Prof Mark Pritchard BSc, MBChB(hons), FRCP(UK), PhD

Professor Cellular and Molecular Physiology

Publications

2020

Systematic review: management of localised low-grade upper gastrointestinal neuroendocrine tumours. (Journal article)

Exarchou, K., Howes, N., & Pritchard, D. M. (2020). Systematic review: management of localised low-grade upper gastrointestinal neuroendocrine tumours.. Alimentary pharmacology & therapeutics. doi:10.1111/apt.15765

DOI: 10.1111/apt.15765

Type III Gastric Neuroendocrine Neoplasms: Is Local Excision Sufficient in Selected Cases? (Conference Paper)

Exarchou, K., Kameniarz, L., Tsoli, M., Victor, A., Oleinikov, K., Khan, M., . . . Toumpanakis, C. (2020). Type III Gastric Neuroendocrine Neoplasms: Is Local Excision Sufficient in Selected Cases?. In NEUROENDOCRINOLOGY Vol. 110 (pp. 283). Retrieved from http://gateway.webofknowledge.com/

Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients. (Journal article)

Hu, H., Zhang, Q., Chen, G., Pritchard, D. M., & Zhang, S. (2020). Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients.. Scientific reports, 10(1), 2582. doi:10.1038/s41598-020-58900-z

DOI: 10.1038/s41598-020-58900-z

Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors. (Journal article)

Lloyd, K. A., Parsons, B. N., Burkitt, M. D., Moore, A. R., Papoutsopoulou, S., Boyce, M., . . . Pritchard, D. M. (2020). Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.. Cellular and molecular gastroenterology and hepatology, 10(1), 113-132. doi:10.1016/j.jcmgh.2020.01.010

DOI: 10.1016/j.jcmgh.2020.01.010

2019

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research (Journal article)

Evans, J. P., Winiarski, B. K., Sutton, P. A., Ressel, L., Duckworth, C. A., Pritchard, D. M., . . . Kitteringham, N. R. (2019). Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research. LABORATORY ANIMALS, 53(6), 598-609. doi:10.1177/0023677219826165

DOI: 10.1177/0023677219826165

NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells (Journal article)

Jones, L. G., Vaida, A., Thompson, L. M., Ikuomola, F. I., Caamaño, J. H., Burkitt, M. D., . . . Duckworth, C. A. (2019). NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells. Cell Death & Disease, 10(12). doi:10.1038/s41419-019-2129-5

DOI: 10.1038/s41419-019-2129-5

A novel FTIR analysis method for rapid high-confidence discrimination of esophageal cancer (Journal article)

Martin, D. S., Barrett, S., Weightman, P., & Smith, C. (2019). A novel FTIR analysis method for rapid high-confidence discrimination ofesophageal cancer. Infrared Physics and Technology, 102. doi:10.1016/j.infrared.2019.103007

DOI: 10.1016/j.infrared.2019.103007

Endoscopic surveillance is a viable alternative management strategy for patients with localised small non-functional low grade duodenal neuroendocrine tumours (dNETs) (Conference Paper)

Exarchou, K., Howes, N., Moore, A., Duckworth, C. A., & Pritchard, D. M. (2019). Endoscopic surveillance is a viable alternative management strategy for patients with localised small non-functional low grade duodenal neuroendocrine tumours (dNETs). In BRITISH JOURNAL OF SURGERY Vol. 106 (pp. 74). Retrieved from http://gateway.webofknowledge.com/

Periodic endoscopic surveillance in patients with low risk Type 1 gastric neuroendocrine tumours (gNETs) also detects associated gastric adenocarcinoma in a subset of patients (Conference Paper)

Exarchou, K., Howes, N., Moore, A., Duckworth, C., & Pritchard, D. M. (2019). Periodic endoscopic surveillance in patients with low risk Type 1 gastric neuroendocrine tumours (gNETs) also detects associated gastric adenocarcinoma in a subset of patients. In BRITISH JOURNAL OF SURGERY Vol. 106 (pp. 85). Retrieved from http://gateway.webofknowledge.com/

Macrophage-Specific NF-kappa B Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients (Journal article)

Papoutsopoulou, S., Burkitt, M. D., Bergey, F., England, H., Hough, R., Schmidt, L., . . . Probert, C. S. (2019). Macrophage-Specific NF-kappa B Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.02168

DOI: 10.3389/fimmu.2019.02168

Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patients (Journal article)

Papoutsopoulou, S., Burkitt, M., Bergey, F., England, H., Hough, R., Schmidt, L., . . . Probert, C. (2019). Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patients. doi:10.1101/535096

DOI: 10.1101/535096

IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (Journal article)

Duckworth, C. A., Pritchard, D. M., Mihailuk, K., Simms, C., Reay, M., Madureira, P., . . . Hill, R. (2019). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas. Cancer Letters. doi:10.1016/j.canlet.2019.05.028

DOI: 10.1016/j.canlet.2019.05.028

British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma (Journal article)

Banks, M., Graham, D., Jansen, M., Gotoda, T., Coda, S., di Pietro, M., . . . Dinis-Ribeiro, M. (2019). British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma. GUT, 68(9), 1545-1575. doi:10.1136/gutjnl-2018-318126

DOI: 10.1136/gutjnl-2018-318126

Replication of Crohn's Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation (Journal article)

Tawfik, A., Knight, P., Duckworth, C. A., Pritchard, D. M., Rhodes, J. M., & Campbell, B. J. (2019). Replication of Crohn's Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation. PATHOGENS, 8(2). doi:10.3390/pathogens8020074

DOI: 10.3390/pathogens8020074

FERRIC MALTOL, UNLIKE FERROUS SULPHATE, DOES NOT ADVERSELY AFFECT THE INTESTINAL MICROBIOME (Conference Paper)

Mahalhal, A., Mansfield, J., Sampson, M., Lewis, S., Lamb, C., Frau, A., . . . Probert, C. (2019). FERRIC MALTOL, UNLIKE FERROUS SULPHATE, DOES NOT ADVERSELY AFFECT THE INTESTINAL MICROBIOME. In GUT Vol. 68 (pp. A84). doi:10.1136/gutjnl-2019-BSGAbstracts.161

DOI: 10.1136/gutjnl-2019-BSGAbstracts.161

RISK FACTORS AND CLINICAL CORRELATES OF NEOPLASTIC TRANSFORMATION IN GASTRIC HYPERPLASTIC POLYPSIN CHINESE PATIENTS (Conference Paper)

Hu, H., Zhang, Q., Chen, G., Pritchard, D. M., & Zhang, S. (2019). RISK FACTORS AND CLINICAL CORRELATES OF NEOPLASTIC TRANSFORMATION IN GASTRIC HYPERPLASTIC POLYPSIN CHINESE PATIENTS. In GUT Vol. 68 (pp. A102). doi:10.1136/gutjnl-2019-IDDFabstracts.193

DOI: 10.1136/gutjnl-2019-IDDFabstracts.193

Recharacterization data for a geriatric gastrin polycolonal antibody. (Journal article)

Dodd, S., Varro, A., Pritchard, D. M., & Dockray, G. J. (2019). Recharacterization data for a geriatric gastrin polycolonal antibody.. Data in brief, 24, 103886. doi:10.1016/j.dib.2019.103886

DOI: 10.1016/j.dib.2019.103886

Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (vol 8, e2939, 2017) (Journal article)

Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., Duckworth, C. A., & Pritchard, D. M. (2019). Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (vol 8, e2939, 2017). CELL DEATH & DISEASE, 10. doi:10.1038/s41419-019-1534-0

DOI: 10.1038/s41419-019-1534-0

Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in PatientsWith Autoimmune Chronic Atrophic Gastritis (Conference Paper)

Boyce, M., Moore, A. R., Parsons, B., Lloyd, K., Sagatun, L., Varro, A., . . . Pritchard, D. M. (2019). Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in PatientsWith Autoimmune Chronic Atrophic Gastritis. In PANCREAS Vol. 48 (pp. 429). Retrieved from http://gateway.webofknowledge.com/

A cohort study of local excision followed by adjuvant therapy incorporating a contact x- ray brachytherapy boost instead of radical resection in 180 patients with rectal cancer. (Journal article)

Smith, F. M., Pritchard, D. M., Wong, H., Whitmarsh, K., Hershman, M. J., & Sun Myint, A. (2019). A cohort study of local excision followed by adjuvant therapy incorporating a contact x- ray brachytherapy boost instead of radical resection in 180 patients with rectal cancer.. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. doi:10.1111/codi.14584

DOI: 10.1111/codi.14584

Endoscopic Surveillance Is a Viable Alternative Management Strategy for Patients with Localised Small Non-Functional Low Grade Duodenal Neuroendocrine Tumours (dNETs) (Conference Paper)

Exarchou, K., Howes, N., Moore, A., Duckworth, C. A., & Pritchard, D. M. (2019). Endoscopic Surveillance Is a Viable Alternative Management Strategy for Patients with Localised Small Non-Functional Low Grade Duodenal Neuroendocrine Tumours (dNETs). In NEUROENDOCRINOLOGY Vol. 108 (pp. 56). Retrieved from http://gateway.webofknowledge.com/

IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (vol 458C, pg 29, 2019) (Journal article)

Mihajluk, K., Simms, C., Reay, M., Madureira, P. A., Howarth, A., Murray, P., . . . Hill, R. (2020). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (vol 458C, pg 29, 2019). CANCER LETTERS, 469, 524-525. doi:10.1016/j.canlet.2019.10.002

DOI: 10.1016/j.canlet.2019.10.002

2018

Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell (Journal article)

Smith, C. I., Siggel-King, M. R. F., Ingham, J., Harrison, P., Martin, D. S., Varro, A., . . . Weightman, P. (2018). Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell. ANALYST, 143(24), 5912-5917. doi:10.1039/c8an01183d

DOI: 10.1039/c8an01183d

Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL (Journal article)

Ingham, J., Craig, T., Smith, C. I., Varro, A., Pritchard, D. M., Barrett, S. D., . . . Siggel-King, M. R. F. (2018). Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL. Biomedical Physics and Engineering Express, 5. doi:10.1088/2057-1976/aaea53

DOI: 10.1088/2057-1976/aaea53

Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice (Journal article)

Reade, S., Williams, J. M., Aggio, R., Duckworth, C. A., Mahalhal, A., Hough, R., . . . Probert, C. S. (2019). Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice. FASEB JOURNAL, 33(3), 3129-3136. doi:10.1096/fj.201800076RR

DOI: 10.1096/fj.201800076RR

Oral iron exacerbates colitis and influences the intestinal microbiome (Journal article)

Mahalhal, A., Williams, J. M., Johnson, S., Ellaby, N., Duckworth, C. A., Burkitt, M. D., . . . Probert, C. S. (2018). Oral iron exacerbates colitis and influences the intestinal microbiome. PLOS ONE, 13(10). doi:10.1371/journal.pone.0202460

DOI: 10.1371/journal.pone.0202460

Contact X-ray Brachytherapy as an Adjunct to a Watch and Wait Approach is an Affordable Alternative to Standard Surgical Management of Rectal Cancer for Patients with a Partial Clinical Response to Chemoradiotherapy (Journal article)

Rao, C., Stewartz, A., Martin, A. P., Collins, B., Pritchard, D. M., Athanasiou, T., & Myint, A. S. (2018). Contact X-ray Brachytherapy as an Adjunct to a Watch and Wait Approach is an Affordable Alternative to Standard Surgical Management of Rectal Cancer for Patients with a Partial Clinical Response to Chemoradiotherapy. CLINICAL ONCOLOGY, 30(10), 625-633. doi:10.1016/j.clon.2018.06.010

DOI: 10.1016/j.clon.2018.06.010

Oral iron exacerbates colitis and influences the intestinal microbiome (Journal article)

Mahalhal, A., Williams, J., Johnson, S., Ellaby, N., Duckworth, C., Burkitt, M., . . . Probert, C. (2018). Oral iron exacerbates colitis and influences the intestinal microbiome. doi:10.1101/385997

DOI: 10.1101/385997

Contact X-Ray Brachytherapy in Organ Preservation for Rectal Cancer Reply (Journal article)

Myint, A. S., Smith, F. M., Gollins, S., Rao, C., & Pritchard, D. M. (2018). Contact X-Ray Brachytherapy in Organ Preservation for Rectal Cancer Reply. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 101(3), 743-744. doi:10.1016/j.ijrobp.2018.03.033

DOI: 10.1016/j.ijrobp.2018.03.033

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer (Journal article)

Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget, 9(43), 27104-27116. doi:10.18632/oncotarget.25497

DOI: 10.18632/oncotarget.25497

Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. (Journal article)

Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2019). Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 10(6), 685. doi:10.18632/oncotarget.26625

DOI: 10.18632/oncotarget.26625

IDENTIFICATION OF A NOVEL THERAPEUTIC AGENT FOR TREATING IBD GUIDED BY SYSTEMS MEDICINE (Conference Paper)

Burkitt, M., Lloyd, K., Papoutsopoulou, S., Smith, E., Stegmaier, P., Pritchard, D. M., . . . Probert, C. (2018). IDENTIFICATION OF A NOVEL THERAPEUTIC AGENT FOR TREATING IBD GUIDED BY SYSTEMS MEDICINE. In GUT Vol. 67 (pp. A52). doi:10.1136/gutjnl-2018-BSGAbstracts.104

DOI: 10.1136/gutjnl-2018-BSGAbstracts.104

INTESTINAL DYSBIOSIS OCCURS IN IRON DEFICIENCY AS WELL AS ACTIVE IBD (Conference Paper)

Mahalhal, A., Subramanian, S., Pritchard, D. M., & Probert, C. S. (2018). INTESTINAL DYSBIOSIS OCCURS IN IRON DEFICIENCY AS WELL AS ACTIVE IBD. In GUT Vol. 67 (pp. A193). doi:10.1136/gutjnl-2018-BSGAbstracts.384

DOI: 10.1136/gutjnl-2018-BSGAbstracts.384

An evaluation of the application of the aperture infrared SNOM technique to biomedical imaging (Journal article)

Ingham, J., Pilling, M. J., Craig, T., Siggel-King, M. R. F., Smith, C. I., Gardner, P., . . . Weightman, P. (n.d.). An evaluation of the application of the aperture infrared SNOM technique to biomedical imaging. Biomedical Physics & Engineering Express, 4(2), 025011. doi:10.1088/2057-1976/aaa0de

DOI: 10.1088/2057-1976/aaa0de

Dose Escalation Using Contact X-ray Brachytherapy After External Beam Radiotherapy as Nonsurgical Treatment Option for Rectal Cancer: Outcomes From a Single-Center Experience (Journal article)

Myint, A. S., Smith, F. M., Gollins, S., Wong, H., Rao, C., Whitmarsh, K., . . . Pritchard, D. M. (2018). Dose Escalation Using Contact X-ray Brachytherapy After External Beam Radiotherapy as Nonsurgical Treatment Option for Rectal Cancer: Outcomes From a Single-Center Experience. International Journal of Radiation: Oncology - Biology - Physics, 100(3), 565-573. doi:10.1016/j.ijrobp.2017.10.022

DOI: 10.1016/j.ijrobp.2017.10.022

SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus (Journal article)

Craig, T., Smith, A. D., Holder, G. M., Ingham, J., Smith, C. I., Varro, A., . . . Siggel-King, M. R. F. (2018). SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus. PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS, 255(4). doi:10.1002/pssb.201700518

DOI: 10.1002/pssb.201700518

(68)Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management (Journal article)

Lamarca, A., Pritchard, D. M., Westwood, T., Papaxoinis, G., Nonaka, D., Vinjamuri, S., . . . Mansoor, W. (2018). (68)Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management. NEUROENDOCRINOLOGY, 106(2), 128-138. doi:10.1159/000472717

DOI: 10.1159/000472717

2017

Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use (Journal article)

parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use. PLoS Pathogens. doi:10.1101/144907

DOI: 10.1101/144907

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use (Journal article)

Parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. PLoS Pathogens, 13(11). doi:10.1371/journal.ppat.1006653

DOI: 10.1371/journal.ppat.1006653

Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance. (Thesis / Dissertation)

Garalla, H. M., Lertkowit, N., Tiszlavicz, L., Reisz, Z., Holmberg, C., Beynon, R., . . . Varro, A. (2018). Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance..

DOI: 10.14814/phy2.13683

Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS) (Journal article)

Beg, S., Ragunath, K., Wyman, A., Banks, M., Trudgill, N., Pritchard, M. D., . . . Veitch, A. (2017). Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS). GUT, 66(11), 1886-1899. doi:10.1136/gutjnl-2017-314109

DOI: 10.1136/gutjnl-2017-314109

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration. (Journal article)

Burkitt, M., Williams, J., Townsend, T., Hough, R., Duckworth, C., & Pritchard, D. M. (2017). Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.. Cell Death and Disease. doi:10.1101/112656

DOI: 10.1101/112656

EXPRESSION OF MADCAM-1 IN THE UPPER GASTROINTESTINAL TRACT: IS THERE A ROLE FOR DISRUPTING INTERACTIONS BETWEEN MADCAM-1 AND ALPHA-4/BETA-7 INTEGRIN IN UPPER GI CROHN'S DISEASE? (Conference Paper)

Ahmed, A., Pritchard, D. M., & Burkitt, M. D. (2017). EXPRESSION OF MADCAM-1 IN THE UPPER GASTROINTESTINAL TRACT: IS THERE A ROLE FOR DISRUPTING INTERACTIONS BETWEEN MADCAM-1 AND ALPHA-4/BETA-7 INTEGRIN IN UPPER GI CROHN'S DISEASE?. In GUT Vol. 66 (pp. A236). doi:10.1136/gutjnl-2017-314472.459

DOI: 10.1136/gutjnl-2017-314472.459

INFECTION WITH STREPTOCOCCUS GALLOLYTICUS INCREASES APOPTOSIS IN THE MURINE COLON (Conference Paper)

Townsend, T., Burkitt, M., & Pritchard, D. M. (2017). INFECTION WITH STREPTOCOCCUS GALLOLYTICUS INCREASES APOPTOSIS IN THE MURINE COLON. In GUT Vol. 66 (pp. A135). doi:10.1136/gutjnl-2017-314472.265

DOI: 10.1136/gutjnl-2017-314472.265

INFLUENCE OF IRON ON GUT MICROBIAL COMPOSITION IN ACUTE DSS-INDUCED COLITIS IN C57BL/6 MICE (Conference Paper)

Mahalhal, A., Campbell, B., Pritchard, D. M., & Probert, C. (2017). INFLUENCE OF IRON ON GUT MICROBIAL COMPOSITION IN ACUTE DSS-INDUCED COLITIS IN C57BL/6 MICE. In GUT Vol. 66 (pp. A234). doi:10.1136/gutjnl-2017-314472.456

DOI: 10.1136/gutjnl-2017-314472.456

LONGITUDINAL INVESTIGATION OF MICROBIOTA DYNAMICS IN A MODEL OF MILD CHRONIC DSSINDUCED COLITIS IN WILD-TYPE (WT) C57BL/6 MICE RECEIVING DIETS WITH DIFFERENT IRON CONTENTS (Conference Paper)

Mahalhal, A., Campbell, B., Pritchard, D. M., & Probert, C. (2017). LONGITUDINAL INVESTIGATION OF MICROBIOTA DYNAMICS IN A MODEL OF MILD CHRONIC DSSINDUCED COLITIS IN WILD-TYPE (WT) C57BL/6 MICE RECEIVING DIETS WITH DIFFERENT IRON CONTENTS. In GUT Vol. 66 (pp. A237). doi:10.1136/gutjnl-2017-314472.463

DOI: 10.1136/gutjnl-2017-314472.463

Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (Journal article)

Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., & Pritchard, D. M. (2017). Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration. CELL DEATH & DISEASE, 8. doi:10.1038/cddis.2017.332

DOI: 10.1038/cddis.2017.332

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury (Journal article)

Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. doi:10.1016/j.pharmthera.2017.01.002

DOI: 10.1016/j.pharmthera.2017.01.002

Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in Patients with Autoimmune Chronic Atrophic Gastritis (Conference Paper)

Boyce, M., Moore, A. R., Parsons, B. N., Lloyd, K. A., Sagatun, L., Thomsen, L., . . . Pritchard, D. M. (2016). Netazepide, a Gastrin/CCK2 Receptor Antagonist, Can Eradicate Gastric Neuroendocrine Tumours in Patients with Autoimmune Chronic Atrophic Gastritis. In NEUROENDOCRINOLOGY Vol. 103 (pp. 78). Retrieved from http://gateway.webofknowledge.com/

Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter fells Infected INS-Gas Mice (Journal article)

Lemos, L. M. S., Miyajima, F., Castilho, G. R. C., Martins, D. T. O., Pritchard, D. M., & Burkitt, M. D. (2017). Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter fells Infected INS-Gas Mice. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00092

DOI: 10.3389/fphar.2017.00092

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models (Journal article)

Burkitt, M. D., Duckworth, C. A., Williams, J. M., & Pritchard, D. M. (2017). Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. DISEASE MODELS & MECHANISMS, 10(2), 89-104. doi:10.1242/dmm.027649

DOI: 10.1242/dmm.027649

Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation? (Journal article)

Myint, A. S., Smith, F. M., Gollins, S. W., Wong, H., Rao, C., Whitmarsh, K., . . . Pritchard, D. M. (2017). Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation?. BRITISH JOURNAL OF RADIOLOGY, 90(1080). doi:10.1259/bjr.20170175

DOI: 10.1259/bjr.20170175

2016

Potential clinical indications for a CCK2 receptor antagonist. (Journal article)

Boyce, M., Lloyd, K. A., & Pritchard, D. M. (2016). Potential clinical indications for a CCK2 receptor antagonist. CURRENT OPINION IN PHARMACOLOGY, 31, 68-75. doi:10.1016/j.coph.2016.09.002

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies. (Journal article)

Calvete, O., Varro, A., Pritchard, D. M., Barroso, A., Oteo, M., Morcillo, M., . . . Benitez, J. (2016). A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.. Disease models & mechanisms, 9(9), 975-984. doi:10.1242/dmm.025890

DOI: 10.1242/dmm.025890

Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1) (Journal article)

Lloyd, K. A., Moore, A. R., Parsons, B. N., O'Hara, A., Boyce, M., Dockray, G. J., . . . Pritchard, D. M. (2016). Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1). ONCOTARGET, 7(29), 45462-45478. doi:10.18632/oncotarget.9990

DOI: 10.18632/oncotarget.9990

Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis (Journal article)

Merga, Y. J., O Hara, A., Burkitt, M. D., Duckworth, C. A., Probert, C. S., Campbell, B. J., & Pritchard, D. M. (2016). Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 310(11), G1081-G1090. doi:10.1152/ajpgi.00026.2016

DOI: 10.1152/ajpgi.00026.2016

Intestinal Preparation Techniques for Histological Analysis in the Mouse. (Journal article)

Williams, J. M., Duckworth, C. A., Vowell, K., Burkitt, M. D., & Pritchard, D. M. (2016). Intestinal Preparation Techniques for Histological Analysis in the Mouse.. Current protocols in mouse biology, 6(2), 148-168. doi:10.1002/cpmo.2

DOI: 10.1002/cpmo.2

Letter: gastric cancer and pernicious anaemia - only a minority of UK pernicious anaemia patients have had a gastroscopy (Journal article)

Pritchard, D. M., & Hooper, M. (2016). Letter: gastric cancer and pernicious anaemia - only a minority of UK pernicious anaemia patients have had a gastroscopy. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 43(10), 1106-1107. doi:10.1111/apt.13595

DOI: 10.1111/apt.13595

2015

The stomach in health and disease (Journal article)

Hunt, R. H., Camilleri, M., Crowe, S. E., El-Omar, E. M., Fox, J. G., Kuipers, E. J., . . . Tack, J. (2015). The stomach in health and disease. GUT, 64(10), 1650-1668. doi:10.1136/gutjnl-2014-307595

DOI: 10.1136/gutjnl-2014-307595

Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population (Journal article)

Geraghty, J., Thumbs, A., Kankwatira, A., Andrews, T., Moore, A., Malamba, R., . . . Gordon, M. (2015). Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population. PloS One, 10(8). doi:10.1371/journal.pone.0132043

DOI: 10.1371/journal.pone.0132043

PAK1 modulates a PPAR gamma/NF-kappa B cascade in intestinal inflammation (Conference Paper)

Dammann, K., Khare, V., Lang, M., Claudel, T., Harpain, F., Granofszky, N., . . . Gasche, C. (2015). PAK1 modulates a PPAR gamma/NF-kappa B cascade in intestinal inflammation. In CANCER RESEARCH Vol. 75. doi:10.1158/1538-7445.AM2015-137

DOI: 10.1158/1538-7445.AM2015-137

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis (Journal article)

Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409

DOI: 10.18632/oncotarget.4409

VOLATILE ORGANIC COMPOUND (VOC) PROFILES AS INDICATORS OF EARLY LESIONS IN MURINE COLON CARCINOGENESIS (Conference Paper)

Reade, S., Williams, J. M., Pritchard, D. M., & Probert, C. S. J. (2015). VOLATILE ORGANIC COMPOUND (VOC) PROFILES AS INDICATORS OF EARLY LESIONS IN MURINE COLON CARCINOGENESIS. In GUT Vol. 64 (pp. A374-A375). doi:10.1136/gutjnl-2015-309861.819

DOI: 10.1136/gutjnl-2015-309861.819

Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour (Journal article)

Calvete, O., Reyes, J., Zuniga, S., Paumard-Hernandez, B., Fernandez, V., Bujanda, L., . . . Benitez, J. (2015). Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour. Human Molecular Genetics, 24(10), 2914-2922. doi:10.1093/hmg/ddv054

DOI: 10.1093/hmg/ddv054

A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and Helicobacter pylori IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort (Conference Paper)

Moore, A. R., Steele, I., Murugesan, S. V., Tiszlavicz, L., Dockray, G. J., Varro, A., & Pritchard, D. M. (2015). A Combination of Fasting Serum Gastrin Concentration, Pepsinogen 1/2 Ratio and Helicobacter pylori IgG Antibody Serotype Accurately Predicts Gastric Mucosal Preneoplasia in a Large European Cohort. In GASTROENTEROLOGY Vol. 148 (pp. S54). Retrieved from http://gateway.webofknowledge.com/

Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis (Conference Paper)

Bharucha, S., Geraghty, J., Duckworth, C. A., Armstrong, J., Szatmary, P., Winn, S. A., . . . Sutton, R. (2015). Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis. In GASTROENTEROLOGY Vol. 148 (pp. S145). Retrieved from http://gateway.webofknowledge.com/

Gastrin Increases miR-222 Expression in AGS(GR) Cells In Vitro and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans In Vivo via Activation of the CCK2 Receptor (Conference Paper)

Lloyd, K. A., Moore, A. R., O'Hara, A., Boyce, M. J., Varro, A., & Pritchard, D. M. (2015). Gastrin Increases miR-222 Expression in AGS(GR) Cells In Vitro and in the Stomachs of Hypergastrinemic INS-GAS Mice and Humans In Vivo via Activation of the CCK2 Receptor. In GASTROENTEROLOGY Vol. 148 (pp. S341). Retrieved from http://gateway.webofknowledge.com/

Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System (Conference Paper)

Burkitt, M. D., Jones, L. G., Caamano, J., Pritchard, D. M., & Duckworth, C. A. (2015). Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System. In GASTROENTEROLOGY Vol. 148 (pp. S8-S9). Retrieved from http://gateway.webofknowledge.com/

NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1 beta Secretion in Bone Marrow Derived Dendritic Cells (Conference Paper)

Tang, J. M., Duckworth, C. A., Pritchard, D. M., Caamano, J., & Burkitt, M. D. (2015). NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1 beta Secretion in Bone Marrow Derived Dendritic Cells. In GASTROENTEROLOGY Vol. 148 (pp. S118). Retrieved from http://gateway.webofknowledge.com/

Passive Transmission of Helicobacter felis Occurs in a Specific Pathogen Free (SPF) Laboratory Environment (Conference Paper)

Tang, J. M., Parsons, B. N., Williams, J. M., Pritchard, D. M., & Burkitt, M. D. (2015). Passive Transmission of Helicobacter felis Occurs in a Specific Pathogen Free (SPF) Laboratory Environment. In GASTROENTEROLOGY Vol. 148 (pp. S553). Retrieved from http://gateway.webofknowledge.com/

Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Conference Paper)

O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from http://gateway.webofknowledge.com/

Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-kappa B Subunit NFKB1 (Conference Paper)

Williams, J. M., Norman, R., Tang, J. M., Caamano, J., Duckworth, C. A., Pritchard, D. M., & Burkitt, M. D. (2015). Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-kappa B Subunit NFKB1. In GASTROENTEROLOGY Vol. 148 (pp. S565). Retrieved from http://gateway.webofknowledge.com/

Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip (Journal article)

Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., & Pritchard, D. M. (2015). Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip. VETERINARY PATHOLOGY, 52(3), 445-455. doi:10.1177/0300985814559404

DOI: 10.1177/0300985814559404

Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration (Journal article)

Kumar, J. D., Steele, I., Moore, A. R., Murugesan, S. V., Rakonczay, Z., Venglovecz, V., . . . Dockray, G. J. (2015). Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(2), G78-G86. doi:10.1152/ajpgi.00084.2015

DOI: 10.1152/ajpgi.00084.2015

Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer. (Journal article)

Duckworth, C. A., Burkitt, M. D., Williams, J. M., Parsons, B. N., Tang, J. M. F., & Pritchard, D. M. (2015). Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.. Current protocols in pharmacology, 69, 14.34.1-14.34.35. doi:10.1002/0471141755.ph1434s69

DOI: 10.1002/0471141755.ph1434s69

NF-B1, NF-B2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice (Journal article)

Burkitt, M. D., Hanedi, A. F., Duckworth, C. A., Williams, J. M., Tang, J. M., O'Reilly, L. A., . . . Pritchard, D. M. (2015). NF-B1, NF-B2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. JOURNAL OF PATHOLOGY, 236(3), 326-336. doi:10.1002/path.4527

DOI: 10.1002/path.4527

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice (Journal article)

Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., Williams, J. M., O'Reilly, L. A., & Pritchard, D. M. (2015). bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(6), G420-G430. doi:10.1152/ajpgi.00404.2014

DOI: 10.1152/ajpgi.00404.2014

2014

Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1 (Journal article)

Zhao, Q., Duckworth, C. A., Wang, W. K., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1. Carcinogenesis, 35(12), 2815-2821. doi:10.1093/carcin/bgu216

DOI: 10.1093/carcin/bgu216

Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance (Journal article)

Rasheed, F., Campbell, B. J., Alfizah, H., Varro, A., Zahra, R., Yamaoka, Y., & Pritchard, D. M. (2014). Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance. HELICOBACTER, 19(5), 387-399. doi:10.1111/hel.12142

DOI: 10.1111/hel.12142

Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis (Journal article)

Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2014). Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. BRITISH JOURNAL OF CANCER, 110(3), 741-752. doi:10.1038/bjc.2013.793

DOI: 10.1038/bjc.2013.793

Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality (Journal article)

Dobson, R., Burgess, M. I., Valle, J. W., Pritchard, D. M., Vora, J., Wong, C., . . . Cuthbertson, D. J. (2014). Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality. BRITISH JOURNAL OF CANCER, 111(9), 1703-1709. doi:10.1038/bjc.2014.468

DOI: 10.1038/bjc.2014.468

The clinical presentation and management of carcinoid heart disease (Journal article)

Dobson, R., Burgess, M. I., Pritchard, D. M., & Cuthbertson, D. J. (2014). The clinical presentation and management of carcinoid heart disease. INTERNATIONAL JOURNAL OF CARDIOLOGY, 173(1), 29-32. doi:10.1016/j.ijcard.2014.02.037

DOI: 10.1016/j.ijcard.2014.02.037

2013

The role of plasminogen activator inhibitor-1 in gastric mucosal protection (Journal article)

Kenny, S., Steele, I., Lyons, S., Moore, A. R., Murugesan, S. V., Tiszlavicz, L., . . . Dockray, G. J. (2013). The role of plasminogen activator inhibitor-1 in gastric mucosal protection. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 304(9), G814-G822. doi:10.1152/ajpgi.00017.2013

DOI: 10.1152/ajpgi.00017.2013

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide (Journal article)

Williams, J. M., Duckworth, C. A., Watson, A. J. M., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. DISEASE MODELS & MECHANISMS, 6(6), 1388-1399. doi:10.1242/dmm.013284

DOI: 10.1242/dmm.013284

CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease (Journal article)

Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215

DOI: 10.1038/clpt.2012.215

Correction: Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis. (Journal article)

Moore, A. R., Boyce, M., Steele, I. A., Campbell, F., Varro, A., & Pritchard, D. M. (2013). Correction: Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis.. PloS one, 8(11). doi:10.1371/annotation/4afd48b1-8dc0-47cc-9c8a-99aba7623116

DOI: 10.1371/annotation/4afd48b1-8dc0-47cc-9c8a-99aba7623116

Effects of EGFR Inhibitor on Helicobacter pylori Induced Gastric Epithelial Pathology in Vivo. (Journal article)

Crabtree, J. E., Jeremy, A. H. T., Duval, C., Dixon, M. F., Danjo, K., Carr, I. M., . . . Robinson, P. A. (2013). Effects of EGFR Inhibitor on Helicobacter pylori Induced Gastric Epithelial Pathology in Vivo.. Pathogens (Basel, Switzerland), 2(4), 571-590. doi:10.3390/pathogens2040571

DOI: 10.3390/pathogens2040571

Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium (Journal article)

Chen, C., Duckworth, C. A., Zhao, Q., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2013). Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium. CLINICAL CANCER RESEARCH, 19(7), 1693-1704. doi:10.1158/1078-0432.CCR-12-2940

DOI: 10.1158/1078-0432.CCR-12-2940

Near-field optical microscopy with an infra-red free electron laser applied to cancer diagnosis (Journal article)

Smith, A. D., Siggel-King, M. R. F., Holder, G. M., Cricenti, A., Luce, M., Harrison, P., . . . Weightman, P. (2013). Near-field optical microscopy with an infra-red free electron laser applied to cancer diagnosis. APPLIED PHYSICS LETTERS, 102(5). doi:10.1063/1.4790436

DOI: 10.1063/1.4790436

Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis (Journal article)

Moore, A. R., Boyce, M., Steele, I. A., Campbell, F., Varro, A., & Pritchard, D. M. (2013). Netazepide, a Gastrin Receptor Antagonist, Normalises Tumour Biomarkers and Causes Regression of Type 1 Gastric Neuroendocrine Tumours in a Nonrandomised Trial of Patients with Chronic Atrophic Gastritis. PLOS ONE, 8(10). doi:10.1371/journal.pone.0076462

DOI: 10.1371/journal.pone.0076462

Peptide receptor radionuclide therapy with Y-90-DOTATATE/Y-90-DOTATOC in patients with progressive metastatic neuroendocrine tumours: assessment of response, survival and toxicity (Journal article)

Vinjamuri, S., Gilbert, T. M., Banks, M., McKane, G., Maltby, P., Poston, G., . . . Cuthbertson, D. J. (2013). Peptide receptor radionuclide therapy with Y-90-DOTATATE/Y-90-DOTATOC in patients with progressive metastatic neuroendocrine tumours: assessment of response, survival and toxicity. BRITISH JOURNAL OF CANCER, 108(7), 1440-1448. doi:10.1038/bjc.2013.103

DOI: 10.1038/bjc.2013.103

Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice (Journal article)

Duckworth, C. A., Clyde, D., Worthley, D. L., Wang, T. C., Varro, A., & Pritchard, D. M. (2013). Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice. GASTROENTEROLOGY, 145(1), 197-+. doi:10.1053/j.gastro.2013.03.012

DOI: 10.1053/j.gastro.2013.03.012

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC) (Journal article)

Hammoudi, A., Song, F., Reed, K. R., Jenkins, R. E., Meniel, V. S., Watson, A. J. M., . . . Jenkins, J. R. (2013). Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 440(3), 364-370. doi:10.1016/j.bbrc.2013.08.076

DOI: 10.1016/j.bbrc.2013.08.076

Signaling mediated by the NF-kappa B sub-units NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice (Journal article)

Burkitt, M. D., Williams, J. M., Duckworth, C. A., O'Hara, A., Hanedi, A., Varro, A., . . . Pritchard, D. M. (2013). Signaling mediated by the NF-kappa B sub-units NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. ONCOGENE, 32(50), 5563-5573. doi:10.1038/onc.2013.334

DOI: 10.1038/onc.2013.334

The Association of a Panel of Biomarkers with the Presence and Severity of Carcinoid Heart Disease: A Cross-Sectional Study (Journal article)

Dobson, R., Burgess, M. I., Banks, M., Pritchard, D. M., Vora, J., Valle, J. W., . . . Cuthbertson, D. J. (2013). The Association of a Panel of Biomarkers with the Presence and Severity of Carcinoid Heart Disease: A Cross-Sectional Study. PLOS ONE, 8(9). doi:10.1371/journal.pone.0073679

DOI: 10.1371/journal.pone.0073679

2012

Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply (Journal article)

Musumba, C., Hopkins, M., Pritchard, D. M., & Pirmohamed, M. (2012). Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(6), 601-602. doi:10.1111/apt.12001

DOI: 10.1111/apt.12001

Commentary: changing aetiology of peptic ulcers - author's reply (Journal article)

Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2012). Commentary: changing aetiology of peptic ulcers - author's reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(3), 292-293. doi:10.1111/j.1365-2036.2012.05176.x

DOI: 10.1111/j.1365-2036.2012.05176.x

Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity (vol 103, pg 19, 1998) (Journal article)

Pritchard, D. M., Jackman, A., Potten, C. S., & Hickman, J. A. (2012). Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity (vol 103, pg 19, 1998). TOXICOLOGY LETTERS, 208(1), 75. doi:10.1016/j.toxlet.2011.10.009

DOI: 10.1016/j.toxlet.2011.10.009

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation (Journal article)

Radulescu, S., Ridgway, R. A., Cordero, J., Athineos, D., Salgueiro, P., Poulsom, R., . . . Sansom, O. J. (2013). Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. ONCOGENE, 32(16), 2048-2057. doi:10.1038/onc.2012.224

DOI: 10.1038/onc.2012.224

CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach (Journal article)

Duckworth, C. A., Clyde, D., & Pritchard, D. M. (2012). CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 303(8), G915-G926. doi:10.1152/ajpgi.00068.2012

DOI: 10.1152/ajpgi.00068.2012

CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE (Journal article)

Musumba, C. O., Eker, D. V., Jorgensen, A., Pritchard, D. M., & Pirmohamed, M. (2012). CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE. GUT, 61, A363. doi:10.1136/gutjnl-2012-302514d.165

DOI: 10.1136/gutjnl-2012-302514d.165

Correlation between a short-term intravenous octreotide suppression test and response to antrectomy in patients with type-1 gastric neuroendocrine tumours (Journal article)

Murugesan, S. V., Steele, I. A., Dimaline, R., Poston, G. J., Shrotri, M., Campbell, F., . . . Pritchard, D. M. (2013). Correlation between a short-term intravenous octreotide suppression test and response to antrectomy in patients with type-1 gastric neuroendocrine tumours. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 25(4), 474-481. doi:10.1097/MEG.0b013e32835cec52

DOI: 10.1097/MEG.0b013e32835cec52

Gastric Helicobacter Infection Induces Iron Deficiency in the INS-GAS Mouse (Journal article)

Thomson, M. J., Pritchard, D. M., Boxall, S. A., Abuderman, A. A., Williams, J. M., Varro, A., & Crabtree, J. E. (2012). Gastric Helicobacter Infection Induces Iron Deficiency in the INS-GAS Mouse. PLOS ONE, 7(11). doi:10.1371/journal.pone.0050194

DOI: 10.1371/journal.pone.0050194

Gastrin receptor pharmacology. (Journal article)

Dockray, G. J., Moore, A., Varro, A., & Pritchard, D. M. (2012). Gastrin receptor pharmacology.. Current gastroenterology reports, 14(6), 453-459. doi:10.1007/s11894-012-0293-1

DOI: 10.1007/s11894-012-0293-1

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease (Journal article)

Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., . . . Watson, A. J. M. (2012). Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut, 61(8), 1146-1153. doi:10.1136/gutjnl-2011-300695

DOI: 10.1136/gutjnl-2011-300695

The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010 (Journal article)

Musumba, C., Jorgensen, A., Sutton, L., Van Eker, D., Moorcroft, J., Hopkins, M., . . . Pirmohamed, M. (2012). The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(1), 48-56. doi:10.1111/j.1365-2036.2012.05118.x

DOI: 10.1111/j.1365-2036.2012.05118.x

2011

Bak deficiency alters gastric epithelial homeostasis and modulates the consequences of Helicobacter felis infection in vivo (Journal article)

Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., & Pritchard, D. M. (2011). Bak deficiency alters gastric epithelial homeostasis and modulates the consequences of Helicobacter felis infection in vivo. Gastroenterology, 140(5), S824.

Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells (Journal article)

Norsett, K. G., Steele, I., Duval, C., Sammut, S. J., Murugesan, S. V. M., Kenny, S., . . . Varro, A. (2011). Gastrin stimulates expression of plasminogen activator inhibitor-1 in gastric epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 301(3), G446-G453. doi:10.1152/ajpgi.00527.2010

DOI: 10.1152/ajpgi.00527.2010

IFN-gamma Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis (Journal article)

Tu, S. P., Quante, M., Bhagat, G., Takaishi, S., Cui, G., Yang, X. D., . . . Wang, T. C. (2011). IFN-gamma Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis. CANCER RESEARCH, 71(12), 4247-4259. doi:10.1158/0008-5472.CAN-10-4009

DOI: 10.1158/0008-5472.CAN-10-4009

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease (Journal article)

Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., . . . Watson, A. J. M. (2012). Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. GUT, 61(8), 1146-1153. doi:10.1136/gutjnl-2011-300695

DOI: 10.1136/gutjnl-2011-300695

Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active in Vivo (Journal article)

Patel, O., Clyde, D., Chang, M., Nordlund, M. S., Steel, R., Kemp, B. E., . . . Baldwin, G. S. (2012). Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active in Vivo. ENDOCRINOLOGY, 153(3), 1082-1092. doi:10.1210/en.2011-1875

DOI: 10.1210/en.2011-1875

Zollinger-Ellison Syndrome: Still a Diagnostic Challenge in the 21st Century? (Journal article)

Pritchard, D. M. (2011). Zollinger-Ellison Syndrome: Still a Diagnostic Challenge in the 21st Century?. GASTROENTEROLOGY, 140(5), 1380-1383. doi:10.1053/j.gastro.2011.03.026

DOI: 10.1053/j.gastro.2011.03.026

2010

Gastrin regulates the urokinase plasminogen activator system (Journal article)

Norsett, K. G., Steele, I., Rainbow, L., Murugesam, S. V. M., Duval, C., Kenny, S., . . . Varro, A. (2010). Gastrin regulates the urokinase plasminogen activator system. REGULATORY PEPTIDES, 164(1), 29. doi:10.1016/j.regpep.2010.07.067

DOI: 10.1016/j.regpep.2010.07.067

Conditional Deletion of I kappa B-Kinase-beta Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia (Journal article)

Shibata, W., Takaishi, S., Muthupalani, S., Pritchard, D. M., Whary, M. T., Rogers, A. B., . . . Wang, T. C. (2010). Conditional Deletion of I kappa B-Kinase-beta Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia. GASTROENTEROLOGY, 138(3), 1022-U295. doi:10.1053/j.gastro.2009.11.054

DOI: 10.1053/j.gastro.2009.11.054

The management of gastric polyps (Journal article)

Goddard, A. F., Badreldin, R., Pritchard, D. M., Walker, M. M., Warren, B., & Gastroenterology, B. S. (2010). The management of gastric polyps. GUT, 59(9), 1270-1276. doi:10.1136/gut.2009.182089

DOI: 10.1136/gut.2009.182089

2009

Importance of gastrin in the pathogenesis and treatment of gastric tumors (Journal article)

Burkitt, M. D., Varro, A., & Pritchard, D. M. (2009). Importance of gastrin in the pathogenesis and treatment of gastric tumors. WORLD JOURNAL OF GASTROENTEROLOGY, 15(1), 1-16. doi:10.3748/wjg.15.1

DOI: 10.3748/wjg.15.1

Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice (Journal article)

Jin, G., Ramanathan, V., Quante, M., Baik, G. H., Yang, X., Wang, S. S. W., . . . Wang, T. C. (2009). Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. JOURNAL OF CLINICAL INVESTIGATION, 119(9), 2691-2701. doi:10.1172/JCI38918

DOI: 10.1172/JCI38918

KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract (Journal article)

Zheng, H., Pritchard, D. M., Yang, X., Bennett, E., Liu, G., Liu, C., & Ai, W. (2009). KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 296(3), G490-G498. doi:10.1152/ajpgi.90393.2008

DOI: 10.1152/ajpgi.90393.2008

Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers (Journal article)

Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2009). Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 30(6), 517-531. doi:10.1111/j.1365-2036.2009.04086.x

DOI: 10.1111/j.1365-2036.2009.04086.x

Review article: strategies to determine whether hypergastrinaemia is due to Zollinger-Ellison syndrome rather than a more common benign cause (Journal article)

Murugesan, S. V. M., Varro, A., & Pritchard, D. M. (2009). Review article: strategies to determine whether hypergastrinaemia is due to Zollinger-Ellison syndrome rather than a more common benign cause. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 29(10), 1055-1068. doi:10.1111/j.1365-2036.2009.03976.x

DOI: 10.1111/j.1365-2036.2009.03976.x

Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of Bak-Null Mice (Journal article)

Duckworth, C. A., & Pritchard, D. M. (2009). Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of Bak-Null Mice. GASTROENTEROLOGY, 136(3), 943-952. doi:10.1053/j.gastro.2008.11.036

DOI: 10.1053/j.gastro.2008.11.036

2008

Hypergastrinemia increases gastric epithelial susceptibility to apoptosis (Journal article)

Przemeck, S. M. C., Varro, A., Berry, D., Steele, I., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2008). Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. Regulatory Peptides, 146(1-3), 147-156. doi:10.1016/j.regpep.2007.09.002

DOI: 10.1016/j.regpep.2007.09.002

Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection (Journal article)

Bodger, K., Ahmed, S., Pazmany, L., Pritchard, D. M., Micheal, A., Khan, A. L., . . . Varro, A. (n.d.). Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection. Journal of Clinical Pathology, 61(1), 72-78. doi:10.1136/jcp.2007.048058

DOI: 10.1136/jcp.2007.048058

Assessment of the efficacy and toxicity of I-131-metaiodobenzylguanidine therapy for metastatic neuroendocrine tumours (Journal article)

Nwosu, A. C., Jones, L., Vora, J., Poston, G. J., Vinjamuri, S., & Pritchard, D. M. (2008). Assessment of the efficacy and toxicity of I-131-metaiodobenzylguanidine therapy for metastatic neuroendocrine tumours. BRITISH JOURNAL OF CANCER, 98(6), 1053-1058. doi:10.1038/sj.bjc.6604273

DOI: 10.1038/sj.bjc.6604273

Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor (Journal article)

Pritchard, D. M., Berry, D., Przemeck, S. M. C., Campbell, F., Edwards, S. W., & Varro, A. (2008). Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 295(4), G798-G805. doi:10.1152/ajpgi.00015.2008

DOI: 10.1152/ajpgi.00015.2008

Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells (Journal article)

Kenny, S., Duval, C., Sammut, S. J., Steele, I., Pritchard, D. M., Atherton, J. C., . . . Varro, A. (2008). Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 295(3), G431-G441. doi:10.1152/ajpgi.90283.2008

DOI: 10.1152/ajpgi.90283.2008

2007

Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling (Journal article)

Varro, A., Kenny, S., Hemers, E., McCaig, C., Przemeck, S., Wang, T. C., . . . Pritchard, D. M. (2007). Increased gastric expression of MMP-7 in hypergastrinemia and significance for epithelial-mesenchymal signaling. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 292(4), G1133-G1140. doi:10.1152/ajpgi.00526.2006

DOI: 10.1152/ajpgi.00526.2006

Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection (Journal article)

Bodger, K., Ahmed, S., Pazmany, L., Pritchard, D. M., Micheal, A., Khan, A. L., . . . Varro, A. (2008). Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection. JOURNAL OF CLINICAL PATHOLOGY, 61(1), 72-78. doi:10.1136/jcp.2007.048058

DOI: 10.1136/jcp.2007.048058

Bak-null mice demonstrate suppression of epithelial apoptosis, crypt hyperplasia and altered differentiation in the colon, and are more susceptible to colonic carcinogenesis (Journal article)

Duckworth, C. A., & Pritchard, D. M. (2007). Bak-null mice demonstrate suppression of epithelial apoptosis, crypt hyperplasia and altered differentiation in the colon, and are more susceptible to colonic carcinogenesis. Gastroenterology, 132(4), A154.

Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements (Journal article)

Steele, I. A., Dimaline, R., Pritchard, D. M., Jr, P. R. M., Wang, T. C., Dockray, G. J., & Varro, A. (2007). Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 293(1), G347-G354. doi:10.1152/ajpgi.00076.2007

DOI: 10.1152/ajpgi.00076.2007

Hypergastrinemia increases gastric epithelial susceptibility to apoptosis (Journal article)

Przemeck, S. M. C., Varro, A., Berry, D., Steele, I., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2008). Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. REGULATORY PEPTIDES, 146(1-3), 147-156. doi:10.1016/j.regpep.2007.09.002

DOI: 10.1016/j.regpep.2007.09.002

Pathogenesis of gastrinomas associated with multiple endocrine neoplasia type 1 (Journal article)

Pritchard, D. M. (2007). Pathogenesis of gastrinomas associated with multiple endocrine neoplasia type 1. GUT, 56(5), 606-607. doi:10.1136/gut.2006.113985

DOI: 10.1136/gut.2006.113985

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2 (Journal article)

Przemeck, S. M. C., Duckworth, C. A., & Pritchard, D. M. (2007). Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 292(2), G620-G627. doi:10.1152/ajpgi.00391.2006

DOI: 10.1152/ajpgi.00391.2006

2006

Review article: pathogenesis and management of gastric carcinoid tumours (Journal article)

Burkitt, M. D., & Pritchard, D. M. (2006). Review article: pathogenesis and management of gastric carcinoid tumours. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 24(9), 1305-1320. doi:10.1111/j.1365-2036.2006.03130.x

DOI: 10.1111/j.1365-2036.2006.03130.x

The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori (Journal article)

McCaig, C., Duval, C., Hemers, E., Steele, I., Pritchard, D. M., Przemeck, S., . . . Varro, A. (2006). The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. GASTROENTEROLOGY, 130(6), 1754-1763. doi:10.1053/j.gastro.2006.02.031

DOI: 10.1053/j.gastro.2006.02.031

Gastrin increases MCL-1 expression in AGS(GR) gastric epithelial cells to cause supression of apoptosis (Conference Paper)

Przemeck, S., Varro, A., & Pritchard, D. M. (2006). Gastrin increases MCL-1 expression in AGS(GR) gastric epithelial cells to cause supression of apoptosis. In GUT Vol. 55 (pp. A27). Retrieved from http://gateway.webofknowledge.com/

Gastrin increases murine intestinal crypt regeneration following injury (Journal article)

Ottewell, P. D., Duckworth, C. A., Varro, A., Dimaline, R., Wang, T. C., Watson, A. J. M., . . . Pritchard, D. M. (2006). Gastrin increases murine intestinal crypt regeneration following injury. GASTROENTEROLOGY, 130(4), 1169-1180. doi:10.1053/j.gastro.2005.12.033

DOI: 10.1053/j.gastro.2005.12.033

The role of matrix metalloprotease-7 in redefining the gastric micro-environment in response to gastrin and H pylori (Conference Paper)

Varro, A., Pritchard, D. M., McCaig, C., Duval, C., Campbell, F., Ahmed, S., . . . Kerrigan, D. D. (2006). The role of matrix metalloprotease-7 in redefining the gastric micro-environment in response to gastrin and H pylori. In GUT Vol. 55 (pp. A114). Retrieved from http://gateway.webofknowledge.com/

Characterization of epithelial cell shedding from human small intestine (Journal article)

Bullen, T. F., Forrest, S., Campbell, F., Dodson, A. R., Hershman, M. J., Pritchard, D. M., . . . Watson, A. J. M. (2006). Characterization of epithelial cell shedding from human small intestine. LABORATORY INVESTIGATION, 86(10), 1052-1063. doi:10.1038/labinvest.3700464

DOI: 10.1038/labinvest.3700464

Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo (Journal article)

Przemeck, S., Duckworth, C. A., Varro, A., Pritchard, D., & Pritchard, M. (2006). Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo. Gut, 55, A61.

Gastrin-induced apoptosis contributes to carcinogenesis in the stomach (Journal article)

Cui, G., Takaishi, S., Ai, W., Betz, K. S., Florholmen, J., Koh, T. J., . . . Wang, T. C. (2006). Gastrin-induced apoptosis contributes to carcinogenesis in the stomach. LABORATORY INVESTIGATION, 86(10), 1037-1051. doi:10.1038/labinvest.3700462

DOI: 10.1038/labinvest.3700462

Helicobacter pylori and gastric cancer (Journal article)

Pritchard, D. M., & Crabtree, J. E. (2006). Helicobacter pylori and gastric cancer. CURRENT OPINION IN GASTROENTEROLOGY, 22(6), 620-625. doi:10.1097/01.mog.0000245539.50765.f6

DOI: 10.1097/01.mog.0000245539.50765.f6

Suppression of colonic epithelial apoptosis and crypt hyperplasia occurs in bak-null mice (Journal article)

Duckworth, C. A., & Pritchard, D. M. (2006). Suppression of colonic epithelial apoptosis and crypt hyperplasia occurs in bak-null mice. GUT, 55, A9. Retrieved from http://gateway.webofknowledge.com/

2005

COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo (Journal article)

Ottewell, P. D., Varro, A., Dockray, G. J., Kirton, C. M., Watson, A. J. M., Wang, T. C., . . . Pritchard, D. M. (2005). COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 288(3), G541-G549. doi:10.1152/ajpgi.00268.2004

DOI: 10.1152/ajpgi.00268.2004

Gastrin induces MDM-2 and suppresses p53 expression in AGS(GR) cells, resulting in resistance to DNA damage induced apoptosis (Journal article)

Przemeck, S. M. C., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Gastrin induces MDM-2 and suppresses p53 expression in AGS(GR) cells, resulting in resistance to DNA damage induced apoptosis. GUT, 54, A87-A88. Retrieved from http://gateway.webofknowledge.com/

Gastrin induces mdm-2 and suppresses p53 protein expression in Ags-GR cells, resulting in resistance to DNA damage induced apoptosis (Journal article)

Przemeck, S. M., Watson, A. J., Varro, A., & Pritichard, D. M. (2005). Gastrin induces mdm-2 and suppresses p53 protein expression in Ags-GR cells, resulting in resistance to DNA damage induced apoptosis. Gastroenterology, 128(4 Supp), A-141.

Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice. (Journal article)

Duckworth, C. A., Ottewell, P. D., Varro, A., Dimaline, R., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. Gastroenterology, 128(4), A203.

Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice (Journal article)

Duckworth, C. A., Ottewell, P. D., Dimaline, R., Varro, A., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, 54, A98. Retrieved from http://gateway.webofknowledge.com/

Models of gastric cancer (Journal article)

Pritchard, D. M. (2005). Models of gastric cancer. Drug Discovery Today: Disease Models, 2(1), 21-26. doi:10.1016/j.ddmod.2005.05.001

DOI: 10.1016/j.ddmod.2005.05.001

Radiation induces gastrin-CCKB receptor expression in IEC-6 and IEC-18 intestinal epithelial cells (Journal article)

Ottewell, P. D., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Radiation induces gastrin-CCKB receptor expression in IEC-6 and IEC-18 intestinal epithelial cells. GUT, 54, A88. Retrieved from http://gateway.webofknowledge.com/

Radiation induces p53 dependent apoptosis in the proliferative zone of mouse gastric epithelium (Journal article)

Przemeck, S. M. C., Ottewell, P. D., Watson, A. J. M., & Pritchard, D. M. (2005). Radiation induces p53 dependent apoptosis in the proliferative zone of mouse gastric epithelium. GUT, 54, A88. Retrieved from http://gateway.webofknowledge.com/

Shedding of human intestinal epithelial cells results in gaps in the epithelial monolayer (Journal article)

Bullen, T. F., Campbell, F., Pritchard, D. M., Hershman, M. J., & Watson, A. J. M. (2005). Shedding of human intestinal epithelial cells results in gaps in the epithelial monolayer. GUT, 54, A25. Retrieved from http://gateway.webofknowledge.com/

Th1 cytokines, but not gastrin increase Helicobacter pylori induced apoptosis in short term primary cultures of murine gastric glands (Journal article)

Przemeck, M. C., Watson, A. J., Varro, A., & Pritchard, D. M. (2005). Th1 cytokines, but not gastrin increase Helicobacter pylori induced apoptosis in short term primary cultures of murine gastric glands. GUT, 54, A61. Retrieved from http://gateway.webofknowledge.com/

2004

New role for gastrin in regulating epithelial-mesenchymal signalling via MMP-7 in gastric carcinoid tumours (Conference Paper)

Hemers, E., Pritchard, D. M., Campbell, F., Ahmed, S., Bodger, K., Kerrigan, D. D., . . . Varro, A. (2004). New role for gastrin in regulating epithelial-mesenchymal signalling via MMP-7 in gastric carcinoid tumours. In REGULATORY PEPTIDES Vol. 122 (pp. 45). Retrieved from http://gateway.webofknowledge.com/

MMP-7 acts as a signal from epithelial cells to myofibroblasts in gastric carcinoid tumours (Conference Paper)

Varro, A., Hemers, E., & Pritchard, D. M. (2004). MMP-7 acts as a signal from epithelial cells to myofibroblasts in gastric carcinoid tumours. In BRITISH JOURNAL OF CANCER Vol. 91 (pp. S10). Retrieved from http://gateway.webofknowledge.com/

Regulation of plasminogen activator inhibitor 2 (PAI-2) by Helicobacter pylori: Role in invasion and in apoptosis (Conference Paper)

Varro, A., Noble, P. J. M., Pritchard, D. M., Kennedy, S., Dimaline, R., Hart, C. A., & Dockray, G. J. (2004). Regulation of plasminogen activator inhibitor 2 (PAI-2) by Helicobacter pylori: Role in invasion and in apoptosis. In GUT Vol. 53 (pp. A15). Retrieved from http://gateway.webofknowledge.com/

Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappa B and RhoA: Implications for invasion and apoptosis (Journal article)

Varro, A., Noble, P. J. M., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004). Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappa B and RhoA: Implications for invasion and apoptosis. CANCER RESEARCH, 64(5), 1695-1702. doi:10.1158/0008-5472.CAN-03-2399

DOI: 10.1158/0008-5472.CAN-03-2399

Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis (Journal article)

Varro, A., Noble, P. J., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004). Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis. Cancer Res, 64(5), 1695-1702. Retrieved from http://www.ncbi.nlm.nih.gov/

Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis (Journal article)

Varro, A., Noble, P. J., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004). Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis. Cancer Res, 64(5), 1695-1702. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/14996729

Review article: how useful are the rodent animal models of gastric adenocarcinoma? (Journal article)

Pritchard, D. M., & Przemeck, S. M. C. (2004). Review article: how useful are the rodent animal models of gastric adenocarcinoma?. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 19(8), 841-859. doi:10.1111/j.1365-2036.2004.01911.x

DOI: 10.1111/j.1365-2036.2004.01911.x

2003

Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer? (Journal article)

Younes, M. (2003). Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer?. GASTROENTEROLOGY, 125(6), 1912. doi:10.1053/j.gastro.2003.04.014

DOI: 10.1053/j.gastro.2003.04.014

Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer? Reply (Journal article)

Haigh, C. R., Kirton, C., Pritchard, D. M., Varro, A., Dimaline, R., Attwood, S. E. A., . . . Jankowski, J. A. (2003). Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer? Reply. GASTROENTEROLOGY, 125(6), 1912-1913. doi:10.1053/j.gastro.2003.10.031

DOI: 10.1053/j.gastro.2003.10.031

Gastrin-induced hyperproliferation in Barrett's esophagus (Journal article)

Fitzgerald, R. C., & Abdalla, S. (2003). Gastrin-induced hyperproliferation in Barrett's esophagus. GASTROENTEROLOGY, 125(6), 1921. doi:10.1053/j.gastro.2003.05.017

DOI: 10.1053/j.gastro.2003.05.017

Gastrin-induced hyperproliferation in Barrett's esophagus - Reply (Journal article)

Haigh, C. R., Kirton, C. M., Pritchard, D. M., Varro, A., Dimaline, R., Attwood, S. E. A., . . . Jankowski, J. A. (2003). Gastrin-induced hyperproliferation in Barrett's esophagus - Reply. GASTROENTEROLOGY, 125(6), 1921-1922. doi:10.1053/j.gastro.2003.10.036

DOI: 10.1053/j.gastro.2003.10.036

Stimulation of matrix metalloproteinase-7 (MMP-7) by Helicobacter pylori in gastric epithelial cells: Role in epithelial cell migration (Conference Paper)

Varro, A., Wroblewski, L. E., Pagliocca, A., Pritchard, D. M., Noble, P. J. M., & Hart, C. A. (2003). Stimulation of matrix metalloproteinase-7 (MMP-7) by Helicobacter pylori in gastric epithelial cells: Role in epithelial cell migration. In GUT Vol. 52 (pp. A53). Retrieved from http://gateway.webofknowledge.com/

Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after gamma radiation (Journal article)

Ottewell, P. D., Watson, A. J. M., Wang, T. C., Varro, A., Dockray, G. J., & Pritchard, D. M. (2003). Elevated plasma concentrations of amidated gastrin cause increased crypt survival in murine intestinal epithelia after gamma radiation. GUT, 52, A8. Retrieved from http://gateway.webofknowledge.com/

Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor (Journal article)

Haigh, C. R., Attwood, S. E. A., Thompson, D. G., Jankowski, J. A., Kirton, C. M., Pritchard, D. M., . . . Dimaline, R. (2003). Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor. GASTROENTEROLOGY, 124(3), 615-625. doi:10.1053/gast.2003.50091

DOI: 10.1053/gast.2003.50091

Progastrin stimulates murine colonic epithelial mitosis after DNA damage. (Journal article)

Ottewell, P. D., Watson, A. J., Wang, T. C., Varro, A., Dockray, G. J., & Pritchard, D. M. (2003). Progastrin stimulates murine colonic epithelial mitosis after DNA damage.. Gastroenterology, 124(5), 1348-1357. doi:10.1016/S0016-5085(03)00288-9

DOI: 10.1016/S0016-5085(03)00288-9

2002

Amidated gastrin induces proliferation via the cholecystokinin type 2 (CCK2) receptor in Barrett's oesophagus (Conference Paper)

Haigh, C. R., Attwood, S. E. A., Thompson, D. G., Kirton, C. M., Pritchard, D. M., Varro, A., & Dimaline, R. (2002). Amidated gastrin induces proliferation via the cholecystokinin type 2 (CCK2) receptor in Barrett's oesophagus. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 50P). Retrieved from http://gateway.webofknowledge.com/

Progastrin stimulates murine colonic epithelial mitosis after DNA damage (Journal article)

Ottewell, P. D., Watson, A. J. M., Wang, T. C., Dockray, G. J., & Pritchard, D. M. (2002). Progastrin stimulates murine colonic epithelial mitosis after DNA damage. GUT, 50, A93. Retrieved from http://gateway.webofknowledge.com/

Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression (Journal article)

Wroblewski, L. E., Pritchard, D. M., Carter, S., & Varro, A. (2002). Gastrin-stimulated gastric epithelial cell invasion: the role and mechanism of increased matrix metalloproteinase 9 expression. BIOCHEMICAL JOURNAL, 365, 873-879. doi:10.1042/BJ20020068

DOI: 10.1042/BJ20020068

2000

Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity (Journal article)

Clarke, S. J., Farrugia, D. C., Aherne, G. W., Pritchard, D. M., Benstead, J., & Jackman, A. L. (2000). Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity. CLINICAL CANCER RESEARCH, 6(1), 285-296. Retrieved from http://gateway.webofknowledge.com/

Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine (Journal article)

Pritchard, D. M., Print, C., O'Reilly, L., Adams, J. M., Potten, C. S., & Hickman, J. A. (2000). Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine. ONCOGENE, 19(34), 3955-3959. doi:10.1038/sj.onc.1203729

DOI: 10.1038/sj.onc.1203729

Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: Lessons from transgenic and knockout mice (Journal article)

Watson, A. J. M., & Pritchard, D. M. (2000). Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: Lessons from transgenic and knockout mice. American Journal of Physiology - Gastrointestinal and Liver Physiology, 278(1 41-1).

Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice (Journal article)

Watson, A. J. M., & Pritchard, D. M. (2000). Lessons from genetically engineered animal models VII. Apoptosis in intestinal epithelium: lessons from transgenic and knockout mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 278(1), G1-G5. Retrieved from http://gateway.webofknowledge.com/

New directions in the treatment of colorectal cancer: a look to the future (Journal article)

Sobrero, A., Kerr, D., Glimelius, B., Van Cutsem, E., Milano, G., Pritchard, D. M., . . . Aapro, M. (2000). New directions in the treatment of colorectal cancer: a look to the future. EUROPEAN JOURNAL OF CANCER, 36(5), 559-566. doi:10.1016/S0959-8049(99)00314-7

DOI: 10.1016/S0959-8049(99)00314-7

The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): Genetic differences between BALB/c and DBA/2 mice (Journal article)

Pritchard, D. M., Bower, L., Potten, C. S., Jackman, A. L., & Hickman, J. A. (2000). The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): Genetic differences between BALB/c and DBA/2 mice. CLINICAL CANCER RESEARCH, 6(11), 4389-4395. Retrieved from http://gateway.webofknowledge.com/

1999

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo (Journal article)

Pritchard, D. M., Potten, C. S., Korsmeyer, S. J., Roberts, S., & Hickman, J. A. (1999). Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. ONCOGENE, 18(51), 7287-7293. doi:10.1038/sj.onc.1203150

DOI: 10.1038/sj.onc.1203150

1998

Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity (Journal article)

Pritchard, D. M., Jackman, A., Potten, C. S., & Hickman, J. A. (1998). Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity. TOXICOLOGY LETTERS, 103, 19-27. doi:10.1016/S0378-4274(98)00273-2

DOI: 10.1016/S0378-4274(98)00273-2

Radiation-induced p53 and p21(WAF-1/CIP1) expression in the murine intestinal epithelium - Apoptosis and cell cycle arrest (Journal article)

Wilson, J. W., Pritchard, D. M., Hickman, J. A., & Potten, C. S. (1998). Radiation-induced p53 and p21(WAF-1/CIP1) expression in the murine intestinal epithelium - Apoptosis and cell cycle arrest. AMERICAN JOURNAL OF PATHOLOGY, 153(3), 899-909. doi:10.1016/S0002-9440(10)65631-3

DOI: 10.1016/S0002-9440(10)65631-3

The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia (Journal article)

Pritchard, D. M., Potten, C. S., & Hickman, J. A. (1998). The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia. CANCER RESEARCH, 58(23), 5453-5465. Retrieved from http://gateway.webofknowledge.com/

1997

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation (Journal article)

Pritchard, D. M., Watson, A. J. M., Potten, C. S., Jackman, A. L., & Hickman, J. A. (1997). Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(5), 1795-1799. doi:10.1073/pnas.94.5.1795

DOI: 10.1073/pnas.94.5.1795

The intestinal epithelial stem cell: the mucosal governor (Journal article)

Potten, C. S., Booth, C., & Pritchard, D. M. (1997). The intestinal epithelial stem cell: the mucosal governor. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 78(4), 219-243. doi:10.1046/j.1365-2613.1997.280362.x

DOI: 10.1046/j.1365-2613.1997.280362.x

1996

Apoptosis and gastrointestinal pharmacology (Journal article)

Pritchard, D. M., & Watson, A. J. M. (1996). Apoptosis and gastrointestinal pharmacology. PHARMACOLOGY & THERAPEUTICS, 72(2), 149-169. doi:10.1016/S0163-7258(96)00102-7

DOI: 10.1016/S0163-7258(96)00102-7