Photo of Prof Chris Sanderson

Prof Chris Sanderson PhD, BSc Hon

Professor (Head of Department) Cellular and Molecular Physiology

    Research

    Research Interest 1

    Human Protein-protein interaction networks

    Research Grants

    Wellcome Trust Four Year Cellular and Molecular Physiology PhD Programme 2018

    WELLCOME TRUST (UK)

    October 2018 - September 2022

    Wellcome Trust Four-Year PhD Studentship with the Cellular and Molecular Physiology PhD Programme

    WELLCOME TRUST (UK)

    October 2015 - September 2019

    The North West Cancer Bioinformatics Fellowship

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

    October 2015 - September 2018

    Four year PhD Programme (2007)

    WELLCOME TRUST (UK)

    October 2007 - September 2011

    Biochemical characterisation of distinct kinetochore states by purification of intact kinetochore-centromere complexes with attached microtubule plus-ends

    ROYAL SOCIETY (CHARITABLE)

    November 2010 - October 2011

    Investigating the potential of Nrf2 induction in airway epithelial cells as a treatment for RSV bronchiolitis

    BRITISH SOCIETY FOR ANTIMICROBIAL CHEMOTHERAPY (UK)

    August 2013 - December 2014

    Developing a collaborative resource for ChIP based analyses of cancer related transcriptional networks

    CANCER RESEARCH UK (CRUK) (UK)

    April 2012 - March 2013

    Four year PhD Programme (2008)

    WELLCOME TRUST (UK)

    October 2008 - December 2012

    Wellcome Trust Four-Year PhD Studentship with the Cellular and Molecular Physiology Programme

    WELLCOME TRUST (UK)

    October 2011 - March 2016

    Comparative network profiling of normal and cancer-derived gastric myofibroblasts.

    NORTH WEST CANCER RESEARCH FUND

    June 2009 - May 2010

    Securing and enhancing Liverpool Biomedical EM cryo-preparation facilities

    WELLCOME TRUST (UK)

    July 2007 - June 2010

    Dynamics and function of the NF-kappaB signalling system

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    May 2008 - July 2014

    Bench fees for Hanan M Garalla

    LIBYAN EMBASSY IN LONDON

    July 2013 - June 2016

    CR-UK Cancer Research Centre - Non Clinical Training Account 2010-2014

    CANCER RESEARCH UK (CRUK) (UK)

    November 2011 - October 2015

    Wellcome trust four-year PhD studentship with the cellular and molecular physiology PhD programme

    WELLCOME TRUST (UK)

    October 2012 - September 2016

    Four year PhD programme for Mr Woodsmith.

    WELLCOME TRUST (UK)

    October 2006 - September 2010

    Exo-Net.

    MEDICAL RESEARCH COUNCIL (MRC)

    June 2006 - May 2009

    Liverpool 3View: a national hub for 3D-EM bioscience research

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2014 - December 2014

    Research Collaborations

    Prof. Munir Pirmohamed

    Internal

    We are in the process of preparing an application for a Wellcome Trust Strategic award. This will focus on Pharmacogenomics of Infants. I will provide supporting expertise in Systems Biology/Network Biology

    Prof. Mike White

    Internal

    I am a co-applicant on Mike's large BBSRC SABR Systems Biology grant. In addition, we also secured funding for 4x 4-year PhD studentshipd form the BBSRC. Finally we are currently developing plans for using microscopic methods to investigate conditional protein-protein interactions in live human cells.

    Prof. Rob Baynon

    Internal

    We are both involved in the BBSRC funded SBR Systems Biology project. In addition we are currently discussing plans for a possible co-appliaction to study global protein degradation/ ubiquitination profilesin eukaryotic cells. These plans are still in an early phase as they must follow publication of our manuscript on the Human E2/E3-RING interaction network.

    Prof. Lu-Yun Lian

    Internal

    We are working together to generate NMR/structural information relating to novel human E2-E3/RING and E2/DUB protein complexes. This work will also form the foundation for a future joint grant application in this field which will be led by myself but with 50% split on credit. It is my intention that together we can establish Liverpool as a recognised centre for the analysis of hirachical/combinatorial protein complexes.

    Dr David Kommander

    External: Laboratory of Molecular Biology, MRC, Cambridge

    We haveve collaborated for about three years on different projects but most recently David performed functional ubiquitination assays in oreder to asses the accuracy of our experimental predictions. This was a very sucessful collaboration which will result in a joint publication. Additional experiments are been discussed to support a future grant application.

    Dr B. Lehner

    External: Centre for Genomic Regulation, Barcelona/EMBL outstation

    using worm genetic networks to investigate human protein-protein interaction networks

    L. Serano/ C. Kiel

    External: Centre for Genomic Regulation, Barcelona/EMBL outstation

    Investigating the molecular basis of partner preferences within the Humanb ubiquitome.

    Dr Evan Reid

    External: The University of Cambridge

    Dr Reid initially came to work as a visiting researcher in my group when I was working at the MRC Rosalind Franklin Centre for Genomics Research in Hinxton Cambridge. During this period we performed several protein interaction studies to identify novel proteins that interact with proteins encoded by genes involved in hereditary Spastic Paraplegia. To date this work produced three publications which provide novel insights into possible mechanisms of neuronal degeneration. In addition this work also led to the identification of novel components of the human endocytic pathway. We are both keen to continue this successful collaboration and as such we are performing several ongoing research projects and applying for joint funding to investigate a new candidate genes which are also linked to spastic paraplegia and neuronal degeneration.

    Dr Sean Munro

    External: The University of Cambridge

    Analysis of interaction partners for a series of human Arl proteins

    Dr Paul Luzio

    External: The University of Cambridge

    Investigation of interaction partners for proteins involved in endocytosis in human cells

    Dr Paul Lehner

    External: The University of Cambridge

    An analysis of interactions between viral ubiquitin ligases and human Ubiquitin cinjugating enzymes (E2s)