Prof Christopher Goldring BSc, PhD

Lecturer Molecular and Clinical Pharmacology

    Publications

    2019

    Stem cell models as an in vitro model for predictive toxicology (Journal article)

    Lynch, S., Pridgeon, C. S., Duckworth, C. A., Sharma, P., Park, B. K., & Goldring, C. E. P. (2019). Stem cell models as an in vitro model for predictive toxicology. BIOCHEMICAL JOURNAL, 476, 1149-1158. doi:10.1042/BCJ20170780

    DOI: 10.1042/BCJ20170780

    2018

    Model-based identification of TNF alpha-induced IKK beta-mediated and I kappa B alpha-mediated regulation of NF kappa B signal transduction as a tool to quantify the impact of drug-induced liver injury compounds (Journal article)

    Oppelt, A., Kaschek, D., Huppelschoten, S., Sison-Young, R., Zhang, F., Buck-Wiese, M., . . . Klingmueuler, U. (2018). Model-based identification of TNF alpha-induced IKK beta-mediated and I kappa B alpha-mediated regulation of NF kappa B signal transduction as a tool to quantify the impact of drug-induced liver injury compounds. NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 4. doi:10.1038/s41540-018-0058-z

    DOI: 10.1038/s41540-018-0058-z

    Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop (Journal article)

    Stacey, G., Andrews, P. W., Asante, C., Barbaric, I., Barry, J., Bisset, L., . . . Williams, D. (2018). Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop. REGENERATIVE MEDICINE, 13(8), 935-944. doi:10.2217/rme-2018-0120

    DOI: 10.2217/rme-2018-0120

    Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development (Journal article)

    Olayanju, A., Jones, L., Greco, K., Goldring, C. E., & Ansari, T. (2019). Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development. JOURNAL OF APPLIED TOXICOLOGY, 39(1), 4-15. doi:10.1002/jat.3641

    DOI: 10.1002/jat.3641

    The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. (Journal article)

    Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 9(43), 27104-27116. doi:10.18632/oncotarget.25497

    DOI: 10.18632/oncotarget.25497

    NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis (Journal article)

    Lister, A., Bourgeois, S., Silva, P. H. I., Rubio-Aliaga, I., Marbet, P., Walsh, J., . . . Odermatt, A. (2018). NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-24000-2

    DOI: 10.1038/s41598-018-24000-2

    Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. (Journal article)

    Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.. Toxicological sciences : an official journal of the Society of Toxicology, 162(2), 655-666. doi:10.1093/toxsci/kfx289

    DOI: 10.1093/toxsci/kfx289

    Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response (Journal article)

    Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. doi:10.1016/j.jprot.2018.02.030

    DOI: 10.1016/j.jprot.2018.02.030

    Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study (Journal article)

    Bell, C., Dankers, A., Lauschke, V., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study. Toxicological Sciences. doi:10.1093/toxsci/kfx289

    DOI: 10.1093/toxsci/kfx289

    Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms (Journal article)

    Pridgeon, C. S., Schlott, C., Wong, M. W., Heringa, M. B., Heckel, T., Leedale, J., . . . Goldring, C. E. P. (2018). Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms. ARCHIVES OF TOXICOLOGY, 92(2), 557-569. doi:10.1007/s00204-018-2152-9

    DOI: 10.1007/s00204-018-2152-9

    Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing (Chapter)

    Wong, M. W., Pridgeon, C. S., Schlott, C., Park, B. K., & Goldring, C. E. P. (2018). Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing. In Methods in Pharmacology and Toxicology (pp. 199-212). Springer New York. doi:10.1007/978-1-4939-7677-5_10

    DOI: 10.1007/978-1-4939-7677-5_10

    2017

    Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation (Chapter)

    LeCluyse, E. L., Norona, L. M., Akingbasote, J. A., Howell, L. S., Woodhead, J. L., Cross, M. J., . . . Goldring, C. E. (2018). Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation. In Comprehensive Toxicology (pp. 651-712). Elsevier. doi:10.1016/b978-0-12-801238-3.64267-8

    DOI: 10.1016/b978-0-12-801238-3.64267-8

    MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury (Journal article)

    Howell, L. S., Ireland, L., Park, B. K., & Goldring, C. E. (2018). MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 18(1), 47-54. doi:10.1080/14737159.2018.1415145

    DOI: 10.1080/14737159.2018.1415145

    Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management (Journal article)

    Sutton, P. A., Jithesh, P. V., Jones, R. P., Evans, J. P., Vimalachandran, D., Malik, H. Z., . . . Kitteringham, N. R. (2018). Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management. EJSO, 44(1), 115-121. doi:10.1016/j.ejso.2017.10.211

    DOI: 10.1016/j.ejso.2017.10.211

    Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. (Journal article)

    Scarfe, L., Brillant, N., Kumar, J. D., Ali, N., Alrumayh, A., Amali, M., . . . Park, B. K. (2017). Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies.. NPJ Regenerative medicine, 2, 28. doi:10.1038/s41536-017-0029-9

    DOI: 10.1038/s41536-017-0029-9

    Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins (Journal article)

    Rowe, C., Shaeri, M., Large, E., Cornforth, T., Robinson, A., Kostrzewski, T., . . . Hughes, D. (2018). Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins. TOXICOLOGY IN VITRO, 46, 29-38. doi:10.1016/j.tiv.2017.09.012

    DOI: 10.1016/j.tiv.2017.09.012

    Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017) (Journal article)

    Heslop, J. A., Kia, R., Pridgeon, C. S., Sison-Young, R. L., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017). STEM CELLS TRANSLATIONAL MEDICINE, 6(8). Retrieved from http://gateway.webofknowledge.com/

    Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo (Journal article)

    Brillant, N., Elmasry, M., Burton, N. C., Rodriguez, J. M., Sharkey, J. W., Fenwick, S., . . . Antoine, D. J. (2017). Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo. TOXICOLOGY AND APPLIED PHARMACOLOGY, 332, 64-74. doi:10.1016/j.taap.2017.07.019

    DOI: 10.1016/j.taap.2017.07.019

    Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development (Chapter)

    Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Kevin Park, B. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In Comprehensive Medicinal Chemistry III (pp. 217-238). Elsevier. doi:10.1016/b978-0-12-409547-2.12384-4

    DOI: 10.1016/b978-0-12-409547-2.12384-4

    Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (Journal article)

    Heslop, J. A., Kia, R., Pridgeon, C. S., Sison-Young, R. L., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells. STEM CELLS TRANSLATIONAL MEDICINE, 6(5), 1321-1331. doi:10.1002/sctm.16-0029

    DOI: 10.1002/sctm.16-0029

    Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo (Journal article)

    Sharkey, J., Lewis, P. J. S., Barrow, M., Alwahsh, S. M., Noble, J., Livingstone, E., . . . Park, B. K. (2017). Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo. CYTOTHERAPY, 19(4), 555-569. doi:10.1016/j.jcyt.2017.01.003

    DOI: 10.1016/j.jcyt.2017.01.003

    Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury (Journal article)

    Goldring, C., Antoine, D. J., Bonner, F., Crozier, J., Denning, C., Fontana, R. J., . . . Park, B. K. (2017). Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury. HEPATOLOGY, 65(2), 710-721. doi:10.1002/hep.28886

    DOI: 10.1002/hep.28886

    2016

    A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat (Journal article)

    Thulin, P., Hornby, R. J., Auli, M., Nordahl, G., Antoine, D. J., Lewis, P. S., . . . Schuppe-Koistinen, I. (2017). A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat. BIOMARKERS, 22(5), 461-469. doi:10.1080/1354750X.2016.1269131

    DOI: 10.1080/1354750X.2016.1269131

    Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation (Journal article)

    Lauschke, V. M., Vorrink, S. U., Moro, S. M. L., Rezayee, F., Nordling, A., Hendriks, D. F. G., . . . Ingelman-Sundberg, M. (2016). Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation. HEPATOLOGY, 64(5), 1743-1756. doi:10.1002/hep.28780

    DOI: 10.1002/hep.28780

    A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity (Journal article)

    Sison-Young, R. L., Lauschke, V. M., Johann, E., Alexandre, E., Antherieu, S., Aerts, H., . . . Park, B. K. (2017). A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. ARCHIVES OF TOXICOLOGY, 91(3), 1385-1400. doi:10.1007/s00204-016-1745-4

    DOI: 10.1007/s00204-016-1745-4

    Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease (Journal article)

    Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., . . . Ingelman-Sundberg, M. (2016). Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. SCIENTIFIC REPORTS, 6. doi:10.1038/srep25187

    DOI: 10.1038/srep25187

    Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile (Journal article)

    Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Park, B. K. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. ARCHIVES OF TOXICOLOGY, 91(1), 439-452. doi:10.1007/s00204-016-1694-y

    DOI: 10.1007/s00204-016-1694-y

    Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites (Journal article)

    Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292

    DOI: 10.1021/acs.jmedchem.5b01292

    UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis (Journal article)

    Abu-Alainin, W., Gana, T., Liloglou, T., Olayanju, A., Barrera, L. N., Ferguson, R., . . . Costello, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. JOURNAL OF PATHOLOGY, 238(3), 423-433. doi:10.1002/path.4665

    DOI: 10.1002/path.4665

    2015

    Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney (Journal article)

    Shelton, L. M., Lister, A., Walsh, J., Jenkins, R. E., Wong, M. H. L., Rowe, C., . . . Copple, I. M. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. KIDNEY INTERNATIONAL, 88(6), 1261-1273. doi:10.1038/ki.2015.286

    DOI: 10.1038/ki.2015.286

    Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study (Journal article)

    Lee, K. C. L., Baker, L. A., Stanzani, G., Alibhai, H., Chang, Y. M., Palacios, C. J., . . . Jalan, R. (2015). Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study. JOURNAL OF HEPATOLOGY, 63(3), 634-642. doi:10.1016/j.jhep.2015.04.020

    DOI: 10.1016/j.jhep.2015.04.020

    MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity (Journal article)

    Kia, R., Kelly, L., Sison-Young, R. L. C., Zhang, F., Pridgeon, C. S., Heslop, J. A., . . . Park, B. K. (2015). MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity. TOXICOLOGICAL SCIENCES, 144(1), 173-185. doi:10.1093/toxsci/kfu269

    DOI: 10.1093/toxsci/kfu269

    Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases (Journal article)

    Sutton, P., Evans, J., Jones, R., Malik, H., Vimalachandran, D., Palmer, D., . . . Kitteringham, N. (2015). Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases. LANCET, 385, 95. Retrieved from http://gateway.webofknowledge.com/

    Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome (Journal article)

    Eakins, R., Walsh, J., Randle, L., Jenkins, R. E., Schuppe-Koistinen, I., Rowe, C., . . . Park, B. K. (2015). Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. SCIENTIFIC REPORTS, 5. doi:10.1038/srep16423

    DOI: 10.1038/srep16423

    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2 (Journal article)

    Olayanju, A., Copple, I. M., Bryan, H. K., Edge, G. T., Sison, R. L., Wong, M. W., . . . Park, B. K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. FREE RADICAL BIOLOGY AND MEDICINE, 78, 202-212. doi:10.1016/j.freeradbiomed.2014.11.003

    DOI: 10.1016/j.freeradbiomed.2014.11.003

    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2. (Journal article)

    Olayanju, A., Copple, I., Bryan, H. K., Edge, G. T., Sison-Young, R., Wong, M. W., . . . Park, K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.. Free Radical Biology & Medicine, 78, 202-212.

    Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice (Journal article)

    Cai, H., Scott, E., Kholghi, A., Andreadi, C., Rufini, A., Karmokar, A., . . . Brown, K. (2015). Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. SCIENCE TRANSLATIONAL MEDICINE, 7(298). doi:10.1126/scitranslmed.aaa7619

    DOI: 10.1126/scitranslmed.aaa7619

    Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication (Journal article)

    Sison-Young, R. L. C., Mitsa, D., Jenkins, R. E., Mottram, D., Alexandre, E., Richert, L., . . . Park, B. K. (2015). Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. TOXICOLOGICAL SCIENCES, 147(2), 412-424. doi:10.1093/toxsci/kfv136

    DOI: 10.1093/toxsci/kfv136

    Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies (Journal article)

    Heslop, J. A., Hammond, T. G., Santeramo, I., Piella, A. T., Hopp, I., Zhou, J., . . . Park, B. K. (2015). Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. STEM CELLS TRANSLATIONAL MEDICINE, 4(4), 389-400. doi:10.5966/sctm.2014-0110

    DOI: 10.5966/sctm.2014-0110

    Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials (Journal article)

    Sutton, P. A., Jones, R. P., Morrison, F., Goldring, C. E., Park, B. K., Palmer, D. H., . . . Kitteringham, N. R. (2015). Evaluation of a novel tissue stabilization gel to facilitate clinical sampling for translational research in surgical trials. BRITISH JOURNAL OF SURGERY, 102(2), E124-E132. doi:10.1002/bjs.9678

    DOI: 10.1002/bjs.9678

    Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes (Journal article)

    Baxter, M., Withey, S., Harrison, S., Segeritz, C. -P., Zhang, F., Atkinson-Dell, R., . . . Hanley, N. A. (2015). Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. JOURNAL OF HEPATOLOGY, 62(3), 581-589. doi:10.1016/j.jhep.2014.10.016

    DOI: 10.1016/j.jhep.2014.10.016

    Understanding and Assessing the Risks of Stem Cell-Based Therapies (Journal article)

    Heslop, J., Hammond, T. G., Santeramo, I., Tort Piella, A., Hopp, I., Zhou, J., . . . Park, B. (2015). Understanding and Assessing the Risks of Stem Cell-Based Therapies. Stem Cells Translational Medicine, 4, 389-400.

    Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure (Journal article)

    Antoine, D. J., Dear, J. W., Goldring, C. E., & Park, B. K. (2015). Understanding the Pathophysiological Regulatory Role of MicroRNAs in Acute Liver Failure. HEPATOLOGY, 61(4), 1439-1440. doi:10.1002/hep.27349

    DOI: 10.1002/hep.27349

    2014

    The role of ERK5 in endothelial cell function (Journal article)

    Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2014). The role of ERK5 in endothelial cell function. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 1584-1589. doi:10.1042/BST20140276

    DOI: 10.1042/BST20140276

    Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids (Journal article)

    Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., . . . Park, B. K. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. TOXICOLOGICAL SCIENCES, 140(2), 462-469. doi:10.1093/toxsci/kfu080

    DOI: 10.1093/toxsci/kfu080

    Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids (Journal article)

    Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., . . . Park, B. K. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. Toxicological Sciences, 140(2), 462-469. doi:10.1093/toxsci/kfu080

    DOI: 10.1093/toxsci/kfu080

    Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis (Journal article)

    Dear, J. W., Antoine, D. J., Starkey-Lewis, P., Goldring, C. E., & Park, B. K. (2014). Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 77(5), 904-905. doi:10.1111/bcp.12214

    DOI: 10.1111/bcp.12214

    Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications (Journal article)

    Walsh, J., Jenkins, R. E., Wong, M., Olayanju, A., Powell, H., Copple, I., . . . Park, B. K. (2014). Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications. JOURNAL OF PROTEOMICS, 108, 171-187. doi:10.1016/j.jprot.2014.05.007

    DOI: 10.1016/j.jprot.2014.05.007

    MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans (Journal article)

    Hornby, R. J., Lewis, P. S., Dear, J., Goldring, C., & Park, B. K. (2014). MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans. EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 7(3), 349-362. doi:10.1586/17512433.2014.904201

    DOI: 10.1586/17512433.2014.904201

    Retro-Orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity (Journal article)

    Vliegenthart, A. D. B., Lewis, P. S., Tucker, C. S., Del Pozo, J., Rider, S., Antoine, D. J., . . . Dear, J. W. (2014). Retro-Orbital Blood Acquisition Facilitates Circulating microRNA Measurement in Zebrafish with Paracetamol Hepatotoxicity. ZEBRAFISH, 11(3), 219-226. doi:10.1089/zeb.2013.0912

    DOI: 10.1089/zeb.2013.0912

    2013

    Safety pharmacology--current and emerging concepts. (Journal article)

    Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology--current and emerging concepts.. Toxicology and applied pharmacology, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039

    DOI: 10.1016/j.taap.2013.04.039

    Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation. (Journal article)

    Rowe, C., Gerrard, D. T., Jenkins, R., Berry, A., Durkin, K., Sundstrom, L., . . . Hanley, N. A. (2013). Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation.. Hepatology (Baltimore, Md.), 58(2), 799-809. doi:10.1002/hep.26414

    DOI: 10.1002/hep.26414

    The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone (Journal article)

    Wright, T., Rea, S. L., Goode, A., Bennett, A. J., Ratajczak, T., Long, J. E., . . . Layfield, R. (2013). The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone. BONE, 52(2), 699-706. doi:10.1016/j.bone.2012.10.023

    DOI: 10.1016/j.bone.2012.10.023

    2012

    Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation (Journal article)

    Goldring, C., Rowe, C., Jenkins, R. E., Kitteringham, N. R., & Park, K. B. (n.d.). Analysis of the rat primary hepatocyte nuclear proteome through sub-cellular fractionation. Journal of Integrated OMICS, 2(2). doi:10.5584/jiomics.v2i2.102

    DOI: 10.5584/jiomics.v2i2.102

    Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics. (Journal article)

    Abdullah, A., Kitteringham, N. R., Jenkins, R. E., Goldring, C., Higgins, L., Yamamoto, M., . . . Park, B. K. (2012). Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.. Pharmacological reports : PR, 64(3), 680-697. doi:10.1016/s1734-1140(12)70863-0

    DOI: 10.1016/s1734-1140(12)70863-0

    ERK5: Structure, regulation and function (Journal article)

    Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2012). ERK5: Structure, regulation and function. CELLULAR SIGNALLING, 24(11), 2187-2196. doi:10.1016/j.cellsig.2012.07.007

    DOI: 10.1016/j.cellsig.2012.07.007

    Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells (Journal article)

    Yeang, H. X. A., Hamdam, J. M., Al-Huseini, L. M. A., Sethu, S., Djouhri, L., Walsh, J., . . . Sathish, J. G. (2012). Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells. Journal of Biological Chemistry, 287(13), 10556-10564. doi:10.1074/jbc.m111.322420

    DOI: 10.1074/jbc.m111.322420

    2011

    Assessing the safety of stem cell therapeutics (Journal article)

    Goldring, C., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, K. (2011). Assessing the safety of stem cell therapeutics. Cell Stem Cell, 8(6), 618-628.

    Assessing the safety of stem cell therapeutics. (Journal article)

    Goldring, C., Duffy, P. A., Benvenisty, N., Andrews, P. W., Ben-David, U., Eakins, R., . . . Park, B. K. (2011). Assessing the safety of stem cell therapeutics.. Unknown Journal, 618-628.

    Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury (Journal article)

    Lewis, P. J. S., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). Circulating MicroRNAs as Potential Markers of Human Drug-Induced Liver Injury. HEPATOLOGY, 54(5), 1767-1776. doi:10.1002/hep.24538

    DOI: 10.1002/hep.24538

    Managing the Challenge of Chemically Reactive Metabolites in Drug Development. (Journal article)

    Park, B. K., Boobis, A., Clarke, S., Goldring, C., Jones, D., Kenna, G., . . . Baillie, T. A. (2011). Managing the Challenge of Chemically Reactive Metabolites in Drug Development.. Unknown Journal, 292-306.

    Managing the challenge of chemically reactive metabolites in drug development. (Journal article)

    Park, B. K., Boobis, A., Clarke, S., Goldring, C., Jones, D., Kenna, J. G., . . . Baillie, T. A. (2011). Managing the challenge of chemically reactive metabolites in drug development.. Nature Reviews Drug Discovery, 10(4), 292-306.

    Novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3 (Journal article)

    Bone, T., & Goldring, C. (2011). Novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J. Cell Science, In press.

    Nrf2 is over-expressed in pancreatic cancer: implications for cell proliferation and therapy (Journal article)

    Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is over-expressed in pancreatic cancer: implications for cell proliferation and therapy. Molecular Cancer, 10, 37.

    Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy (Journal article)

    Lister, A., Nedjadi, T., Kitteringham, N. R., Campbell, F., Costello, E., Lloyd, B., . . . Park, B. K. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. MOLECULAR CANCER, 10. doi:10.1186/1476-4598-10-37

    DOI: 10.1186/1476-4598-10-37

    Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression (Journal article)

    Tonack, S., Patel, S., Jalali, M., Nedjadi, T., Jenkins, R. E., Goldring, C., . . . Costello, E. (2011). Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression. WORLD JOURNAL OF GASTROENTEROLOGY, 17(15), 1947-1960. doi:10.3748/wjg.v17.i15.1947

    DOI: 10.3748/wjg.v17.i15.1947

    miRNAs in biofluids as markers of human drug-induced liver injury (Journal article)

    Starkey-Lewis, P. J., Dear, J., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., . . . Park, B. K. (2011). miRNAs in biofluids as markers of human drug-induced liver injury. Hepatology, In Press.

    2010

    Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB (Journal article)

    Chia, A. J. L., Goldring, C. E., Kitteringham, N. R., Wong, S. Q., Morgan, P., & Park, B. K. (2010). Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB. Biochemical Pharmacology, 80(3), 410-421. doi:10.1016/j.bcp.2010.04.004

    DOI: 10.1016/j.bcp.2010.04.004

    Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. (Journal article)

    Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.. Journal of proteomics, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018

    DOI: 10.1016/j.jprot.2010.03.018

    Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening (Journal article)

    Baxter, M. A., Rowe, C., Alder, J., Harrison, S., Hanley, K. P., Park, K., . . . Hanley, N. A. (2010). Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Unknown Journal, 5(1), 4-22. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20483202

    Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening (Journal article)

    Baxter, M. A., Rowe, C., Alder, J., Harrison, S., Hanley, K. P., Park, B. K., . . . Hanley, N. A. (2010). Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Stem Cell Research, 5(1), 4-22. doi:10.1016/j.scr.2010.02.002

    DOI: 10.1016/j.scr.2010.02.002

    Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach. (Journal article)

    Rowe, C., Goldring, C. E. P., Kitteringham, N. R., Jenkins, R. E., Lane, B. S., Sanderson, C., . . . Park, B. K. (2010). Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.. Journal of proteome research, 9(5), 2658-2668. doi:10.1021/pr1001687

    DOI: 10.1021/pr1001687

    Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway (Journal article)

    Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., . . . Park, B. K. (2010). Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(22), 16782-16788. doi:10.1074/jbc.M109.096545

    DOI: 10.1074/jbc.M109.096545

    The Keap1-Nrf2 cellular defense pathway: Mechanisms of regulation and role in protection against drug-induced toxicity (Journal article)

    Copple, I., Goldring, C., Kitteringham, N., & Park, K. (2010). The Keap1-Nrf2 cellular defense pathway: Mechanisms of regulation and role in protection against drug-induced toxicity. Handbook of Experimental Pharmacology, 196, 233-266.

    The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity. (Journal article)

    Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2010). The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.. Handbook of experimental pharmacology, (196), 233-266. doi:10.1007/978-3-642-00663-0_9

    DOI: 10.1007/978-3-642-00663-0_9

    2009

    An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype (Conference Paper)

    Curley, P., Kelly, L., Shaw, R., Kitteringham, N., Jenkins, R., Alder, J., . . . Park, K. (2009). An Investigation of the expression of cytochrome P450 3A7 and cytochrome P450 3A4 during stem cell differentiation for use as markers of emerging hepatic phenotype. In British Pharmacology Society Winter Meeting. London, UK.

    Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro (Journal article)

    Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringham, N. R., & Park, B. K. (2009). Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro. PHYTOMEDICINE, 16(5), 451-455. doi:10.1016/j.phymed.2008.11.001

    DOI: 10.1016/j.phymed.2008.11.001

    Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1 (Journal article)

    Megherbi, R., Kiorpelidou, E., Foster, B., Rowe, C., Naisbitt, D. J., Goldring, C. E., & Park, B. K. (2009). Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1. TOXICOLOGY AND APPLIED PHARMACOLOGY, 238(2), 120-132. doi:10.1016/j.taap.2009.05.001

    DOI: 10.1016/j.taap.2009.05.001

    Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells. (Journal article)

    Ignatova, I. D., Kostadinova, R. M., Goldring, C. E., Nawrocki, A. R., Frey, F. J., & Frey, B. M. (2009). Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.. Am J Physiol Endocrinol Metab.

    2008

    Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC) (Journal article)

    Liu, X. -P., Goldring, C. E. P., Wang, H. -Y., Copple, I. M., Kitteringharn, N. R., Park, B. K., & Wei, W. (2008). Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC). PHYTOTHERAPY RESEARCH, 22(3), 367-371. doi:10.1002/ptr.2328

    DOI: 10.1002/ptr.2328

    Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites. (Journal article)

    Jenkins, R. E., Kitteringham, N. R., Goldring, C. E. P., Dowdall, S. M. J., Hamlett, J., Lane, C. S., . . . Park, B. K. (2008). Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.. Proteomics, 8(2), 301-315. doi:10.1002/pmic.200700843

    DOI: 10.1002/pmic.200700843

    The Nrf2-Keap1 defence pathway: Role in protection against drug-induced toxicity (Journal article)

    Copple, I., Goldring, C., Kitteringham, N., & Park, K. (2008). The Nrf2-Keap1 defence pathway: Role in protection against drug-induced toxicity. Toxicology, 246, 24-33.

    The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system (Journal article)

    Copple, I. M., Goldring, C. E., Jenkins, R. E., Chia, A. J. L., Randle, L. E., Hayes, J. D., . . . Park, B. K. (2008). The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. HEPATOLOGY, 48(4), 1292-1301. doi:10.1002/hep.22472

    DOI: 10.1002/hep.22472

    2007

    Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene (Journal article)

    Kitteringham, N. R., Palmer, L., Owen, A., Lian, L. -Y., Jenkins, R., Dowdall, S., . . . Goldring, C. E. (2007). Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1240-1247. doi:10.1016/j.bbagen.2007.05.001

    DOI: 10.1016/j.bbagen.2007.05.001

    Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway (Journal article)

    Liu, X. -P., Goldring, C. E. P., Copple, I. M., Wang, H. -Y., Wei, W., Kitteringham, N. R., & Park, B. K. (2007). Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. LIFE SCIENCES, 80(17), 1586-1591. doi:10.1016/j.lfs.2007.01.034

    DOI: 10.1016/j.lfs.2007.01.034

    Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice. (Journal article)

    Randle, L. E., Goldring, C., Benson, C. A., Metcalfe, P. N., Kitteringham, N. R., Park, B. K., & Williams, D. P. (2007). Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.. Toxicology.

    The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity (Journal article)

    Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2008). The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity. TOXICOLOGY, 246(1), 24-33. doi:10.1016/j.tox.2007.10.029

    DOI: 10.1016/j.tox.2007.10.029

    2006

    Activation of the Nrf2/are antioxidant pathway by N-acetyl-p-benzoquinoneimine (NAPQI) (Journal article)

    Copple, I. M., Goldring, C., Jenkins, R., Kitteringham, N., & Park, B. K. (2006). Activation of the Nrf2/are antioxidant pathway by N-acetyl-p-benzoquinoneimine (NAPQI). Drug Metabolism Reviews, 38, 49.

    Analysis of inter-individual variation in the Nrf2/Keap1 genes responsible for induction of the antioxidant response (Journal article)

    Wang, H., Goldring, C., Kitteringham, N., & Park, B. K. (2006). Analysis of inter-individual variation in the Nrf2/Keap1 genes responsible for induction of the antioxidant response. Drug Metabolism Reviews, 38, 84-85.

    Chemical modification of glutathione S-transferase PI: A model for characterization of chemically reactive metabolites (Journal article)

    Jenkins, R., Kitteringham, N., Goldring, C., Metcalfe, P., Dowdall, S., & Park, B. K. (2006). Chemical modification of glutathione S-transferase PI: A model for characterization of chemically reactive metabolites. Drug Metabolism Reviews, 38, 154-155.

    Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes (Journal article)

    Goldring, C. E. P., Kitteringham, N. R., Jenkins, R., Lovatt, C. A., Randle, L. E., Abdullah, A., . . . Park, B. K. (2006). Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 290(1), C104-C115. doi:10.1152/ajpcell.00133.2005

    DOI: 10.1152/ajpcell.00133.2005

    Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements (Journal article)

    Owen, A., Goldring, C., Morgan, P., Park, B. K., & Pirmohamed, M. (2006). Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 62(2), 237-242. doi:10.1111/j.1365-2125.2006.02587.x

    DOI: 10.1111/j.1365-2125.2006.02587.x

    Mechanisms of defence during chemical-induced hepatotoxicity (Journal article)

    Randle, L. E., Williams, D. P., Goldring, C., & Park, B. K. (2006). Mechanisms of defence during chemical-induced hepatotoxicity. Drug Metabolism Reviews, 38, 56-58.

    Pharmacogenetic and functional analysis of a novel GSTP1 polymorphism (Journal article)

    Palmer, L., Goldring, C., Kitteringham, N., Owen, A., Gilmore, I., & Park, K. (2006). Pharmacogenetic and functional analysis of a novel GSTP1 polymorphism. Drug Metabolism Reviews, 38, 91.

    Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements (Journal article)

    Goldring, C., Kitteringham, N., Jenkins, R., Copple, I., Jeannin, J. F., & Park, B. K. (2006). Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements. JOURNAL OF EXPERIMENTAL BIOLOGY, 209(12), 2337-2343. doi:10.1242/jeb.02209

    DOI: 10.1242/jeb.02209

    Tetracycline-inducible pancreatic cancer cell lines (Journal article)

    Patel, S. I., Bier, M., Goldring, C., Hillen, W., & Costello, E. (2006). Tetracycline-inducible pancreatic cancer cell lines. Pancreas, 33(4), 489.

    2005

    Interindividual variation in the expression of the cellular redox sensor Keap1 and its novel splice variants in human lymphocytes (Journal article)

    Abdullah, A., Goldring, C., Owen, A., Kitteringham, N., & Park, K. (2005). Interindividual variation in the expression of the cellular redox sensor Keap1 and its novel splice variants in human lymphocytes. Toxicology, 213(3), 261-262.

    Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2 (Journal article)

    Kitteringham, N., Abdullah, A., Jenkins, R., Goldring, C., Hayes, J. D., & Park, K. (2005). Proteomic analysis of liver protein expression in transgenic mice deficient in the transcription factor Nrf2. Drug Metabolism Reviews, 37, 23.

    Relationship between the C3435T and G(2677)T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver (Journal article)

    Owen, A., Goldring, C., Morgan, P., Chadwick, D., Park, B. K., & Pirmohamed, M. (2005). Relationship between the C3435T and G(2677)T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(3), 365-370. doi:10.1111/j.1365-2125.2005.02229.x

    DOI: 10.1111/j.1365-2125.2005.02229.x

    2004

    Activation of hepatic Nrf2in vivo by acetaminophen in CD-1 mice (Journal article)

    Goldring, C. E. P., Kitteringham, N. R., Elsby, R., Randle, L. E., Clement, Y. N., Williams, D. P., . . . Park, B. K. (2004). Activation of hepatic Nrf2in vivo by acetaminophen in CD-1 mice. Hepatology, 39(5), 1267-1276. doi:10.1002/hep.20183

    DOI: 10.1002/hep.20183

    2003

    Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking GlutathioneS-Transferase Pi (Journal article)

    Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., . . . Park, B. K. (2003). Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking GlutathioneS-Transferase Pi. Journal of Biological Chemistry, 278(25), 22243-22249. doi:10.1074/jbc.m301211200

    DOI: 10.1074/jbc.m301211200

    2002

    In VivoFootprinting of the Human 11β-Hydroxysteroid Dehydrogenase Type 2 Promoter (Journal article)

    Nawrocki, A. R., Goldring, C. E., Kostadinova, R. M., Frey, F. J., & Frey, B. M. (2002). In VivoFootprinting of the Human 11β-Hydroxysteroid Dehydrogenase Type 2 Promoter. Journal of Biological Chemistry, 277(17), 14647-14656. doi:10.1074/jbc.m111549200

    DOI: 10.1074/jbc.m111549200

    2000

    Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene (Journal article)

    GOLDRING, C. E. P., REVENEAU, S., CHANTOME, A., PANCE, A., FLEURY, C., HUME, D. A., . . . JEANNIN, J. -F. (2000). Heat shock enhances transcriptional activation of the murine-inducible nitric oxide synthase gene. The FASEB Journal, 14(15), 2393-2395. doi:10.1096/fj.98-0509fje

    DOI: 10.1096/fj.98-0509fje