Publications
2024
Myoferlin: A Potential Marker of Response to Radiation Therapy and Survival in Locally Advanced Rectal Cancer.
Fowler, H., Clifford, R. E., Bowden, D., Sutton, P. A., Govindarajah, N., Fok, M., . . . Vimalachandran, D. (2024). Myoferlin: A Potential Marker of Response to Radiation Therapy and Survival in Locally Advanced Rectal Cancer.. International journal of radiation oncology, biology, physics, S0360-3016(24)00696-5. doi:10.1016/j.ijrobp.2024.05.030
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence.
Fabbrizi, M. R., Nickson, C. M., Hughes, J. R., Robinson, E. A., Vaidya, K., Rubbi, C. P., . . . Parsons, J. L. (2024). Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence.. Cell death & disease, 15(2), 150. doi:10.1038/s41419-024-06541-9
2021
Metabolic Plasticity and Combinatorial Radiosensitisation Strategies in Human Papillomavirus-Positive Squamous Cell Carcinoma of the Head and Neck Cell Lines
Wilkie, M. D., Anaam, E. A., Lau, A. S., Rubbi, C. P., Vlatkovic, N., Jones, T. M., & Boyd, M. T. (2021). Metabolic Plasticity and Combinatorial Radiosensitisation Strategies in Human Papillomavirus-Positive Squamous Cell Carcinoma of the Head and Neck Cell Lines. CANCERS, 13(19). doi:10.3390/cancers13194836
2020
TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies
Wilkie, M. D., Anaam, E. A., Lau, A. S., Rubbi, C. P., Jones, T. M., Boyd, M. T., & Vlatković, N. (2020). TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies. Cancer Letters, 478, 107-121. doi:10.1016/j.canlet.2020.02.032
2017
Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity
Nickson, C. M., Moori, P., Carter, R. J., Rubbi, C. P., & Parsons, J. L. (2017). Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity. Oncotarget, 8(18), 29963-29975. doi:10.18632/oncotarget.16265
2015
Actinomycin D Sensitizes Chemotherapy Resistant Suit-2 Pancreatic Cancer Cell Lines to Gemcitabine
Mann, K., Rogoyski, B., Ghaneh, P., Rubbi, C., & Greenhalf, W. (2015). Actinomycin D Sensitizes Chemotherapy Resistant Suit-2 Pancreatic Cancer Cell Lines to Gemcitabine. Pancreas, 44(8), 1395-1396. Retrieved from https://journals.lww.com/
CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p
Farahani, M., Rubbi, C., Liu, L., Slupsky, J. R., & Kalakonda, N. (2015). CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p. PLOS ONE, 10(10). doi:10.1371/journal.pone.0141429
2014
Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism
Polanski, R., Noon, A. P., Blaydes, J., Phillips, A., Rubbi, C. P., Parsons, K., . . . Boyd, M. T. (2014). Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism. Cancer Letters, 353(2), 211-219. doi:10.1016/j.canlet.2014.07.024
Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy
Vlatkovic, N., Boyd, M. T., & Rubbi, C. P. (2014). Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy. CELLULAR AND MOLECULAR LIFE SCIENCES, 71(5), 771-791. doi:10.1007/s00018-013-1361-x
CLL DERIVED EXOSOMES ENCAPSULATE SPECIFIC MICRORNAS AND INFLUENCE STROMAL CELL BEHAVIOUR
Farahani, M., Angelillo, P., Kelly, M., Liu, L., Rubbi, C., & Kalakonda, N. (2014). CLL DERIVED EXOSOMES ENCAPSULATE SPECIFIC MICRORNAS AND INFLUENCE STROMAL CELL BEHAVIOUR. In HAEMATOLOGICA Vol. 99 (pp. 40-41). Retrieved from https://www.webofscience.com/
2013
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Targeted Drug Delivery Vehicles in Pancreatic Cancer Cell Lines
Sykes, P., Hasan, E., Lydon, D., Rubbi, C., Neoptolemos, J., Sutton, R., . . . Halloran, C. (2013). Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Targeted Drug Delivery Vehicles in Pancreatic Cancer Cell Lines. In PANCREAS Vol. 42 (pp. 1384). Retrieved from https://www.webofscience.com/
2011
The nucleolus directly regulates p53 export and degradation
Boyd, M. T., Vlatkovic, N., & Rubbi, C. P. (2011). The nucleolus directly regulates p53 export and degradation. JOURNAL OF CELL BIOLOGY, 194(5), 689-703. doi:10.1083/jcb.201105143
MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility
Polanski, R., Maguire, M., Nield, P. C., Jenkins, R. E., Park, B. K., Krawczynska, K., . . . Boyd, M. T. (2011). MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility. CARCINOGENESIS, 32(8), 1133-1142. doi:10.1093/carcin/bgr070
Loss of MTBP Expression Is Associated With Reduced Survival in a Biomarker-Defined Subset of Patients With Squamous Cell Carcinoma of the Head and Neck
Vlatkovic, N., El-Fert, A., Devling, T., Ray-Sinha, A., Gore, D. M., Rubbi, C. P., . . . Boyd, M. T. (2011). Loss of MTBP Expression Is Associated With Reduced Survival in a Biomarker-Defined Subset of Patients With Squamous Cell Carcinoma of the Head and Neck. CANCER, 117(13), 2939-2950. doi:10.1002/cncr.25864
Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.
Vlatkovic, N., El-Fert, A., Devling, T., Ray-Sinha, A., Gore, D., Rubbi, C., . . . Boyd, M. (2011). Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.. Cancer, 117(13), 2939-2950.
Tissue-Specific Therapeutic Targeting of p53 in Cancer: One Size Does Not Fit All
Vlatkovic, N., Crawford, K., Rubbi, C. P., & Boyd, M. T. (2011). Tissue-Specific Therapeutic Targeting of p53 in Cancer: One Size Does Not Fit All. CURRENT PHARMACEUTICAL DESIGN, 17(6), 618-630. doi:10.2174/138161211795222568
Tissue-specific therapeutic targeting of p53 in cancer: one size does not fit all
Vlatkovic, N., Crawford, K., Rubbi, C. P., & Boyd, M. T. (2011). Tissue-specific therapeutic targeting of p53 in cancer: one size does not fit all. Curr Pharm Des, 17(6), 618-630.
2010
MDM2 promotes cell motility and invasiveness through a RING-finger independent mechanism
Polanski, R., Warburton, H. E., Ray-Sinha, A., Devling, T., Pakula, H., Rubbi, C. P., . . . Boyd, M. T. (2010). MDM2 promotes cell motility and invasiveness through a RING-finger independent mechanism. FEBS LETTERS, 584(22), 4695-4702. doi:10.1016/j.febslet.2010.10.049
Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53
Arya, A. K., El-Fert, A., Devling, T., Eccles, R. M., Aslam, M. A., Rubbi, C. P., . . . Boyd, M. T. (2010). Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53. BRITISH JOURNAL OF CANCER, 103(2), 186-195. doi:10.1038/sj.bjc.6605739
2005
P53: Gatekeeper, Caretaker or Both?
Rubbi, C. P., & Milner, J. (2007). P53: Gatekeeper, Caretaker or Both?. In 25 Years of p53 Research (pp. 233-253). Springer Netherlands. doi:10.1007/978-1-4020-2922-6_11
p53: Gatekeeper, Caretaker Or Both?
Rubbi, C. P., & Milner, J. (2005). p53: Gatekeeper, Caretaker Or Both?. In P. Hainaut, & K. Wiman (Eds.), 25 years of p53 research (pp. 2-237). Dordrecht: Kluwer Academic Publishers.
2004
Gel-based application of siRNA to human epithelial cancer cells induces RNAi-dependent apoptosis.
Jiang, M., Rubbi, C. P., & Milner, J. (2004). Gel-based application of siRNA to human epithelial cancer cells induces RNAi-dependent apoptosis.. Oligonucleotides, 14(4), 239-248. doi:10.1089/oli.2004.14.239
2003
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses.
Rubbi, C. P., & Milner, J. (2003). Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses.. The EMBO journal, 22(22), 6068-6077. doi:10.1093/emboj/cdg579
UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML.
Seker, H., Rubbi, C., Linke, S. P., Bowman, E. D., Garfield, S., Hansen, L., . . . Harris, C. C. (2003). UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML.. Oncogene, 22(11), 1620-1628. doi:10.1038/sj.onc.1206140
p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage.
Rubbi, C. P., & Milner, J. (2003). p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage.. The EMBO journal, 22(4), 975-986. doi:10.1093/emboj/cdg082
p53--guardian of a genome's guardian?
Rubbi, C. P., & Milner, J. (2003). p53--guardian of a genome's guardian?. Cell cycle (Georgetown, Tex.), 2(1), 20-21. doi:10.4161/cc.2.1.297
2002
The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage
Okorokov, A. L., Rubbi, C. P., Metcalfe, S., & Milner, J. (2002). The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage. Oncogene, 21(3), 356-367. doi:10.1038/sj.onc.1205112
The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.
Okorokov, A. L., Rubbi, C. P., Metcalfe, S., & Milner, J. (2002). The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.. Oncogene, 21(3), 356-367. doi:10.1038/sj.onc.1205112
2001
p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.
Jiang, M., Axe, T., Holgate, R., Rubbi, C. P., Okorokov, A. L., Mee, T., & Milner, J. (2001). p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.. Oncogene, 20(39), 5449-5458. doi:10.1038/sj.onc.1204705
Analysis of nucleotide excision repair by detection of single-stranded DNA transients.
Rubbi, C. P., & Milner, J. (2001). Analysis of nucleotide excision repair by detection of single-stranded DNA transients.. Carcinogenesis, 22(11), 1789-1796. doi:10.1093/carcin/22.11.1789
2000
Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus.
Rubbi, C. P., & Milner, J. (2000). Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus.. Oncogene, 19(1), 85-96. doi:10.1038/sj.onc.1203378
1996
A simple immunomagnetic bead-based technique for the detection of surface molecules capable of inducing T cell functional polarisation.
Rubbi, C. P., & Rickwood, D. (1996). A simple immunomagnetic bead-based technique for the detection of surface molecules capable of inducing T cell functional polarisation.. Journal of immunological methods, 192(1-2), 157-164. doi:10.1016/0022-1759(96)00046-4
1995
Separation of T and B lymphocytes from human peripheral blood mononuclear cells using density perturbation methods.
Patel, D., Rubbi, C. P., & Rickwood, D. (1995). Separation of T and B lymphocytes from human peripheral blood mononuclear cells using density perturbation methods.. Clinica chimica acta; international journal of clinical chemistry, 240(2), 187-193. doi:10.1016/0009-8981(95)06141-9
1994
An investigation into the use of protein cross-linking agents as cell fixatives for confocal microscopy.
Rubbi, C. P., Qiu, J., & Rickwood, D. (1994). An investigation into the use of protein cross-linking agents as cell fixatives for confocal microscopy.. European journal of histochemistry : EJH, 38(4), 269-280.
Removal of LPS from a Brucella cytoplasmic fraction by affinity chromatography with an anti-LPS monoclonal antibody as immunosorbent.
Goldbaum, F. A., Rubbi, C. P., & Fossati, C. A. (1994). Removal of LPS from a Brucella cytoplasmic fraction by affinity chromatography with an anti-LPS monoclonal antibody as immunosorbent.. Journal of medical microbiology, 40(3), 174-178. doi:10.1099/00222615-40-3-174
Light Microscopy - Essential data
Rubbi, C. P. (1994). Light Microscopy - Essential data. Chichester: John Wiley & Sons.
1993
Evidence of surface antigen detachment during incubation of cells with immunomagnetic beads.
Rubbi, C. P., Patel, D., & Rickwood, D. (1993). Evidence of surface antigen detachment during incubation of cells with immunomagnetic beads.. Journal of immunological methods, 166(2), 233-241. doi:10.1016/0022-1759(93)90364-d
Use of density perturbation to isolate immunologically distinct populations of cells.
Patel, D., Rubbi, C. P., & Rickwood, D. (1993). Use of density perturbation to isolate immunologically distinct populations of cells.. Journal of immunological methods, 163(2), 241-251. doi:10.1016/0022-1759(93)90128-t
1992
Differentiation between active and inactive human brucellosis by measuring anti-protein humoral immune responses
Goldbaum, F. A., Rubbi, C. P., Wallach, J. C., Miguel, S. E., Baldi, P. C., & Fossati, C. A. (1992). Differentiation between active and inactive human brucellosis by measuring anti-protein humoral immune responses. J. Clin. Microbiol., 30(3), 604-607.