Prof Ana Alfirevic MD, PhD

Professor Molecular and Clinical Pharmacology

    Publications

    2019

    Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink. (Journal article)

    Carr, D. F., Francis, B., Jorgensen, A. L., Zhang, E., Chinoy, H., Heckbert, S. R., . . . Pirmohamed, M. (2019). Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink.. Clinical pharmacology and therapeutics, 106(6), 1353-1361. doi:10.1002/cpt.1557

    DOI: 10.1002/cpt.1557

    Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools (Journal article)

    Gonzalez-Galarza, F. F., McCabe, A., Santos, E. J. M. D., Jones, J., Takeshita, L., Ortega-Rivera, N. D., . . . Jones, A. R. (n.d.). Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools. Nucleic Acids Research. doi:10.1093/nar/gkz1029

    DOI: 10.1093/nar/gkz1029

    Public involvement in the dissemination of the North West Coast Household Health Survey: Experiences and lessons of co-producing research together (Journal article)

    Giebel, C., Hassan, S., McIntyre, J. C., Corcoran, R., Barr, B., Gabbay, M., . . . Alfirevic, A. (2019). Public involvement in the dissemination of the North West Coast Household Health Survey: Experiences and lessons of co-producing research together. HEALTH EXPECTATIONS, 22(4), 643-649. doi:10.1111/hex.12940

    DOI: 10.1111/hex.12940

    Genetic testing for prevention of severe drug-induced skin rash (Journal article)

    Alfirevic, A., Pirmohamed, M., Marinovic, B., Harcourt-Smith, L., Jorgensen, A. L., & Cooper, T. E. (2019). Genetic testing for prevention of severe drug-induced skin rash. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (7). doi:10.1002/14651858.CD010891.pub2

    DOI: 10.1002/14651858.CD010891.pub2

    Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. (Journal article)

    Floyd, J. S., Bloch, K. M., Brody, J. A., Maroteau, C., Siddiqui, M. K., Gregory, R., . . . PREDICTION-ADR Consortium and EUDRAGENE. (2019). Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.. PloS one, 14(6), e0218115. doi:10.1371/journal.pone.0218115

    DOI: 10.1371/journal.pone.0218115

    Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions. (Journal article)

    Nicoletti, P., Barrett, S., McEvoy, L., Daly, A. K., Aithal, G., Lucena, M. I., . . . Pirmohamed, M. (2019). Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.1493

    DOI: 10.1002/cpt.1493

    Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics (Journal article)

    Fitzgerald, G., Prince, C., Downing, J., Reynolds, J., Zhang, J. E., Hanson, A., . . . Pirmohamed, M. (2019). Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics. PHARMACOGENOMICS, 20(8), 599-608. doi:10.2217/pgs-2019-0021

    DOI: 10.2217/pgs-2019-0021

    Trends in BRCA testing over time and socioeconomic deprivation (Journal article)

    Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (n.d.). Trends in BRCA testing over time and socioeconomic deprivation. European Journal of Human Genetics. doi:10.1038/s41431-019-0424-3

    DOI: 10.1038/s41431-019-0424-3

    Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study (Journal article)

    Jorgensen, A. L., Prince, C., Fitzgerald, G., Hanson, A., Downing, J., Reynolds, J., . . . Pirmohamed, M. (2019). Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study. BMC MEDICINE, 17. doi:10.1186/s12916-019-1308-7

    DOI: 10.1186/s12916-019-1308-7

    Aspirin nonresponsiveness in pregnant women at high risk of pre-eclampsia (Conference Paper)

    Navaratnam, K., Agarwal, U., Alfirevic, A., & Alfirevic, Z. (2019). Aspirin nonresponsiveness in pregnant women at high risk of pre-eclampsia. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 126 (pp. 4). Retrieved from http://gateway.webofknowledge.com/

    Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin (Journal article)

    Navaratnam, K., Abreu, P., Clarke, H., Jorgensen, A., Alfirevic, A., & Alfirevic, Z. (2019). Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 32(2), 179-187. doi:10.1080/14767058.2017.1373760

    DOI: 10.1080/14767058.2017.1373760

    What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England. (Journal article)

    Giebel, C., McIntyre, J. C., Daras, K., Gabbay, M., Downing, J., Pirmohamed, M., . . . Barr, B. (2019). What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England.. BMJ open, 9(1), e022820. doi:10.1136/bmjopen-2018-022820

    DOI: 10.1136/bmjopen-2018-022820

    2018

    Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies (Journal article)

    Martin, A. P., Downing, J., Cochrane, M., Collins, B., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 130, 92-107. doi:10.1016/j.critrevonc.2018.07.012

    DOI: 10.1016/j.critrevonc.2018.07.012

    Trends in BRCA testing and socioeconomic deprivation (Conference Paper)

    Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (2019). Trends in BRCA testing and socioeconomic deprivation. In EUROPEAN JOURNAL OF HUMAN GENETICS Vol. 27 (pp. 1351-1360). doi:10.1038/s41431-019-0424-3

    DOI: 10.1038/s41431-019-0424-3

    TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES (Conference Paper)

    Martin, A. P., Downing, J., Collins, B., Cochrane, M., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES. In VALUE IN HEALTH Vol. 21 (pp. S43). doi:10.1016/j.jval.2018.04.248

    DOI: 10.1016/j.jval.2018.04.248

    Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures (Conference Paper)

    Mone, F., Phelan, M., Alfirevic, A., & McAuliffe, F. M. (2018). Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 66). Retrieved from http://gateway.webofknowledge.com/

    Genetic factors and response to low dose aspirin in pregnancy (Conference Paper)

    Alfirevic, A., Navaratnam, K., Alfirevic, Z., & Zhang, E. (2018). Genetic factors and response to low dose aspirin in pregnancy. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 104-105). Retrieved from http://gateway.webofknowledge.com/

    The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017) (Journal article)

    Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019

    DOI: 10.4049/jimmunol.1800019

    Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity (Journal article)

    Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030

    DOI: 10.1021/acs.chemrestox.8b00030

    Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia (Journal article)

    Navaratnam, K., Alfirevic, A., Jorgensen, A., & Alfirevic, Z. (2018). Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 221, 144-150. doi:10.1016/j.ejogrb.2017.12.052

    DOI: 10.1016/j.ejogrb.2017.12.052

    2017

    A common missense variant of LILRB5 is associated with statin intolerance and myalgia (Journal article)

    Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). A common missense variant of LILRB5 is associated with statin intolerance and myalgia. EUROPEAN HEART JOURNAL, 38(48), 3569-3U31. doi:10.1093/eurheartj/ehx467

    DOI: 10.1093/eurheartj/ehx467

    An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review (Journal article)

    Martin, A., Downing, J., Maden, M., Fleeman, N., Alfirevic, A., Haycox, A., & Pirmohamed, M. (2017). An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review. PHARMACOGENOMICS, 18(16), 1541-1550. doi:10.2217/pgs-2017-0076

    DOI: 10.2217/pgs-2017-0076

    Whole exome sequencing in individuals with statin-induced myopathy (Conference Paper)

    Bloch, K. M., Carr, D., Pirmohamed, M., Morris, A., Maroteau, C., Eriksson, N., . . . Alfirevic, A. (2017). Whole exome sequencing in individuals with statin-induced myopathy. In DRUG SAFETY Vol. 40 (pp. 1026). Retrieved from http://gateway.webofknowledge.com/

    Patient ethnicity and the risk of immune-mediated adverse drug reactions (Journal article)

    Alfirevic, A. (2017). Patient ethnicity and the risk of immune-mediated adverse drug reactions. PHARMACOGENOMICS, 18(15), 1375-1378. doi:10.2217/pgs-2017-0124

    DOI: 10.2217/pgs-2017-0124

    How important is aspirin adherence when evaluating effectiveness of low-dose aspirin? (Journal article)

    Navaratnam, K., Alfirevic, Z., Pirmohamed, M., & Alfirevic, A. (2017). How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 219, 1-9. doi:10.1016/j.ejogrb.2017.10.004

    DOI: 10.1016/j.ejogrb.2017.10.004

    Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout (Journal article)

    Plumpton, C. O., Alfirevic, A., Pirmohamed, M., & Hughes, D. A. (2017). Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. RHEUMATOLOGY, 56(10), 1729-1739. doi:10.1093/rheumatology/kex253

    DOI: 10.1093/rheumatology/kex253

    Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon susceptibility to hepatotoxicity (Conference Paper)

    Ball, A., Alfirevic, A., Lyon, J., & Chadwick, A. (2017). Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon susceptibility to hepatotoxicity. In DRUG SAFETY Vol. 40 (pp. 1024-1025). Retrieved from http://gateway.webofknowledge.com/

    CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia (Journal article)

    Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia. CIRCULATION-CARDIOVASCULAR GENETICS, 10(4). doi:10.1161/CIRCGENETICS.117.001737

    DOI: 10.1161/CIRCGENETICS.117.001737

    The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors (Journal article)

    Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. doi:10.4049/jimmunol.1602029

    DOI: 10.4049/jimmunol.1602029

    Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response (Journal article)

    Zhang, J. E., Klein, K., Jorgensen, A. L., Francis, B., Alfirevic, A., Bourgeois, S., . . . Pirmohamed, M. (2017). Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00323

    DOI: 10.3389/fphar.2017.00323

    HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study (Journal article)

    Bluett, J., Owen, S. -A., Massey, J., Alfirevic, A., Pirmohamed, M., Plant, D., . . . Consortium, P. S. (2017). HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study. ANNALS OF THE RHEUMATIC DISEASES, 76(12). doi:10.1136/annrheumdis-2017-211512

    DOI: 10.1136/annrheumdis-2017-211512

    EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES (Conference Paper)

    Martin, A. P., Haycox, A., Downing, J., Alfirevic, A., & Pirmohamed, M. (2016). EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES. In VALUE IN HEALTH Vol. 19 (pp. A266). doi:10.1016/j.jval.2016.03.771

    DOI: 10.1016/j.jval.2016.03.771

    Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population (Journal article)

    Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L. Y., Morris, A. P., Castro, E. M. C., . . . Pirmohamed, M. (2017). Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 72(4), 1152-1162. doi:10.1093/jac/dkw545

    DOI: 10.1093/jac/dkw545

    Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity (Journal article)

    Ghattaoraya, G. S., Middleton, D., Santos, E. J. M., Dickson, R., Jones, A. R., & Alfirevic, A. (2017). Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 44(1), 7-26. doi:10.1111/iji.12304

    DOI: 10.1111/iji.12304

    Genomics of Adverse Drug Reactions (Journal article)

    Alfirevic, A., & Pirmohamed, M. (2017). Genomics of Adverse Drug Reactions. TRENDS IN PHARMACOLOGICAL SCIENCES, 38(1), 100-109. doi:10.1016/j.tips.2016.11.003

    DOI: 10.1016/j.tips.2016.11.003

    New Approaches to Investigate Drug-Induced Hypersensitivity (Journal article)

    Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333

    DOI: 10.1021/acs.chemrestox.6b00333

    2016

    Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity (Journal article)

    Faulkner, L., Gibson, A., Sullivan, A., Tailor, A., Usui, T., Alfirevic, A., . . . Park, B. K. (2016). Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. TOXICOLOGICAL SCIENCES, 154(2), 416-429. doi:10.1093/toxsci/kfw177

    DOI: 10.1093/toxsci/kfw177

    Semi-systematic review of definitions and diagnostic tests for aspirin resistance: an opportunity to stratify prevention of placental disease (Conference Paper)

    Navaratnam, K., Alfirevic, A., & Alfirevic, Z. (2016). Semi-systematic review of definitions and diagnostic tests for aspirin resistance: an opportunity to stratify prevention of placental disease. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 123 (pp. E10-E11). Retrieved from http://gateway.webofknowledge.com/

    Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells (Journal article)

    Ball, A. L., Kamalian, L., Alfirevic, A., Lyon, J. J., & Chadwick, A. E. (2016). Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells. TOXICOLOGICAL SCIENCES, 153(2), 341-351. doi:10.1093/toxsci/kfw126

    DOI: 10.1093/toxsci/kfw126

    Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia (Journal article)

    Legge, S. E., Hamshere, M. L., Ripke, S., Pardinas, A. F., Goldstein, J. I., Rees, E., . . . Walters, J. T. R. (2017). Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Molecular Psychiatry, 22(10), 1502-1508. doi:10.1038/mp.2016.97

    DOI: 10.1038/mp.2016.97

    Pharmacogenetics and Pharmacogenomics (Chapter)

    Alfirevic, A., & Pirmohamed, M. (2016). Pharmacogenetics and Pharmacogenomics. In Medical and Health Genomics (pp. 121-137). Elsevier. doi:10.1016/b978-0-12-420196-5.00010-1

    DOI: 10.1016/b978-0-12-420196-5.00010-1

    Low dose aspirin and pregnancy: how important is aspirin resistance? (Journal article)

    Navaratnam, K., Alfirevic, A., & Alfirevic, Z. (2016). Low dose aspirin and pregnancy: how important is aspirin resistance?. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 123(9), 1481-1487. doi:10.1111/1471-0528.13914

    DOI: 10.1111/1471-0528.13914

    A web resource for mining HLA associations with adverse drug reactions: HLA-ADR. (Journal article)

    Ghattaoraya, G. S., Dundar, Y., González-Galarza, F. F., Maia, M. H. T., Santos, E. J. M., da Silva, A. L. S., . . . Jones, A. R. (2016). A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.. Database : the journal of biological databases and curation, 2016. doi:10.1093/database/baw069

    DOI: 10.1093/database/baw069

    2015

    Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses (Conference Paper)

    Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from http://gateway.webofknowledge.com/

    HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis (Journal article)

    Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546

    DOI: 10.1111/cea.12546

    Cost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy (Journal article)

    Plumpton, C. O., Yip, V. L., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy. Epilepsia.

    Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Conference Paper)

    O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from http://gateway.webofknowledge.com/

    Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Journal article)

    O'Hara, A., Burkitt, M., Carr, D., Alfirevic, A., Moore, A., Murugesan, S., . . . Pritchard, M. (2015). Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy.

    HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis (Journal article)

    Castro, E. M. C., Carr, D. F., Jorgensen, A. L., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis. PHARMACOGENETICS AND GENOMICS, 25(4), 186-198. doi:10.1097/FPC.0000000000000124

    DOI: 10.1097/FPC.0000000000000124

    Cost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy (Journal article)

    Plumpton, C. O., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost-effectiveness of screening for HLA-A*31:01 prior to initiation of carbamazepine in epilepsy. EPILEPSIA, 56(4), 556-563. doi:10.1111/epi.12937

    DOI: 10.1111/epi.12937

    Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry (Journal article)

    Alfirevic, A., Durocher, J., Elati, A., Leon, W., Dickens, D., Raedisch, S., . . . Winikoff, B. (2015). Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry. PHARMACOGENOMICS, 16(9), 919-928. doi:10.2217/pgs.15.53

    DOI: 10.2217/pgs.15.53

    2014

    Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations (Journal article)

    Gonzalez-Galarza, F. F., Takeshita, L. Y. C., Santos, E. J. M., Kempson, F., Thomaz Maia, M. H., Soares da Silva, A. L., . . . Middleton, D. (2015). Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. NUCLEIC ACIDS RESEARCH, 43(D1), D784-D788. doi:10.1093/nar/gku1166

    DOI: 10.1093/nar/gku1166

    Phenotype Standardization for Statin-Induced Myotoxicity (Journal article)

    Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., . . . Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 470-476. doi:10.1038/clpt.2014.121

    DOI: 10.1038/clpt.2014.121

    Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System (Journal article)

    Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q. -Y., . . . Palmer, C. N. A. (2014). Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 477-481. doi:10.1038/clpt.2014.138

    DOI: 10.1038/clpt.2014.138

    Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review (Journal article)

    Yip, V. L. M., Alfirevic, A., & Pirmohamed, M. (2015). Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 48(2-3), 165-175. doi:10.1007/s12016-014-8418-y

    DOI: 10.1007/s12016-014-8418-y

    Pharmacogenetics of antiepileptic drug-induced hypersensitivity (Journal article)

    Bloch, K. M., Sills, G. J., Pirmohamed, M., & Alfirevic, A. (2014). Pharmacogenetics of antiepileptic drug-induced hypersensitivity. PHARMACOGENOMICS, 15(6), 857-868. doi:10.2217/PGS.14.65

    DOI: 10.2217/PGS.14.65

    HLA restriction of carbamazepine-specific T-Cell clones from an HLA-A*31:01-positive hypersensitive patient. (Journal article)

    Lichtenfels, M., Farrell, J., Ogese, M., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-Cell clones from an HLA-A*31:01-positive hypersensitive patient.. Chemical Research in Toxicology, 27(2), 175-177.

    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles (Journal article)

    Goldstein, J. I., Jarskog, L. F., Hilliard, C., Alfirevic, A., Duncan, L., Fourches, D., . . . Sullivan, P. F. (2014). Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. NATURE COMMUNICATIONS, 5. doi:10.1038/ncomms5757

    DOI: 10.1038/ncomms5757

    GATM gene variants and statin myopathy risk (Journal article)

    Carr, D. F., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014). GATM gene variants and statin myopathy risk. NATURE, 513(7518), E1. doi:10.1038/nature13628

    DOI: 10.1038/nature13628

    HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient (Journal article)

    Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient. CHEMICAL RESEARCH IN TOXICOLOGY, 27(2), 175-177. doi:10.1021/tx400460w

    DOI: 10.1021/tx400460w

    Is the Interleukin 8 Promoter Polymorphism rs4073/-251T > A Associated With Clostridium difficile Infection? (Journal article)

    Miyajima, F., Swale, A., Zhang, J. E., Alfirevic, A., Little, M., Beeching, N. J., . . . Pirmohamed, M. (2014). Is the Interleukin 8 Promoter Polymorphism rs4073/-251T > A Associated With Clostridium difficile Infection?. CLINICAL INFECTIOUS DISEASES, 58(12), E148-E151. doi:10.1093/cid/ciu152

    DOI: 10.1093/cid/ciu152

    Pathway Analysis of Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes (Journal article)

    Capece, A., Vasieva, O., Meher, S., Alfirevic, Z., & Alfirevic, A. (2014). Pathway Analysis of Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes. PLOS ONE, 9(9). doi:10.1371/journal.pone.0108578

    DOI: 10.1371/journal.pone.0108578

    Pharmacogenomics: Current State-of-the-Art (Journal article)

    Carr, D. F., Alfirevic, A., & Pirmohamed, M. (2014). Pharmacogenomics: Current State-of-the-Art. GENES, 5(2), 430-443. doi:10.3390/genes5020430

    DOI: 10.3390/genes5020430

    2013

    Genetic testing for prevention of severe drug-induced skin rash (Journal article)

    Alfirevic, A., Pirmohamed, M., Marinovic, B., Jorgensen, A. L., & Harcourt-Smith, L. (n.d.). Genetic testing for prevention of severe drug-induced skin rash. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd010891

    DOI: 10.1002/14651858.cd010891

    Safety pharmacology--current and emerging concepts. (Journal article)

    Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology--current and emerging concepts.. Toxicology and applied pharmacology, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039

    DOI: 10.1016/j.taap.2013.04.039

    Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)

    Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

    DOI: 10.1016/j.jaci.2013.02.045

    The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK (Journal article)

    Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73

    DOI: 10.2217/PGS.13.73

    T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)

    Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p

    DOI: 10.1021/tx400060p

    Response to "HLA allelic variants and carbamazepine-induced hypersensitivity". (Journal article)

    Yip, V., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".. Clinical Pharmacology and Therapeutics, 93(5), 387.

    A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp (Journal article)

    Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLOS ONE, 8(5). doi:10.1371/journal.pone.0064854

    DOI: 10.1371/journal.pone.0064854

    A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material (Journal article)

    Bediaga, N. G., Davies, M. P. A., Acha-Sagredo, A., Hyde, R., Raji, O. Y., Page, R., . . . Liloglou, T. (2013). A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material. BRITISH JOURNAL OF CANCER, 109(9), 2404-2411. doi:10.1038/bjc.2013.623

    DOI: 10.1038/bjc.2013.623

    A multi-system approach assessing the interaction of anticonvulsants with P-gp. (Journal article)

    Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A multi-system approach assessing the interaction of anticonvulsants with P-gp.. PloS One, 8(5), e64854.

    ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein (Journal article)

    Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein. PHARMACOGENETICS AND GENOMICS, 23(6), 314-323. doi:10.1097/FPC.0b013e328360d10c

    DOI: 10.1097/FPC.0b013e328360d10c

    Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population (Journal article)

    Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021

    DOI: 10.1093/cid/cit021

    Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)

    Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

    DOI: 10.1002/hep.26077

    Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity" (Journal article)

    Yip, V. L. M., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity". CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(5), 387. doi:10.1038/clpt.2013.5

    DOI: 10.1038/clpt.2013.5

    2012

    HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review. (Journal article)

    Yip, V., Marson, T., Jorgensen, A., Pirmohamed, M., & Alfirevic, A. (2012). HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.. Clinical Pharmacology and Therapeutics, 92(6), 757-765.

    5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands (Journal article)

    Fox, J. C., Daly, A., Cascorbi, I., Alfirevic, A., Linden, H., & Maitland-van der Zee, A. H. (2012). 5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands. Pharmacogenomics, 13(7), 747-749.

    Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity (Journal article)

    Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146

    DOI: 10.2217/PGS.12.146

    HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review (Journal article)

    Yip, V. L., Marson, A. G., Jorgensen, A. L., Pirmohamed, M., & Alfirevic, A. (2012). HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 757-765. doi:10.1038/clpt.2012.189

    DOI: 10.1038/clpt.2012.189

    HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)

    Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.

    In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers (Journal article)

    Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350

    DOI: 10.1186/gm350

    Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility (Journal article)

    Alfirevic, A., & Pirmohamed, M. (2012). Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(3), 376-380. doi:10.1038/clpt.2012.107

    DOI: 10.1038/clpt.2012.107

    Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal (Journal article)

    Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. BRITISH JOURNAL OF DERMATOLOGY, 166(1), 12-14. doi:10.1111/j.1365-2133.2011.10760.x

    DOI: 10.1111/j.1365-2133.2011.10760.x

    Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. (Journal article)

    Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal.. British Journal of Dermatology, 166(1), 12-14.

    2011

    Drug Induced Hypersensitivity and the HLA Complex. (Journal article)

    Alfirevic, A., & Pirmohamed, M. (2011). Drug Induced Hypersensitivity and the HLA Complex.. Pharmaceuticals (Basel, Switzerland), 4(1), 69-90. doi:10.3390/ph4010069

    DOI: 10.3390/ph4010069

    HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans (Journal article)

    McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans. NEW ENGLAND JOURNAL OF MEDICINE, 364(12), 1134-1143. doi:10.1056/NEJMoa1013297

    DOI: 10.1056/NEJMoa1013297

    HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans (Journal article)

    McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperavičiūtė, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med, 364(12), 1134-1143.

    Lamotrigine is a substrate for OCT1 in brain endothelial cells (Journal article)

    Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B., . . . Pirmohamed, M. (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. BIOCHEMICAL PHARMACOLOGY, 83(6), 805-814. doi:10.1016/j.bcp.2011.12.032

    DOI: 10.1016/j.bcp.2011.12.032

    Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors (Journal article)

    Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. PHARMACOGENETICS AND GENOMICS, 21(5), 297-302. doi:10.1097/FPC.0b013e3283441b95

    DOI: 10.1097/FPC.0b013e3283441b95

    Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing (Journal article)

    Wadelius, M., & Alfirevic, A. (2011). Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing. Genome Medicine, 3(12), 78.

    Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics (Journal article)

    Becquemont, L., Alfirevic, A., Amstutz, U., Brauch, H., Jacqz-Aigrain, E., Laurent-Puig, P., . . . Daly, A. K. (2011). Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics. Pharmacogenomics, 12(1), 113-124.

    Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine. (Journal article)

    Carr, D. F., & Alfirevic, A. (2011). Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine.. Pharmacogenomics, 12(3), 315-317. doi:10.2217/pgs.10.217

    DOI: 10.2217/pgs.10.217

    2010

    Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future (Journal article)

    Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. PHARMACOGENOMICS, 11(4), 497-499. doi:10.2217/PGS.10.12

    DOI: 10.2217/PGS.10.12

    Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. (Journal article)

    Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.. Pharmacogenomics, 11(4), 497-499.

    Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. (Journal article)

    Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2010). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.. Pharmacogenetics and Genomics, 21(5), 297-302.

    Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice. (Journal article)

    Maitland-van der Zee, A. H., & Alfirevic, A. (2010). Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice.. Genome Medicine, 2(9), 69.

    Pharmacogenetics in reproductive and perinatal medicine (Journal article)

    Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. Pharmacogenomics, 11(1), 65-79.

    Pharmacogenetics in reproductive and perinatal medicine (Journal article)

    Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. PHARMACOGENOMICS, 11(1), 65-79. doi:10.2217/PGS.09.153

    DOI: 10.2217/PGS.09.153

    Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy (Journal article)

    Amara, A. B., Sharma, A., Alexander, J. L., Alfirevic, A., Mohiuddin, A., Pirmohamed, M., . . . Rustom, R. (2010). Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy. TRANSPLANTATION, 89(1), 104-114. doi:10.1097/TP.0b013e3181bf13d9

    DOI: 10.1097/TP.0b013e3181bf13d9

    2009

    The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy (Journal article)

    Adetunji, O. R., MacFarlane, I. A., Javadpour, M., Alfirevic, A., Pirmohamed, M., & Blair, J. C. (2009). The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 161(4), 541-546. doi:10.1530/EJE-09-0405

    DOI: 10.1530/EJE-09-0405

    Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients (Journal article)

    Adetunji, O. R., Blair, J. C., Javadpour, M., Alfirevic, A., Pirmohamed, M., & MacFarlane, I. A. (2010). Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients. CLINICAL ENDOCRINOLOGY, 72(3), 422-423. doi:10.1111/j.1365-2265.2009.03638.x

    DOI: 10.1111/j.1365-2265.2009.03638.x

    Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)

    Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347

    DOI: 10.1097/FPC.0b013e3283311347

    Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)

    Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. Pharmacogenetics and Genomics, 10, 781-789.

    Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review (Journal article)

    Carr, D. F., Whiteley, G., Alfirevic, A., Pirmohamed, M., & Team, F. S. (2009). Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. PHARMACOGENOMICS JOURNAL, 9(5), 291-305. doi:10.1038/tpj.2009.29

    DOI: 10.1038/tpj.2009.29

    TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole (Journal article)

    Alfirevic, A., Vilar, F. J., Alsbou, M., Jawaid, A., Thomson, W., Ollier, W. E. R., . . . Pirmohamed, M. (2009). TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. PHARMACOGENOMICS, 10(4), 531-540. doi:10.2217/PGS.09.6

    DOI: 10.2217/PGS.09.6

    2008

    Adverse drug reactions and pharmacogenomics: recent advances (Journal article)

    Alfirevic, A., & Pirmohamed, M. (2008). Adverse drug reactions and pharmacogenomics: recent advances. PERSONALIZED MEDICINE, 5(1), 11-23. doi:10.2217/17410541.5.1.11

    DOI: 10.2217/17410541.5.1.11

    Pharmacogenetics and pharmacogenomics: adverse drug reactions. (Journal article)

    Jorgensen, A., & Alfirevic, A. (2008). Pharmacogenetics and pharmacogenomics: adverse drug reactions.. Pharmacogenomics, 9(10), 1397-1401. doi:10.2217/14622416.9.10.1397

    DOI: 10.2217/14622416.9.10.1397

    2007

    Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity (Journal article)

    Carr, D. F., Alfirevic, A., Tugwood, J. D., Barratt, B. J., Sherwood, J., Smith, J., . . . Park, B. K. (2007). Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 17(11), 961-972. doi:10.1097/FPC.0b013e3282f00919

    DOI: 10.1097/FPC.0b013e3282f00919

    Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective (Journal article)

    Alfirevic, A., & Pirmohamed, M. (2008). Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective. Journal of Applied Therapeutic Research, 6(3), 3-8.

    Pharmacogenetics of adverse drug reactions: a pharmacovigilance perspective. (Journal article)

    Alfirevic, A., & Pirmohamed, M. (2007). Pharmacogenetics of adverse drug reactions: a pharmacovigilance perspective.. Pharmacovigilance Review, 1(3), 22-25.

    Tacrine-induced liver damage: an analysis of 19 candidate genes (Journal article)

    Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Jawaid, A., Sherwood, J., . . . Pirmohamed, M. (2007). Tacrine-induced liver damage: an analysis of 19 candidate genes. PHARMACOGENETICS AND GENOMICS, 17(12), 1091-1100. doi:10.1097/FPC.0b013e3282f1f12b

    DOI: 10.1097/FPC.0b013e3282f1f12b

    2006

    HLA-B locus in Caucasian patients with carbamazepine hypersensitivity (Journal article)

    Alfirevic, A., Jorgensen, A. L., Williamson, P. R., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2006). HLA-B locus in Caucasian patients with carbamazepine hypersensitivity. PHARMACOGENOMICS, 7(6), 813-818. doi:10.2217/14622416.7.6.813

    DOI: 10.2217/14622416.7.6.813

    Pharmacogenetics of Adverse Drug Reactions (Chapter)

    Alfirevic, A., Park, B. K., & Pirmohamed, M. (2006). Pharmacogenetics of Adverse Drug Reactions. In I. Hall, & M. Pirmohamed (Eds.), Textbook of Pharmacogenetics (pp. in press). New York: Marcel Dekker.

    Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster (Journal article)

    Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2006). Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. PHARMACOGENETICS AND GENOMICS, 16(4), 287-296. doi:10.1097/01.fpc.0000189800.88596.7a

    DOI: 10.1097/01.fpc.0000189800.88596.7a

    The 2nd International Drug Hypersensitivity Meeting (Journal article)

    Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting. Expert Opinion on Drug Safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729

    DOI: 10.1517/14740338.5.5.729

    2005

    Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster (Journal article)

    Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2005). Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster. TOXICOLOGY, 213(3), 264-265. Retrieved from http://gateway.webofknowledge.com/

    Molecular aspects of carbamazepine-induced hypersensitivity reactions (Thesis / Dissertation)

    Alfirevic, A. (2005). Molecular aspects of carbamazepine-induced hypersensitivity reactions. (PhD Thesis, The University of Liverpool).

    2004

    Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. (Journal article)

    Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.. Pharmacogenetics, 14(6), 335-342. doi:10.1097/00008571-200406000-00002

    DOI: 10.1097/00008571-200406000-00002

    Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity (Journal article)

    Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. PHARMACOGENETICS, 14(6), 335-342. doi:10.1097/00008571-200406000-00002

    DOI: 10.1097/00008571-200406000-00002

    2003

    Erratum (Journal article)

    Erratum (n.d.). British Journal of Clinical Pharmacology, 55(4), 417. doi:10.1046/j.1365-2125.2003.01815.x

    DOI: 10.1046/j.1365-2125.2003.01815.x

    Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity (Journal article)

    Alfirevic, A., Stalford, A. C., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2003). Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(2), 158-165. doi:10.1046/j.1365-2125.2003.01754.x

    DOI: 10.1046/j.1365-2125.2003.01754.x

    2002

    TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy (Journal article)

    Maher, B., Alfirevic, A., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2002). TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS, 16(15), 2013-2018. doi:10.1097/00002030-200210180-00005

    DOI: 10.1097/00002030-200210180-00005

    2000

    Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity (Journal article)

    Pirmohamed, M., Alfirevic, A., Vilar, J., Stalford, A., Wilkins, E. G. L., Sim, E., & Park, B. K. (2000). Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity. PHARMACOGENETICS, 10(8), 705-713. doi:10.1097/00008571-200011000-00005

    DOI: 10.1097/00008571-200011000-00005

    1989

    Correlation between bone scans and serum levels of osteocalcin, prostate-specific antigen, and prostatic acid phosphatase in monitoring patients with disseminated cancer of the prostate (Journal article)

    Tarle, M., Kovaćić, K., & Strelkov-Alfirević, A. (1989). Correlation between bone scans and serum levels of osteocalcin, prostate-specific antigen, and prostatic acid phosphatase in monitoring patients with disseminated cancer of the prostate. The Prostate, 15(3), 211-219. doi:10.1002/pros.2990150302

    DOI: 10.1002/pros.2990150302