Photo of Dr Ishwar Singh

Dr Ishwar Singh MSc, MPhil, Ph.D. MRSC

Reader Pharmacology & Therapeutics

    Publications

    2020

    Mode of action of teixobactins in cellular membranes (Journal article)

    Shukla, R., Medeiros-Silva, J., Parmar, A., Vermeulen, B. J. A., Das, S., Paioni, A. L., . . . Weingarth, M. (2020). Mode of action of teixobactins in cellular membranes. Nature Communications, 11(1). doi:10.1038/s41467-020-16600-2

    DOI: 10.1038/s41467-020-16600-2

    2019

    Teixobactins: a new class of 21st century antibiotics to combat multidrug-resistant bacterial pathogens (Journal article)

    Iyer, A., Madder, A., & Singh, I. (2019). Teixobactins: a new class of 21st century antibiotics to combat multidrug-resistant bacterial pathogens.

    2018

    Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo. (Journal article)

    Parmar, A., Lakshminarayanan, R., Iyer, A., Mayandi, V., Leng Goh, E. T., Lloyd, D. G., . . . Singh, I. (2018). Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo.. Journal of medicinal chemistry, 61(5), 2009-2017. doi:10.1021/acs.jmedchem.7b01634

    DOI: 10.1021/acs.jmedchem.7b01634

    Cysteines and disulfide-bridged macrocyclic mimics of teixobactin analogues and their antibacterial activity evaluation against methicillin-resistant Staphylococcus aureus (MRSA) (Journal article)

    Malkawi, R., Iyer, A., Parmar, A., Lloyd, D. G., Goh, L., Tze, E., . . . Lakshminarayanan, R. (2018). Cysteines and disulfide-bridged macrocyclic mimics of teixobactin analogues and their antibacterial activity evaluation against methicillin-resistant Staphylococcus aureus (MRSA). Pharmaceutics, 10(4), 183.

    First Steps for the Direct Purification of l-Leu-l-Leu Dipeptide through Co-Crystallization (Journal article)

    Lucaioli, P., Nauha, E., Singh, I., & Blagden, N. (2018). First Steps for the Direct Purification of l-Leu-l-Leu Dipeptide through Co-Crystallization. Crystal Growth & Design, 18(2), 1062-1069.

    Serendipitous isolation of a disappearing conformational polymorph of succinic acid challenges computational polymorph prediction (Journal article)

    Lucaioli, P., Nauha, E., Gimondi, I., Price, L. S., Guo, R., Iuzzolino, L., . . . Blagden, N. (2018). Serendipitous isolation of a disappearing conformational polymorph of succinic acid challenges computational polymorph prediction. CrystEngComm, 20(28), 3971-3977.

    Simplified teixobactin analogues to target superbugs (Journal article)

    Singh, I. (2018). Simplified teixobactin analogues to target superbugs. Future medicinal chemistry, 10(02), 133-134.

    The Impact of Trifluoroacetic Acid on Peptide Cocrystallization: Multicomponent Crystals of l-Leu-l-Leu Dipeptides (Journal article)

    Lucaioli, P., Nauha, E., Singh, I., & Blagden, N. (2018). The Impact of Trifluoroacetic Acid on Peptide Cocrystallization: Multicomponent Crystals of l-Leu-l-Leu Dipeptides. Crystal Growth & Design, 18(8), 4682-4690.

    2017

    Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of l-allo-enduracididine with its isosteres. (Journal article)

    Parmar, A., Iyer, A., Lloyd, D. G., Vincent, C. S., Prior, S. H., Madder, A., . . . Singh, I. (2017). Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of l-allo-enduracididine with its isosteres.. Chemical communications (Cambridge, England), 53(55), 7788-7791. doi:10.1039/c7cc04021k

    DOI: 10.1039/c7cc04021k

    Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities. (Journal article)

    Parmar, A., Prior, S. H., Iyer, A., Vincent, C. S., Van Lysebetten, D., Breukink, E., . . . Singh, I. (2017). Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities.. Chemical communications (Cambridge, England), 53(12), 2016-2019. doi:10.1039/c6cc09490b

    DOI: 10.1039/c6cc09490b

    Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding (Journal article)

    Parmar, A., Iyer, A., Prior, S. H., Lloyd, D. G., Leng Goh, E. T., Vincent, C. S., . . . Singh, I. (n.d.). Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chemical Science, 8(12), 8183-8192. doi:10.1039/c7sc03241b

    DOI: 10.1039/c7sc03241b

    Teixobactin and its analogues: a new hope in antibiotic discovery (Journal article)

    Fiers, W. D., Craighead, M., & Singh, I. (2017). Teixobactin and its analogues: a new hope in antibiotic discovery. ACS infectious diseases, 3(10), 688-690.

    2016

    Efficient total syntheses and biological activities of two teixobactin analogues. (Journal article)

    Parmar, A., Iyer, A., Vincent, C. S., Van Lysebetten, D., Prior, S. H., Madder, A., . . . Singh, I. (2016). Efficient total syntheses and biological activities of two teixobactin analogues.. Chemical communications (Cambridge, England), 52(36), 6060-6063. doi:10.1039/c5cc10249a

    DOI: 10.1039/c5cc10249a

    DNA-directed spatial assembly of photosynthetic light-harvesting proteins (Journal article)

    Henry, S. L., Withers, J. M., Singh, I., Cooper, J. M., Clark, A. W., Burley, G. A., & Cogdell, R. J. (2016). DNA-directed spatial assembly of photosynthetic light-harvesting proteins. Organic & biomolecular chemistry, 14(4), 1359-1362.

    2015

    Isoxazole linked oligonucleotide conjugates by on resin and previously clicked nitrile oxide alkyne cycloadditions (Journal article)

    Freeman, C., Cheallaigh, A. N., Singh, I., & Heaney, F. (2015). Isoxazole linked oligonucleotide conjugates by on resin and previously clicked nitrile oxide alkyne cycloadditions. Collection of Czechoslovak Chemical Communications, 12, 333.

    Metal free click chemistry on nucleosides and oligonucleotides (Journal article)

    Singh, I., Heaney, F., Batchelor, C., & Vyle, J. S. (2015). Metal free click chemistry on nucleosides and oligonucleotides. Collection of Czechoslovak Chemical Communications, 10, 451.

    2014

    Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach (Journal article)

    Fallows, A. J., Singh, I., Dondi, R., Cullis, P. M., & Burley, G. A. (2014). Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic letters, 16(17), 4654-4657.

    Particle characterisation in drug delivery (Journal article)

    Vllasaliu, D., & Singh, I. (2014). Particle characterisation in drug delivery. European Pharmaceutical Review, 2014(4).

    2013

    General discussion on self-assembly of biopolymers (Journal article)

    Singh, I. (2013). General discussion on self-assembly of biopolymers. Faraday Discussions, 166, 331-348.

    Sequence-selective detection of double-stranded DNA sequences using pyrrole–imidazole polyamide microarrays (Journal article)

    Singh, I., Wendeln, C., Clark, A. W., Cooper, J. M., Ravoo, B. J., & Burley, G. A. (2013). Sequence-selective detection of double-stranded DNA sequences using pyrrole–imidazole polyamide microarrays. Journal of the American Chemical Society, 135(9), 3449-3457.

    2012

    Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides (Journal article)

    Krpetic´, Z., Singh, I., Su, W., Guerrini, L., Faulds, K., Burley, G. A., & Graham, D. (2012). Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides. Journal of the American Chemical Society, 134(20), 8356-8359.

    Fast RNA conjugations on solid phase by strain-promoted cycloadditions (Journal article)

    Singh, I., Freeman, C., Madder, A., Vyle, J. S., & Heaney, F. (2012). Fast RNA conjugations on solid phase by strain-promoted cycloadditions. Organic & biomolecular chemistry, 10(33), 6633-6639.

    Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions (Journal article)

    Wendeln, C., Singh, I., Rinnen, S., Schulz, C., Arlinghaus, H. F., Burley, G. A., & Ravoo, B. J. (2012). Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions. Chemical Science, 3(8), 2479-2484.

    2011

    Efficient Synthesis of DNA Conjugates by Strain-Promoted Azide–Cyclooctyne Cycloaddition in the Solid Phase (Journal article)

    Singh, I., Freeman, C., & Heaney, F. (2011). Efficient Synthesis of DNA Conjugates by Strain-Promoted Azide–Cyclooctyne Cycloaddition in the Solid Phase. European Journal of Organic Chemistry, 2011(33), 6739-6746.

    Orthogonal modification of polymer chain-ends via sequential nitrile oxide–alkyne and azide–alkyne Huisgen cycloadditions (Journal article)

    Singh, I., Zarafshani, Z., Heaney, F., & Lutz, J. (2011). Orthogonal modification of polymer chain-ends via sequential nitrile oxide–alkyne and azide–alkyne Huisgen cycloadditions. Polymer Chemistry, 2(2), 372-375.

    Solid phase strain promoted “click” modification of DNA via [3+ 2]-nitrile oxide–cyclooctyne cycloadditions (Journal article)

    Singh, I., & Heaney, F. (2011). Solid phase strain promoted “click” modification of DNA via [3+ 2]-nitrile oxide–cyclooctyne cycloadditions. Chemical Communications, 47(9), 2706-2708.

    The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus (Journal article)

    Davis, C., Carberry, S., Schrettl, M., Singh, I., Stephens, J. C., Barry, S. M., . . . Doyle, S. (2011). The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus. Chemistry & biology, 18(4), 542-552.

    2010

    Designed thiazole orange nucleotides for the synthesis of single labelled oligonucleotides that fluoresce upon matched hybridization (Journal article)

    Bethge, L., Singh, I., & Seitz, O. (2010). Designed thiazole orange nucleotides for the synthesis of single labelled oligonucleotides that fluoresce upon matched hybridization. Organic & biomolecular chemistry, 8(10), 2439-2448.

    Metal free,“click and click–click” conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase (Journal article)

    Singh, I., & Heaney, F. (2010). Metal free,“click and click–click” conjugation of ribonucleosides and 2'-OMe oligoribonucleotides on the solid phase. Organic & biomolecular chemistry, 8(2), 451-456.

    Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide–alkyne 1, 3-dipolar cycloaddition (Journal article)

    Algay, V., Singh, I., & Heaney, F. (2010). Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide–alkyne 1, 3-dipolar cycloaddition. Organic & biomolecular chemistry, 8(2), 391-397.

    2009

    Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation (Journal article)

    Singh, I., Vyle, J. S., & Heaney, F. (2009). Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical communications, (22), 3276-3278.

    Metal-free “click” chemistry: efficient polymer modification via 1, 3-dipolar cycloaddition of nitrile oxides and alkynes (Journal article)

    Singh, I., Zarafshani, Z., Lutz, J., & Heaney, F. (2009). Metal-free “click” chemistry: efficient polymer modification via 1, 3-dipolar cycloaddition of nitrile oxides and alkynes. Macromolecules, 42(15), 5411-5413.

    Supporting Information: Fast, Copper-Free Click Chemistry, A Convenient Solid-Phase Approach to Oligonucleotide Conjugation (Journal article)

    Singh, I., Vyle, J. S., & Heaney, F. (2009). Supporting Information: Fast, Copper-Free Click Chemistry, A Convenient Solid-Phase Approach to Oligonucleotide Conjugation.

    2007

    Synthesis of C-aryl-nucleosides and O-aryl-glycosides via cuprate glycosylation (Journal article)

    Hainke, S., Singh, I., Hemmings, J., & Seitz, O. (2007). Synthesis of C-aryl-nucleosides and O-aryl-glycosides via cuprate glycosylation. The Journal of organic chemistry, 72(23), 8811-8819.

    2006

    Diastereoselective Synthesis of ß-Aryl-C-nucleosides from 1, 2-Anhydrosugars (Journal article)

    Singh, I., & Seitz, O. (2006). Diastereoselective Synthesis of ß-Aryl-C-nucleosides from 1, 2-Anhydrosugars. Organic letters, 8(19), 4319-4322.

    2005

    Forced intercalation as a tool in gene diagnostics and in studying DNA–protein interactions (Journal article)

    Köhler, O., Jarikote, D. V., Singh, I., Parmar, V. S., Weinhold, E., & Seitz, O. (2005). Forced intercalation as a tool in gene diagnostics and in studying DNA–protein interactions. Pure and Applied Chemistry, 77(1), 327-338.

    2004

    Abasic site stabilization by aromatic DNA base surrogates: High-affinity binding to a base-flipping DNA-methyltransferase (Journal article)

    Singh, I., Beuck, C., Bhattacharya, A., Hecker, W., Parmar, V. S., Weinhold, E., & Seitz, O. (2004). Abasic site stabilization by aromatic DNA base surrogates: High-affinity binding to a base-flipping DNA-methyltransferase. Pure and applied chemistry, 76(7-8), 1563-1570.

    2003

    Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 10: identification of inhibitors for the liver microsomal acetoxycoumarin: protein transacetylase (Journal article)

    Raj, H. G., Singh, I., Kohli, E., Kumari, R., Gupta, G., Tyagi, Y. K., . . . Olsen, C. E. (2003). Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 10: identification of inhibitors for the liver microsomal acetoxycoumarin: protein transacetylase. Bioorganic & medicinal chemistry, 11(6), 1015-1019.

    Polycyclic Aromatic DNA-Base Surrogates: High-Affinity Binding to an Adenine-Specific Base-Flipping DNA Methyltransferase (Journal article)

    Beuck, C., Singh, I., Bhattacharya, A., Hecker, W., Parmar, V. S., Seitz, O., & Weinhold, E. (2003). Polycyclic Aromatic DNA-Base Surrogates: High-Affinity Binding to an Adenine-Specific Base-Flipping DNA Methyltransferase. Angewandte Chemie International Edition, 42(33), 3958-3960.

    Polycyclische aromatische DNA-Basensurrogate: stark erhöhte Bindungsaffinitäten zu einer Adenin-spezifischen, basenausklappenden DNA-Methyltransferase (Journal article)

    Beuck, C., Singh, I., Bhattacharya, A., Hecker, W., Parmar, V. S., Seitz, O., & Weinhold, E. (2003). Polycyclische aromatische DNA-Basensurrogate: stark erhöhte Bindungsaffinitäten zu einer Adenin-spezifischen, basenausklappenden DNA-Methyltransferase. Angewandte Chemie, 115(33), 4088-4091.

    Synthesis of novel heterocyclic compounds: Routes to pyrazolyl 1, 2, 3-triazoles and their biological activity evaluation (Journal article)

    Kumar, A., Husain, M., Prasad, A. K., Singh, I., Vats, A., Sharma, N. K., . . . Bracke, M. E. (2003). Synthesis of novel heterocyclic compounds: Routes to pyrazolyl 1, 2, 3-triazoles and their biological activity evaluation.

    Synthesis of novel heterocyclic compounds: Routes to pyrazolyl 1, 2, 3-ttriazoles and their biological activity avaluation (Journal article)

    Kumar, A., Husain, M., Prasad, A. K., Singh, I., Vats, A., Sharma, N. K., . . . Bracke, M. E. (2003). Synthesis of novel heterocyclic compounds: Routes to pyrazolyl 1, 2, 3-ttriazoles and their biological activity avaluation. Ind. J. Chem, (421), 1050-1057.

    Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds (Journal article)

    Parmar, V. S., Sharma, N. K., Husain, M., Watterson, A. C., Kumar, J., Samuelson, L. A., . . . Malhotra, S. (2003). Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds. Bioorganic & medicinal chemistry, 11(6), 913-929.

    Synthetic and novel biocatalytic resolution studies on (±)-5/6/7-acetoxy-4-aryl-3, 4-dihydrocoumarins (Journal article)

    Singh, I., Prasad, A. K., Sharma, A. K., Saxena, R. K., Olsen, C. E., Cholli, A. L., . . . Parmar, V. S. (2003). Synthetic and novel biocatalytic resolution studies on (±)-5/6/7-acetoxy-4-aryl-3, 4-dihydrocoumarins. Bioorganic & medicinal chemistry, 11(4), 529-538.

    2002

    Local disruption of DNA-base stacking by bulky base surrogates (Journal article)

    Singh, I., Hecker, W., Prasad, A. K., Parmar, V. S., & Seitz, O. (2002). Local disruption of DNA-base stacking by bulky base surrogates. Chemical Communications, (5), 500-501.

    Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 9: comparison of acetoxy 4-methylcoumarins and other polyphenolic acetates reveal the specificity to acetoxy drug: protein transacetylase for pyran carbonyl group in proximity to the oxygen heteroatom (Journal article)

    Singh, I., Kohli, E., Raj, H. G., Gyanda, K., Jain, S. K., Tyagi, Y. K., . . . Pal, G. (2002). Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 9: comparison of acetoxy 4-methylcoumarins and other polyphenolic acetates reveal the specificity to acetoxy drug: protein transacetylase for pyran carbonyl group in proximity to the oxygen heteroatom. Bioorganic & medicinal chemistry, 10(12), 4103-4111.

    Xanthones as inhibitors of microsomal lipid peroxidation and TNF-a induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) (Journal article)

    Madan, B., Singh, I., Kumar, A., Prasad, A. K., Raj, H. G., Parmar, V. S., & Ghosh, B. (2002). Xanthones as inhibitors of microsomal lipid peroxidation and TNF-a induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs). Bioorganic & medicinal chemistry, 10(11), 3431-3436.

    2001

    7-Acetoxy-4-(1-chloroethyl) coumarin (Journal article)

    Errington, W., Parmar, V. S., Singh, A., & Singh, I. (2001). 7-Acetoxy-4-(1-chloroethyl) coumarin. Acta Crystallographica Section E: Structure Reports Online, 57(10), o939-o940.

    2000

    Asymmetric PTC C-alkylation catalyzed by chiral derivatives of tartaric acid and aminophenols. Synthesis of (R)-and (S)-a-methyl amino acids (Journal article)

    Belokon, Y. N., Kochetkov, K. A., Churkina, T. D., Ikonnikov, N. S., Chesnokov, A. A., Larionov, O. V., . . . Kagan, H. B. (2000). Asymmetric PTC C-alkylation catalyzed by chiral derivatives of tartaric acid and aminophenols. Synthesis of (R)-and (S)-a-methyl amino acids. The Journal of organic chemistry, 65(21), 7041-7048.

    Immobilization of hog pancreas lipase in macroporous poly (vinyl alcohol)-cryogel carrier for the biocatalysis in water-poor media (Journal article)

    Plieva, F. M., Kochetkov, K. A., Singh, I., Parmar, V. S., Belokon, Y. N., & Lozinsky, V. I. (2000). Immobilization of hog pancreas lipase in macroporous poly (vinyl alcohol)-cryogel carrier for the biocatalysis in water-poor media. Biotechnology Letters, 22(7), 551-554.