . . Smith, P. E. (2021). The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. LANCET, 397(10282), 1363-1374. Retrieved from https://www.webofscience.com/
The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., . . . Smith, P. E. (2021). The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. LANCET, 397(10282), 1375-1386. Retrieved from https://www.webofscience.com/
Content of Health Economics Analysis Plans (HEAPs) for Trial-Based Economic Evaluations: Expert Delphi Consensus Survey
Thorn, J. C., Davies, C. F., Brookes, S. T., Noble, S. M., Dritsaki, M., Gray, E., . . . Hollingworth, W. (2020). Content of Health Economics Analysis Plans (HEAPs) for Trial-Based Economic Evaluations: Expert Delphi Consensus Survey. VALUE IN HEALTH, 24(4), 539-547. doi:10.1016/j.jval.2020.10.002
Mycophenolate mofetil versus cyclophosphamide for remission induction in childhood polyarteritis nodosa: An open label, randomised, Bayesian, non-inferiority trial.
Brogan, P. A., Arch, B., Hickey, H., Anton, J., Iglesias, E., Baildam, E., . . . Eleftheriou, D. (2021). Mycophenolate mofetil versus cyclophosphamide for remission induction in childhood polyarteritis nodosa: An open label, randomised, Bayesian, non-inferiority trial.. Arthritis & rheumatology (Hoboken, N.J.). doi:10.1002/art.41730
Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales
Gillespie, D., Knapper, C., Hughes, D., Couzens, Z., Wood, F., de Bruin, M., . . . Hood, K. (2021). Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales. SEXUALLY TRANSMITTED INFECTIONS, 97(2), 85-87. doi:10.1136/sextrans-2020-054598
Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE)
Cullinan, J., Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., de Korwin, J. -D., . . . Wang-Steverding, X. (2021). Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE). MEDICINA-LITHUANIA, 57(3). doi:10.3390/medicina57030208
EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data (IPD)
Cividini, S., Sinha, I., Donegan, S., Maden, M., Culeddu, G., Rose, K., . . . Tudur Smith, C. (2021). EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data (IPD). BMJ Open, 11(2), e040528. doi:10.1136/bmjopen-2020-040528
Acceptability of generic versus innovator oral medicines: not only a matter of taste
Tuleu, C., Hughes, D. A., Clapham, D., Vallet, T., & Ruiz, F. (2020). Acceptability of generic versus innovator oral medicines: not only a matter of taste. DRUG DISCOVERY TODAY, 26(2), 329-343. doi:10.1016/j.drudis.2020.11.008
What should patients do if they miss a dose? A systematic review of patient information leaflets and summaries of product characteristics
Albassam, A., & Hughes, D. A. (2021). What should patients do if they miss a dose? A systematic review of patient information leaflets and summaries of product characteristics. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 77(2), 251-260. doi:10.1007/s00228-020-03003-x
Utilising benefit-risk assessments within clinical trials-a protocol for the BRAINS project
Totton, N., Julious, S., Hughes, D., Cook, J., Biggs, K., Coates, L., . . . Day, S. (2021). Utilising benefit-risk assessments within clinical trials-a protocol for the BRAINS project. TRIALS, 22(1). doi:10.1186/s13063-021-05022-0
Utilising Benefit-Risk Assessments within Clinical Trials – A Protocol for the BRAINS project
Totton, N., Julious, S., Hughes, D., Cook, J., Biggs, K., Coates, L., . . . Day, S. (2021). Utilising Benefit-Risk Assessments within Clinical Trials – A Protocol for the BRAINS project. doi:10.21203/rs.3.rs-22996/v3
Combining Model-Based Clinical Trial Simulation, Pharmacoeconomics, and Value of Information to Optimize Trial Design
Hill-McManus, D., & Hughes, D. A. (2021). Combining Model-Based Clinical Trial Simulation, Pharmacoeconomics, and Value of Information to Optimize Trial Design. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 10(1), 75-83. doi:10.1002/psp4.12579
Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs Introduction
Marson, A. G., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., . . . Smith, P. E. M. (2021). Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs Introduction. HEALTH TECHNOLOGY ASSESSMENT, 25(75), 1-+. doi:10.3310/hta25750
Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT.
Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., . . . Williamson, P. R. (2021). Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT.. Health Technology Assessment, 25(24), 1-86. doi:10.3310/hta25240
Patient and public engagement in medication adherence research
Holmes, E. A. F., Gillespie, D., & Hughes, D. A. (2021). Patient and public engagement in medication adherence research. In INTERNATIONAL JOURNAL OF CLINICAL PHARMACY Vol. 43 (pp. 305). Retrieved from https://www.webofscience.com/
Quantitative Evidence Synthesis Methods for the Assessment of the Effectiveness of Treatment Sequences for Clinical and Economic Decision Making: A Review and Taxonomy of Simplifying Assumptions
Lewis, R. A., Hughes, D., Sutton, A. J., & Wilkinson, C. (2021). Quantitative Evidence Synthesis Methods for the Assessment of the Effectiveness of Treatment Sequences for Clinical and Economic Decision Making: A Review and Taxonomy of Simplifying Assumptions. PHARMACOECONOMICS, 39(1), 25-61. doi:10.1007/s40273-020-00980-w
2020
A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE)
Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J. -D., . . . Wang-Steverding, X. (2021). A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE). MEDICINA-LITHUANIA, 57(1). doi:10.3390/medicina57010007
Impact of Relaxing Covid-19 Social Distancing Measures on Rural North Wales: A Simulation Analysis
Hughes, R. P., & Hughes, D. A. (2020). Impact of Relaxing Covid-19 Social Distancing Measures on Rural North Wales: A Simulation Analysis. FRONTIERS IN PUBLIC HEALTH, 8. doi:10.3389/fpubh.2020.562473
A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)
Pheby, D., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J. -D., . . . Wang-Steverding, X. (2020). A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE). doi:10.20944/preprints202011.0735.v1
Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam
Hughes, D. A. (2020). Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam. BRITISH JOURNAL OF PHARMACOLOGY, 177(21), 4975-4989. doi:10.1111/bph.15101
RTID-10. SURGEONS TRIAL OF PROPHYLAXIS FOR EPILEPSY IN SEIZURE NAÏVE PATIENTS WITH MENINGIOMA: A RANDOMIZED CONTROLLED TRIAL (STOP ‘EM)
Jenkinson, M., Helmy, A., Huckey, H., Mills, S., Grant, R., Hughes, D., . . . Gamble, C. (2020). RTID-10. SURGEONS TRIAL OF PROPHYLAXIS FOR EPILEPSY IN SEIZURE NAÏVE PATIENTS WITH MENINGIOMA: A RANDOMIZED CONTROLLED TRIAL (STOP ‘EM). Neuro-oncology, 22(Suppl 2), ii195.
Management of Patients Symptomatically Unresponsive to Levothyroxine: Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and Liothyronine? A Research Priority
Heald, A., Livingston, M., & Hughes, D. (2020). Management of Patients Symptomatically Unresponsive to Levothyroxine: Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and Liothyronine? A Research Priority. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 128(9), 596-598. doi:10.1055/a-1062-6167
Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II).
Balabanova, S., Taylor, C., Sills, G., Burnside, G., Plumpton, C., Smith, P. E. M., . . . Marson, A. G. (2020). Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II).. BMJ open, 10(8), e040635. doi:10.1136/bmjopen-2020-040635
Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT
Poolman, M., Roberts, J., Wright, S., Hendry, A., Goulden, N., Holmes, E. A. F., . . . Wilkinson, C. (2020). Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT. HEALTH TECHNOLOGY ASSESSMENT, 24(25), 1-+. doi:10.3310/hta24250
TEOS: A framework for constructing operational definitions of medication adherence based on Timelines – Events – Objectives – Sources
Dima, A., Allemann, S., Dunbar-Jacob, J., Hughes, D., Vrijens, B., & Wilson, I. (2020). TEOS: A framework for constructing operational definitions of medication adherence based on Timelines – Events – Objectives – Sources. doi:10.31234/osf.io/2ndmq
Seizure First Aid Training For people with Epilepsy (SAFE) frequently attending emergency departments and their significant others: results of a UK multi-centre randomised controlled pilot trial
Noble, A., Snape, D., Nevitt, S., Holmes, E. A. F., Morgan, M., Tudur Smith, C., . . . Marson, A. G. (2020). Seizure First Aid Training For people with Epilepsy (SAFE) frequently attending emergency departments and their significant others: results of a UK multi-centre randomised controlled pilot trial. BMJ Open, 10(4). doi:10.1136/bmjopen-2019-035516
Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT
Noble, A., Nevitt, S., Holmes, E., Ridsdale, L., Morgan, M., Tudur-Smith, C., . . . Snape, D. (2020). Seizure first aid training for people with epilepsy attending emergency departments and their significant others: the SAFE intervention and feasibility RCT.
The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE)
Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J. -D., . . . Wang-Steverding, X. (2020). The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE). HEALTHCARE, 8(2). doi:10.3390/healthcare8020088
Medication adherence-Key considerations for clinical pharmacologists
Hughes, D. A. (2020). Medication adherence-Key considerations for clinical pharmacologists. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 86(4), 628-629. doi:10.1111/bcp.14228
Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT
Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Moitt, T., . . . Gamble, C. (2020). Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT. HEALTH TECHNOLOGY ASSESSMENT, 24(17), 1-+. doi:10.3310/hta24170
The New and Non-Transparent Cancer Drugs Fund
Wood, E. M., & Hughes, D. A. (2020). The New and Non-Transparent Cancer Drugs Fund. PHARMACOECONOMICS, 38(1), 1-4. doi:10.1007/s40273-019-00871-9
2019
Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D Feasibility): a randomised feasibility trial protocol.
Farmer, A., Allen, J., Bartlett, K., Bower, P., Chi, Y., French, D., . . . SuMMiT-D Collaborative Group. (2019). Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D Feasibility): a randomised feasibility trial protocol.. BMJ open, 9(12), e033504. doi:10.1136/bmjopen-2019-033504
Value Assessment and Quantitative Benefit-Risk Modelling of Biosimilar Infliximab for Crohn's Disease
Catt, H., Bodger, K., Kirkham, J. J., & Hughes, D. A. (2019). Value Assessment and Quantitative Benefit-Risk Modelling of Biosimilar Infliximab for Crohn's Disease. PHARMACOECONOMICS, 37(12), 1509-1523. doi:10.1007/s40273-019-00826-0
Developing patient-centred, feasible alternative care for adult emergency department users with epilepsy: protocol for the mixed-methods observational 'Collaborate' project
Noble, A. J., Mathieson, A., Ridsdale, L., Holmes, E. A., Morgan, M., McKinlay, A., . . . Marson, A. G. (2019). Developing patient-centred, feasible alternative care for adult emergency department users with epilepsy: protocol for the mixed-methods observational 'Collaborate' project. BMJ OPEN, 9(11). doi:10.1136/bmjopen-2019-031696
Health Utilities and Costs for Motor Neurone Disease
Moore, A., Young, C. A., & Hughes, D. A. (2019). Health Utilities and Costs for Motor Neurone Disease. VALUE IN HEALTH, 22(11), 1257-1265. doi:10.1016/j.jval.2019.05.011
Statistical Methods for Adjusting Estimates of Treatment Effectiveness for Patient Nonadherence in the Context of Time-to-Event Outcomes and Health Technology Assessment: A Systematic Review of Methodological Papers
Alshreef, A., Latimer, N., Tappenden, P., Wong, R., Hughes, D., Fotheringham, J., & Dixon, S. (2019). Statistical Methods for Adjusting Estimates of Treatment Effectiveness for Patient Nonadherence in the Context of Time-to-Event Outcomes and Health Technology Assessment: A Systematic Review of Methodological Papers. MEDICAL DECISION MAKING, 39(8), 910-925. doi:10.1177/0272989X19881654
Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation
Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Dalton, J., . . . Gamble, C. (2019). Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation. Lancet, 394(10208), 1530-1539. doi:10.1016/S0140-6736(19)31603-4
Medicines Shortages in the United Kingdom
Hughes, D. A. (2019). Medicines Shortages in the United Kingdom. CLINICAL PHARMACOLOGY & THERAPEUTICS, 106(4), 712. doi:10.1002/cpt.1495
Challenges for Economic Evaluation of Health Care Strategies to Contain Antimicrobial Resistance
Holmes, E. A. F., & Hughes, D. A. (2019). Challenges for Economic Evaluation of Health Care Strategies to Contain Antimicrobial Resistance. ANTIBIOTICS-BASEL, 8(4). doi:10.3390/antibiotics8040166
A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System
McIntyre, K. M., Bolton, F. J., Christley, R. M., Cleary, P., Deja, E., Durie, A. E., . . . O'Brien, S. J. (2019). A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System. JMIR RESEARCH PROTOCOLS, 8(9). doi:10.2196/13941
Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials
Johnson, D., Hughes, D., Pirmohamed, M., & Jorgensen, A. (2019). Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials. JOURNAL OF PERSONALIZED MEDICINE, 9(3). doi:10.3390/jpm9030042
Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout
Hill-McManus, D., Marshall, S., Soto, E., & Hughes, D. A. (2019). Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout. CLINICAL PHARMACOLOGY & THERAPEUTICS, 106(3), 652-660. doi:10.1002/cpt.1454
Pharmacists must embrace pharmacogenetic services before other professions beat them to it
Pharmacists must embrace pharmacogenetic services before other professions beat them to it (2019). Pharmaceutical Journal. doi:10.1211/pj.2019.20206906
What really matters? A mixed methods study of treatment preferences and priorities among people with epilepsy in the UK
Ring, A., Jacoby, A., Baker, G., Holmes, E., Hughes, D., Kierans, C., & Marson, A. (2019). What really matters? A mixed methods study of treatment preferences and priorities among people with epilepsy in the UK. EPILEPSY & BEHAVIOR, 95, 181-191. doi:10.1016/j.yebeh.2019.03.033
Cost‐Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework
Plumpton, C. O., Pirmohamed, M., & Hughes, D. A. (2019). Cost‐Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework. Clinical pharmacology and therapeutics, 105(6), 1429-1438. doi:10.1002/cpt.1312
Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus
Crudgington, H., Rogers, M., Bray, L., Carter, B., Currier, J., Dunkley, C., . . . Morris, C. (2019). Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus. EPILEPSIA, 60(5), 857-871. doi:10.1111/epi.14735
Improving Medication Adherence Research Reporting European Society for Patient Adherence, Compliance and Persistence Medication Adherence Reporting Guideline
De Geest, S., Zullig, L. L., Dunbar-Jacob, J., Hughes, D., Wilson, I. B., & Vrijens, B. (2019). Improving Medication Adherence Research Reporting European Society for Patient Adherence, Compliance and Persistence Medication Adherence Reporting Guideline. JOURNAL OF CARDIOVASCULAR NURSING, 34(3), 199-200. doi:10.1097/JCN.0000000000000572
Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation
Blair, J. C., Mckay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . Investigators, S. C. I. P. I. (2019). Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation. BMJ: British Medical Journal, 365. doi:10.1136/bmj.l1226
Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation.
Blair, J. C., McKay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . SCIPI investigators. (2019). Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation.. BMJ (Clinical research ed.), 365, l1226. doi:10.1136/bmj.l1226
Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT
Ramanan, A. V., Dick, A. D., Jones, A. P., Hughes, D. A., McKay, A., Rosala-Halas, A., . . . Grp, S. Y. C. A. M. O. R. E. S. (2019). Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT. HEALTH TECHNOLOGY ASSESSMENT, 23(15), 1-139. doi:10.3310/hta23150
Improving medication adherence research reporting: ESPACOMP Medication Adherence Reporting Guideline (EMERGE)
De Geest, S., Zullig, L. L., Dunbar-Jacob, J., Hughes, D., Wilson, I. B., & Vrijens, B. (2019). Improving medication adherence research reporting: ESPACOMP Medication Adherence Reporting Guideline (EMERGE). EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING, 18(4), 258-259. doi:10.1177/1474515119830298
Systematic Review: Outcomes and Adverse Events From Randomised Trials in Crohn's Disease
Catt, H., Hughes, D., Kirkham, J., & Bodger, K. (2019). Systematic Review: Outcomes and Adverse Events From Randomised Trials in Crohn's Disease. Alimentary Pharmacology and Therapeutics, 49(8), 978-996. doi:10.1111/apt.15174
A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System (Preprint)
McIntyre, K. M., Bolton, F. J., Christley, R. M., Cleary, P., Deja, E., Durie, A. E., . . . O’Brien, S. J. (2019). A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System (Preprint). doi:10.2196/preprints.13941
Cost-Effectiveness Analysis of Adalimumab for the Treatment of Uveitis Associated with Juvenile Idiopathic Arthritis
Hughes, D. A., Culeddu, G., Plumpton, C. O., Wood, E., Dick, A. D., Jones, A. P., . . . Ramanan, A. V. (2019). Cost-Effectiveness Analysis of Adalimumab for the Treatment of Uveitis Associated with Juvenile Idiopathic Arthritis. Ophthalmology, 126(3), 415-424. doi:10.1016/j.ophtha.2018.09.043
Patient-Focused Drug Development Methods for Benefit-Risk Assessments: A Case Study Using a Discrete Choice Experiment for Antiepileptic Drugs
Holmes, E. A. F., Plumpton, C., Baker, G. A., Jacoby, A., Ring, A., Williamson, P., . . . Hughes, D. A. (2019). Patient-Focused Drug Development Methods for Benefit-Risk Assessments: A Case Study Using a Discrete Choice Experiment for Antiepileptic Drugs. CLINICAL PHARMACOLOGY & THERAPEUTICS, 105(3), 672-683. doi:10.1002/cpt.1231
Reply.
Hughes, D. A., Culeddu, G., Plumpton, C., Wood, E., Dick, A. D., Beresford, M. W., & Ramanan, A. V. (2019). Reply.. Ophthalmology, 126(3), e24-e25. doi:10.1016/j.ophtha.2018.12.005
CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial
Poolman, M., Roberts, J., Byrne, A., Perkins, P., Hoare, Z., Nelson, A., . . . Wilkinson, C. (2019). CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial. TRIALS, 20. doi:10.1186/s13063-019-3179-9
CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial
Poolman, M., Roberts, J., Byrne, A., Perkins, P., Hoare, Z., Nelson, A., . . . Wilkinson, C. (2019). CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial. doi:10.21203/rs.2.122/v2
Community views on factors affecting medicines resource allocation: cross-sectional survey of 3080 adults in Australia
Chim, L., Salkeld, G., Kelly, P. J., Lipworth, W., Hughes, D. A., & Stockler, M. R. (2019). Community views on factors affecting medicines resource allocation: cross-sectional survey of 3080 adults in Australia. AUSTRALIAN HEALTH REVIEW, 43(3), 254-260. doi:10.1071/AH16209
Re: Hughes et al.: Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with juvenile idiopathic arthritis REPLY
Hughes, D. A., Culeddu, G., Plumpton, C., Wood, E., Dick, A. D., Beresford, M. W., & Ramanan, A. V. (2019). Re: Hughes et al.: Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with juvenile idiopathic arthritis REPLY. OPHTHALMOLOGY, 126(3), E24-E25. doi:10.1016/j.ophtha.2018.12.005
2018
Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care
Holmes, E. A. F., Harris, S. D., Hughes, A., Craine, N., & Hughes, D. A. (2018). Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care. ANTIBIOTICS-BASEL, 7(4). doi:10.3390/antibiotics7040106
Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model
Hill-McManus, D., Marshall, S., Soto, E., Lane, S., & Hughes, D. (2018). Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model. VALUE IN HEALTH, 21(12), 1373-1381. doi:10.1016/j.jval.2018.06.002
Mapping ALSFRS-R and ALSUI to EQ-5D in Patients with Motor Neuron Disease
Moore, A., Young, C. A., & Hughes, D. A. (2018). Mapping ALSFRS-R and ALSUI to EQ-5D in Patients with Motor Neuron Disease. VALUE IN HEALTH, 21(11), 1322-1329. doi:10.1016/j.jval.2018.05.005
Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma
Jenkinson, M. D., Weber, D. C., Haylock, B. J., Sherratt, F. C., Young, B., Weller, M., . . . Gamble, C. (2018). Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma. JOURNAL OF NEUROSURGERY, 129(4), 1104-1105. doi:10.3171/2018.6.JNS181418
QUANTITATIVE BENEFIT-RISK MODELLING OF BIOSIMILARS: A CASE STUDY OF INFLIXIMAB IN CROHN'S DISEASE.
Catt, H., Bodger, K., Kirkham, J., & Hughes, D. A. (2018). QUANTITATIVE BENEFIT-RISK MODELLING OF BIOSIMILARS: A CASE STUDY OF INFLIXIMAB IN CROHN'S DISEASE.. In VALUE IN HEALTH Vol. 21 (pp. S380). doi:10.1016/j.jval.2018.09.2262
Nerve root block versus surgery (NERVES) for the treatment of radicular pain secondary to a prolapsed intervertebral disc herniation: study protocol for a multi-centre randomised controlled trial
Wilby, M. J., Hopkins, C., Bedson, E., Howlin, S., Burnside, G., Conroy, E. J., . . . Williamson, P. (2018). Nerve root block versus surgery (NERVES) for the treatment of radicular pain secondary to a prolapsed intervertebral disc herniation: study protocol for a multi-centre randomised controlled trial. TRIALS, 19. doi:10.1186/s13063-018-2677-5
Innovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care
Swift, B., Jain, L., White, C., Chandrasekaran, V., Bhandari, A., Hughes, D. A., & Jadhav, P. R. (2018). Innovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(5), 450-460. doi:10.1111/cts.12559
Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT
Blair, J., McKay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . Gamble, C. (2018). Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT. Health Technology Assessment, 22(42). doi:10.3310/hta22420
Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., . . . Wilkinson, C. (2018). Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC). TRIALS, 19. doi:10.1186/s13063-018-2801-6
ESPACOMP Medication Adherence Reporting Guideline (EMERGE)
De Geest, S., Zullig, L. L., Dunbar-Jacob, J., Helmy, R., Hughes, D. A., Wilson, I. B., & Vrijens, B. (2018). ESPACOMP Medication Adherence Reporting Guideline (EMERGE). ANNALS OF INTERNAL MEDICINE, 169(1), 30-+. doi:10.7326/M18-0543
Core Items for a Standardized Resource Use Measure: Expert Delphi Consensus Survey
Thorn, J. C., Brookes, S. T., Ridyard, C., Riley, R., Hughes, D. A., Wordsworth, S., . . . Hollingworth, W. (2018). Core Items for a Standardized Resource Use Measure: Expert Delphi Consensus Survey. VALUE IN HEALTH, 21(6), 640-649. doi:10.1016/j.jval.2017.06.011
Economics of Pharmacogenetic-Guided Treatments: Underwhelming or Overstated?
Hughes, D. A. (2018). Economics of Pharmacogenetic-Guided Treatments: Underwhelming or Overstated?. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103(5), 749-751. doi:10.1002/cpt.1030
New Medicines in Wales: The All Wales Medicines Strategy Group (AWMSG) Appraisal Process and Outcomes
Varnava, A., Bracchi, R., Samuels, K., Hughes, D. A., & Routledge, P. A. (2018). New Medicines in Wales: The All Wales Medicines Strategy Group (AWMSG) Appraisal Process and Outcomes. PHARMACOECONOMICS, 36(5), 613-624. doi:10.1007/s40273-018-0632-7
Societal Preferences for Funding Orphan Drugs in the United Kingdom: An Application of Person Trade-Off and Discrete Choice Experiment Methods
Bourke, S. M., Plumpton, C. O., & Hughes, D. A. (2018). Societal Preferences for Funding Orphan Drugs in the United Kingdom: An Application of Person Trade-Off and Discrete Choice Experiment Methods. VALUE IN HEALTH, 21(5), 538-546. doi:10.1016/j.jval.2017.12.026
Seizure First Aid Training for People with Epilepsy who Attend Emergency Departments and Their Family and Friends: Results from a Pilot Randomised Controlled Trial
Snape, D., Nevitt, S., Tudur-Smith, C., Goodacre, S., Hughes, D. A., Morgan, M., . . . Noble, A. J. (2018). Seizure First Aid Training for People with Epilepsy who Attend Emergency Departments and Their Family and Friends: Results from a Pilot Randomised Controlled Trial. In EPILEPSIA Vol. 59 (pp. S140). Retrieved from https://www.webofscience.com/
Rare disease prevention and treatment: the need for a level playing field
Hughes, D. A., & Plumpton, C. O. (2018). Rare disease prevention and treatment: the need for a level playing field. PHARMACOGENOMICS, 19(3), 243-247. doi:10.2217/pgs-2017-0300
Access to High-Cost Medicines in Wales
Varnava, A., Rind, S., Bracchi, R., Samuels, K., Routledge, P. A., & Hughes, D. A. (2018). Access to High-Cost Medicines in Wales. In Equitable Access to High-Cost Pharmaceuticals (pp. 199-213). Elsevier. doi:10.1016/b978-0-12-811945-7.00013-0
Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout
Hill-McManus, D., Soto, E., Marshall, S., Lane, S., & Hughes, D. (2018). Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 84(1), 142-152. doi:10.1111/bcp.13427
Impact of the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales
Alam, M. F., Cohen, D., Dunstan, F., Hughes, D., & Routledge, P. (2018). Impact of the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales. HEALTH ECONOMICS, 27(1), 236-243. doi:10.1002/hec.3530
2017
Economic Impact of Emergency Visits due to Drug-Related Morbidity on a Brazilian Hospital.
Freitas, G. R. M. D., Tramontina, M. Y., Balbinotto, G., Hughes, D. A., & Heineck, I. (2017). Economic Impact of Emergency Visits due to Drug-Related Morbidity on a Brazilian Hospital.. Value in health regional issues, 14, 1-8. doi:10.1016/j.vhri.2017.03.003
Core Health Outcomes In Childhood Epilepsy (CHOICE): protocol for the selection of a core outcome set
Morris, C., Dunkley, C., Gibbon, F. M., Currier, J., Roberts, D., Rogers, M., . . . Pal, D. K. (2017). Core Health Outcomes In Childhood Epilepsy (CHOICE): protocol for the selection of a core outcome set. TRIALS, 18. doi:10.1186/s13063-017-2323-7
COST-EFFECTIVENESS OF A MULTI -GENE PANEL IN THE CONTEXT OF REDUCING ADVERSE DRUG REACTIONS
Plumpton, C. O., Pirmohamed, M., & Hughes, D. A. (2017). COST-EFFECTIVENESS OF A MULTI -GENE PANEL IN THE CONTEXT OF REDUCING ADVERSE DRUG REACTIONS. In VALUE IN HEALTH Vol. 20 (pp. A753). doi:10.1016/j.jval.2017.08.2111
Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout
Plumpton, C. O., Alfirevic, A., Pirmohamed, M., & Hughes, D. A. (2017). Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. Rheumatology (Oxford, England), 56(10), 1729-1739. doi:10.1093/rheumatology/kex253
Renal transplant patients' preference for the supply and delivery of immunosuppressants in Wales: a discrete choice experiment
Hagemi, A., Plumpton, C., & Hughes, D. A. (2017). Renal transplant patients' preference for the supply and delivery of immunosuppressants in Wales: a discrete choice experiment. BMC NEPHROLOGY, 18. doi:10.1186/s12882-017-0720-5
CONTINUOUS SUBCUTANEOUS INFUSION VERSUS MULTIPLE DOSE INJECTION OF INSULIN FOR NEWLY-DIAGNOSED T1D PAEDIATRIC PATIENTS: A COST UTILITY ANALYSIS
Ridyard, C. H., Blair, J., & Hughes, D. A. (2017). CONTINUOUS SUBCUTANEOUS INFUSION VERSUS MULTIPLE DOSE INJECTION OF INSULIN FOR NEWLY-DIAGNOSED T1D PAEDIATRIC PATIENTS: A COST UTILITY ANALYSIS. In VALUE IN HEALTH Vol. 20 (pp. A582). doi:10.1016/j.jval.2017.08.1042
Cost-effectiveness of <i>HLA-B*15:02</i> screening in Malaysia
Plumpton, C., & Hughes, D. (2017). Cost-effectiveness of <i>HLA-B*15:02</i> screening in Malaysia. BRITISH JOURNAL OF DERMATOLOGY, 177(4), 904-905. doi:10.1111/bjd.15832
PATTERNS IN WORKING DAYS LOST BY PARENTS OF CHILDREN NEWLY DIAGNOSED WITH TYPE 1 DIABETES (T1D)
Ridyard, C. H., Blair, J., & Hughes, D. A. (2017). PATTERNS IN WORKING DAYS LOST BY PARENTS OF CHILDREN NEWLY DIAGNOSED WITH TYPE 1 DIABETES (T1D). In VALUE IN HEALTH Vol. 20 (pp. A590). doi:10.1016/j.jval.2017.08.1086
PUMP-DOWNLOADED INSULIN USAGE FOR THE FIRST 12 MONTHS IN A COHORT OF CHILDREN NEWLY-DIAGNOSED WITH TYPE 1 DIABETES (T1D)
Ridyard, C. H., Blair, J., & Hughes, D. A. (2017). PUMP-DOWNLOADED INSULIN USAGE FOR THE FIRST 12 MONTHS IN A COHORT OF CHILDREN NEWLY-DIAGNOSED WITH TYPE 1 DIABETES (T1D). In VALUE IN HEALTH Vol. 20 (pp. A481-A482). doi:10.1016/j.jval.2017.08.470
Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., . . . Wilkinson, C. (2017). Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica. HEALTH TECHNOLOGY ASSESSMENT, 21(60), 1-+. doi:10.3310/hta21600
USE OF THE IMS CORE DIABETES MODEL (CDM) IN A LONG-TERM PROJECTED HEALTH ECONOMIC COMPARISON OF CSII AND MDI TREATMENTS OF TYPE 1 DIABETES (T1D) IN A NEWLY-DIAGNOSED POPULATION OF PAEDIATRIC PATIENTS
Ridyard, C. H., Blair, J., & Hughes, D. A. (2017). USE OF THE IMS CORE DIABETES MODEL (CDM) IN A LONG-TERM PROJECTED HEALTH ECONOMIC COMPARISON OF CSII AND MDI TREATMENTS OF TYPE 1 DIABETES (T1D) IN A NEWLY-DIAGNOSED POPULATION OF PAEDIATRIC PATIENTS. In VALUE IN HEALTH Vol. 20 (pp. A580). doi:10.1016/j.jval.2017.08.1029
Cost-Effectiveness of Pediatric Central Venous Catheters in the UK: A Secondary Publication from the CATCH Clinical Trial
Ridyard, C. H., Plumpton, C. O., Gilbert, R. E., & Hughes, D. A. (2017). Cost-Effectiveness of Pediatric Central Venous Catheters in the UK: A Secondary Publication from the CATCH Clinical Trial. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00644
Using routinely recorded data in the UK to assess outcomes in a randomised controlled trial: The Trials of Access
Powell, G., Bonnett, L., Tudur-Smith, C., Hughes, D., Marson, A., & Williamson, P. (2017). Using routinely recorded data in the UK to assess outcomes in a randomised controlled trial: The Trials of Access. TRIALS, 18. Retrieved from http://gateway.webofknowledge.com/
P12.10 The ROAM / EORTC 1308 trial: Radiation versus observation following surgical resection of atypical meningioma - study update
Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Bulbeck, H., Farrell, M., . . . Weber, D. (2017). P12.10 The ROAM / EORTC 1308 trial: Radiation versus observation following surgical resection of atypical meningioma - study update. Neuro-oncology, 19(Suppl 3), iii97.
Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis
Ramanan, A. V., Dick, A. D., Jones, A. P., McKay, A., Williamson, P. R., Compeyrot-Lacassagne, S., . . . Grp, S. Y. C. A. M. O. R. E. S. (2017). Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis. New England Journal of Medicine, 376(17), 1637-1646. doi:10.1056/NEJMoa1614160
Do guidelines for treating chest disease in children use Cochrane Reviews effectively? A systematic review
Prayle, A. P., Cox, T., Smith, S. J., Rycroft-Malone, J., Thomas, K. S., Hughes, D. A., & Smyth, A. R. (2018). Do guidelines for treating chest disease in children use Cochrane Reviews effectively? A systematic review. THORAX, 73(7), 670-673. doi:10.1136/thoraxjnl-2016-208790
Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D.
Mulhern, B., Pink, J., Rowen, D., Borghs, S., Butt, T., Hughes, D., . . . Brazier, J. (2017). Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D.. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 20(4), 687-693. doi:10.1016/j.jval.2016.03.1860
Economic Studies in Motor Neurone Disease: A Systematic Methodological Review
Moore, A., Young, C. A., & Hughes, D. A. (2017). Economic Studies in Motor Neurone Disease: A Systematic Methodological Review. PHARMACOECONOMICS, 35(4), 397-413. doi:10.1007/s40273-016-0478-9
Societal perspective on access to publicly subsidised medicines: A cross sectional survey of 3080 adults in Australia
Chim, L., Salkeld, G., Kelly, P., Lipworth, W., Hughes, D. A., & Stockler, M. R. (2017). Societal perspective on access to publicly subsidised medicines: A cross sectional survey of 3080 adults in Australia. PLOS ONE, 12(3). doi:10.1371/journal.pone.0172971
ESPACOMP Medication Adherence Reporting Guidelines (EMERGE): a reactive-Delphi study protocol
Helmy, R., Zullig, L. L., Dunbar-Jacob, J., Hughes, D. A., Vrijens, B., Wilson, I. B., & De Geest, S. (2017). ESPACOMP Medication Adherence Reporting Guidelines (EMERGE): a reactive-Delphi study protocol. BMJ OPEN, 7(2). doi:10.1136/bmjopen-2016-013496
Affordable orphan drugs: a role for not-for-profit organizations
Davies, E. H., Fulton, E., Brook, D., & Hughes, D. A. (2017). Affordable orphan drugs: a role for not-for-profit organizations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 83(7), 1595-1601. doi:10.1111/bcp.13240
Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D
Mulhern, B., Pink, J., Rowen, D., Borghs, S., Butt, T., Hughes, D., . . . Brazier, J. (2017). Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D. VALUE IN HEALTH, 20(4), 687-693. doi:10.1016/j.jval.2016.03.1860
Patient preferences for outcomes in clinical trials: implications for medicines optimization
Holmes, E., Marson, A. G., & Hughes, D. A. (2017). Patient preferences for outcomes in clinical trials: implications for medicines optimization. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/
2016
A randomised, patient-assessor blinded, sham-controlled trial of external non-invasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial
Johnson, S., Goebel, A., Richey, R., Holmes, E., & Hughes, D. (2016). A randomised, patient-assessor blinded, sham-controlled trial of external non-invasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial. TRIALS, 17. doi:10.1186/s13063-016-1709-2
How pharmaceutical companies profit from drugs for rare diseases
Poletti-Hughes, J., & Hughes, D. (2016). How pharmaceutical companies profit from drugs for rare diseases.
How pharmaceutical companies profit from drugs for rare diseases. The Conversation
Poletti-Hughes, J., & Hughes, D. (2016). How pharmaceutical companies profit from drugs for rare diseases. The Conversation. Retrieved from https://theconversation.com/profiles/jannine-poletti-hughes-302844/articles
Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden
Verhoef, T. I., Redekop, W. K., Langenskiold, S., Kamali, F., Wadelius, M., Burnside, G., . . . Pirmohamed, M. (2016). Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden. PHARMACOGENOMICS JOURNAL, 16(5), 478-484. doi:10.1038/tpj.2016.41
Profitability and Market Value of Orphan Drug Companies: A Retrospective, Propensity-Matched Case-Control Study
Hughes, D. A., & Poletti-Hughes, J. (2016). Profitability and Market Value of Orphan Drug Companies: A Retrospective, Propensity-Matched Case-Control Study. PLOS ONE, 11(10). doi:10.1371/journal.pone.0164681
A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions
Plumpton, C. O., Roberts, D., Pirmohamed, M., & Hughes, D. A. (2016). A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions. PHARMACOECONOMICS, 34(8), 771-793. doi:10.1007/s40273-016-0397-9
A Systematic Review of Patients' Perspectives on the Subcutaneous Route of Medication Administration
Ridyard, C. H., Dawoud, D. M. M., Tuersley, L. V., & Hughes, D. A. (2016). A Systematic Review of Patients' Perspectives on the Subcutaneous Route of Medication Administration. PATIENT-PATIENT CENTERED OUTCOMES RESEARCH, 9(4), 281-292. doi:10.1007/s40271-015-0160-x
Prof. John Urquhart Obituary
Breckenridge, A., & Hughes, D. (2016). Prof. John Urquhart Obituary. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 82(2), 573. doi:10.1111/bcp.12974
Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches
Hughes, D., Charles, J., Dawoud, D., Edwards, R. T., Holmes, E., Jones, C., . . . Yeo, S. T. (2016). Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches. PHARMACOECONOMICS, 34(5), 447-461. doi:10.1007/s40273-015-0371-y
Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial
Gilbert, R. E., Mok, Q., Dwan, K., Harron, K., Moitt, T., Millar, M., . . . Investigators, C. A. T. C. H. T. (2016). Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial. The Lancet, 387(10029), 1732-1742. doi:10.1016/S0140-6736(16)00340-8
Opportunity costs and local health service spending decisions: a qualitative study from Wales
Schaffer, S. K., Sussex, J., Hughes, D., & Devlin, N. (2016). Opportunity costs and local health service spending decisions: a qualitative study from Wales. BMC HEALTH SERVICES RESEARCH, 16. doi:10.1186/s12913-016-1354-1
CATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children
Harron, K., Mok, Q., Dwan, K., Ridyard, C. H., Moitt, T., Millar, M., . . . Gilbert, R. E. (2016). CATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children. HEALTH TECHNOLOGY ASSESSMENT, 20(18), 1-+. doi:10.3310/hta20180
Generalisability and Cost-Impact of Antibiotic-Impregnated Central Venous Catheters for Reducing Risk of Bloodstream Infection in Paediatric Intensive Care Units in England
Harron, K., Mok, Q., Hughes, D., Muller-Pebody, B., Parslow, R., Ramnarayan, P., & Gilbert, R. (2016). Generalisability and Cost-Impact of Antibiotic-Impregnated Central Venous Catheters for Reducing Risk of Bloodstream Infection in Paediatric Intensive Care Units in England. PLOS ONE, 11(3). doi:10.1371/journal.pone.0151348
Multiple imputation of multiple multi-item scales when a full imputation model is infeasible.
Plumpton, C. O., Morris, T., Hughes, D. A., & White, I. R. (2016). Multiple imputation of multiple multi-item scales when a full imputation model is infeasible.. BMC research notes, 9, 45. doi:10.1186/s13104-016-1853-5
What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients
Holmes, E. A. F., Morrison, V. L., & Hughes, D. A. (2016). What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 82(2), 522-531. doi:10.1111/bcp.12971
2015
HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE
Nakamura, C. A., Roberts, P., Beadsworth, M., O'Brien, S., Pirmohamed, M., Hughes, D., & Miyajima, F. (2015). HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE. VALUE IN HEALTH, 18(7), A582. doi:10.1016/j.jval.2015.09.1947
The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial
Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Gillard, H., Vinten, J., . . . Weber, D. C. (2015). The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial. TRIALS, 16. doi:10.1186/s13063-015-1040-3
IDENTIFICATION OF ITEMS FORA STANDARDISED RESOURCE-USE MEASURE: REVIEW OF CURRENT INSTRUMENTS
Thorn, J. C., Ridyard, C. H., Riley, R., Brookes, S., Hughes, D., Wordsworth, S., . . . Hollingworth, W. (2015). IDENTIFICATION OF ITEMS FORA STANDARDISED RESOURCE-USE MEASURE: REVIEW OF CURRENT INSTRUMENTS. VALUE IN HEALTH, 18(7), A688. doi:10.1016/j.jval.2015.09.2549
Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery
Powell, G., Holmes, E. A. F., Plumpton, C. O., Ring, A., Baker, G. A., Jacoby, A., . . . Hughes, D. A. (2015). Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(5), 1149-1159. doi:10.1111/bcp.12715
Evaluation of a consultant audit and feedback programme to improve the quality of antimicrobial prescribing in acute medical admissions
Roberts, E., Dawoud, D. M., Hughes, D. A., & Cefai, C. (2015). Evaluation of a consultant audit and feedback programme to improve the quality of antimicrobial prescribing in acute medical admissions. INTERNATIONAL JOURNAL OF PHARMACY PRACTICE, 23(5), 333-339. doi:10.1111/ijpp.12173
Rare Disease Terminology and Definitions-A Systematic Global Review: Report of the ISPOR Rare Disease Special Interest Group
Richter, T., Nestler-Parr, S., Babela, R., Khan, Z. M., Tesoro, T., Molsen, E., & Hughes, D. A. (2015). Rare Disease Terminology and Definitions-A Systematic Global Review: Report of the ISPOR Rare Disease Special Interest Group. VALUE IN HEALTH, 18(6), 906-914. doi:10.1016/j.jval.2015.05.008
Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke
Kilarski, L. L., Rutten-Jacobs, L. C. A., Bevan, S., Baker, R., Hassan, A., Hughes, D. A., & Markus, H. S. (2015). Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke. PLOS ONE, 10(8). doi:10.1371/journal.pone.0136352
'Seizure First Aid Training' for people with epilepsy who attend emergency departments, and their family and friends: study protocol for intervention development and a pilot randomised controlled trial
Noble, A. J., Marson, A. G., Tudur-Smith, C., Morgan, M., Hughes, D. A., Goodacre, S., & Ridsdale, L. (2015). 'Seizure First Aid Training' for people with epilepsy who attend emergency departments, and their family and friends: study protocol for intervention development and a pilot randomised controlled trial. BMJ OPEN, 5(7). doi:10.1136/bmjopen-2015-009040
Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria
Loetsch, F., Auer-Hackenberg, L., Groger, M., Rehman, K., Morrison, V., Holmes, E., . . . Ramharter, M. (2015). Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria. WIENER KLINISCHE WOCHENSCHRIFT, 127(9-10), 379-384. doi:10.1007/s00508-015-0782-y
GOVERNMENT UNDERMINING OF NICE NICE recommendations: why no disinvestment recommendations to offset investment decisions?
Hughes, D. A., Wood, E. M., & Tuersley, L. (2015). GOVERNMENT UNDERMINING OF NICE NICE recommendations: why no disinvestment recommendations to offset investment decisions?. BMJ-BRITISH MEDICAL JOURNAL, 350. doi:10.1136/bmj.h2656
Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections
Blair, J., Gregory, J. W., Hughes, D., Ridyard, C. H., Gamble, C., Mckay, A., . . . Peak, M. (2015). Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections. TRIALS, 16. doi:10.1186/s13063-015-0658-5
Climate influences on the cost-effectiveness of vector-based interventions against malaria in elimination scenarios
Parham, P. E., & Hughes, D. A. (2015). Climate influences on the cost-effectiveness of vector-based interventions against malaria in elimination scenarios. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 370(1665). doi:10.1098/rstb.2013.0557
Cost‐effectiveness of screening for HLA ‐A *31:01 prior to initiation of carbamazepine in epilepsy
Plumpton, C. O., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost‐effectiveness of screening for HLA ‐A *31:01 prior to initiation of carbamazepine in epilepsy. EPILEPSIA, 56(04), 556-563. doi:10.1111/epi.12937
Economic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence
Plumpton, C. O., Brown, I., Reuber, M., Marson, A. G., & Hughes, D. A. (2015). Economic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence. EPILEPSY & BEHAVIOR, 45, 180-186. doi:10.1016/j.yebeh.2015.01.035
Predictors of Self-Reported Adherence to Antihypertensive Medicines: A Multinational, Cross-Sectional Survey
Morrison, V. L., Holmes, E. A. F., Parveen, S., Plumpton, C. O., Clyne, W., De Geest, S., . . . Hughes, D. A. (2015). Predictors of Self-Reported Adherence to Antihypertensive Medicines: A Multinational, Cross-Sectional Survey. VALUE IN HEALTH, 18(2), 206-216. doi:10.1016/j.jval.2014.12.013
TAXONOMY FOR METHODS OF RESOURCE USE MEASUREMENT
Ridyard, C. H., & Hughes, D. A. (2015). TAXONOMY FOR METHODS OF RESOURCE USE MEASUREMENT. HEALTH ECONOMICS, 24(3), 372-378. doi:10.1002/hec.3029
Identification of items for a standardised resource-use measure: review of current instruments
Thorn, J., Ridyard, C., Riley, R., Brookes, S., Hughes, D., Wordsworth, S., . . . Hollingworth, W. (2015). Identification of items for a standardised resource-use measure: review of current instruments. TRIALS, 16. doi:10.1186/1745-6215-16-S2-O26
The trials and tribulations of accessing data from routine sources
Powell, G., Marson, T., Hughes, D., Williamson, P., & Tudur-Smith, C. (2015). The trials and tribulations of accessing data from routine sources. In TRIALS Vol. 16. doi:10.1186/1745-6215-16-S2-P225
2014
Does Electronic Monitoring Influence Adherence to Medication? Randomized Controlled Trial of Measurement Reactivity
Sutton, S., Kinmonth, A. -L., Hardeman, W., Hughes, D., Boase, S., Prevost, A. T., . . . Farmer, A. (2014). Does Electronic Monitoring Influence Adherence to Medication? Randomized Controlled Trial of Measurement Reactivity. ANNALS OF BEHAVIORAL MEDICINE, 48(3), 293-299. doi:10.1007/s12160-014-9595-x
Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research
Holmes, E. A. F., Hughes, D. A., & Morrison, V. L. (2014). Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research. VALUE IN HEALTH, 17(8), 863-876. doi:10.1016/j.jval.2014.08.2671
OPPORTUNITY COSTS OF IMPLEMENTING NICE DECISIONS IN NHS WALES
Schaffer, K. S., Sussex, J., Hughes, D., & Devlin, N. (2014). OPPORTUNITY COSTS OF IMPLEMENTING NICE DECISIONS IN NHS WALES. VALUE IN HEALTH, 17(7), A422. doi:10.1016/j.jval.2014.08.1043
Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.
Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., . . . Williams, N. (2014). Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.. Health Technology Assessment, 18(48). doi:10.3310/hta18480
Cost-effectiveness of pharmacogenetic guided warfarin therapy versus alternative anticoagulation in atrial fibrillation
Pink, J., Pirmohamed, M., Lane, S., & Hughes, D. A. (2014). Cost-effectiveness of pharmacogenetic guided warfarin therapy versus alternative anticoagulation in atrial fibrillation. Clinical Pharmacology and Therapeutics, 95(2), 199-207. doi:10.1038/clpt.2013.190
A Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost-Effectiveness of Adalimumab in Combination with Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis
Ramanan, A. V., Dick, A. D., McKay, A., Jones, A., Williamson, P., Compeyrot-Lacassagne, S., . . . Beresford, M. W. (2015). A Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost-Effectiveness of Adalimumab in Combination with Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis. ARTHRITIS & RHEUMATOLOGY, 67. Retrieved from https://www.webofscience.com/
A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial)
Ramanan, A. V., Dick, A. D., Benton, D., Compeyrot-Lacassagne, S., Dawoud, D., Hardwick, B., . . . The SYCAMORE Trial Management Group. (2014). A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial). Trials, 15. doi:10.1186/1745-6215-15-14
The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol
Jenkinson, M. D., Gamble, C., Hartley, J. C., Hickey, H., Hughes, D., Blundell, M., . . . Mallucci, C. L. (2014). The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol. TRIALS, 15. doi:10.1186/1745-6215-15-4
Valuations of epilepsy-specific health states: a comparison of patients with epilepsy and the general population
Mulhern, B., Rowen, D., Snape, D., Jacoby, A., Marson, T., Hughes, D., . . . Brazier, J. (2014). Valuations of epilepsy-specific health states: a comparison of patients with epilepsy and the general population. EPILEPSY & BEHAVIOR, 36, 12-17. doi:10.1016/j.yebeh.2014.04.011
2013
ANTIEPILEPTIC DRUGS New advice on switching antiepileptic drugs might be a false economy
Holmes, E., Plumpton, C., Duerden, M., Marson, T., & Hughes, D. (2013). ANTIEPILEPTIC DRUGS New advice on switching antiepileptic drugs might be a false economy. BMJ-BRITISH MEDICAL JOURNAL, 347. doi:10.1136/bmj.f7471
Interventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group
Hiligsmann, M., Salas, M., Hughes, D. A., Manias, E., Gwadry-Sridhar, F. H., Linck, P., & Cowell, W. (2013). Interventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group. OSTEOPOROSIS INTERNATIONAL, 24(12), 2907-2918. doi:10.1007/s00198-013-2364-z
Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation
Pink, J., Pirmohamed, M., & Hughes, D. A. (2013). Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(2), 269-276. doi:10.1038/clpt.2013.83
SOCIETAL VIEWS ON NICE, CANCER DRUGS FUND AND VALUE-BASED PRICING CRITERIA FOR PRIORITISING MEDICINES: A CROSS-SECTIONAL SURVEY OF 4118 ADULTS IN GREAT BRITAIN
Linley, W. G., & Hughes, D. A. (2013). SOCIETAL VIEWS ON NICE, CANCER DRUGS FUND AND VALUE-BASED PRICING CRITERIA FOR PRIORITISING MEDICINES: A CROSS-SECTIONAL SURVEY OF 4118 ADULTS IN GREAT BRITAIN. HEALTH ECONOMICS, 22(8), 948-964. doi:10.1002/hec.2872
Resource-use measurement based on patient recall: issues and challenges for economic evaluation.
Thorn, J. C., Coast, J., Cohen, D., Hollingworth, W., Knapp, M., Noble, S. M., . . . Hughes, D. (2013). Resource-use measurement based on patient recall: issues and challenges for economic evaluation.. Applied health economics and health policy, 11(3), 155-161. doi:10.1007/s40258-013-0022-4
Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis
Demonceau, J., Ruppar, T., Kristanto, P., Hughes, D. A., Fargher, E., Kardas, P., . . . Vrijens, B. (2013). Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis. DRUGS, 73(6), 545-562. doi:10.1007/s40265-013-0041-3
Decision-Makers' Preferences for Approving New Medicines in Wales: A Discrete-Choice Experiment with Assessment of External Validity
Linley, W. G., & Hughes, D. A. (2013). Decision-Makers' Preferences for Approving New Medicines in Wales: A Discrete-Choice Experiment with Assessment of External Validity. PHARMACOECONOMICS, 31(4), 345-355. doi:10.1007/s40273-013-0030-0
Adherence and variability in warfarin dose requirements: assessment in a prospective cohort
Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199
Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group
Gwadry-Sridhar, F. H., Manias, E., Lal, L., Salas, M., Hughes, D. A., Ratzki-Leewing, A., & Grubisic, M. (2013). Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group. VALUE IN HEALTH, 16(5), 863-871. doi:10.1016/j.jval.2013.03.1631
Pharmacogenetic tests: the need for a level playing field
Pirmohamed, M., & Hughes, D. A. (2013). Pharmacogenetic tests: the need for a level playing field. NATURE REVIEWS DRUG DISCOVERY, 12(1), 3-4. doi:10.1038/nrd3921
Review of the use of resource use instruments based on patient recall in relation to other methods of resource use estimation
Ridyard, C., & Hughes, D. (2013). Review of the use of resource use instruments based on patient recall in relation to other methods of resource use estimation. Trials, 14(Suppl 1), O22. doi:10.1186/1745-6215-14-s1-o22
Using discrete choice experiments to define patient preferences for outcomes in trials
Fargher, E., Hughes, D., Ring, A., Jacoby, A., Rawnsley, M., & Marson, A. (2013). Using discrete choice experiments to define patient preferences for outcomes in trials. Trials, 14(Suppl 1), O33. doi:10.1186/1745-6215-14-s1-o33
2012
Challenges in the Development and Reimbursement of Personalized Medicine-Payer and Manufacturer Perspectives and Implications for Health Economics and Outcomes Research: A Report of the ISPOR Personalized Medicine Special Interest Group
Faulkner, E., Annemans, L., Garrison, L., Helfand, M., Holtorf, A. -P., Hornberger, J., . . . Watkins, J. (2012). Challenges in the Development and Reimbursement of Personalized Medicine-Payer and Manufacturer Perspectives and Implications for Health Economics and Outcomes Research: A Report of the ISPOR Personalized Medicine Special Interest Group. VALUE IN HEALTH, 15(8), 1162-1171. doi:10.1016/j.jval.2012.05.006
Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs
Verhoef, T. I., Redekop, W. K., van Schie, R. M. F., Bayat, S., Daly, A. K., Geitona, M., . . . Maitland-van der Zee, A. -H. (2012). Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs. PHARMACOGENOMICS, 13(12), 1405-1417. doi:10.2217/PGS.12.124
Reimbursement Decisions of the All Wales Medicines Strategy Group Influence of Policy and Clinical and Economic Factors
Linley, W. G., & Hughes, D. A. (2012). Reimbursement Decisions of the All Wales Medicines Strategy Group Influence of Policy and Clinical and Economic Factors. PHARMACOECONOMICS, 30(9), 779-794. doi:10.2165/11591530-000000000-00000
Making Co-Enrolment Feasible for Randomised Controlled Trials in Paediatric Intensive Care
Harron, K., Lee, T., Ball, T., Mok, Q., Gamble, C., Macrae, D., & Gilbert, R. (2012). Making Co-Enrolment Feasible for Randomised Controlled Trials in Paediatric Intensive Care. PLOS ONE, 7(8). doi:10.1371/journal.pone.0041791
Development of a Database of Instruments for Resource-Use Measurement: Purpose, Feasibility, and Design
Ridyard, C. H., & Hughes, D. A. (2012). Development of a Database of Instruments for Resource-Use Measurement: Purpose, Feasibility, and Design. VALUE IN HEALTH, 15(5), 650-655. doi:10.1016/j.jval.2012.03.004
Pharmacoeconomics
Hughes, D. A. (2012). Pharmacoeconomics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(6), 968-972. doi:10.1111/j.1365-2125.2012.04247.x
A Risk-Benefit Assessment of Prasugrel, Clopidogrel, and Genotype-Guided Therapy in Patients Undergoing Percutaneous Coronary Intervention
Guzauskas, G. F., Hughes, D. A., Bradley, S. M., & Veenstra, D. L. (2012). A Risk-Benefit Assessment of Prasugrel, Clopidogrel, and Genotype-Guided Therapy in Patients Undergoing Percutaneous Coronary Intervention. CLINICAL PHARMACOLOGY & THERAPEUTICS, 91(5), 829-837. doi:10.1038/clpt.2011.303
A new taxonomy for describing and defining adherence to medications
Vrijens, B., De Geest, S., Hughes, D. A., Przemyslaw, K., Demonceau, J., Ruppar, T., . . . Urquhart, J. (2012). A new taxonomy for describing and defining adherence to medications. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(5), 691-705. doi:10.1111/j.1365-2125.2012.04167.x
The development of a QALY measure for epilepsy: NEWQOL-6D
Mulhern, B., Rowen, D., Jacoby, A., Marson, T., Snape, D., Hughes, D., . . . Brazier, J. E. (2012). The development of a QALY measure for epilepsy: NEWQOL-6D. EPILEPSY & BEHAVIOR, 24(1), 36-43. doi:10.1016/j.yebeh.2012.02.025
Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma
Pink, J., Lane, S., & Hughes, D. A. (2012). Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma. PHARMACOECONOMICS, 30(5), 413-429. doi:10.2165/11591540-000000000-00000
An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes
Farmer, A., Hardeman, W., Hughes, D., Prevost, A. T., Kim, Y., Craven, A., . . . Kinmonth, A. -L. (2012). An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes. BMC FAMILY PRACTICE, 13. doi:10.1186/1471-2296-13-30
Defining rewardable innovation in drug therapy
Aronson, J. K., Ferner, R. E., & Hughes, D. A. (2012). Defining rewardable innovation in drug therapy. NATURE REVIEWS DRUG DISCOVERY, 11(4), 253-254. doi:10.1038/nrd3715
The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors
Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., . . . Pirmohamed, M. (2012). The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(1), 66-76. doi:10.1111/j.1365-2125.2011.04051.x
2011
DABIGATRAN V WARFARIN Authors' reply to Zermansky and Khatib
Hughes, D. A., Pink, J., Lane, S., & Pirmohamed, M. (2011). DABIGATRAN V WARFARIN Authors' reply to Zermansky and Khatib. BRITISH MEDICAL JOURNAL, 343. doi:10.1136/bmj.d7718
PHARMACEUTICAL INNOVATION: DEFINITION, AND MECHANISMS FOR REWARD
Hughes, D. (2011). PHARMACEUTICAL INNOVATION: DEFINITION, AND MECHANISMS FOR REWARD. In VALUE IN HEALTH Vol. 14 (pp. A363). doi:10.1016/j.jval.2011.08.713
Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses
Pink, J., Lane, S., Pirmohamed, M., & Hughes, D. A. (2011). Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses. BMJ-BRITISH MEDICAL JOURNAL, 343. doi:10.1136/bmj.d6333
Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units
Harron, K., Ramachandra, G., Mok, Q., & Gilbert, R. (2011). Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units. INTENSIVE CARE MEDICINE, 37(10), 1641-1647. doi:10.1007/s00134-011-2343-9
Ring-fencing a budget for cancer drugs: is it fair?
Graham, J., Cassidy, J., Hughes, D., & Duerden, M. (2011). Ring-fencing a budget for cancer drugs: is it fair?. The journal of the Royal College of Physicians of Edinburgh, 41(3), 224-228. doi:10.4997/jrcpe.2011.310
Value-Based Pricing Incentive for Innovation or Zero Net Benefit?
Hughes, D. A. (2011). Value-Based Pricing Incentive for Innovation or Zero Net Benefit?. PHARMACOECONOMICS, 29(9), 731-735. doi:10.2165/11592570-000000000-00000
Generic substitution: authors' response
Hughes, D. A., & Duerden, M. G. (2011). Generic substitution: authors' response. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 71(6), 968. doi:10.1111/j.1365-2125.2010.03878.x
MOST EFFECTIVE ADHERENCE-ENHANCING INTERVENTIONS FOR OSTEOPOROSIS MEDICATIONS
Hiligsmann, M., Salas, M., Hughes, D. A., Manias, E., Gwadry-Sridhar, F., Linck, P., & Cowell, W. (2011). MOST EFFECTIVE ADHERENCE-ENHANCING INTERVENTIONS FOR OSTEOPOROSIS MEDICATIONS. In VALUE IN HEALTH Vol. 14 (pp. A130). doi:10.1016/j.jval.2011.02.724
Erratum
Erratum (2011). International Journal of Pharmacy Practice, 19(1), 79. doi:10.1111/j.2042-7174.2011.00090.x
HTAs and rare diseases: How to assess their cost-effectiveness
Phillips, C. J., & Hughes, D. A. (2011). HTAs and rare diseases: How to assess their cost-effectiveness. Pharmaceuticals, Policy and Law, 13(3,4), 161-165. doi:10.3233/ppl-2011-0321
Interventions To Improve Patients Compliance with Lipid Lowering Medications: A Systematic Review of the Literature
Zuluaga, A., Salas, M., Gwadry-Sridhar, F. H., Manias, E., & Hughes, D. A. (2011). Interventions To Improve Patients Compliance with Lipid Lowering Medications: A Systematic Review of the Literature. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 20 (pp. S356). Retrieved from https://www.webofscience.com/
Letters: Involving colleagues can be challenging
Fargher, E., & Hughes, D. (2011). Letters: Involving colleagues can be challenging. Pharmaceutical Journal, 286(7647), 404.
MOST EFFECTIVE INTERVENTIONS TO IMPROVE PATIENT COMPLIANCE WITH OSTEOPOROSIS MEDICATIONS
Hiligsmann, M., Salas, M., Hughes, D., Manias, E., Gwadry-Sridhar, F., Linck, P., & Cowell, W. (2011). MOST EFFECTIVE INTERVENTIONS TO IMPROVE PATIENT COMPLIANCE WITH OSTEOPOROSIS MEDICATIONS. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. 335). Retrieved from https://www.webofscience.com/
PHARMACOECONOMIC ASPECTS OF RATIONAL MEDICINES USE
Hughes, D. (2011). PHARMACOECONOMIC ASPECTS OF RATIONAL MEDICINES USE. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 109 (pp. 49). Retrieved from https://www.webofscience.com/
Where is the evidence?
Hughes, D. A. (2011). Where is the evidence?. Pharmaceutical Journal, 286(7634-7635), 9.
2010
The problem of orphan drugs
Ferner, R. E., & Hughes, D. A. (2010). The problem of orphan drugs. BRITISH MEDICAL JOURNAL, 341. doi:10.1136/bmj.c6456
Abolition of prescription charges in Wales: the impact on medicines use in those who used to pay.
Groves, S., Cohen, D., Alam, M. F., Dunstan, F. D. J., Routledge, P. A., Hughes, D. A., & Myles, S. (2010). Abolition of prescription charges in Wales: the impact on medicines use in those who used to pay.. The International journal of pharmacy practice, 18(6), 332-340. doi:10.1111/j.2042-7174.2010.00063.x
ABOLITION OF PRESCRIPTION CO-PAYMENTS IN WALES: AN OBSERVATIONAL STUDY ON DISPENSING RATES
Cohen, D., Alam, F., Dunstan, F., Myles, S., Hughes, D., & Routledge, P. (2010). ABOLITION OF PRESCRIPTION CO-PAYMENTS IN WALES: AN OBSERVATIONAL STUDY ON DISPENSING RATES. In JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH Vol. 64 (pp. A25). doi:10.1136/jech.2010.120956.62
From NCE to NICE: the role of pharmacoeconomics
Hughes, D. A. (2010). From NCE to NICE: the role of pharmacoeconomics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(3), 317-319. doi:10.1111/j.1365-2125.2010.03708.x
Generic and therapeutic substitutions in the UK: are they a good thing?
Duerden, M. G., & Hughes, D. A. (2010). Generic and therapeutic substitutions in the UK: are they a good thing?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(3), 335-341. doi:10.1111/j.1365-2125.2010.03718.x
Is exercise effective in promoting mental well-being in older age? A systematic review
Windle, G., Hughes, D., Linck, P., Russell, I., & Woods, B. (2010). Is exercise effective in promoting mental well-being in older age? A systematic review. AGING & MENTAL HEALTH, 14(6), 652-669. doi:10.1080/13607861003713232
A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives
Verhoef, T. I., Redekop, W. K., Darba, J., Geitona, M., Hughes, D. A., Siebert, U., . . . Zee, A. -H. M. -V. D. (2010). A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives. PHARMACOGENOMICS, 11(7), 989-1002. doi:10.2217/PGS.10.74
A BENEFIT-RISK ASSESSMENT OF USING CYP2C19 GENOTYPE INFORMATION TO GUIDE ANTIPLATELET THERAPY IN PATIENTS WITH ACUTE CORONARY SYNDROME
Guzauskas, G. F., Veenstra, D., & Hughes, D. (2010). A BENEFIT-RISK ASSESSMENT OF USING CYP2C19 GENOTYPE INFORMATION TO GUIDE ANTIPLATELET THERAPY IN PATIENTS WITH ACUTE CORONARY SYNDROME. In VALUE IN HEALTH Vol. 13 (pp. A152-A153). doi:10.1016/S1098-3015(10)72741-8
INTERVENTIONS TO IMPROVE COMPLIANCE WITH LIPID LOWERING MEDICATIONS: A SYSTEMATIC REVIEW OF THE LITERATURE
Zuluaga, A., Salas, M., Gwadry-Sridhar, F., Manias, E., & Hughes, D. (2010). INTERVENTIONS TO IMPROVE COMPLIANCE WITH LIPID LOWERING MEDICATIONS: A SYSTEMATIC REVIEW OF THE LITERATURE. In VALUE IN HEALTH Vol. 13 (pp. A168). doi:10.1016/S1098-3015(10)72819-9
TRENDS IN THE PRESCRIBING OF CONVENTIONAL ANTIRHEUMATIC THERAPY AMONG CANADIANS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE COHORT STUDY
Gomez-Galicia, D. L., Kezouh, A., Salas, M., Gwadry-Sridhar, F., Manias, E., Reyes-Esparza, J. A., & Hughes, D. (2010). TRENDS IN THE PRESCRIBING OF CONVENTIONAL ANTIRHEUMATIC THERAPY AMONG CANADIANS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE COHORT STUDY. In VALUE IN HEALTH Vol. 13 (pp. A131). doi:10.1016/S1098-3015(10)72635-8
New drugs for old: Disinvestment and NICE
Hughes, D., & Ferner, R. (2010). New drugs for old: Disinvestment and NICE. BMJ (Online), 340(7748), 690-692.
Biosimilars: Evidential Standards for Health Technology Assessment
Hughes, D. A. (2010). Biosimilars: Evidential Standards for Health Technology Assessment. CLINICAL PHARMACOLOGY & THERAPEUTICS, 87(3), 257-261. doi:10.1038/clpt.2009.112
New drugs for old: disinvestment and NICE
Hughes, D. A., & Ferner, R. E. (2010). New drugs for old: disinvestment and NICE. BMJ-BRITISH MEDICAL JOURNAL, 340. doi:10.1136/bmj.c572
NICE and new: Appraising innovation
Ferner, R., Hughes, D. A., & Aronson, J. (2010). NICE and new: Appraising innovation. BMJ (Online), 340(7740), 245-247.
NICE and new: appraising innovation
Ferner, R. E., Hughes, D. A., & Aronson, J. K. (2010). NICE and new: appraising innovation. BMJ-BRITISH MEDICAL JOURNAL, 340. doi:10.1136/bmj.b5493
A Systematic Review and Empirical Analysis of the Relation Between Dose and Duration of Drug Action
Hughes, D. A., & Aronson, J. K. (2010). A Systematic Review and Empirical Analysis of the Relation Between Dose and Duration of Drug Action. JOURNAL OF CLINICAL PHARMACOLOGY, 50(1), 17-26. doi:10.1177/0091270008329555
Abolition of Prescription Copayments in Wales: An Observational Study on Dispensing Rates
Cohen, D., Alam, M. F., Dunstan, F. D. J., Myles, S., Hughes, D. A., & Routledge, P. A. (2010). Abolition of Prescription Copayments in Wales: An Observational Study on Dispensing Rates. VALUE IN HEALTH, 13(5), 675-680. doi:10.1111/j.1524-4733.2010.00717.x
Methods for the Collection of Resource Use Data within Clinical Trials: A Systematic Review of Studies Funded by the UK Health Technology Assessment Program
Ridyard, C. H., & Hughes, D. A. (2010). Methods for the Collection of Resource Use Data within Clinical Trials: A Systematic Review of Studies Funded by the UK Health Technology Assessment Program. VALUE IN HEALTH, 13(8), 867-872. doi:10.1111/j.1524-4733.2010.00788.x
2009
Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008)
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008). BMC PSYCHIATRY, 9. doi:10.1186/1471-244X-9-14
Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study
Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5
Estimating Drug Costs in Economic Evaluations in Ireland and the UK An Analysis of Practice and Research Recommendations
Hughes, D. A., Tilson, L., & Drummond, M. (2009). Estimating Drug Costs in Economic Evaluations in Ireland and the UK An Analysis of Practice and Research Recommendations. PHARMACOECONOMICS, 27(8), 635-643. doi:10.2165/10899570-000000000-00000
Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi
Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., . . . Lalloo, D. G. (2009). Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. MALARIA JOURNAL, 8. doi:10.1186/1475-2875-8-204
Cost and clinical consequence of antibiotic non-adherence in acute exacerbations of chronic bronchitis
Sorensen, S. V., Baker, T., Fleurence, R., Dixon, J., Roberts, C., Haider, S., & Hughes, D. (2009). Cost and clinical consequence of antibiotic non-adherence in acute exacerbations of chronic bronchitis. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 13(8), 945-954. Retrieved from https://www.webofscience.com/
Cost-effectiveness of biological therapy for Crohn's disease: Markov cohort analyses incorporating United Kingdom patient-level cost data
Bodger, K., Kikuchi, T., & Hughes, D. (2009). Cost-effectiveness of biological therapy for Crohn's disease: Markov cohort analyses incorporating United Kingdom patient-level cost data. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 30(3), 265-274. doi:10.1111/j.1365-2036.2009.04033.x
Follow-up of cancer in primary care versus secondary care: systematic review
Lewis, R. A., Neal, R. D., Williams, N. H., France, B., Hendry, M., Russell, D., . . . Wilkinson, C. (2009). Follow-up of cancer in primary care versus secondary care: systematic review. BRITISH JOURNAL OF GENERAL PRACTICE, 59(564), 525-532. doi:10.3399/bjgp09X453567
Patients' and healthcare professionals' views of cancer follow-up: systematic review
Lewis, R. A., Neal, R. D., Hendry, M., France, B., Williams, N. H., Russell, D., . . . Wilkinson, C. (2009). Patients' and healthcare professionals' views of cancer follow-up: systematic review. BRITISH JOURNAL OF GENERAL PRACTICE, 59(564), 533-540. doi:10.3399/bjgp09X453576
ABOLITION OF PRESCRIPTION CO-PAYMENTS: AN ANALYSIS OF ITEMS DISPENSED IN WALES
Hughes, D. A., Alam, F. M., Cohen, D., Dunstan, F., Groves, S., & Routledge, P. A. (2009). ABOLITION OF PRESCRIPTION CO-PAYMENTS: AN ANALYSIS OF ITEMS DISPENSED IN WALES. In VALUE IN HEALTH Vol. 12 (pp. A80). doi:10.1016/S1098-3015(10)73460-4
ECONOMIC EVALUATION OF INFLIXIMAB AND ADALIMUMAB FOR CROHN'S DISEASE
Hughes, D. A., Kikuchi, T., & Bodger, K. (2009). ECONOMIC EVALUATION OF INFLIXIMAB AND ADALIMUMAB FOR CROHN'S DISEASE. In VALUE IN HEALTH Vol. 12 (pp. A59). doi:10.1016/S1098-3015(10)73358-1
ESTIMATING DRUG COSTS IN ECONOMIC EVALUATIONS IN IRELAND AND THE UK: AN ANALYSIS OF PRACTICE AND RESEARCH RECOMMENDATIONS
Hughes, D. A., Tilson, L., & Drummond, M. F. (2009). ESTIMATING DRUG COSTS IN ECONOMIC EVALUATIONS IN IRELAND AND THE UK: AN ANALYSIS OF PRACTICE AND RESEARCH RECOMMENDATIONS. In VALUE IN HEALTH Vol. 12 (pp. A6-A7). doi:10.1016/S1098-3015(10)73093-X
IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS
Hughes, D. A., Al-Zubiedi, S., Hanson, A., Jorgensen, A., & Pirmohamed, M. (2009). IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS. VALUE IN HEALTH, 12(3), A3-A4. doi:10.1016/S1098-3015(10)73081-3
Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC Psychiatry, 9(1). doi:10.1186/1471-244x-9-14
Nurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review
Lewis, R., Neal, R. D., Williams, N. H., France, B., Wilkinson, C., Hendry, M., . . . Weller, D. (2009). Nurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review. JOURNAL OF ADVANCED NURSING, 65(4), 706-723. doi:10.1111/j.1365-2648.2008.04927.x
A Framework for Planning and Critiquing Medication Compliance and Persistence Research Using Prospective Study Designs
Gwadry-Sridhar, F. H., Manias, E., Zhang, Y., Roy, A., Yu-Isenberg, K., Hughes, D. A., & Nichol, M. B. (2009). A Framework for Planning and Critiquing Medication Compliance and Persistence Research Using Prospective Study Designs. CLINICAL THERAPEUTICS, 31(2), 421-435. doi:10.1016/j.clinthera.2009.02.021
A SYSTEMATIC REVIEW AND EMPIRICAL ANALYSIS OF THE RELATION BETWEEN DOSE AND DURATION OF DRUG ACTION
Hughes, D. A., & Aronson, J. K. (2009). A SYSTEMATIC REVIEW AND EMPIRICAL ANALYSIS OF THE RELATION BETWEEN DOSE AND DURATION OF DRUG ACTION. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 32). Retrieved from https://www.webofscience.com/
Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC psychiatry, 9, 14.
Costs of Medication Nonadherence in Patients with Diabetes Mellitus: A Systematic Review and Critical Analysis of the Literature
Salas, M., Hughes, D., Zuluaga, A., Vardeva, K., & Lebmeier, M. (2009). Costs of Medication Nonadherence in Patients with Diabetes Mellitus: A Systematic Review and Critical Analysis of the Literature. VALUE IN HEALTH, 12(6), 915-922. doi:10.1111/j.1524-4733.2009.00539.x
IMPACT OF THE ABOLITION OF THE PRESCRIPTION CHARGE IN WALES
Hughes, D., Alam, F., Cohen, D., Dunstan, F., Groves, S., & Routledge, P. (2009). IMPACT OF THE ABOLITION OF THE PRESCRIPTION CHARGE IN WALES. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 94). Retrieved from https://www.webofscience.com/
Pharmacoeconomics: principles and relevance to the activities of drug and therapeutics committees
Hughes, D., & Reynolds, D. J. M. (2009). Pharmacoeconomics: principles and relevance to the activities of drug and therapeutics committees. CLINICAL MEDICINE, 9(5), 490-492. doi:10.7861/clinmedicine.9-5-490
2008
NHS and charitable funding for children and young people with cancer in England and Wales
Linck, P., Tunnage, B., Hughes, D. A., & Edwards, R. T. (2008). NHS and charitable funding for children and young people with cancer in England and Wales. JOURNAL OF CHILD HEALTH CARE, 12(2), 156-168. doi:10.1177/1367493508090173
METHODOLOGICAL ISSUES IN THE LITERATURE ON COSTS OF NON-COMPLIANCE IN CHRONIC DISEASES
Salas, M., Zuluaga, A., Hughes, D., Cowell, W., Lebmeier, M., Vardeva, K., . . . Shinogle, J. (2008). METHODOLOGICAL ISSUES IN THE LITERATURE ON COSTS OF NON-COMPLIANCE IN CHRONIC DISEASES. In VALUE IN HEALTH Vol. 11 (pp. A571-A572). doi:10.1016/S1098-3015(10)66879-9
Medicines concordance and game theory
Hughes, D. (2008). Medicines concordance and game theory. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 66(4), 577. doi:10.1111/j.1365-2125.2008.03260.x
Costs of chiral switching
Hughes, D. A. (2008). Costs of chiral switching. Pharmaceutical Journal, 281(7516), 213.
Estimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens
Hughes, D. A. (2008). Estimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 65(6), 871-878. doi:10.1111/j.1365-2125.2008.03124.x
Costs of non-compliance with antipsychotic medications among patients with schizophrenia
Salas, M., Zuluaga, A., Hughes, D., Lebmeier, M., Vardeva, K., Pisu, M., & Shinogle, J. (2008). Costs of non-compliance with antipsychotic medications among patients with schizophrenia. In VALUE IN HEALTH Vol. 11 (pp. A125). doi:10.1016/S1098-3015(10)70399-5
Effects of the abolition of prescription charges in Wales: A preliminary analysis
Cohen, D., Alam, M. F., Hughes, D., Dunstan, F., & Routledge, P. (2008). Effects of the abolition of prescription charges in Wales: A preliminary analysis. International Journal of Pharmacy Practice, 16(SUPPL. 1).
A global survey of antibiotic leftovers in the outpatient setting (vol 30, pg 530, 2007)
Kardas, P., Pechere, J. -C., Hughes, D. A., & Cornaglia, G. (2008). A global survey of antibiotic leftovers in the outpatient setting (vol 30, pg 530, 2007). INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 31(2), 188. doi:10.1016/j.ijantimicag.2007.11.002
A SYSTEMATIC REVIEW OF THE EFFECTIVENESS OF PUBLIC HEALTH INTERVENTIONS AIMED AT PROMOTING MENTAL WELL-BEING IN OLDER PEOPLE
Windle, G., Russell, I., Linck, P., Woods, R., & Hughes, D. (2008). A SYSTEMATIC REVIEW OF THE EFFECTIVENESS OF PUBLIC HEALTH INTERVENTIONS AIMED AT PROMOTING MENTAL WELL-BEING IN OLDER PEOPLE. In GERONTOLOGIST Vol. 48 (pp. 740). Retrieved from https://www.webofscience.com/
Statistical comments are unfounded
Hughes, D., Cowell, W., Koncz, T., & Cramer, J. (2008). Statistical comments are unfounded. VALUE IN HEALTH, 11(2), 346. doi:10.1111/j.1524-4733.2008.00317.x
The cost-effectiveness of biological therapies for Crohn's disease: Markov cohort analyses incorporating UK patient-level cost data
Bodger, K., Kikuchi, T., & Hughes, D. A. (2008). The cost-effectiveness of biological therapies for Crohn's disease: Markov cohort analyses incorporating UK patient-level cost data. In GASTROENTEROLOGY Vol. 134 (pp. A139-A140). Retrieved from https://www.webofscience.com/
The cost-effectiveness of biological therapies for crohn's disease: markov cohort analyses incorporating uk patient-level cost data
Bodger, K., Kikuchi, T., & Hughes, D. A. (2008). The cost-effectiveness of biological therapies for crohn's disease: markov cohort analyses incorporating uk patient-level cost data. GUT, 57, A48. Retrieved from https://www.webofscience.com/
The pharmacokinetic profile of warfarin: a systematic review
Al-Zubiedi, S., Hughes, D., & Pirmohamed, M. (2008). The pharmacokinetic profile of warfarin: a systematic review. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1002-1003). Retrieved from https://www.webofscience.com/
Understanding medication compliance and persistence from an economics perspective
Elliott, R. A., Shinogle, J. A., Peele, P., Bhosle, M., & Hughes, D. A. (2008). Understanding medication compliance and persistence from an economics perspective. VALUE IN HEALTH, 11(4), 600-610. doi:10.1111/j.1524-4733.2007.00304.x
2007
Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial
Roberts, S. H., Bedson, E., Hughes, D., Lloyd, K., Moat, S., Pirmohamed, M., . . . Russell, I. (2007). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC PSYCHIATRY, 7. doi:10.1186/1471-244X-7-65
Literature review on the costs of non-compliance in osteoporosis
Cowell, W., Palmer, K., & Hughes, D. (2007). Literature review on the costs of non-compliance in osteoporosis. In VALUE IN HEALTH Vol. 10 (pp. A394-A395). doi:10.1016/S1098-3015(10)65383-1
Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire
Hughes, D. A. (2007). Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire. QUALITY OF LIFE RESEARCH, 16(8), 1419-1423. doi:10.1007/s11136-007-9238-9
Current assessment of risk-benefit by regulators: Is it time to introduce decision analyses?
Hughes, D. A., Bayoumi, A. M., & Pirmohamed, M. (2007). Current assessment of risk-benefit by regulators: Is it time to introduce decision analyses?. CLINICAL PHARMACOLOGY & THERAPEUTICS, 82(2), 123-127. doi:10.1038/sj.clpt.6100240
Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?
Hughes, D. A., Bayoumi, A. M., & Pirmohamed, M. (2007). Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?. Clinical pharmacology and therapeutics, 82(2), 123-127. doi:10.1038/sj.clpt.6100240
When drugs don't work - Economic assessment of enhancing compliance with interventions supported by electronic monitoring devices
Hughes, D. (2007). When drugs don't work - Economic assessment of enhancing compliance with interventions supported by electronic monitoring devices. PHARMACOECONOMICS, 25(8), 621-635. doi:10.2165/00019053-200725080-00001
Adverse drug reactions in economic evaluations
Hughes, D. (2007). Adverse drug reactions in economic evaluations. In VALUE IN HEALTH Vol. 10 (pp. A109-A110). doi:10.1016/S1098-3015(10)68871-7
Assessing the association between compliance and therapeutic failure for antiretroviral drugs in hiv positive patients
Hughes, D. (2007). Assessing the association between compliance and therapeutic failure for antiretroviral drugs in hiv positive patients. In VALUE IN HEALTH Vol. 10 (pp. A171). doi:10.1016/S1098-3015(10)69058-4
Biological agents for the management of Crohn's disease in adults: A systematic review, meta-analysis and multiple treatment comparison
Hughes, D., Kikuchi, T., & Bodger, K. (2007). Biological agents for the management of Crohn's disease in adults: A systematic review, meta-analysis and multiple treatment comparison. In VALUE IN HEALTH Vol. 10 (pp. A147). doi:10.1016/S1098-3015(10)68985-1
Factors influencing user choices to visit either general practitioners or community pharmacists for minor ailments - A discrete choice experiment
Hughes, D., Myles, S., Longo, M., Lisles, C., & Hood, K. (2007). Factors influencing user choices to visit either general practitioners or community pharmacists for minor ailments - A discrete choice experiment. In VALUE IN HEALTH Vol. 10 (pp. A23). doi:10.1016/S1098-3015(10)68601-9
Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire
Hughes, D. (2007). Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire. In VALUE IN HEALTH Vol. 10 (pp. A189-A190). doi:10.1016/S1098-3015(10)69119-X
Parenting programme for parents of children at risk of developing conduct disorder:: cost effectiveness analysis
Edwards, R. T., Ceilleachair, A., Bywater, T., Hughes, D. A., & Hutchings, J. (2007). Parenting programme for parents of children at risk of developing conduct disorder:: cost effectiveness analysis. BRITISH MEDICAL JOURNAL, 334(7595), 682-685. doi:10.1136/bmj.39126.699421.55
Non-compliance with antibiotic therapy for acute community infections:: a global survey
Pechere, J. -C., Hughes, D., Kardas, P., & Cornaglia, G. (2007). Non-compliance with antibiotic therapy for acute community infections:: a global survey. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 29(3), 245-253. doi:10.1016/j.ijantimicag.2006.09.026
A global survey of antibiotic leftovers in the outpatient setting
Kardas, P., Pechere, J. -C., Hughes, D. A., & Cornaglia, G. (2007). A global survey of antibiotic leftovers in the outpatient setting. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 30(6), 530-536. doi:10.1016/j.ijantimicag.2007.08.005
Costs of non-compliance and non-persistence with medications for diabetes mellitus
Salas, M., Vardeva, K., Lebmeier, M., & Hughes, D. (2007). Costs of non-compliance and non-persistence with medications for diabetes mellitus. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 16 (pp. S140). Retrieved from https://www.webofscience.com/
Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations
Hughes, D., Cowell, W., Koncz, T., & Cramer, J. (2007). Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations. VALUE IN HEALTH, 10(6), 498-509. doi:10.1111/j.1524-4733.2007.00205.x
The effect of compliance upon clinical effectiveness of chlorproguanil-dapsone (CD) and artemether-lumefantrine (AL) when compared to sulfadoxine-pyrimethamine (SP) for the treatment of uncomplicated falciparum malaria in Malawi - A randomised controlled trial
Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., . . . Lalloo, D. G. (2007). The effect of compliance upon clinical effectiveness of chlorproguanil-dapsone (CD) and artemether-lumefantrine (AL) when compared to sulfadoxine-pyrimethamine (SP) for the treatment of uncomplicated falciparum malaria in Malawi - A randomised controlled trial. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 77 (pp. 287). Retrieved from https://www.webofscience.com/
Warfarin pharmacogenetics: Economic considerations
Hughes, D. A., & Pirmohamed, M. (2007). Warfarin pharmacogenetics: Economic considerations. PHARMACOECONOMICS, 25(11), 899-902. doi:10.2165/00019053-200725110-00001
2006
Comments on NICE do not reflect expertise available within the profession [12]
Hughes, D. A., Elliott, R., & Payne, K. (2006). Comments on NICE do not reflect expertise available within the profession [12]. Pharmaceutical Journal, 277(7423), 484.
Rationing of drugs for rare diseases
Hughes, D. (2006). Rationing of drugs for rare diseases. PHARMACOECONOMICS, 24(4), 315-316. doi:10.2165/00019053-200624040-00001
Less is more: Medicines that require less frequent administration improve adherence, but are they better?
Hughes, D. (2006). Less is more: Medicines that require less frequent administration improve adherence, but are they better?. PHARMACOECONOMICS, 24(3), 211-213. doi:10.2165/00019053-200624030-00001
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone
Simpson, J. A., Hughes, D., Manyando, C., Bojang, K., Aarons, L., Winstanley, P., . . . Ward, S. (2006). Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 61(3), 289-300. doi:10.1111/j.1365-2125.2005.02567.x
Beyond registration - measuring the public-health potential of new treatments for malaria in Africa
Lang, T., Hughes, D., Kanyok, T., Kengeya-Kayondo, J., Marsh, V., Haaland, A., . . . Winstanley, P. (2006). Beyond registration - measuring the public-health potential of new treatments for malaria in Africa. LANCET INFECTIOUS DISEASES, 6(1), 46-52. doi:10.1016/S1473-3099(05)70326-1
Orphan drugs revisited: author's response
Hughes, D. (2006). Orphan drugs revisited: author's response. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 99(5), 350-351. doi:10.1093/qjmed/hcl046
2005
Economic analysis of on-demand maintenance therapy with proton pump inhibitors in patients with non-erosive reflux disease
Hughes, D. A., Bodger, K., Bytzer, P., de Herdt, D., & Dubois, D. (2005). Economic analysis of on-demand maintenance therapy with proton pump inhibitors in patients with non-erosive reflux disease. PHARMACOECONOMICS, 23(10), 1031-1041. doi:10.2165/00019053-200523100-00006
Drugs for exceptionally rare diseases: do they deserve special status for funding?
Hughes, D. A., Tunnage, B., & Yeo, S. T. (2005). Drugs for exceptionally rare diseases: do they deserve special status for funding?. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 98(11), 829-836. doi:10.1093/qjmed/hci128
Public funding of drugs for orphan diseases
Hughes, D. (2005). Public funding of drugs for orphan diseases. In VALUE IN HEALTH Vol. 8 (pp. A192-A193). doi:10.1016/S1098-3015(10)67739-X
Trends and influences on use of antidiabetic drugs in England, 1992-2003
Walley, T., Hughes, D., & Kendall, H. (2005). Trends and influences on use of antidiabetic drugs in England, 1992-2003. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 14(11), 769-773. doi:10.1002/pds.1089
Cisplatin plus vinorelbine or gemcitabine in patients with advanced non-small cell lung cancer: Pharmacoeconomic considerations
Hughes, D. A. (2005). Cisplatin plus vinorelbine or gemcitabine in patients with advanced non-small cell lung cancer: Pharmacoeconomic considerations. EUROPEAN JOURNAL OF CANCER, 41(11), 1655. doi:10.1016/j.ejca.2005.02.033
Cost minimization of on-demand maintenance therapy with proton pump inhibitors in nonerosive gastroesophageal reflux disease.
Hughes, D. A., Marchetti, M., & Colombo, G. (2005). Cost minimization of on-demand maintenance therapy with proton pump inhibitors in nonerosive gastroesophageal reflux disease.. Expert review of pharmacoeconomics & outcomes research, 5(1), 29-38. doi:10.1586/14737167.5.1.29
Trends in and influences on use of antidiabetic drugs in primary care in the United Kingdom, 1992-2003
Walley, T., Hughes, D., & Kendall, H. (2005). Trends in and influences on use of antidiabetic drugs in primary care in the United Kingdom, 1992-2003. In EUROPEAN JOURNAL OF PUBLIC HEALTH Vol. 15 (pp. 95). Retrieved from https://www.webofscience.com/
2004
Cost-effectiveness analysis of extended-release formulations of oxybutynin and tolterodine for the management of urge incontinence
Hughes, D. A., & Dubois, D. (2004). Cost-effectiveness analysis of extended-release formulations of oxybutynin and tolterodine for the management of urge incontinence. PHARMACOECONOMICS, 22(16), 1047-1059. doi:10.2165/00019053-200422160-00002
Economic evaluation of on-demand maintenance therapy with proton pump inhibitors in patients with symptomatic gastroesophageal reflux disease - A Monte-Carlo analysis for Italy
Hughes, D. A., Marchetti, M., & Colombo, G. L. (2004). Economic evaluation of on-demand maintenance therapy with proton pump inhibitors in patients with symptomatic gastroesophageal reflux disease - A Monte-Carlo analysis for Italy. In VALUE IN HEALTH Vol. 7 (pp. 753-754). doi:10.1016/S1098-3015(10)66004-4
HLA-B*5701 and abacavir hypersensitivity
Watson, M. E., Pimenta, J. M., Spreen, W. R., & Hernandez, J. E. (2004). HLA-B*5701 and abacavir hypersensitivity. PHARMACOGENETICS, 14(11), 783-784. doi:10.1097/00008571-200411000-00011
HLA-B*5701 and abacavir hypersensitivity - Reply
Hughes, D., Park, B. K., & Pirmohamed, M. (2004). HLA-B*5701 and abacavir hypersensitivity - Reply. PHARMACOGENETICS, 14(11), 784. doi:10.1097/00008571-200411000-00012
The difference between effectiveness and efficacy of antimalarial drugs in Kenya
Amin, A. A., Hughes, D. A., Marsh, V., Abuya, T. O., Kokwaro, G. O., Winstanley, P. A., . . . Snow, R. W. (2004). The difference between effectiveness and efficacy of antimalarial drugs in Kenya. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 9(9), 967-974. doi:10.1111/j.1365-3156.2004.01291.x
Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance
Atuah, K. N., Hughes, D., & Pirmohamed, M. (2004). Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance. DRUG SAFETY, 27(8), 535-554. doi:10.2165/00002018-200427080-00006
Cost-effectiveness analysis of HLA <i>B</i>*<i>5701</i> genotyping in preventing abacavir hypersensitivity
Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA <i>B</i>*<i>5701</i> genotyping in preventing abacavir hypersensitivity. PHARMACOGENETICS, 14(6), 335-342. doi:10.1097/00008571-200406000-00002
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.
Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.. Pharmacogenetics, 14(6), 335-342. doi:10.1097/00008571-200406000-00002
Reply
Hughes, D., Park, B. K., & Pirmohamed, M. (2004). Reply. Pharmacogenetics, 14(11), 784. doi:10.1097/00008571-200411000-00012
2003
Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective?
Hughes, D. A., & Pirmohamed, M. (2003). Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective?. In VALUE IN HEALTH Vol. 6 (pp. 749). doi:10.1016/S1098-3015(10)61908-0
Cost-utility analysis of "on demand" rabeprazole and esomeprazole for symptomatic gastro oesophageal reflux disease
Hughes, D. A., & Dubois, D. (2003). Cost-utility analysis of "on demand" rabeprazole and esomeprazole for symptomatic gastro oesophageal reflux disease. In VALUE IN HEALTH Vol. 6 (pp. 613). doi:10.1016/S1098-3015(10)61575-6
Predicting "real world" effectiveness by integrating adherence with pharmacodynamic modeling
Hughes, D. A., & Walley, T. (2003). Predicting "real world" effectiveness by integrating adherence with pharmacodynamic modeling. CLINICAL PHARMACOLOGY & THERAPEUTICS, 74(1), 1-8. doi:10.1016/S0009-9236(03)00091-2
2002
Economic impact of poor compliance with pharmaceuticals.
Hughes, D. A. (2002). Economic impact of poor compliance with pharmaceuticals.. Expert review of pharmacoeconomics & outcomes research, 2(4), 327-335. doi:10.1586/14737167.2.4.327
2001
The impact of non-compliance on the cost-effectiveness of pharmaceuticals: A review of the literature
Hughes, D. A., Bagust, A., Haycox, A., & Walley, T. (2001). The impact of non-compliance on the cost-effectiveness of pharmaceuticals: A review of the literature. HEALTH ECONOMICS, 10(7), 601-615. doi:10.1002/hec.609
Accounting for noncompliance in pharmacoeconomic evaluations
Hughes, D. A., Bagust, A., Haycox, A., & Walley, T. (2001). Accounting for noncompliance in pharmacoeconomic evaluations. PHARMACOECONOMICS, 19(12), 1185-1197. doi:10.2165/00019053-200119120-00001
Economic evaluations during early (phase II) drug development - A role for clinical trial simulations?
Hughes, D. A., & Walley, T. (2001). Economic evaluations during early (phase II) drug development - A role for clinical trial simulations?. PHARMACOECONOMICS, 19(11), 1069-1077. doi:10.2165/00019053-200119110-00001
2000
Patient compliance with drug therapy for diabetic nephropathy
Hughes, D., & Manns, B. (2000). Patient compliance with drug therapy for diabetic nephropathy. CANADIAN MEDICAL ASSOCIATION JOURNAL, 162(11), 1553. Retrieved from https://www.webofscience.com/
Patient compliance with drug therapy for diabetic nephropathy.
Hughes, D., & Manns, B. (2000). Patient compliance with drug therapy for diabetic nephropathy.. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 162(11), 1553-1554.
1999
Review of therapeutically equivalent alternatives to short acting β<sub>2</sub> adrenoceptor agonists delivered via chlorofluorocarbon-containing inhalers
Hughes, D. A., Woodcock, A., & Walley, T. (1999). Review of therapeutically equivalent alternatives to short acting β<sub>2</sub> adrenoceptor agonists delivered via chlorofluorocarbon-containing inhalers. THORAX, 54(12), 1087-1092. doi:10.1136/thx.54.12.1087
1998
Mechanisms contributing to the interaction of diazepam with the cascade of events following β-adrenoceptor stimulation in isolated atria
Hughes, D. A., & Coker, S. J. (1998). Mechanisms contributing to the interaction of diazepam with the cascade of events following β-adrenoceptor stimulation in isolated atria. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 124 (pp. U15). Retrieved from https://www.webofscience.com/
Mefloquine potentiates halofantrine-induced QTc prolongation by altering the distribution of halofantrine
Coker, S. J., Lightbown, I. D., Hughes, D. A., Lambert, J. P., & Edwards, G. (1998). Mefloquine potentiates halofantrine-induced QTc prolongation by altering the distribution of halofantrine. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 123 (pp. U63). Retrieved from https://www.webofscience.com/
1997
A microdialysis study of the effects of fluoxetine infusion on noradrenaline (NA) efflux in the frontal cortex of saline or DSP-4-treated rats
Hughes, Z. A., & Stanford, S. C. (1997). A microdialysis study of the effects of fluoxetine infusion on noradrenaline (NA) efflux in the frontal cortex of saline or DSP-4-treated rats. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 122 (pp. U28). Retrieved from https://www.webofscience.com/
Attenuation of the negative inotropic effects of chloroquine by combined administration of diazepam and adrenaline in anaesthetized rats
Hughes, D. A., & Coker, S. J. (1997). Attenuation of the negative inotropic effects of chloroquine by combined administration of diazepam and adrenaline in anaesthetized rats. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 120 (pp. P24). Retrieved from https://www.webofscience.com/
1996
Effects of diazepam on chloroquine intoxicated, anaesthetized rats
Hughes, D. A., & Coker, S. J. (1996). Effects of diazepam on chloroquine intoxicated, anaesthetized rats. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 119 (pp. P152). Retrieved from https://www.webofscience.com/