Photo of Professor Samar Hasnain

Professor Samar Hasnain BSc (Honours) MSc PhD

Max Perutz Professor of Molecular Biophysics Biochemistry & Systems Biology

Publications

2021

obituary John C. H. Spence (1946-2021) (Journal article)

Chapman, H. N., Hasnain, S. S., & Weierstall, U. (2021). obituary John C. H. Spence (1946-2021). IUCRJ, 8, 705-708. doi:10.1107/S2052252521007879

DOI: 10.1107/S2052252521007879

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives (Journal article)

Amporndanai, K., Meng, X., Shang, W., Jin, Z., Zhao, Y., Rao, Z., . . . Rogers, M. (2021). Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23313-7

DOI: 10.1038/s41467-021-23313-7

An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures (Journal article)

Rose, S. L., Antonyuk, S. V., Sasaki, D., Yamashita, K., Hirata, K., Ueno, G., . . . Hasnain, S. S. (2021). An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures. SCIENCE ADVANCES, 7(1). doi:10.1126/sciadv.abd8523

DOI: 10.1126/sciadv.abd8523

Reverse protein engineering of a novel 4-domain copper nitrite reductase reveals functional regulation by protein-protein interaction (Journal article)

Sasaki, D., Watanabe, T. F., Eady, R. R., Garratt, R. C., Antonyuk, S. V., & Hasnain, S. S. (2021). Reverse protein engineering of a novel 4-domain copper nitrite reductase reveals functional regulation by protein-protein interaction. FEBS JOURNAL, 288(1), 262-280. doi:10.1111/febs.15324

DOI: 10.1111/febs.15324

2020

Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis (Journal article)

Hough, M. A., Conradie, J., Strange, R. W., Antonyuk, S. V., Eady, R. R., Ghosh, A., & Hasnain, S. S. (n.d.). Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis. Chemical Science. doi:10.1039/d0sc04797j

DOI: 10.1039/d0sc04797j

Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis (Journal article)

Amporndanai, K., Rogers, M., Watanabe, S., Yamanaka, K., O'Neill, P. M., & Hasnain, S. S. (2020). Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis. EBIOMEDICINE, 59. doi:10.1016/j.ebiom.2020.102980

DOI: 10.1016/j.ebiom.2020.102980

Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases (Journal article)

Wright, G. S. A., Watanabe, T. F., Amporndanai, K., Plotkin, S. S., Cashman, N. R., Antonyuk, S. V., & Hasnain, S. S. (2020). Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases. iScience, 23(6). doi:10.1016/j.isci.2020.101159

DOI: 10.1016/j.isci.2020.101159

Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene (Journal article)

Panmanee, J., Antonyuk, S. V., & Hasnain, S. S. (2020). Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 76, 594-607. doi:10.1107/S2059798320006002

DOI: 10.1107/S2059798320006002

Structures of substrate- and product-bound forms of a multi-domain copper nitrite reductase shed light on the role of domain tethering in protein complexes (Journal article)

Sasaki, D., Watanabe, T. F., Eady, R. R., Garratt, R. C., Antonyuk, S. V., & Hasnain, S. S. (2020). Structures of substrate- and product-bound forms of a multi-domain copper nitrite reductase shed light on the role of domain tethering in protein complexes. IUCrJ, 7(3), 557-565. doi:10.1107/s2052252520005230

DOI: 10.1107/s2052252520005230

The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer (Journal article)

Jamali, M. A. M., Gopalasingam, C. C., Johnson, R. M., Tosha, T., Muramoto, K., Muench, S. P., . . . Hasnain, S. S. (2020). The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer. IUCrJ, 7(3), 404-415. doi:10.1107/s2052252520003656

DOI: 10.1107/s2052252520003656

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (vol 6, 29179, 2016) (Journal article)

McPhillie, M., Zhou, Y., El Bissati, K., Dubey, J., Lorenzi, H., Capper, M., . . . McLeod, R. (2020). New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (vol 6, 29179, 2016). SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-62323-1

DOI: 10.1038/s41598-020-62323-1

Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy (Journal article)

Chantadul, V., Wright, G. S. A., Amporndanai, K., Shahid, M., Antonyuk, S. V., Washbourn, G., . . . Hasnain, S. S. (2020). Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-0826-3

DOI: 10.1038/s42003-020-0826-3

2019

The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis. (Journal article)

Wright, G. S. A., Antonyuk, S. V., & Hasnain, S. S. (2019). The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis.. Quarterly reviews of biophysics, 52, e12. doi:10.1017/s003358351900012x

DOI: 10.1017/s003358351900012x

Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo–electron microscopy (Journal article)

Gopalasingam, C. C., Johnson, R. M., Chiduza, G. N., Tosha, T., Yamamoto, M., Shiro, Y., . . . Samar Hasnain, S. (2019). Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo–electron microscopy. Science Advances, 5(8). doi:10.1126/sciadv.aax1803

DOI: 10.1126/sciadv.aax1803

THE SOD1-HCCS MECHANISM INVOLVED IN COPPER HOMEOSTASIS (Conference Paper)

Sala, F. A., Wrigth, G., Antonyuk, S., Garratt, R. C., & Hasnain, S. S. (2019). THE SOD1-HCCS MECHANISM INVOLVED IN COPPER HOMEOSTASIS. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 75 (pp. E71). doi:10.1107/S2053273319094853

DOI: 10.1107/S2053273319094853

Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis (Journal article)

Hedison, T. M., Shenoy, R. T., Iorgu, A. I., Heyes, D. J., Fisher, K., Wright, G. S. A., . . . Scrutton, N. S. (2019). Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis. ACS Catalysis, 9(7), 6087-6099. doi:10.1021/acscatal.9b01266

DOI: 10.1021/acscatal.9b01266

Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography (Journal article)

Halsted, T. P., Yamashita, K., Gopalasingam, C. C., Shenoy, R. T., Hirata, K., Ago, H., . . . Hasnain, S. S. (2019). Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography. IUCRJ, 6, 761-772. doi:10.1107/S2052252519008285

DOI: 10.1107/S2052252519008285

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM (Journal article)

Chiduza, G. N., Johnson, R. M., Wright, G. S. A., Antonyuk, S. V., Muench, S. P., & Hasnain, S. S. (2019). LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 75, 660-669. doi:10.1107/S2059798319009094

DOI: 10.1107/S2059798319009094

Synchrotron science in the UK: NINA, the SRS and Diamond (Journal article)

Hasnain, S. S., & Catlow, C. R. A. (2019). Synchrotron science in the UK: NINA, the SRS and Diamond. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 377(2147). doi:10.1098/rsta.2019.0147

DOI: 10.1098/rsta.2019.0147

Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory ß subunit and quinolone-based compounds (Journal article)

Panmanee, J., Bradley-Clarke, J., Mato, J. M., O'Neill, P. M., Antonyuk, S. V., & Hasnain, S. S. (2019). Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory ß subunit and quinolone-based compounds. The Federation of European Biochemical Societies (FEBS) Journal, 286(11), 2135-2154. doi:10.1111/febs.14790

DOI: 10.1111/febs.14790

The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM (Journal article)

Muench, S. P., Antonyuk, S. V., & Hasnain, S. S. (2019). The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM. IUCRJ, 6(2), 167-177. doi:10.1107/S2052252519002422

DOI: 10.1107/S2052252519002422

Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS (Journal article)

Sala, F. A., Wright, G. S. A., Antonyuk, S. V., Garratt, R. C., & Hasnain, S. S. (2019). Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. PLOS BIOLOGY, 17(2). doi:10.1371/journal.pbio.3000141

DOI: 10.1371/journal.pbio.3000141

2018

Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties (Journal article)

David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371

DOI: 10.1021/acsmedchemlett.8b00371

Identification of a tyrosine switch in copper-haem nitrite reductases (Journal article)

Dong, J., Sasaki, D., Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2018). Identification of a tyrosine switch in copper-haem nitrite reductases. IUCrJ, 5(4), 510-518. doi:10.1107/S2052252518008242

DOI: 10.1107/S2052252518008242

Structural studies of human superoxide dismutase (SOD1) with its metallochaperone (Conference Paper)

Sala, F. A., Wright, G. S. A., Antonyuk, S. V., Garratt, R. C., & Hasnain, S. S. (2018). Structural studies of human superoxide dismutase (SOD1) with its metallochaperone. In FEBS OPEN BIO Vol. 8 (pp. 432-433). Retrieved from http://gateway.webofknowledge.com/

Enzyme catalysis captured using multiple structures from one crystal at varying temperatures (Journal article)

Horrell, S., Kekilli, D., Sen, K., Owen, R. U., Dworkowski, F. S. N., Antonyuk, S. V., . . . Hough, M. A. (2018). Enzyme catalysis captured using multiple structures from one crystal at varying temperatures. IUCRJ, 5, 283-292. doi:10.1107/S205225251800386X

DOI: 10.1107/S205225251800386X

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation (Journal article)

Capper, M. J., Wright, G. S. A., Barbieri, L., Luchinat, E., Mercatelli, E., McAlary, L., . . . Hasnain, S. S. (2018). The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04114-x

DOI: 10.1038/s41467-018-04114-x

Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system (Journal article)

Wright, G. S. A., Saeki, A., Hikima, T., Nishizono, Y., Hisano, T., Kamaya, M., . . . Sawai, H. (2018). Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system. SCIENCE SIGNALING, 11(525). doi:10.1126/scisignal.aaq0825

DOI: 10.1126/scisignal.aaq0825

Hiromichi Kamitsubo (1933-2017) obituary (Journal article)

Ishikawa, T., & Hasnain, S. (2018). Hiromichi Kamitsubo (1933-2017) obituary. JOURNAL OF SYNCHROTRON RADIATION, 25, 304-305. doi:10.1107/S1600577518002795

DOI: 10.1107/S1600577518002795

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery (Journal article)

Amporndanai, K., Johnson, R. M., O'Neill, P., Fishwick, C. W. G., Jamson, A. H., Rawson, S., . . . Hasnain, S. (2018). X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery. IUCrJ, 5(Pt 2), 200-210. doi:10.1107/S2052252518001616

DOI: 10.1107/S2052252518001616

Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme (Journal article)

Gonska, N., Young, D., Yuki, R., Okamoto, T., Hisano, T., Antonyuk, S., . . . Adelroth, P. (2018). Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-21804-0

DOI: 10.1038/s41598-018-21804-0

Characterization of the quinoldependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme (Journal article)

Antonyuk, S. V., Hasnain, S., Gonska, N., Young, D., Yuki, R., Okamoto, T., . . . Ädelroth, P. (n.d.). Characterization of the quinoldependent nitric oxide reductasefrom the pathogen Neisseria meningitidis, an electrogenic enzyme. Scientific Reports. doi:10.1038/s41598-018-21804-0

DOI: 10.1038/s41598-018-21804-0

An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase (Journal article)

Halsted, T. P., Yamashita, K., Hirata, K., Ago, H., Ueno, G., Tosha, T., . . . Hasnain, S. S. (2018). An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase. IUCRJ, 5, 22-31. doi:10.1107/S2052252517016128

DOI: 10.1107/S2052252517016128

2017

MSOX crystallography and simulations to capture redox enzyme catalysis (Conference Paper)

Hough, M. A., Kekilli, D., Horrell, S., Sen, K., Yong, C., Keal, T. W. K., . . . Strange, R. W. (2017). MSOX crystallography and simulations to capture redox enzyme catalysis. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 73 (pp. C651). doi:10.1107/S2053273317089227

DOI: 10.1107/S2053273317089227

Seventy years of publications (Journal article)

Hasnain, S. S. (2017). Seventy years of publications. JOURNAL OF SYNCHROTRON RADIATION, 24, 904-905. doi:10.1107/S1600577517012292

DOI: 10.1107/S1600577517012292

Seventy years of publications (Journal article)

Hasnain, S. S. (2017). Seventy years of publications. IUCRJ, 4, 512-513. doi:10.1107/S205225251701168X

DOI: 10.1107/S205225251701168X

Seventy years of publications (Journal article)

Hasnain, S. S. (2017). Seventy years of publications. ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 73, 652-653. doi:10.1107/S205322961701172X

DOI: 10.1107/S205322961701172X

INTRA- AND INTER-MOLECULAR SIGNAL TRANSDUCTION MECHANISMS OF HEME SENSING SYSTEMS (Conference Paper)

Sawai, H., Wright, G. S. A., Saeki, A., Hikima, T., Yamamoto, M., Antonyuk, S., . . . Shiro, Y. (2017). INTRA- AND INTER-MOLECULAR SIGNAL TRANSDUCTION MECHANISMS OF HEME SENSING SYSTEMS. In AMERICAN JOURNAL OF HEMATOLOGY Vol. 92 (pp. E463). Retrieved from http://gateway.webofknowledge.com/

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. (Journal article)

Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (n.d.). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.. Scientific Reports, 7. doi:10.1038/srep43580

DOI: 10.1038/srep43580

2016

Impact and influence of crystallography across the sciences (Journal article)

Hasnain, S. (2016). Impact and influence of crystallography across the sciences. IUCRJ, 3, 389-390. doi:10.1107/S2052252516017012

DOI: 10.1107/S2052252516017012

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (Journal article)

McPhillie, M., Zhou, Y., El Bissati, K., Dubey, J., Lorenzi, H., Capper, M., . . . McLeod, R. (2016). New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. SCIENTIFIC REPORTS, 6, 23 pages. doi:10.1038/srep29179

DOI: 10.1038/srep29179

Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal (Journal article)

Horrell, S., Antonyuk, S. V., Eady, R. R., Hasnain, S. S., Hough, M. A., & Strange, R. W. (2016). Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal. IUCrJ, 3(Part 4), 271-281. doi:10.1107/S205225251600823X

DOI: 10.1107/S205225251600823X

A faulty interaction between SOD1 and hCCS in neurodegenerative disease (Journal article)

Wright, G. S. A., Antonyuk, S. V., & Hasnain, S. S. (2016). A faulty interaction between SOD1 and hCCS in neurodegenerative disease. SCIENTIFIC REPORTS, 6. doi:10.1038/srep27691

DOI: 10.1038/srep27691

Fresh insight to functioning of selected enzymes of the nitrogen cycle (Journal article)

Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2016). Fresh insight to functioning of selected enzymes of the nitrogen cycle. CURRENT OPINION IN CHEMICAL BIOLOGY, 31, 103-112. doi:10.1016/j.cbpa.2016.02.009

DOI: 10.1016/j.cbpa.2016.02.009

Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes (Journal article)

Murray, B., Antonyuk, S. V., Marina, A., Lu, S. C., Mato, J. M., Hasnain, S. S., & Rojas, A. L. (2016). Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes. Proceedings of the National Academy of Sciences of USA, 113(8), 2104-2109. doi:10.1073/pnas.1510959113

DOI: 10.1073/pnas.1510959113

2015

Crystallography in the 21st century: pure and applied (Journal article)

Hasnain, S. S. (2015). Crystallography in the 21st century: pure and applied. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 48, 1611-1613. doi:10.1107/S1600576715019524

DOI: 10.1107/S1600576715019524

Crystallography in the 21st century (Journal article)

Hasnain, S. S. (2015). Crystallography in the 21st century. JOURNAL OF SYNCHROTRON RADIATION, 22, 1331-1333. doi:10.1107/S1600577515019578

DOI: 10.1107/S1600577515019578

Crystallography in the 21st century (Journal article)

Hasnain, S. S. (2015). Crystallography in the 21st century. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 71, 559-561. doi:10.1107/S2053273315019464

DOI: 10.1107/S2053273315019464

Crystallography in the 21st century (Journal article)

Hasnain, S. S. (2015). Crystallography in the 21st century. IUCrJ, 2, 602-604. doi:10.1107/S2052252515017509

DOI: 10.1107/S2052252515017509

Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential (Journal article)

Blakeley, M. P., Hasnain, S. S., & Antonyuk, S. V. (2015). Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential. IUCRJ, 2, 464-474. doi:10.1107/S2052252515011239

DOI: 10.1107/S2052252515011239

Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 (Journal article)

Capper, M., O'Neill, P., Fisher, N., Strange, R., Moss, D., Ward, S., . . . Antonyuk, S. (2015). Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Proceedings of the National Academy of Sciences of the United States of America, 112(3), 755-760. doi:10.1073/pnas.1416611112

DOI: 10.1073/pnas.1416611112

IUCrJ celebrates its first year of publication (Journal article)

Hasnain, S. S. (2015). IUCrJ celebrates its first year of publication. IUCRJ, 2, 1-2. doi:10.1107/S205225251402750X

DOI: 10.1107/S205225251402750X

2014

Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase (Journal article)

Leferink, N. G. H., Antonyuk, S., Houwman, J. A., Scrutton, N., Eady, R. R., & Hasnain, S. S. (2014). Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase. Nature Communications, 5. doi:10.1038/ncomms5395

DOI: 10.1038/ncomms5395

Acta E transforms from Structure Reports Online to Crystallographic Communications. (Journal article)

Hasnain, S. S. (2014). Acta E transforms from Structure Reports Online to Crystallographic Communications.. Acta crystallographica. Section E, Structure reports online, 70(Pt 7), 1-2. doi:10.1107/s1600536814011775

DOI: 10.1107/s1600536814011775

Structure and function study of the complex that synthesizes S-adenosylmethionine (Journal article)

Murray, B., Antonyuk, S. V., Marina, A., Van Liempd, S. M., Lu, S. C., Mato, J. M., . . . Rojas, A. L. (2014). Structure and function study of the complex that synthesizes S-adenosylmethionine. IUCRJ, 1, 240-249. doi:10.1107/S2052252514012585

DOI: 10.1107/S2052252514012585

Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging (Journal article)

Hasnain, S. (2014). Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging. Nature Communications, 5. doi:10.1038/ncomms4798

DOI: 10.1038/ncomms4798

Fingerprinting redox and ligand states in haemprotein crystal structures using resonance Raman spectroscopy (Journal article)

Kekilli, D., Dworkowski, F. S. N., Pompidor, G., Fuchs, M. R., Andrew, C. R., Antonyuk, S., . . . Hough, M. A. (2014). Fingerprinting redox and ligand states in haemprotein crystal structures using resonance Raman spectroscopy. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 70, 1289-1296. doi:10.1107/S1399004714004039

DOI: 10.1107/S1399004714004039

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life (Journal article)

Austin, J. A., Wright, G. S. A., Watanabe, S., Grossmann, J. G., Antonyuk, S. V., Yamanaka, K., & Hasnain. (2014). Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. Proceedings of the National Academy of Sciences of the United States of America, 111(11), 4309-4314. doi:10.1073/pnas.1317317111

DOI: 10.1073/pnas.1317317111

Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies (Journal article)

Iram, N., Shah, M. S., Ismat, F., Habib, M., Iqbal, M., Hasnain, S. S., & Rahman, M. (2014). Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 98(4), 1691-1701. doi:10.1007/s00253-013-5043-2

DOI: 10.1007/s00253-013-5043-2

100 years of crystallography: the IUCr launches a comprehensive open-access journal, IUCrJ (Journal article)

Hasnain, S. S. (2014). 100 years of crystallography: the IUCr launches a comprehensive open-access journal, IUCrJ. IUCRJ, 1, 1-2. doi:10.1107/S2052252513033691

DOI: 10.1107/S2052252513033691

Fingerprinting Redox and Ligand States in Haem Protein Crystal Structures using Resonance Raman Spectroscopy (Journal article)

Kekili, D., Dworkowski, F. S. N., Pompidor, G., Fuchs, M. R., Andrew, C. R., Antonyuk, S. V., . . . Hough, M. A. (2014). Fingerprinting Redox and Ligand States in Haem Protein Crystal Structures using Resonance Raman Spectroscopy. ACTA CRYST D: Biological Crystallography, 70, 1289-1296.

Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase (Journal article)

Leferink, N. G. H., Antonyuk, S. V., Houwman, J. A., Scrutton, N. S., Eady, R. R., & Hasnain, S. S. (2014). Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase. Nature Communications.

MSOX crystallography and simulations to capture redox enzyme catalysis (Conference Paper)

Hough, M. A., Kekilli, D., Horrell, S., Sen, K., Yong, C., Keal, T. W. K., . . . Strange, R. W. (2014). MSOX crystallography and simulations to capture redox enzyme catalysis. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 70 (pp. C651). Retrieved from http://gateway.webofknowledge.com/

Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging (Journal article)

Gallagher-Jones, M., Bessho, Y., Kim, S., Park, J., Kim, S., Nam, D., . . . Song, C. (2014). Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging. Nature Communications, 5, 3798.

2013

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Raedisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). BIOCHEMICAL PHARMACOLOGY, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI: 10.1016/j.bcp.2013.03.022

Ligand binding and aggregation of pathogenic SOD1 (Journal article)

Wright, G. S. A., Antonyuk, S. V., Kershaw, N. M., Strange, R. W., & Hasnain, S. S. (2013). Ligand binding and aggregation of pathogenic SOD1. NATURE COMMUNICATIONS, 4. doi:10.1038/ncomms2750

DOI: 10.1038/ncomms2750

Structures of protein-protein complexes involved in electron transfer (Journal article)

Antonyuk, S. V., Han, C., Eady, R. R., & Hasnain, S. S. (2013). Structures of protein-protein complexes involved in electron transfer. NATURE, 496(7443), 123-127. doi:10.1038/nature11996

DOI: 10.1038/nature11996

Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426 (Journal article)

Padmanabhan, B., Nakamura, Y., Antonyuk, S. V., Strange, R. W., Hasnain, S. S., Yokoyama, S., & Bessho, Y. (2013). Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 69, 342-345. doi:10.1107/S1744309113003369

DOI: 10.1107/S1744309113003369

The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation (Journal article)

Wright, G. S. A., Lee, H. C., Schulze-Briese, C., Grossmann, J. G., Strange, R. W., & Hasnain, S. S. (2013). The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation. JOURNAL OF SYNCHROTRON RADIATION, 20, 383-385. doi:10.1107/S0909049513001866

DOI: 10.1107/S0909049513001866

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens,, D., Webb,, S. D., Antonyuk,, S., Giannoudis,, A., Owen,, A., Rädisch,, S., . . . Pirmohamed,, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85, 1672-1683.

X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions (Journal article)

Kershaw, N. M., Wright, G. S. A., Sharma, R., Antonyuk, S. V., Strange, R. W., Berry, N. G., . . . Hasnain, S. S. (2013). X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions. CURRENT MEDICINAL CHEMISTRY, 20(4), 569-575. Retrieved from http://gateway.webofknowledge.com/

2012

Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase (Journal article)

Strange, R. W., Hough, M. A., Antonyuk, S. V., & Hasnain, S. S. (2012). Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase. PLOS ONE, 7(9). doi:10.1371/journal.pone.0044811

DOI: 10.1371/journal.pone.0044811

Characterization of a novel copper-haem c dissimilatory nitrite reductase from Ralstonia pickettii (Journal article)

Han, C., Wright, G. S. A., Fisher, K., Rigby, S. E. J., Eady, R. R., & Hasnain, S. S. (2012). Characterization of a novel copper-haem c dissimilatory nitrite reductase from Ralstonia pickettii. BIOCHEMICAL JOURNAL, 444, 219-226. doi:10.1042/BJ20111623

DOI: 10.1042/BJ20111623

Laser-flash photolysis indicates that internal electron transfer is triggered by proton uptake by Alcaligenes xylosoxidans copper-dependent nitrite reductase (Journal article)

Leferink, N. G. H., Eady, R. R., Hasnain, S. S., & Scrutton, N. S. (2012). Laser-flash photolysis indicates that internal electron transfer is triggered by proton uptake by Alcaligenes xylosoxidans copper-dependent nitrite reductase. FEBS Journal, 279(12), 2174-2181. doi:10.1111/j.1742-4658.2012.08601.x

DOI: 10.1111/j.1742-4658.2012.08601.x

A Distal Pocket Leu Residue Inhibits the Binding of O2 and NO at the Distal Heme Site of Cytochrome c' (Journal article)

Garton, E. M., Pixton, D. A., Petersen, C. A., Eady, R. R., Hasnain, S. S., & Andrew, C. R. (2012). A Distal Pocket Leu Residue Inhibits the Binding of O2 and NO at the Distal Heme Site of Cytochrome c'. Journal of the American Chemical Society, 134(3), 1461-1463. doi:10.1021/ja209770p

DOI: 10.1021/ja209770p

Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography (Journal article)

Doutch, J., Hough, M. A., Hasnain, S. S., & Strange, R. W. (2012). Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography. Journal of Synchrotron Radiation, 19(1), 19-29. doi:10.1107/s0909049511049004

DOI: 10.1107/s0909049511049004

Characterization of a novel copperheme c dissimilatory nitrite reductase from Ralstonia pickettii (Journal article)

Han, C., Wright, G. S. A., Fisher, K., Rigby, S. E. J., Eady, R. R., & Hasnain, S. S. (2012). Characterization of a novel copperheme c dissimilatory nitrite reductase from Ralstonia pickettii. Biochemical Journal, 444, 216-219.

Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase (Journal article)

Leferink, N. G., Pudney, C. R., Brenner, S., Heyes, D. J., Eady, R. R., Hasnain, S. S., . . . Scrutton, N. S. (2012). Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase. FEBS Lett, 586, 578-584.

2011

The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies (Journal article)

Wright, G. S. A., Hasnain, S. S., & Grossmann, J. G. (2011). The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies. BIOCHEMICAL JOURNAL, 439, 39-44. doi:10.1042/BJ20110948

DOI: 10.1042/BJ20110948

Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins (Journal article)

Antonyuk, S. V., Rustage, N., Petersen, C. A., Arnst, J. L., Heyes, D. J., Sharma, R., . . . Hasnain, S. S. (2011). Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(38), 15780-15785. doi:10.1073/pnas.1109051108

DOI: 10.1073/pnas.1109051108

Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase (Journal article)

Leferink, N. G. H., Han, C., Antonyuk, S. V., Heyes, D. J., Rigby, S. E. J., Hough, M. A., . . . Hasnain, S. S. (2011). Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase. BIOCHEMISTRY, 50(19), 4121-4131. doi:10.1021/bi200246f

DOI: 10.1021/bi200246f

Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket (Journal article)

Hough, M. A., Antonyuk, S. V., Barbieri, S., Rustage, N., McKay, A. L., Servid, A. E., . . . Hasnain, S. S. (2011). Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket. JOURNAL OF MOLECULAR BIOLOGY, 405(2), 395-409. doi:10.1016/j.jmb.2010.10.035

DOI: 10.1016/j.jmb.2010.10.035

Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket (Journal article)

Hough, M. A., Antonyuk, S. V., Barbieri, S., Rustage, N., McKay, A. L., Servid, A. E., . . . Hasnain, S. S. (2011). Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket. Journal of Molecular Biology, 405(2), 395-409. doi:10.1016/j.jmb.2010.10.035

DOI: 10.1016/j.jmb.2010.10.035

Gating Mechanisms for Biological Electron Transfer: Integrating Structure with Biophysics Reveals the Nature of Redox Control in Cytochrome P450 reductase and Copper-Dependent Nitrite Reductase. (Journal article)

Leferink, N. G. H., Pudney, C. R., Brenner, S., Heys, D. J., Eady, R. R., Hasnain, S. S., . . . Scrutton, N. S. (2011). Gating Mechanisms for Biological Electron Transfer: Integrating Structure with Biophysics Reveals the Nature of Redox Control in Cytochrome P450 reductase and Copper-Dependent Nitrite Reductase.. FEBS Letters, 586, 578-584.

Mechanism of Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase (Journal article)

Leferink, N. G. H., Han, C., Antonyuk, S. V., Heyes, D. J., Rigby, S. E. J., Hough, M. A., . . . Hasnain, S. S. (2011). Mechanism of Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase. Biochemistry, 50, 4121-4131. doi:10.1021/bi

DOI: 10.1021/bi

2010

Advances in biophysical methods: characterisation and visualization of molecules, cells and organism (Journal article)

Hasnain, S. S., & Wakatsuki, S. (2010). Advances in biophysical methods: characterisation and visualization of molecules, cells and organism. Current Opinion in Structural Biology, 20(5), 584-586. doi:10.1016/j.sbi.2010.09.004

DOI: 10.1016/j.sbi.2010.09.004

Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli. (Journal article)

Harris, R. L., Barbieri, S., Paraskevopoulos, K., Murphy, L. M., Eady, R. R., Hasnain, S. S., & Sawers, R. G. (2010). Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli.. Journal of molecular microbiology and biotechnology, 18(2), 102-108. doi:10.1159/000287989

DOI: 10.1159/000287989

Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization (Journal article)

Antonyuk, S., Strange, R. W., & Hasnain, S. S. (2010). Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization. JOURNAL OF MEDICINAL CHEMISTRY, 53(3), 1402-1406. doi:10.1021/jm9017948

DOI: 10.1021/jm9017948

Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli (Journal article)

Harris, R. L., Barbieri, S., Paraskevopoulos, K., Murphy, L. M., Eady, R. R., Hasnain, S. S., & Sawers, R. G. (2010). Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli. J Mol Microbiol Biotechnol., 18(2), 102-108.

Structural discovery of small molecule binding sites in SOD1 FALS mutants provides insights for lead optimisation (Journal article)

Antonyuk, S. V., Strange, R. W., & Hasnain, S. S. (2010). Structural discovery of small molecule binding sites in SOD1 FALS mutants provides insights for lead optimisation. Journal of Medicinal Chemistry, 53, 1402-1406.

2009

Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate) (Journal article)

Antonyuk, S. V., Strange, R. W., Ellis, M. J., Bessho, Y., Kuramitsu, S., Inoue, Y., . . . Hasnain, S. S. (2009). Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1209-1213. doi:10.1107/S1744309109044935

DOI: 10.1107/S1744309109044935

Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 angstrom resolution (Journal article)

Antonyuk, S. V., Ellis, M. J., Strange, R. W., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 angstrom resolution. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1204-1208. doi:10.1107/S1744309109043814

DOI: 10.1107/S1744309109043814

Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima (Journal article)

Strange, R. W., Antonyuk, S. V., Ellis, M. J., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1218-1221. doi:10.1107/S1744309109046302

DOI: 10.1107/S1744309109046302

Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii (Journal article)

Padmanabhan, B., Strange, R. W., Antonyuk, S. V., Ellis, M. J., Hasnain, S. S., Iino, H., . . . Yokoyama, S. (2009). Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1222-1226. doi:10.1107/S174430910904651X

DOI: 10.1107/S174430910904651X

Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophile Methanocaldococcus jannaschii (Journal article)

Malay, A. D., Bessho, Y., Ellis, M. J., Antonyuk, S. V., Strange, R. W., Hasnain, S. S., . . . Yokoyama, S. (2009). Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophile Methanocaldococcus jannaschii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1227-1233. doi:10.1107/S1744309109047046

DOI: 10.1107/S1744309109047046

Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii (Journal article)

Antonyuk, S. V., Strange, R. W., Ellis, M. J., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1200-1203. doi:10.1107/S1744309109043772

DOI: 10.1107/S1744309109043772

Structure of putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus HB8 (Journal article)

Padmanabhan, B., Bessho, Y., Ebihara, A., Antonyuk, S. V., Ellis, M. J., Strange, R. W., . . . Yokoyama, S. (2009). Structure of putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus HB8. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1234-1239. doi:10.1107/S1744309109050052

DOI: 10.1107/S1744309109050052

The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603) (Journal article)

Strange, R. W., Antonyuk, S. V., Ellis, M. J., Bessho, Y., Kuramitsu, S., Yokoyama, S., & Hasnain, S. S. (2009). The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1214-1217. doi:10.1107/S1744309109044923

DOI: 10.1107/S1744309109044923

Demonstration of Proton-coupled Electron Transfer in the Copper-containing Nitrite Reductases (Journal article)

Brenner, S., Heyes, D. J., Hay, S., Hough, M. A., Eady, R. R., Hasnain, S. S., & Scrutton, N. S. (2009). Demonstration of Proton-coupled Electron Transfer in the Copper-containing Nitrite Reductases. Journal of Biological Chemistry, 284(38), 25973-25983. doi:10.1074/jbc.m109.012245

DOI: 10.1074/jbc.m109.012245

Digital Ion Trap Mass Spectrometer for Probing the Structure of Biological Macromolecules by Gas Phase X-ray Scattering (Journal article)

McCullough, B. J., Entwistle, A., Konishi, I., Buffey, S., Hasnain, S. S., Brancia, F. L., . . . Gaskell, S. J. (2009). Digital Ion Trap Mass Spectrometer for Probing the Structure of Biological Macromolecules by Gas Phase X-ray Scattering. Analytical Chemistry, 81(9), 3392-3397. doi:10.1021/ac802662d

DOI: 10.1021/ac802662d

The Structure of Human Extracellular Copper-Zinc Superoxide Dismutase at 1.7 angstrom Resolution: Insights into Heparin and Collagen Binding (Journal article)

Antonyuk, S. V., Strange, R. W., Marklund, S. L., & Hasnain, S. S. (2009). The Structure of Human Extracellular Copper-Zinc Superoxide Dismutase at 1.7 angstrom Resolution: Insights into Heparin and Collagen Binding. JOURNAL OF MOLECULAR BIOLOGY, 388(2), 310-326. doi:10.1016/j.jmb.2009.03.026

DOI: 10.1016/j.jmb.2009.03.026

Crystal structure of human prion protein bound to a therapeutic antibody (Journal article)

Antonyuk, S. V., Trevitt, C. R., Strange, R. W., Jackson, G. S., Sangar, D., Batchelor, M., . . . Collinge, J. (2009). Crystal structure of human prion protein bound to a therapeutic antibody. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(8), 2554-2558. doi:10.1073/pnas.0809170106

DOI: 10.1073/pnas.0809170106

Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A (Journal article)

Galaleldeen, A., Strange, R. W., Whitson, L. J., Antonyuk, S. V., Narayana, N., Taylor, A. B., . . . Hart, P. J. (2009). Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 492(1-2), 40-47. doi:10.1016/j.abb.2009.09.020

DOI: 10.1016/j.abb.2009.09.020

2008

Identification of the Proton Channel to the Active Site Type 2 Cu Center of Nitrite Reductase: Structural and Enzymatic Properties of the His254Phe and Asn90Ser Mutants, (Journal article)

Hough, M. A., Eady, R. R., & Hasnain, S. S. (2008). Identification of the Proton Channel to the Active Site Type 2 Cu Center of Nitrite Reductase: Structural and Enzymatic Properties of the His254Phe and Asn90Ser Mutants,. Biochemistry, 47(51), 13547-13553. doi:10.1021/bi801369y

DOI: 10.1021/bi801369y

Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis (Journal article)

Cao, X., Antonyuk, S. V., Seetharaman, S. V., Whitson, L. J., Taylor, A. B., Holloway, S. P., . . . Hart, P. J. (2008). Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(23), 16169-16177. doi:10.1074/jbc.M801522200

DOI: 10.1074/jbc.M801522200

Modulation of NO binding to cytochrome c' by distal and proximal haem pocket residues (Journal article)

Barbieri, S., Murphy, L. M., Sawers, R. G., Eady, R. R., & Hasnain, S. S. (2008). Modulation of NO binding to cytochrome c' by distal and proximal haem pocket residues. JBIC Journal of Biological Inorganic Chemistry, 13(4), 531-540. doi:10.1007/s00775-008-0341-3

DOI: 10.1007/s00775-008-0341-3

Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase (Journal article)

Hough, M. A., Antonyuk, S. V., Strange, R. W., Eady, R. R., & Hasnain, S. S. (2008). Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase. JOURNAL OF MOLECULAR BIOLOGY, 378(2), 353-361. doi:10.1016/j.jmb.2008.01.097

DOI: 10.1016/j.jmb.2008.01.097

2007

Genomic analysis reveals widespread occurrence of new classes of copper nitrite reductases (Journal article)

Ellis, M. J., Grossmann, J. G., Eady, R. R., & Hasnain, S. S. (2007). Genomic analysis reveals widespread occurrence of new classes of copper nitrite reductases. JBIC Journal of Biological Inorganic Chemistry, 12(8), 1119-1127. doi:10.1007/s00775-007-0282-2

DOI: 10.1007/s00775-007-0282-2

Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase (Journal article)

Strange, R. W., Yong, C. W., Smith, W., & Hasnain, S. S. (2007). Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase. Proceedings of the National Academy of Sciences, 104(24), 10040-10044. doi:10.1073/pnas.0703857104

DOI: 10.1073/pnas.0703857104

X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy (Journal article)

Arcovito, A., Benfatto, M., Cianci, M., Hasnain, S. S., Nienhaus, K., Nienhaus, G. U., . . . Della Longa, S. (2007). X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy. Proceedings of the National Academy of Sciences, 104(15), 6211-6216. doi:10.1073/pnas.0608411104

DOI: 10.1073/pnas.0608411104

Nitrous oxide reductase (Chapter)

Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2007). Nitrous oxide reductase. In A. Messerschmidt (Ed.), Handbook of Metalloproteins (pp. 1). london: John Wiley & Sons.

2006

Insight into catalysis of nitrous oxide reductase from high-resolution structures of resting and inhibitor-bound enzyme from Achromobacter cycloclastes (Journal article)

Paraskevopoulos, K., Antonyuk, S. V., Sawers, R. G., Eady, R. R., & Hasnain, S. S. (2006). Insight into catalysis of nitrous oxide reductase from high-resolution structures of resting and inhibitor-bound enzyme from Achromobacter cycloclastes. JOURNAL OF MOLECULAR BIOLOGY, 362(1), 55-65. doi:10.1016/j.jmb.2006.06.064

DOI: 10.1016/j.jmb.2006.06.064

Variable metallation of human superoxide dismutase: Atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes (Journal article)

Strange, R. W., Antonyuk, S. V., Hough, M. A., Doucette, P. A., Valentine, J. S., & Hasnain, S. S. (2006). Variable metallation of human superoxide dismutase: Atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes. JOURNAL OF MOLECULAR BIOLOGY, 356(5), 1152-1162. doi:10.1016/j.jmb.2005.11.081

DOI: 10.1016/j.jmb.2005.11.081

Atomic Resolution Crystal Structures, EXAFS, and Quantum Chemical Studies of Rusticyanin and Its Two Mutants Provide Insight into Its Unusual Properties, (Journal article)

Barrett, M. L., Harvey, I., Sundararajan, M., Surendran, R., Hall, J. F., Ellis, M. J., . . . Hasnain, S. S. (2006). Atomic Resolution Crystal Structures, EXAFS, and Quantum Chemical Studies of Rusticyanin and Its Two Mutants Provide Insight into Its Unusual Properties,. Biochemistry, 45(9), 2927-2939. doi:10.1021/bi052372w

DOI: 10.1021/bi052372w

2005

Atomic resolution structures of resting-state, substrate- and product-complexed Cu-nitrite reductase provide insight into catalytic mechanism (Journal article)

Antonyuk, S. V., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2005). Atomic resolution structures of resting-state, substrate- and product-complexed Cu-nitrite reductase provide insight into catalytic mechanism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(34), 12041-12046. doi:10.1073/pnas.0504207102

DOI: 10.1073/pnas.0504207102

High resolution structural studies of mutants provide insights into catalysis and electron transfer processes in copper nitrite reductase (Journal article)

Hough, M. A., Ellis, M. J., Antonyuk, S., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2005). High resolution structural studies of mutants provide insights into catalysis and electron transfer processes in copper nitrite reductase. JOURNAL OF MOLECULAR BIOLOGY, 350(2), 300-309. doi:10.1016/j.jmb.2005.04.006

DOI: 10.1016/j.jmb.2005.04.006

A high-throughput structural biology/proteomics beamline at the SRS on a new multipole wiggler (Conference Paper)

Cianci, M., Antonyuk, S., Bliss, N., Bailey, M. W., Buffey, S. G., Cheung, K. C., . . . Hasnain, S. S. (2005). A high-throughput structural biology/proteomics beamline at the SRS on a new multipole wiggler. In JOURNAL OF SYNCHROTRON RADIATION Vol. 12 (pp. 455-466). doi:10.1107/S0909049505009131

DOI: 10.1107/S0909049505009131

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg (Journal article)

Antonyuk, S., Elam, J. S., Hough, M. A., Strange, R. W., Doucette, P. A., Rodriguez, J. A., . . . Hasnain, S. S. (2005). Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg. PROTEIN SCIENCE, 14(5), 1201-1213. doi:10.1110/ps.041256705

DOI: 10.1110/ps.041256705

A high throughput structural biology / proteomics beamline at the SRS on a new multipole wiggler. (Journal article)

Cianci, M., Antonyuk, S., Bliss, N., Buffet, S. G., Cheung, K. C., Clarke, J. A., . . . Hasnain, S. S. (2005). A high throughput structural biology / proteomics beamline at the SRS on a new multipole wiggler.. J. Synchr. Rad., 12, 442-452.

Combined use of XAFS and crystallography for studying protein-ligand interactions in metalloproteins. (Journal article)

Strange, R. W., & Hasnain, S. S. (2005). Combined use of XAFS and crystallography for studying protein-ligand interactions in metalloproteins.. Methods in Molecular Biology, 305, 167-196.

2004

Insights into redox partner interactions and substrate binding in nitrite reductase from Alcaligenes xylosoxidans: Crystal structures of the TrP138His and His313Gln mutants (Journal article)

Barrett, M. L., Harris, R. L., Antonyuk, S., Hough, M. A., Ellis, M. J., Sawers, G., . . . Hasnain, S. S. (2004). Insights into redox partner interactions and substrate binding in nitrite reductase from Alcaligenes xylosoxidans: Crystal structures of the TrP138His and His313Gln mutants. BIOCHEMISTRY, 43(51), 16311-16319. doi:10.1021/bi048682g

DOI: 10.1021/bi048682g

Observation of an unprecedented Cu bis-His site: Crystal structure of the H129V mutant of nitrite reductase (Journal article)

Ellis, M. J., Antonyuk, S. V., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2004). Observation of an unprecedented Cu bis-His site: Crystal structure of the H129V mutant of nitrite reductase. INORGANIC CHEMISTRY, 43(24), 7591-7593. doi:10.1021/ic048966p

DOI: 10.1021/ic048966p

Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants (Journal article)

Hough, M. A., Grossmann, J. G., Antonyuk, S. V., Strange, R. W., Doucette, P. A., Rodriguez, J. A., . . . Hasnain, S. S. (2004). Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(16), 5976-5981. doi:10.1073/pnas.0305143101

DOI: 10.1073/pnas.0305143101

2003

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS (Journal article)

Elam, J. S., Taylor, A. B., Strange, R., Antonyuk, S., Doucette, P. A., Rodriguez, J. A., . . . Hart, P. J. (2003). Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. NATURE STRUCTURAL BIOLOGY, 10(6), 461-467. doi:10.1038/nsb935

DOI: 10.1038/nsb935

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis (Journal article)

Strange, R. W., Antonyuk, S., Hough, M. A., Doucette, P. A., Rodriguez, J. A., Hart, P. J., . . . Hasnain, S. S. (2003). The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis. JOURNAL OF MOLECULAR BIOLOGY, 328(4), 877-891. doi:10.1016/S0022-2836(03)00355-3

DOI: 10.1016/S0022-2836(03)00355-3

The structure of glyceraldehyde 3-phosphate dehydrogenase from Alcaligenes xylosoxidans at 1.7 angstrom resolution (Journal article)

Antonyuk, S. V., Eady, R. R., Strange, R. W., & Hasnain, S. S. (2003). The structure of glyceraldehyde 3-phosphate dehydrogenase from Alcaligenes xylosoxidans at 1.7 angstrom resolution. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 59, 835-842. doi:10.1107/S0907444903041441

DOI: 10.1107/S0907444903041441

2002

Crystal structures of the Met148Leu and Ser86Asp mutants of rusticyanin from Thiobacillus ferrooxidans: Insights into the structural relationship with the cupredoxins and the multi copper proteins (Journal article)

Kanbi, L. D., Antonyuk, S., Hough, M. A., Hall, J. F., Dodd, F. E., & Hasnain, S. S. (2002). Crystal structures of the Met148Leu and Ser86Asp mutants of rusticyanin from Thiobacillus ferrooxidans: Insights into the structural relationship with the cupredoxins and the multi copper proteins. JOURNAL OF MOLECULAR BIOLOGY, 320(2), 263-275. doi:10.1016/S0022-2836(02)00443-6

DOI: 10.1016/S0022-2836(02)00443-6

Resolution improvement from 'in situ annealing' of copper nitrite reductase crystals (Journal article)

Ellis, M. J., Antonyuk, S., & Hasnain, S. S. (2002). Resolution improvement from 'in situ annealing' of copper nitrite reductase crystals. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 58, 456-458. doi:10.1107/S0907444902000136

DOI: 10.1107/S0907444902000136

1986

Iron K-edge EXAFS data on [Fe(o-C6H4(PMe2)2)2Cl2][BF4]n (n = 0-2). The structure of an iron(IV) complex of o-phenylenebis(dimethylphosphine) (Journal article)

Harbron, S. K., Higgins, S. J., Levason, W., Garner, C. D., Steel, A. T., Feiters, M. C., & Hasnain, S. S. (1986). Iron K-edge EXAFS data on [Fe(o-C6H4(PMe2)2)2Cl2][BF4]n (n = 0-2). The structure of an iron(IV) complex of o-phenylenebis(dimethylphosphine). Journal of the American Chemical Society, 108(3), 526-528. doi:10.1021/ja00263a039

DOI: 10.1021/ja00263a039