Photo of Dr Marie Phelan

Dr Marie Phelan

Shared Research Facility Manager, NMR Centre HLS Technology Directorate

Publications

2019

Metabolomic analysis of synovial fluid from Thoroughbred racehorses diagnosed with palmar osteochondral disease using magnetic resonance imaging. (Journal article)

Graham, R. J. T. Y., Anderson, J. R., Phelan, M. M., Cillan-Garcia, E., Bladon, B. M., & Taylor, S. E. (2019). Metabolomic analysis of synovial fluid from Thoroughbred racehorses diagnosed with palmar osteochondral disease using magnetic resonance imaging.. Equine veterinary journal. doi:10.1111/evj.13199

DOI: 10.1111/evj.13199

2018

A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling (Journal article)

Chokesuwattanaskul, S., Phelan, M., Edwards, S., & Wright, H. L. (2018). A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling. PLoS One.

H-1 NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints (Journal article)

Anderson, J. R., Chokesuwattanaskul, S., Phelan, M. M., Welting, T. J. M., Lian, L. -Y., Peffers, M. J., & Wright, H. L. (2018). H-1 NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints. JOURNAL OF PROTEOME RESEARCH, 17(11), 3780-3790. doi:10.1021/acs.jproteome.8b00455

DOI: 10.1021/acs.jproteome.8b00455

Effects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model (Journal article)

Al-Mutawa, Y. K., Herrmann, A., Corbishley, C., Losty, P. D., Phelan, M., & See, V. (2018). Effects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model. BIOSCIENCE REPORTS, 38. doi:10.1042/BSR20180185

DOI: 10.1042/BSR20180185

Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies (Journal article)

Anderson, J. R., Phelan, M. M., Clegg, P. D., Peffers, M. J., & Rubio-Martinez, L. M. (2018). Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies. JOURNAL OF PROTEOME RESEARCH, 17(8), 2735-2743. doi:10.1021/acs.jproteome.8b00190

DOI: 10.1021/acs.jproteome.8b00190

alpha-Methyl-alpha-phenylsuccinimide ameliorates neurodegeneration in a C-elegans model of TDP-43 proteinopathy (Journal article)

Wong, S. Q., Pontifex, M. G., Phelan, M. M., Pidathala, C., Kraemer, B. C., Barclay, J. W., . . . Morgan, A. (2018). alpha-Methyl-alpha-phenylsuccinimide ameliorates neurodegeneration in a C-elegans model of TDP-43 proteinopathy. NEUROBIOLOGY OF DISEASE, 118, 40-54. doi:10.1016/j.nbd.2018.06.013

DOI: 10.1016/j.nbd.2018.06.013

Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures (Conference Paper)

Mone, F., Phelan, M., Alfirevic, A., & McAuliffe, F. M. (2018). Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 66). Retrieved from http://gateway.webofknowledge.com/

SYNOVIAL FLUID METABOLITE PROFILES DIFFER BETWEEN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS (Conference Paper)

Anderson, J. R., Chokesuwattanaskul, S., Phelan, M. P., Welting, T. J. M., Lian, L. -Y., Peffers, M. J., & Wright, H. L. (2018). SYNOVIAL FLUID METABOLITE PROFILES DIFFER BETWEEN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 57. Retrieved from http://gateway.webofknowledge.com/

THE EFFECT OF JAK INHIBITION ON NEUTROPHIL KILLING, NETOSIS AND METABOLISM IN RHEUMATOID ARTHRITIS (Conference Paper)

Chokesuwattanaskul, S., Mangalakumaran, S., Chapman, E., Cross, A., Phelan, M. M., Lian, L. -Y., . . . Wright, H. L. (2018). THE EFFECT OF JAK INHIBITION ON NEUTROPHIL KILLING, NETOSIS AND METABOLISM IN RHEUMATOID ARTHRITIS. In RHEUMATOLOGY Vol. 57. Retrieved from http://gateway.webofknowledge.com/

2017

THE INFLUENCE OF RITUXIMAB ON THE METABOLOME OF JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS (JSLE) PATIENTS (Conference Paper)

Glaser, A., Wright, H. L., Midgley, A., Phelan, M. M., Peak, M., & Beresford, M. W. (2017). THE INFLUENCE OF RITUXIMAB ON THE METABOLOME OF JUVENILE-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS (JSLE) PATIENTS. In RHEUMATOLOGY Vol. 56. Retrieved from http://gateway.webofknowledge.com/

Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein (Journal article)

Phelan, M. M., Caamano-Gutierrez, E., Gant, M. S., Grosman, R. X., & Madine, J. (2017). Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein. METABOLOMICS, 13(12). doi:10.1007/s11306-017-1289-5

DOI: 10.1007/s11306-017-1289-5

METABOLIC ANALYSIS OF RHEUMATOID ARTHRITIS NEUTROPHILS: A NEW WAY TO MEASURE ACTIVATION OF CELLS IN DISEASE (Conference Paper)

Chokesuwattanaskul, S., Phelan, M. M., Moots, R. J., Edwards, S. W., & Wright, H. L. (2017). METABOLIC ANALYSIS OF RHEUMATOID ARTHRITIS NEUTROPHILS: A NEW WAY TO MEASURE ACTIVATION OF CELLS IN DISEASE. In RHEUMATOLOGY Vol. 56 (pp. 146-147). Retrieved from http://gateway.webofknowledge.com/

Probing Medin Monomer Structure and its Amyloid Nucleation Using C-13-Direct Detection NMR in Combination with Structural Bioinformatics (Journal article)

Davies, H. A., Rigden, D. J., Phelan, M. M., & Madine, J. (2017). Probing Medin Monomer Structure and its Amyloid Nucleation Using C-13-Direct Detection NMR in Combination with Structural Bioinformatics. SCIENTIFIC REPORTS, 7. doi:10.1038/srep45224

DOI: 10.1038/srep45224

A novel MKRN3 nonsense mutation causing familial central precocious puberty. (Journal article)

Christoforidis, A., Skordis, N., Fanis, P., Dimitriadou, M., Sevastidou, M., Phelan, M. M., . . . Phylactou, L. A. (2017). A novel MKRN3 nonsense mutation causing familial central precocious puberty.. Endocrine, 56(2), 446-449. doi:10.1007/s12020-017-1232-6

DOI: 10.1007/s12020-017-1232-6

2016

SCREENING FOR MC4R MUTATIONS IN CYPRIOT CHILDREN WITH SEVERE EARLY ONSET OBESITY AND TALL STATURE IDENTIFIED A NOVEL MC4R DELETION (Conference Paper)

Neocleous, V., Shammas, C., Phelan, M. M., Fanis, P., Pantelidou, M., Stylianou, C., . . . Toumba, M. (2016). SCREENING FOR MC4R MUTATIONS IN CYPRIOT CHILDREN WITH SEVERE EARLY ONSET OBESITY AND TALL STATURE IDENTIFIED A NOVEL MC4R DELETION. In ACTA PAEDIATRICA Vol. 106 (pp. 25). Retrieved from http://gateway.webofknowledge.com/

A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity. (Journal article)

Neocleous, V., Shammas, C., Phelan, M. M., Fanis, P., Pantelidou, M., Skordis, N., . . . Toumba, M. (2016). A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.. Hormones (Athens, Greece), 15(3), 445-452. doi:10.14310/horm.2002.1686

DOI: 10.14310/horm.2002.1686

Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation. (Journal article)

Shammas, C., Byrou, S., Phelan, M. M., Toumba, M., Stylianou, C., Skordis, N., . . . Phylactou, L. A. (2016). Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.. Hormones (Athens, Greece), 15(2), 235-242. doi:10.14310/horm.2002.1651

DOI: 10.14310/horm.2002.1651

NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes (Journal article)

Margaret Phelan, M., & Lian, L. -Y. (2016). NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes. Current Metabolomics, 4(1), 78-81. doi:10.2174/2213235x03666151006220726

DOI: 10.2174/2213235x03666151006220726

Microform Holoprosencephaly with Bilateral Congenital Elbow Dislocation; Increasing the Phenotypic Spectrum of Steinfeld Syndrome (Journal article)

Jones, G. E., Robertson, L., Maniyar, A., Shammas, C., Phelan, M. M., Vasudevan, P. C., & Tanteles, G. A. (2016). Microform Holoprosencephaly with Bilateral Congenital Elbow Dislocation; Increasing the Phenotypic Spectrum of Steinfeld Syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 170(3), 754-759. doi:10.1002/ajmg.a.37511

DOI: 10.1002/ajmg.a.37511

In silico analysis of a novel MKRN3 missense mutation in familial central precocious puberty. (Journal article)

Neocleous, V., Shammas, C., Phelan, M. M., Nicolaou, S., Phylactou, L. A., & Skordis, N. (2016). In silico analysis of a novel MKRN3 missense mutation in familial central precocious puberty.. Clinical endocrinology, 84(1), 80-84. doi:10.1111/cen.12854

DOI: 10.1111/cen.12854

2015

H-1, N-15 and C-13 assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques (Journal article)

Davies, H. A., Phelan, M. M., & Madine, J. (2016). H-1, N-15 and C-13 assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques. BIOMOLECULAR NMR ASSIGNMENTS, 10(1), 75-77. doi:10.1007/s12104-015-9641-z

DOI: 10.1007/s12104-015-9641-z

Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid (Journal article)

Davies, H. A., Phelan, M. M., Wilkinson, M. C., Migrino, R. Q., Truran, S., Franco, D. A., . . . Madine, J. (2015). Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid. BIOPHYSICAL JOURNAL, 109(11), 2363-2370. doi:10.1016/j.bpj.2015.10.034

DOI: 10.1016/j.bpj.2015.10.034

2014

The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin (Journal article)

Phelan, M., McLean, L., Armstrong, S. D., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin. PLOS ONE. doi:10.1371/journal.pone.0108415

DOI: 10.1371/journal.pone.0108415

NMR elucidation of the role of Mg2+ in the structure and stability of the conserved RNA motifs of the EMCV IRES element. (Journal article)

Mohammed, S., Phelan, M. M., Rasul, U., & Ramesh, V. (2014). NMR elucidation of the role of Mg2+ in the structure and stability of the conserved RNA motifs of the EMCV IRES element.. Organic & biomolecular chemistry, 12(9), 1495-1509. doi:10.1039/c3ob41840e

DOI: 10.1039/c3ob41840e

Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling (Journal article)

Phelan, M. M., McLean, L., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 866-872. doi:10.1042/BST20140082

DOI: 10.1042/BST20140082

The Structure, Stability and Pheromone Binding of the Male Mouse Protein Sex Pheromone Darcin (Journal article)

Phelan, M. M., McLean, L., Armstrong, S. D., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). The Structure, Stability and Pheromone Binding of the Male Mouse Protein Sex Pheromone Darcin. PLOS ONE, 9(10). doi:10.1371/journal.pone.0108415

DOI: 10.1371/journal.pone.0108415

The major urinary protein system in the rat (Journal article)

Gomez-Baena, G., Armstrong, S. D., Phelan, M. M., Hurst, J. L., & Beynon, R. J. (2014). The major urinary protein system in the rat. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 886-892. doi:10.1042/BST20140083

DOI: 10.1042/BST20140083

2013

A report of 2 new cases of MODY2 and review of the literature: Implications in the search for type 2 Diabetes drugs (Journal article)

Shammas, C., Neodeous, V., Phelan, M. M., Lian, L. Y., Skordis, N., & Phylactou, L. A. (2013). A report of 2 new cases of MODY2 and review of the literature: Implications in the search for type 2 Diabetes drugs. METABOLISM-CLINICAL AND EXPERIMENTAL, 62(11), 1535-1542.

Cooperative Catalysis through Noncovalent Interactions (Journal article)

Tang, W., Johnston, S., Iggo, J. A., Berry, N. G., Phelan, M., Lian, L., . . . Xiao, J. (2013). Cooperative Catalysis through Noncovalent Interactions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(6), 1668-1672. doi:10.1002/anie.201208774

DOI: 10.1002/anie.201208774

2012

Conformational Characterization of Synapse-Associated Protein 97 by Nuclear Magnetic Resonance and Small-Angle X-ray Scattering Shows Compact and Elongated Forms (Journal article)

Tully, M. D., Grossmann, J. G., Phelan, M., Pandelaneni, S., Leyland, M., & Lian, L. -Y. (2012). Conformational Characterization of Synapse-Associated Protein 97 by Nuclear Magnetic Resonance and Small-Angle X-ray Scattering Shows Compact and Elongated Forms. Biochemistry, 51(4), 899-908. doi:10.1021/bi201178v

DOI: 10.1021/bi201178v

Evidence for Metabolic Cleavage of a PEGylated Proteinin VivoUsing Multiple Analytical Methodologies (Journal article)

Elliott, V. L., Edge, G. T., Phelan, M. M., Lian, L. -Y., Webster, R., Finn, R. F., . . . Kitteringham, N. R. (2012). Evidence for Metabolic Cleavage of a PEGylated Proteinin VivoUsing Multiple Analytical Methodologies. Molecular Pharmaceutics, 9(5), 1291-1301. doi:10.1021/mp200587m

DOI: 10.1021/mp200587m

NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast (Journal article)

Herbert, A. P., Riesen, M., Bloxam, L., Kosmidou, E., Wareing, B. M., Johnson, J. R., . . . Morgan, A. (2012). NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast. PLOS ONE, 7(7). doi:10.1371/journal.pone.0041975

DOI: 10.1371/journal.pone.0041975

Structure and Assembly of a Trans-Periplasmic Channel for Type IV Pili in Neisseria meningitidis (Journal article)

Berry, J. -L., Phelan, M. M., Collins, R. F., Adomavicius, T., Tønjum, T., Frye, S. A., . . . Derrick, J. P. (n.d.). Structure and Assembly of a Trans-Periplasmic Channel for Type IV Pili in Neisseria meningitidis. PLoS Pathogens, 8(9), e1002923. doi:10.1371/journal.ppat.1002923

DOI: 10.1371/journal.ppat.1002923

The structure and selectivity of the SR protein SRSF2 RRM domain with RNA (Journal article)

Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2012). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA. Nucleic Acids Research, 40(7), 3232-3244. doi:10.1093/nar/gkr1164

DOI: 10.1093/nar/gkr1164

2011

The structure and selectivity of the SR protein SRSF2 RRM domain with RNA. (Journal article)

Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic Acids Research.

2010

1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein. (Journal article)

Phelan, M. M., McLean, L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2010). 1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein.. Biomolecular NMR assignments, 4(2), 239-241. doi:10.1007/s12104-010-9253-6

DOI: 10.1007/s12104-010-9253-6

Building up a picture of C7 on the basis of high-resolution structure of its component modules (Journal article)

Clark, C., Phelan, M., Ford, S., Ogata, R., Bramham, J., & Barlow, P. N. (2010). Building up a picture of C7 on the basis of high-resolution structure of its component modules. Molecular Immunology, 47(13), 2261.

Characterisation of the dynamics and interactions of detergent micelles and the Neisseria meningitidis outer membrane protein OpcA (Conference Paper)

Phelan, M., Caldwell, Z., Derrick, J., & Lian, L. -Y. (2010). Characterisation of the dynamics and interactions of detergent micelles and the Neisseria meningitidis outer membrane protein OpcA. In XXIVth International Conference on Magnetic Resonance in Biological Systems (pp. 308). Cairns: International Conference on Magnetic Resonance in Biological Systems Committee.

H-1, N-15 and C-13 resonance assignment of darcin, a mouse major urinary protein (Journal article)

Phelan, M. M., McLean, L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2010). H-1, N-15 and C-13 resonance assignment of darcin, a mouse major urinary protein. BIOMOLECULAR NMR ASSIGNMENTS, 4(2), 239-241. doi:10.1007/s12104-010-9253-6

DOI: 10.1007/s12104-010-9253-6

The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing (Journal article)

Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2011). The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. Biomolecular NMR Assignments, 5(1), 7-10. doi:10.1007/s12104-010-9254-5

DOI: 10.1007/s12104-010-9254-5

2009

Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement (Journal article)

Phelan, M. M., Thai, C. -T., Soares, D. C., Ogata, R. T., Barlow, P. N., & Bramham, J. (2009). Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement. Journal of Biological Chemistry, 284(29), 19637-19649. doi:10.1074/jbc.m901993200

DOI: 10.1074/jbc.m901993200

1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7 (Journal article)

Phelan, M. M., Thai, C. -T., Herbert, A. P., Bella, J., Uhrín, D., Ogata, R. T., . . . Bramham, J. (2009). 1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7. Biomolecular NMR Assignments, 3(1), 49-52. doi:10.1007/s12104-008-9139-z

DOI: 10.1007/s12104-008-9139-z

2008

The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC (Journal article)

Phelan, M., Ogata, R., Barlow, P., & Bramham, J. (2008). The 3D structure of factor I-like modules from C7 provides structural and functional insights into assembly of the MAC. Molecular Immunology, 45(16), 4121.

2007

) Structural investigation of C terminal region of C7, 11th European Meeting on Complement in Human Disease (Journal article)

Phelan, M. M., & Bramham, J. (2007). ) Structural investigation of C terminal region of C7, 11th European Meeting on Complement in Human Disease. Molecular Immunology, 44(16), 3987.

2004

NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element (Journal article)

Phelan, M. (2004). NMR studies of the structure and Mg2+ binding properties of a conserved RNA motif of EMCV picornavirus IRES element. Nucleic Acids Research, 32(16), 4715-4724. doi:10.1093/nar/gkh805

DOI: 10.1093/nar/gkh805