Professor Sarah Coupland MBBS, PhD, FRCPath, FARVO, FSB

George Holt Chair in Pathology, Honorary Consultant Histopathologist Molecular & Clinical Cancer Medicine

    Research

    Research Interest 1

    Ocular oncology
    Lymphoma; intraocular and ocular adnexal lymphomas
    Uveal melanoma, conjunctival melanoma
    Cutaneous melanoma

    Research Group Membership

    Research Grants

    Modelling the interplay between uveal melanoma cells and macrophages

    SIGHT RESEARCH UK (UK)

    February 2022 - November 2022

    UM Cure 2020: New therapies for uveal melanoma

    EUROPEAN COMMISSION

    January 2016 - June 2021

    To address DNA repair mechanisms in uveal melanoma

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    October 2015 - March 2020

    Exosome biogenesis: the role of sortilin in cancer development and progression

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    January 2016 - April 2019

    Liverpool Health Genomics Laboratory

    LIVERPOOL HEALTH PARTNERS (UK)

    March 2015 - February 2018

    Joint PhD Studentship Between University of Szegad, Hungary and the University of Liverpool - Study to Investigate Tumour Associated Macrophages

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    October 2015 - March 2019

    2014 allocation - Wellcome ISSF non clinical fellowships

    WELLCOME TRUST (UK)

    May 2015 - October 2018

    DTP studentships and cancer inequality research

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    October 2015 - September 2022

    Investigating in vivo resistance mechanisms to MEK inhibitors in uveal melanoma to enable novel combinatorial therapies.

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    March 2016 - May 2019

    Chick Embryo in vivo xenograft model for Ocular Cancer studies

    BRITISH COUNCIL (UK)

    April 2017 - March 2021

    Bench fees - Sophie Thornton: Refining the Liverpool Uveal Melanoma Molecular Prognostication Model

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    October 2016 - September 2020

    Bridging Support for Associated Postdoctoral Research Assistant and Consumables

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    April 2018 - December 2018

    Northern (N6) Academic Pathology Network

    INNOVATE UK (UK)

    February 2019 - January 2023

    North West Cancer Research Bid

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    January 2018 - September 2023

    PhD in Pathology

    THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)

    October 2015 - September 2020

    Integrative analysis of BAP1-dependencies to identify novel therapeutic targets for uveal melanoma: learning lessons from the lung

    FIGHT FOR SIGHT (UK)

    October 2019 - December 2022

    Uveal melanoma - PhD Studentship

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    September 2010 - December 2022

    Biosample collection from the SUAVE trial in uveal melanoma – TRANS-SUAVE

    CANCER RESEARCH UK (CRUK) (UK)

    November 2010 - October 2013

    Investigation into Malt Lymphoma Project.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    November 2006 - July 2009

    Metastasis in uveal melanoma study

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    January 2012 - December 2012

    Personalised epigenetic therapy for follicular lymphoma

    CANCER RESEARCH UK (CRUK) (UK)

    February 2013 - January 2016

    Multiplex ligation-dependent probe amplification (MLPA) analysis in metastasizing cutaneous malignant melanoma.

    NORTH WEST CANCER RESEARCH FUND

    April 2008 - June 2009

    Multiplex Ligation-Dependent Probe Amplification (MLPA) in Uveal Melanoma.

    FIGHT FOR SIGHT (UK)

    January 2008 - December 2009

    Risk stratification: modelling and accessibility

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    June 2010 - May 2011

    Molecular characteristics of metastatic liver lesions in uveal melanoma: the search for therapeutic targets.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    January 2012 - December 2022

    Molecular genetics of ocular tumours

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    December 2010 - November 2015

    Genetic abnormalities in conjunctival melanoma: a multicentre study

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    February 2011 - August 2017

    Stretching the supply routes: ErbB2 gene amplification and endocytic recycling in metastatic breast cancer

    BREAST CANCER NOW (UK)

    January 2015 - January 2019

    Identification of regulators of metastasis in uveal melanoma

    NORTH WEST CANCER RESEARCH FUND

    October 2010 - March 2013

    The development and characterisation of in vitro and in vivo models of uveal melanoma

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    October 2012 - December 2015

    Multiplex Ligation-Dependent Probe Amplification (MLPA) in Uveal Melanoma.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    January 2010 - June 2010

    PACIFICO Phase III multicentre trial comparing two different Rituximab-Chemotherapy induction regimens for Follicular Lymphoma in Older patients (PACIFIC)

    CANCER RESEARCH UK (CRUK) (UK)

    November 2008 - July 2021

    Applying innovative technologies to improve the benefit-risk ratio of drugs: developing a national resource underpinned by the infrastructure of the MRC Centre for Drug Safety Science

    MEDICAL RESEARCH COUNCIL (MRC)

    April 2015 - March 2016

    Novel isogenic models of BAP1-deficient uveal melanoma for drug discovery

    FIGHT FOR SIGHT (UK)

    October 2014 - September 2018

    The role of exosomes in uveal melanoma

    THE PATHOLOGICAL SOCIETY (UK)

    October 2014 - December 2020

    Multiplex ligation-dependent probe amplification (MLPA) assessment of clinical uveal melanoma (UM) samples

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    March 2009 - February 2015

    Identification of regulators of metastasis in uveal melanoma (UM)

    CANCER RESEARCH UK (CRUK) (UK)

    July 2010 - March 2014

    Multiplex ligation-dependent probe amplification (MLPA)in Uveal Melanoma.

    ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST CHARITABLE FUNDS (UK)

    September 2007 - August 2010

    The role of chemokines and integrins in the localisation of B-cell Non-Hodgkin’s Lymphomas (B-NHL)

    LYMPHOMA RESEARCH TRUST

    January 2013 - December 2013

    CR-UK Cancer Research Centre - Infrastructure Grant 2012-14

    CANCER RESEARCH UK (CRUK) (UK)

    November 2012 - March 2015

    Ocular oncology research

    CLATTERBRIDGE CENTRE FOR ONCOLOGY, ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK), THE CLATTERBRIDGE CANCER CENTRE NHS FOUNDATION TRUST (UK)

    February 2008 - January 2020

    Bench fees for Rasha Swadi

    REPUBLIC OF IRAQ MINISTRY OF EDUCATION

    October 2014 - September 2018

    The North West Cancer Research Cancer Centre

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

    April 2014 - September 2023

    Biosample collection from the ITEM trial in Uveal Melanoma.

    CANCER RESEARCH UK (CRUK) (UK)

    September 2008 - February 2011

    Bench fees to support PhD student Omar Alishlash

    THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)

    January 2013 - December 2015

    Impact of tumour-associated myeloid cells on cancer stemness and chemotherapy-resistance

    NORTH WEST CANCER RESEARCH FUND

    March 2013 - December 2016

    NITRO Trial: Neoadjuvant IntraviTreal Ranibizumab treatment in high risk Ocular melanoma patients: A two stage single centre Phase II single arm study.

    CANCER RESEARCH UK (CRUK) (UK), ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

    October 2011 - September 2015

    Research Collaborations

    Henrik Vorum, Bent Honoré, Steen Fiil Urbak

    External: University of Aarhus, Denmark

    Examining proteomics of uveal melanomas with and without monosomy 3

    Paul Finger

    External: American Joint Committee Against Cancer (AJCC)

    Committee member revising and designing staging systems of the tumours in and around the eye

    Prof. B. Damato

    Internal

    Prof. A Pettit

    Internal