Photo of Dr Svetlana Antonyuk

Dr Svetlana Antonyuk Ph.D.

Reader Biochemistry & Systems Biology

Publications

2021

An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures (Journal article)

Rose, S. L., Antonyuk, S. V., Sasaki, D., Yamashita, K., Hirata, K., Ueno, G., . . . Hasnain, S. S. (2021). An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures. SCIENCE ADVANCES, 7(1). doi:10.1126/sciadv.abd8523

DOI: 10.1126/sciadv.abd8523

Reverse protein engineering of a novel 4-domain copper nitrite reductase reveals functional regulation by protein-protein interaction (Journal article)

Sasaki, D., Watanabe, T. F., Eady, R. R., Garratt, R. C., Antonyuk, S. V., & Hasnain, S. S. (2021). Reverse protein engineering of a novel 4-domain copper nitrite reductase reveals functional regulation by protein-protein interaction. FEBS JOURNAL, 288(1), 262-280. doi:10.1111/febs.15324

DOI: 10.1111/febs.15324

2020

Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis (Journal article)

Hough, M. A., Conradie, J., Strange, R. W., Antonyuk, S. V., Eady, R. R., Ghosh, A., & Hasnain, S. S. (n.d.). Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis. Chemical Science. doi:10.1039/d0sc04797j

DOI: 10.1039/d0sc04797j

AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand (Journal article)

Pongchaikul, P., Santanirand, P., Antonyuk, S., Winstanley, C., & Darby, A. C. (2020). AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand. FEMS MICROBIOLOGY LETTERS, 367(14). doi:10.1093/femsle/fnaa109

DOI: 10.1093/femsle/fnaa109

Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases (Journal article)

Wright, G. S. A., Watanabe, T. F., Amporndanai, K., Plotkin, S. S., Cashman, N. R., Antonyuk, S. V., & Hasnain, S. S. (2020). Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases. iScience, 23(6). doi:10.1016/j.isci.2020.101159

DOI: 10.1016/j.isci.2020.101159

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites (Journal article)

McPhillie, M. J., Zhou, Y., Hickman, M. R., Gordon, J. A., Weber, C. R., Li, Q., . . . McLeod, R. (n.d.). Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites. Frontiers in Cellular and Infection Microbiology, 10. doi:10.3389/fcimb.2020.00203

DOI: 10.3389/fcimb.2020.00203

Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene (Journal article)

Panmanee, J., Antonyuk, S. V., & Hasnain, S. S. (2020). Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 76, 594-607. doi:10.1107/S2059798320006002

DOI: 10.1107/S2059798320006002

Structures of substrate- and product-bound forms of a multi-domain copper nitrite reductase shed light on the role of domain tethering in protein complexes (Journal article)

Sasaki, D., Watanabe, T. F., Eady, R. R., Garratt, R. C., Antonyuk, S. V., & Hasnain, S. S. (2020). Structures of substrate- and product-bound forms of a multi-domain copper nitrite reductase shed light on the role of domain tethering in protein complexes. IUCrJ, 7(3), 557-565. doi:10.1107/s2052252520005230

DOI: 10.1107/s2052252520005230

The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer (Journal article)

Jamali, M. A. M., Gopalasingam, C. C., Johnson, R. M., Tosha, T., Muramoto, K., Muench, S. P., . . . Hasnain, S. S. (2020). The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer. IUCrJ, 7(3), 404-415. doi:10.1107/s2052252520003656

DOI: 10.1107/s2052252520003656

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (vol 6, 29179, 2016) (Journal article)

McPhillie, M., Zhou, Y., El Bissati, K., Dubey, J., Lorenzi, H., Capper, M., . . . McLeod, R. (2020). New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (vol 6, 29179, 2016). SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-62323-1

DOI: 10.1038/s41598-020-62323-1

Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy (Journal article)

Chantadul, V., Wright, G. S. A., Amporndanai, K., Shahid, M., Antonyuk, S. V., Washbourn, G., . . . Hasnain, S. S. (2020). Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-0826-3

DOI: 10.1038/s42003-020-0826-3

Long-QT Syndrome-Associated Calmodulin Mutations and Their Interactions at the K(v)7.1 Potassium Channel (Conference Paper)

McCormick, L. F., Gupta, N., Haynes, L. P., Antonyuk, S., Dart, C., & Helassa, N. (2020). Long-QT Syndrome-Associated Calmodulin Mutations and Their Interactions at the K(v)7.1 Potassium Channel. In BIOPHYSICAL JOURNAL Vol. 118 (pp. 404A). Retrieved from http://gateway.webofknowledge.com/

Prevotella intermedia produces two proteins homologous to Porphyromonas gingivalis HmuY but with different heme coordination mode (Journal article)

Bielecki, M., Antonyuk, S., Strange, R. W., Sieminska, K., Smalley, J. W., Mackiewicz, P., . . . Olczak, T. (2020). Prevotella intermedia produces two proteins homologous to Porphyromonas gingivalis HmuY but with different heme coordination mode. Biochemical Journal, 477(2), 381-405. doi:10.1042/bcj20190607

DOI: 10.1042/bcj20190607

2019

The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis. (Journal article)

Wright, G. S. A., Antonyuk, S. V., & Hasnain, S. S. (2019). The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis.. Quarterly reviews of biophysics, 52, e12. doi:10.1017/s003358351900012x

DOI: 10.1017/s003358351900012x

Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo–electron microscopy (Journal article)

Gopalasingam, C. C., Johnson, R. M., Chiduza, G. N., Tosha, T., Yamamoto, M., Shiro, Y., . . . Samar Hasnain, S. (2019). Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo–electron microscopy. Science Advances, 5(8). doi:10.1126/sciadv.aax1803

DOI: 10.1126/sciadv.aax1803

Crystal Structure of the Japanese Encephalitis Virus Capsid Protein (Journal article)

Poonsiri, T., Wright, G., Solomon, T., & Antonyuk, S. V. (2019). Crystal Structure of the Japanese Encephalitis VirusCapsid Protein. Viruses, 11(7). doi:10.3390/v11070623

DOI: 10.3390/v11070623

Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis (Journal article)

Hedison, T. M., Shenoy, R. T., Iorgu, A. I., Heyes, D. J., Fisher, K., Wright, G. S. A., . . . Scrutton, N. S. (2019). Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis. ACS Catalysis, 9(7), 6087-6099. doi:10.1021/acscatal.9b01266

DOI: 10.1021/acscatal.9b01266

Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography (Journal article)

Halsted, T. P., Yamashita, K., Gopalasingam, C. C., Shenoy, R. T., Hirata, K., Ago, H., . . . Hasnain, S. S. (2019). Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography. IUCRJ, 6, 761-772. doi:10.1107/S2052252519008285

DOI: 10.1107/S2052252519008285

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM (Journal article)

Chiduza, G. N., Johnson, R. M., Wright, G. S. A., Antonyuk, S. V., Muench, S. P., & Hasnain, S. S. (2019). LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 75, 660-669. doi:10.1107/S2059798319009094

DOI: 10.1107/S2059798319009094

Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory ß subunit and quinolone-based compounds (Journal article)

Panmanee, J., Bradley-Clarke, J., Mato, J. M., O'Neill, P. M., Antonyuk, S. V., & Hasnain, S. S. (2019). Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory ß subunit and quinolone-based compounds. The Federation of European Biochemical Societies (FEBS) Journal, 286(11), 2135-2154. doi:10.1111/febs.14790

DOI: 10.1111/febs.14790

The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM (Journal article)

Muench, S. P., Antonyuk, S. V., & Hasnain, S. S. (2019). The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM. IUCRJ, 6(2), 167-177. doi:10.1107/S2052252519002422

DOI: 10.1107/S2052252519002422

Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS (Journal article)

Sala, F. A., Wright, G. S. A., Antonyuk, S. V., Garratt, R. C., & Hasnain, S. S. (2019). Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. PLOS BIOLOGY, 17(2). doi:10.1371/journal.pbio.3000141

DOI: 10.1371/journal.pbio.3000141

Noncovalent Complexes Formed between Metal-Substituted Polyoxometalates and Hen Egg White Lysozyme (Journal article)

Vandebroek, L., Mampaey, Y., Antonyuk, S., Van Meervelt, L., & Parac-Vogt, T. N. (2019). Noncovalent Complexes Formed between Metal-Substituted Polyoxometalates and Hen Egg White Lysozyme. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, (3-4), 506-511. doi:10.1002/ejic.201801113

DOI: 10.1002/ejic.201801113

Talaromyces marneffei Mp1 protein, a novel virulence factor, carries two arachidonic acid-binding domains to suppress inflammatory responses in hosts. (Journal article)

Lam, W. -H., Sze, K. -H., Ke, Y., Tse, M. -K., Zhang, H., Woo, P. C. Y., . . . Hao, Q. (2019). Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts. INFECTION AND IMMUNITY, 87(4). doi:10.1128/IAI.00679-18

DOI: 10.1128/iai.00679-18

2018

Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties (Journal article)

David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371

DOI: 10.1021/acsmedchemlett.8b00371

Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties (Journal article)

Bielecki, M., Antonyuk, S., Strange, R. W., Smalley, J. W., Mackiewicz, P., Smiga, M., . . . Olczak, T. (2018). Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties. BIOSCIENCE REPORTS, 38. doi:10.1042/BSR20181325

DOI: 10.1042/BSR20181325

Porphyromonas gingivalis HmuY and Tannerella forsythia Tfo - two homologous proteins with different heme-binding properties (Conference Paper)

Bielecki, M., Antonyuk, S., Strange, R. W., Smalley, J. W., Smiga, M., Stepien, P., . . . Olczak, T. (2018). Porphyromonas gingivalis HmuY and Tannerella forsythia Tfo - two homologous proteins with different heme-binding properties. In FEBS OPEN BIO Vol. 8 (pp. 428). Retrieved from http://gateway.webofknowledge.com/

Structural and functional insights into the unique CBS–CP12 fusion protein family in cyanobacteria (Journal article)

Hackenberg, C., Hakanpaeae, J., Cai, F., Antonyuk, S., Eigner, C., Meissner, S., . . . Lamzin, V. S. (2018). Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(27), 7141-7146. doi:10.1073/pnas.1806668115

DOI: 10.1073/pnas.1806668115

Activation of superoxide dismutase-1 by its copper chaperone is orchestrated by a single methyl group (Conference Paper)

Wright, G., Sala, F., Antonyuk, S., Garratt, R., & Hasnain, S. (2018). Activation of superoxide dismutase-1 by its copper chaperone is orchestrated by a single methyl group. In FEBS OPEN BIO Vol. 8 (pp. 37). Retrieved from http://gateway.webofknowledge.com/

EM studies of cytochrome bc(1) to elucidate inhibitor binding (Conference Paper)

Amporndanai, K., Fishwick, C., Hasnain, S., Antonyuk, S., & Muench, S. (2018). EM studies of cytochrome bc(1) to elucidate inhibitor binding. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 74 (pp. A121). Retrieved from http://gateway.webofknowledge.com/

Identification of a tyrosine switch in copper-haem nitrite reductases (Journal article)

Dong, J., Sasaki, D., Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2018). Identification of a tyrosine switch in copper-haem nitrite reductases. IUCrJ, 5(4), 510-518. doi:10.1107/S2052252518008242

DOI: 10.1107/S2052252518008242

Prevotella intermedia produces two homologous proteins to Porphyromonas gingivalis HmuY with different heme-binding properties (Conference Paper)

Bielecki, M., Antonyuk, S., Strange, R. W., Smalley, J. W., Smiga, M., Stepien, P., . . . Olczak, T. (2018). Prevotella intermedia produces two homologous proteins to Porphyromonas gingivalis HmuY with different heme-binding properties. In FEBS OPEN BIO Vol. 8 (pp. 429). Retrieved from http://gateway.webofknowledge.com/

Structural studies of human superoxide dismutase (SOD1) with its metallochaperone (Conference Paper)

Sala, F. A., Wright, G. S. A., Antonyuk, S. V., Garratt, R. C., & Hasnain, S. S. (2018). Structural studies of human superoxide dismutase (SOD1) with its metallochaperone. In FEBS OPEN BIO Vol. 8 (pp. 432-433). Retrieved from http://gateway.webofknowledge.com/

Enzyme catalysis captured using multiple structures from one crystal at varying temperatures (Journal article)

Horrell, S., Kekilli, D., Sen, K., Owen, R. U., Dworkowski, F. S. N., Antonyuk, S. V., . . . Hough, M. A. (2018). Enzyme catalysis captured using multiple structures from one crystal at varying temperatures. IUCRJ, 5, 283-292. doi:10.1107/S205225251800386X

DOI: 10.1107/S205225251800386X

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation (Journal article)

Capper, M. J., Wright, G. S. A., Barbieri, L., Luchinat, E., Mercatelli, E., McAlary, L., . . . Hasnain, S. S. (2018). The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04114-x

DOI: 10.1038/s41467-018-04114-x

Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system (Journal article)

Wright, G. S. A., Saeki, A., Hikima, T., Nishizono, Y., Hisano, T., Kamaya, M., . . . Sawai, H. (2018). Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system. SCIENCE SIGNALING, 11(525). doi:10.1126/scisignal.aaq0825

DOI: 10.1126/scisignal.aaq0825

Structural study of the C-terminal domain of non-structural protein 1 from Japanese encephalitis virus (Journal article)

Poonsiri, T., Wright, G. S. A., Diamond, M. S., Turtle, L., Solomon, T., & Antonyuk, S. V. (2018). Structural study of the C-terminal domain of non-structural protein 1 from Japanese encephalitis virus. Journal of Virology, 92(7). doi:10.1128/jvi.01868-17

DOI: 10.1128/jvi.01868-17

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery (Journal article)

Amporndanai, K., Johnson, R. M., O'Neill, P., Fishwick, C. W. G., Jamson, A. H., Rawson, S., . . . Hasnain, S. (2018). X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery. IUCrJ, 5(Pt 2), 200-210. doi:10.1107/S2052252518001616

DOI: 10.1107/S2052252518001616

Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme (Journal article)

Gonska, N., Young, D., Yuki, R., Okamoto, T., Hisano, T., Antonyuk, S., . . . Adelroth, P. (2018). Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-21804-0

DOI: 10.1038/s41598-018-21804-0

Characterization of the quinoldependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme (Journal article)

Antonyuk, S. V., Hasnain, S., Gonska, N., Young, D., Yuki, R., Okamoto, T., . . . Ädelroth, P. (n.d.). Characterization of the quinoldependent nitric oxide reductasefrom the pathogen Neisseria meningitidis, an electrogenic enzyme. Scientific Reports. doi:10.1038/s41598-018-21804-0

DOI: 10.1038/s41598-018-21804-0

Dystonia-Associated Hippocalcin Mutants Dysregulate Cellular Calcium Influx (Conference Paper)

Helassa, N., Antonyuk, S. V., Lian, L. -Y., Haynes, L. P., & Burgoyne, R. D. (2018). Dystonia-Associated Hippocalcin Mutants Dysregulate Cellular Calcium Influx. In BIOPHYSICAL JOURNAL Vol. 114 (pp. 467A-468A). Retrieved from http://gateway.webofknowledge.com/

An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase (Journal article)

Halsted, T. P., Yamashita, K., Hirata, K., Ago, H., Ueno, G., Tosha, T., . . . Hasnain, S. S. (2018). An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase. IUCRJ, 5, 22-31. doi:10.1107/S2052252517016128

DOI: 10.1107/S2052252517016128

2017

MSOX crystallography and simulations to capture redox enzyme catalysis (Conference Paper)

Hough, M. A., Kekilli, D., Horrell, S., Sen, K., Yong, C., Keal, T. W. K., . . . Strange, R. W. (2017). MSOX crystallography and simulations to capture redox enzyme catalysis. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 73 (pp. C651). doi:10.1107/S2053273317089227

DOI: 10.1107/S2053273317089227

INTRA- AND INTER-MOLECULAR SIGNAL TRANSDUCTION MECHANISMS OF HEME SENSING SYSTEMS (Conference Paper)

Sawai, H., Wright, G. S. A., Saeki, A., Hikima, T., Yamamoto, M., Antonyuk, S., . . . Shiro, Y. (2017). INTRA- AND INTER-MOLECULAR SIGNAL TRANSDUCTION MECHANISMS OF HEME SENSING SYSTEMS. In AMERICAN JOURNAL OF HEMATOLOGY Vol. 92 (pp. E463). Retrieved from http://gateway.webofknowledge.com/

Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia (Journal article)

Helassa, N., Antonyuk, S. V., Lian, L. -Y., Haynes, L. P., & Burgoyne, R. D. (2017). Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Human molecular genetics, 26(13), 2426-2435. doi:10.1093/hmg/ddx133

DOI: 10.1093/hmg/ddx133

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. (Journal article)

Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (n.d.). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.. Scientific Reports, 7. doi:10.1038/srep43580

DOI: 10.1038/srep43580

2016

Single Crystal Serial Crystallography to Capture Redox Enzyme Catalysis and Dynamics (Conference Paper)

Schneider, G., Pearson, A., Hough, M., Kekilli, D., Horrell, S., Dworkowski, F. S. N., . . . Strange, R. W. (2016). Single Crystal Serial Crystallography to Capture Redox Enzyme Catalysis and Dynamics. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 72 (pp. S38). doi:10.1107/S205327331609940X

DOI: 10.1107/S205327331609940X

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (Journal article)

McPhillie, M., Zhou, Y., El Bissati, K., Dubey, J., Lorenzi, H., Capper, M., . . . McLeod, R. (2016). New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. SCIENTIFIC REPORTS, 6, 23 pages. doi:10.1038/srep29179

DOI: 10.1038/srep29179

Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal (Journal article)

Horrell, S., Antonyuk, S. V., Eady, R. R., Hasnain, S. S., Hough, M. A., & Strange, R. W. (2016). Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal. IUCrJ, 3(Part 4), 271-281. doi:10.1107/S205225251600823X

DOI: 10.1107/S205225251600823X

A faulty interaction between SOD1 and hCCS in neurodegenerative disease (Journal article)

Wright, G. S. A., Antonyuk, S. V., & Hasnain, S. S. (2016). A faulty interaction between SOD1 and hCCS in neurodegenerative disease. SCIENTIFIC REPORTS, 6. doi:10.1038/srep27691

DOI: 10.1038/srep27691

Fresh insight to functioning of selected enzymes of the nitrogen cycle (Journal article)

Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2016). Fresh insight to functioning of selected enzymes of the nitrogen cycle. CURRENT OPINION IN CHEMICAL BIOLOGY, 31, 103-112. doi:10.1016/j.cbpa.2016.02.009

DOI: 10.1016/j.cbpa.2016.02.009

Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes (Journal article)

Murray, B., Antonyuk, S. V., Marina, A., Lu, S. C., Mato, J. M., Hasnain, S. S., & Rojas, A. L. (2016). Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes. Proceedings of the National Academy of Sciences of USA, 113(8), 2104-2109. doi:10.1073/pnas.1510959113

DOI: 10.1073/pnas.1510959113

2015

Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential (Journal article)

Blakeley, M. P., Hasnain, S. S., & Antonyuk, S. V. (2015). Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential. IUCRJ, 2, 464-474. doi:10.1107/S2052252515011239

DOI: 10.1107/S2052252515011239

Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 (Journal article)

Capper, M., O'Neill, P., Fisher, N., Strange, R., Moss, D., Ward, S., . . . Antonyuk, S. (2015). Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Proceedings of the National Academy of Sciences of the United States of America, 112(3), 755-760. doi:10.1073/pnas.1416611112

DOI: 10.1073/pnas.1416611112

2014

Structure and function study of the complex that synthesizes S-adenosylmethionine (Journal article)

Murray, B., Antonyuk, S. V., Marina, A., Van Liempd, S. M., Lu, S. C., Mato, J. M., . . . Rojas, A. L. (2014). Structure and function study of the complex that synthesizes S-adenosylmethionine. IUCRJ, 1, 240-249. doi:10.1107/S2052252514012585

DOI: 10.1107/S2052252514012585

Fingerprinting redox and ligand states in haemprotein crystal structures using resonance Raman spectroscopy (Journal article)

Kekilli, D., Dworkowski, F. S. N., Pompidor, G., Fuchs, M. R., Andrew, C. R., Antonyuk, S., . . . Hough, M. A. (2014). Fingerprinting redox and ligand states in haemprotein crystal structures using resonance Raman spectroscopy. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 70, 1289-1296. doi:10.1107/S1399004714004039

DOI: 10.1107/S1399004714004039

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life (Journal article)

Austin, J. A., Wright, G. S. A., Watanabe, S., Grossmann, J. G., Antonyuk, S. V., Yamanaka, K., & Hasnain. (2014). Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. Proceedings of the National Academy of Sciences of the United States of America, 111(11), 4309-4314. doi:10.1073/pnas.1317317111

DOI: 10.1073/pnas.1317317111

The structure of a purple acid phosphatase involved in plant growth and pathogen defence exhibits a novel immunoglobulin-like fold (Journal article)

Antonyuk, S. V., Olczak, M., Olczak, T., Ciuraszkiewicz, J., & Strange, R. W. (2014). The structure of a purple acid phosphatase involved in plant growth and pathogen defence exhibits a novel immunoglobulin-like fold. IUCRJ, 1, 101-109. doi:10.1107/S205225251400400X

DOI: 10.1107/S205225251400400X

Fingerprinting Redox and Ligand States in Haem Protein Crystal Structures using Resonance Raman Spectroscopy (Journal article)

Kekili, D., Dworkowski, F. S. N., Pompidor, G., Fuchs, M. R., Andrew, C. R., Antonyuk, S. V., . . . Hough, M. A. (2014). Fingerprinting Redox and Ligand States in Haem Protein Crystal Structures using Resonance Raman Spectroscopy. ACTA CRYST D: Biological Crystallography, 70, 1289-1296.

Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase (Journal article)

Leferink, N. G. H., Antonyuk, S. V., Houwman, J. A., Scrutton, N. S., Eady, R. R., & Hasnain, S. S. (2014). Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase. Nature Communications.

MSOX crystallography and simulations to capture redox enzyme catalysis (Conference Paper)

Hough, M. A., Kekilli, D., Horrell, S., Sen, K., Yong, C., Keal, T. W. K., . . . Strange, R. W. (2014). MSOX crystallography and simulations to capture redox enzyme catalysis. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 70 (pp. C651). Retrieved from http://gateway.webofknowledge.com/

2013

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Raedisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). BIOCHEMICAL PHARMACOLOGY, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI: 10.1016/j.bcp.2013.03.022

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Rädisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI: 10.1016/j.bcp.2013.03.022

Ligand binding and aggregation of pathogenic SOD1 (Journal article)

Wright, G. S. A., Antonyuk, S. V., Kershaw, N. M., Strange, R. W., & Hasnain, S. S. (2013). Ligand binding and aggregation of pathogenic SOD1. NATURE COMMUNICATIONS, 4. doi:10.1038/ncomms2750

DOI: 10.1038/ncomms2750

Structures of protein-protein complexes involved in electron transfer (Journal article)

Antonyuk, S. V., Han, C., Eady, R. R., & Hasnain, S. S. (2013). Structures of protein-protein complexes involved in electron transfer. NATURE, 496(7443), 123-127. doi:10.1038/nature11996

DOI: 10.1038/nature11996

Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426 (Journal article)

Padmanabhan, B., Nakamura, Y., Antonyuk, S. V., Strange, R. W., Hasnain, S. S., Yokoyama, S., & Bessho, Y. (2013). Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 69, 342-345. doi:10.1107/S1744309113003369

DOI: 10.1107/S1744309113003369

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens,, D., Webb,, S. D., Antonyuk,, S., Giannoudis,, A., Owen,, A., Rädisch,, S., . . . Pirmohamed,, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85, 1672-1683.

X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions (Journal article)

Kershaw, N. M., Wright, G. S. A., Sharma, R., Antonyuk, S. V., Strange, R. W., Berry, N. G., . . . Hasnain, S. S. (2013). X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions. CURRENT MEDICINAL CHEMISTRY, 20(4), 569-575. Retrieved from http://gateway.webofknowledge.com/

2012

Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase (Journal article)

Strange, R. W., Hough, M. A., Antonyuk, S. V., & Hasnain, S. S. (2012). Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase. PLOS ONE, 7(9). doi:10.1371/journal.pone.0044811

DOI: 10.1371/journal.pone.0044811

Crystal structure of D-serine dehydratase from Escherichia coli (Journal article)

Urusova, D. V., Isupov, M. N., Antonyuk, S., Kachalova, G. S., Obmolova, G., Vagin, A. A., . . . Schnackerz, K. D. (2012). Crystal structure of D-serine dehydratase from Escherichia coli. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1824(3), 422-432. doi:10.1016/j.bbapap.2011.10.017

DOI: 10.1016/j.bbapap.2011.10.017

2011

Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins (Journal article)

Antonyuk, S. V., Rustage, N., Petersen, C. A., Arnst, J. L., Heyes, D. J., Sharma, R., . . . Hasnain, S. S. (2011). Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(38), 15780-15785. doi:10.1073/pnas.1109051108

DOI: 10.1073/pnas.1109051108

Monitoring and validating active site redox states in protein crystals (Journal article)

Antonyuk, S. V., & Hough, M. A. (2011). Monitoring and validating active site redox states in protein crystals. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1814(6), 778-784. doi:10.1016/j.bbapap.2010.12.017

DOI: 10.1016/j.bbapap.2010.12.017

Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase (Journal article)

Leferink, N. G. H., Han, C., Antonyuk, S. V., Heyes, D. J., Rigby, S. E. J., Hough, M. A., . . . Hasnain, S. S. (2011). Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase. BIOCHEMISTRY, 50(19), 4121-4131. doi:10.1021/bi200246f

DOI: 10.1021/bi200246f

Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket (Journal article)

Hough, M. A., Antonyuk, S. V., Barbieri, S., Rustage, N., McKay, A. L., Servid, A. E., . . . Hasnain, S. S. (2011). Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket. Journal of Molecular Biology, 405(2), 395-409. doi:10.1016/j.jmb.2010.10.035

DOI: 10.1016/j.jmb.2010.10.035

Mechanism of Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase (Journal article)

Leferink, N. G. H., Han, C., Antonyuk, S. V., Heyes, D. J., Rigby, S. E. J., Hough, M. A., . . . Hasnain, S. S. (2011). Mechanism of Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase. Biochemistry, 50, 4121-4131. doi:10.1021/bi

DOI: 10.1021/bi

2010

Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization (Journal article)

Antonyuk, S., Strange, R. W., & Hasnain, S. S. (2010). Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization. JOURNAL OF MEDICINAL CHEMISTRY, 53(3), 1402-1406. doi:10.1021/jm9017948

DOI: 10.1021/jm9017948

2009

Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate) (Journal article)

Antonyuk, S. V., Strange, R. W., Ellis, M. J., Bessho, Y., Kuramitsu, S., Inoue, Y., . . . Hasnain, S. S. (2009). Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1209-1213. doi:10.1107/S1744309109044935

DOI: 10.1107/S1744309109044935

Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 angstrom resolution (Journal article)

Antonyuk, S. V., Ellis, M. J., Strange, R. W., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 angstrom resolution. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1204-1208. doi:10.1107/S1744309109043814

DOI: 10.1107/S1744309109043814

Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima (Journal article)

Strange, R. W., Antonyuk, S. V., Ellis, M. J., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1218-1221. doi:10.1107/S1744309109046302

DOI: 10.1107/S1744309109046302

Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii (Journal article)

Padmanabhan, B., Strange, R. W., Antonyuk, S. V., Ellis, M. J., Hasnain, S. S., Iino, H., . . . Yokoyama, S. (2009). Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1222-1226. doi:10.1107/S174430910904651X

DOI: 10.1107/S174430910904651X

Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophile Methanocaldococcus jannaschii (Journal article)

Malay, A. D., Bessho, Y., Ellis, M. J., Antonyuk, S. V., Strange, R. W., Hasnain, S. S., . . . Yokoyama, S. (2009). Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophile Methanocaldococcus jannaschii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1227-1233. doi:10.1107/S1744309109047046

DOI: 10.1107/S1744309109047046

Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii (Journal article)

Antonyuk, S. V., Strange, R. W., Ellis, M. J., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1200-1203. doi:10.1107/S1744309109043772

DOI: 10.1107/S1744309109043772

Structure of putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus HB8 (Journal article)

Padmanabhan, B., Bessho, Y., Ebihara, A., Antonyuk, S. V., Ellis, M. J., Strange, R. W., . . . Yokoyama, S. (2009). Structure of putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus HB8. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1234-1239. doi:10.1107/S1744309109050052

DOI: 10.1107/S1744309109050052

The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603) (Journal article)

Strange, R. W., Antonyuk, S. V., Ellis, M. J., Bessho, Y., Kuramitsu, S., Yokoyama, S., & Hasnain, S. S. (2009). The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1214-1217. doi:10.1107/S1744309109044923

DOI: 10.1107/S1744309109044923

The Structure of Human Extracellular Copper-Zinc Superoxide Dismutase at 1.7 angstrom Resolution: Insights into Heparin and Collagen Binding (Journal article)

Antonyuk, S. V., Strange, R. W., Marklund, S. L., & Hasnain, S. S. (2009). The Structure of Human Extracellular Copper-Zinc Superoxide Dismutase at 1.7 angstrom Resolution: Insights into Heparin and Collagen Binding. JOURNAL OF MOLECULAR BIOLOGY, 388(2), 310-326. doi:10.1016/j.jmb.2009.03.026

DOI: 10.1016/j.jmb.2009.03.026

Crystal structure of human prion protein bound to a therapeutic antibody (Journal article)

Antonyuk, S. V., Trevitt, C. R., Strange, R. W., Jackson, G. S., Sangar, D., Batchelor, M., . . . Collinge, J. (2009). Crystal structure of human prion protein bound to a therapeutic antibody. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(8), 2554-2558. doi:10.1073/pnas.0809170106

DOI: 10.1073/pnas.0809170106

Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A (Journal article)

Galaleldeen, A., Strange, R. W., Whitson, L. J., Antonyuk, S. V., Narayana, N., Taylor, A. B., . . . Hart, P. J. (2009). Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 492(1-2), 40-47. doi:10.1016/j.abb.2009.09.020

DOI: 10.1016/j.abb.2009.09.020

2008

Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis (Journal article)

Cao, X., Antonyuk, S. V., Seetharaman, S. V., Whitson, L. J., Taylor, A. B., Holloway, S. P., . . . Hart, P. J. (2008). Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(23), 16169-16177. doi:10.1074/jbc.M801522200

DOI: 10.1074/jbc.M801522200

Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase (Journal article)

Hough, M. A., Antonyuk, S. V., Strange, R. W., Eady, R. R., & Hasnain, S. S. (2008). Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase. JOURNAL OF MOLECULAR BIOLOGY, 378(2), 353-361. doi:10.1016/j.jmb.2008.01.097

DOI: 10.1016/j.jmb.2008.01.097

2007

Nitrous oxide reductase (Chapter)

Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2007). Nitrous oxide reductase. In A. Messerschmidt (Ed.), Handbook of Metalloproteins (pp. 1). london: John Wiley & Sons.

2006

X-ray diffraction study of the complex of the enzyme SAICAR synthase with the reaction product (Journal article)

Urusova, D. V., Levdikov, V. M., Antonyuk, S. V., Grebenko, A. I., Lamzin, V. S., & Melik-Adamyan, V. R. (2006). X-ray diffraction study of the complex of the enzyme SAICAR synthase with the reaction product. CRYSTALLOGRAPHY REPORTS, 51(5), 824-827. doi:10.1134/S1063774506050129

DOI: 10.1134/S1063774506050129

Insight into catalysis of nitrous oxide reductase from high-resolution structures of resting and inhibitor-bound enzyme from Achromobacter cycloclastes (Journal article)

Paraskevopoulos, K., Antonyuk, S. V., Sawers, R. G., Eady, R. R., & Hasnain, S. S. (2006). Insight into catalysis of nitrous oxide reductase from high-resolution structures of resting and inhibitor-bound enzyme from Achromobacter cycloclastes. JOURNAL OF MOLECULAR BIOLOGY, 362(1), 55-65. doi:10.1016/j.jmb.2006.06.064

DOI: 10.1016/j.jmb.2006.06.064

Variable metallation of human superoxide dismutase: Atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes (Journal article)

Strange, R. W., Antonyuk, S. V., Hough, M. A., Doucette, P. A., Valentine, J. S., & Hasnain, S. S. (2006). Variable metallation of human superoxide dismutase: Atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes. JOURNAL OF MOLECULAR BIOLOGY, 356(5), 1152-1162. doi:10.1016/j.jmb.2005.11.081

DOI: 10.1016/j.jmb.2005.11.081

2005

Atomic resolution structures of resting-state, substrate- and product-complexed Cu-nitrite reductase provide insight into catalytic mechanism (Journal article)

Antonyuk, S. V., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2005). Atomic resolution structures of resting-state, substrate- and product-complexed Cu-nitrite reductase provide insight into catalytic mechanism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(34), 12041-12046. doi:10.1073/pnas.0504207102

DOI: 10.1073/pnas.0504207102

High resolution structural studies of mutants provide insights into catalysis and electron transfer processes in copper nitrite reductase (Journal article)

Hough, M. A., Ellis, M. J., Antonyuk, S., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2005). High resolution structural studies of mutants provide insights into catalysis and electron transfer processes in copper nitrite reductase. JOURNAL OF MOLECULAR BIOLOGY, 350(2), 300-309. doi:10.1016/j.jmb.2005.04.006

DOI: 10.1016/j.jmb.2005.04.006

A high-throughput structural biology/proteomics beamline at the SRS on a new multipole wiggler (Conference Paper)

Cianci, M., Antonyuk, S., Bliss, N., Bailey, M. W., Buffey, S. G., Cheung, K. C., . . . Hasnain, S. S. (2005). A high-throughput structural biology/proteomics beamline at the SRS on a new multipole wiggler. In JOURNAL OF SYNCHROTRON RADIATION Vol. 12 (pp. 455-466). doi:10.1107/S0909049505009131

DOI: 10.1107/S0909049505009131

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg (Journal article)

Antonyuk, S., Elam, J. S., Hough, M. A., Strange, R. W., Doucette, P. A., Rodriguez, J. A., . . . Hasnain, S. S. (2005). Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg. PROTEIN SCIENCE, 14(5), 1201-1213. doi:10.1110/ps.041256705

DOI: 10.1110/ps.041256705

A high throughput structural biology / proteomics beamline at the SRS on a new multipole wiggler. (Journal article)

Cianci, M., Antonyuk, S., Bliss, N., Buffet, S. G., Cheung, K. C., Clarke, J. A., . . . Hasnain, S. S. (2005). A high throughput structural biology / proteomics beamline at the SRS on a new multipole wiggler.. J. Synchr. Rad., 12, 442-452.

2004

Insights into redox partner interactions and substrate binding in nitrite reductase from Alcaligenes xylosoxidans: Crystal structures of the TrP138His and His313Gln mutants (Journal article)

Barrett, M. L., Harris, R. L., Antonyuk, S., Hough, M. A., Ellis, M. J., Sawers, G., . . . Hasnain, S. S. (2004). Insights into redox partner interactions and substrate binding in nitrite reductase from Alcaligenes xylosoxidans: Crystal structures of the TrP138His and His313Gln mutants. BIOCHEMISTRY, 43(51), 16311-16319. doi:10.1021/bi048682g

DOI: 10.1021/bi048682g

Observation of an unprecedented Cu bis-His site: Crystal structure of the H129V mutant of nitrite reductase (Journal article)

Ellis, M. J., Antonyuk, S. V., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2004). Observation of an unprecedented Cu bis-His site: Crystal structure of the H129V mutant of nitrite reductase. INORGANIC CHEMISTRY, 43(24), 7591-7593. doi:10.1021/ic048966p

DOI: 10.1021/ic048966p

Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants (Journal article)

Hough, M. A., Grossmann, J. G., Antonyuk, S. V., Strange, R. W., Doucette, P. A., Rodriguez, J. A., . . . Hasnain, S. S. (2004). Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(16), 5976-5981. doi:10.1073/pnas.0305143101

DOI: 10.1073/pnas.0305143101

2003

X-ray diffraction study of the complex of the enzyme SAICAR synthase with substrate analogues (Journal article)

Urusova, D. V., Antonyuk, S. V., Grebenko, A. I., Lamzin, V. S., & Melik-Adamyan, V. R. (2003). X-ray diffraction study of the complex of the enzyme SAICAR synthase with substrate analogues. CRYSTALLOGRAPHY REPORTS, 48(5), 763-767. doi:10.1134/1.1612597

DOI: 10.1134/1.1612597

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS (Journal article)

Elam, J. S., Taylor, A. B., Strange, R., Antonyuk, S., Doucette, P. A., Rodriguez, J. A., . . . Hart, P. J. (2003). Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. NATURE STRUCTURAL BIOLOGY, 10(6), 461-467. doi:10.1038/nsb935

DOI: 10.1038/nsb935

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis (Journal article)

Strange, R. W., Antonyuk, S., Hough, M. A., Doucette, P. A., Rodriguez, J. A., Hart, P. J., . . . Hasnain, S. S. (2003). The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis. JOURNAL OF MOLECULAR BIOLOGY, 328(4), 877-891. doi:10.1016/S0022-2836(03)00355-3

DOI: 10.1016/S0022-2836(03)00355-3

The structure of glyceraldehyde 3-phosphate dehydrogenase from Alcaligenes xylosoxidans at 1.7 angstrom resolution (Journal article)

Antonyuk, S. V., Eady, R. R., Strange, R. W., & Hasnain, S. S. (2003). The structure of glyceraldehyde 3-phosphate dehydrogenase from Alcaligenes xylosoxidans at 1.7 angstrom resolution. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 59, 835-842. doi:10.1107/S0907444903041441

DOI: 10.1107/S0907444903041441

X-ray diffraction study of the complex of the enzyme SAICAR synthase with substrate analogues (Journal article)

Urusova, D. V., Antonyuk, S. V., Grebenko, A. I., Lamzin, V. S., & Melik-Adamyan, V. R. (2003). X-ray diffraction study of the complex of the enzyme SAICAR synthase with substrate analogues. Kristallografiya, 48(5), 821-826.

2002

Crystal structures of the Met148Leu and Ser86Asp mutants of rusticyanin from Thiobacillus ferrooxidans: Insights into the structural relationship with the cupredoxins and the multi copper proteins (Journal article)

Kanbi, L. D., Antonyuk, S., Hough, M. A., Hall, J. F., Dodd, F. E., & Hasnain, S. S. (2002). Crystal structures of the Met148Leu and Ser86Asp mutants of rusticyanin from Thiobacillus ferrooxidans: Insights into the structural relationship with the cupredoxins and the multi copper proteins. JOURNAL OF MOLECULAR BIOLOGY, 320(2), 263-275. doi:10.1016/S0022-2836(02)00443-6

DOI: 10.1016/S0022-2836(02)00443-6

Resolution improvement from 'in situ annealing' of copper nitrite reductase crystals (Journal article)

Ellis, M. J., Antonyuk, S., & Hasnain, S. S. (2002). Resolution improvement from 'in situ annealing' of copper nitrite reductase crystals. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 58, 456-458. doi:10.1107/S0907444902000136

DOI: 10.1107/S0907444902000136

2001

X-ray diffraction study of the complexes of SAICAR synthase with adenosinetriphosphate (Journal article)

Antonyuk, S. V., Grebenko, A. I., Levdikov, V. M., Urusova, D. V., Melik-Adamyan, V. R., Lamzin, V. S., & Wilson, K. S. (2001). X-ray diffraction study of the complexes of SAICAR synthase with adenosinetriphosphate. Kristallografiya, 46(4), 687-691.

X-ray diffraction study of the complexes of SAICAR synthase with adenosinetriphosphate (Journal article)

Antonyuk, S. V., Grebenko, A. I., Levdikov, V. M., Urusova, D. V., Melik-Adamyan, V. R., Lamzin, V. S., & Wilson, K. S. (2001). X-ray diffraction study of the complexes of SAICAR synthase with adenosinetriphosphate. CRYSTALLOGRAPHY REPORTS, 46(4), 620-625. doi:10.1134/1.1387127

DOI: 10.1134/1.1387127

Crystal structure of manganese catalase from Lactobacillus plantarum (Journal article)

Barynin, V. V., Whittaker, M. M., Antonyuk, S. V., Lamzin, V. S., Harrison, P. M., Artymiuk, P. J., & Whittaker, J. W. (2001). Crystal structure of manganese catalase from Lactobacillus plantarum. STRUCTURE, 9(8), 725-738. doi:10.1016/S0969-2126(01)00628-1

DOI: 10.1016/S0969-2126(01)00628-1

2000

Structures of macromolecular compounds: Three-dimensional structure of the enzyme dimanganese catalase from Thermus thermophilus at 1 Å resolution (Journal article)

Antonyuk, S. V., Melik-Adamyan, V. R., Popov, A. N., Lamzin, V. S., Hempstead, P. D., HarrisoN, R. M., . . . Barynin, V. V. (2000). Structures of macromolecular compounds: Three-dimensional structure of the enzyme dimanganese catalase from Thermus thermophilus at 1 Å resolution. Kristallografiya, 45(1), 111-122.

Improving the X-ray resolution by reversible flash-cooling combined with concentration screening, as exemplified with PPase (Journal article)

Samygina, V. R., Antonyuk, S. V., Lamzin, V. S., & Popov, A. N. (2000). Improving the X-ray resolution by reversible flash-cooling combined with concentration screening, as exemplified with PPase. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 56, 595-603. doi:10.1107/S0907444900002493

DOI: 10.1107/S0907444900002493

The structure of dimanganese catalase from Thermus thermophilus at 1 Å resolution. (Journal article)

Antonyuk, S. V., Melik-Adamyan, W. R., Popov, A. N., Lamzin, V. S., Hepstread, P. D., Harrison, P. M., . . . Barynin, V. V. (2000). The structure of dimanganese catalase from Thermus thermophilus at 1 Å resolution.. Cryst. Reports, 45(1), 11-22.

Three-dimensional structure of the enzyme dimanganese catalase from Thermus thermophilus at 1 angstrom resolution (Journal article)

Antonyuk, S. V., Melik-Adamyan, V. R., Popov, A. N., Lamzin, V. S., Hempstead, P. D., Harrison, P. M., . . . Barynin, V. V. (2000). Three-dimensional structure of the enzyme dimanganese catalase from Thermus thermophilus at 1 angstrom resolution. CRYSTALLOGRAPHY REPORTS, 45(1), 105-116. doi:10.1134/1.171145

DOI: 10.1134/1.171145

1999

The oxidized (3,3) state of manganese catalase. Comparison of enzymes from Thermus thermophilus and Lactobacillus plantarum (Journal article)

Whittaker, M. M., Barynin, V. V., Antonyuk, S. V., & Whittaker, J. (1999). The oxidized (3,3) state of manganese catalase. Comparison of enzymes from Thermus thermophilus and Lactobacillus plantarum. BIOCHEMISTRY, 38(28), 9126-9136. doi:10.1021/bi990499d

DOI: 10.1021/bi990499d

1990

MANGANESE-CONTAINING CATALASE FROM THERMUS-THERMOPHILUS PEROXIDE-INDUCED REDOX TRANSFORMATION OF MANGANESE IONS IN PRESENCE OF SPECIFIC INHIBITORS OF CATALASE ACTIVITY (Journal article)

KHANGULOV, S. V., BARYNIN, V. V., & ANTONYUKBARYNINA, S. V. (1990). MANGANESE-CONTAINING CATALASE FROM THERMUS-THERMOPHILUS PEROXIDE-INDUCED REDOX TRANSFORMATION OF MANGANESE IONS IN PRESENCE OF SPECIFIC INHIBITORS OF CATALASE ACTIVITY. BIOCHIMICA ET BIOPHYSICA ACTA, 1020(1), 25-33. doi:10.1016/0005-2728(90)90089-M

DOI: 10.1016/0005-2728(90)90089-M

Manganese-containing catalase from Thermus thermophilus peroxide induce redox transformations of binuclear cluster of manganese ions. (Journal article)

Khangulov, S. V., Barynin, V. V., & Barynina-Antonyuk, S. V. (1990). Manganese-containing catalase from Thermus thermophilus peroxide induce redox transformations of binuclear cluster of manganese ions.. Biochim. and Biophis. Acta, 1041(2), 25-33.