Professor Samar Hasnain BSc (Honours) MSc PhD
Max Perutz Professor of Molecular Biophysics Biochemistry & Systems Biology
- +44 (0)151 795 5149
- Work email S.S.Hasnain@liverpool.ac.uk
- Personal Websitehttps://www.biophysics.liv.ac.uk
Publications
2021
obituary John C. H. Spence (1946-2021) (Journal article)
Chapman, H. N., Hasnain, S. S., & Weierstall, U. (2021). obituary John C. H. Spence (1946-2021). IUCRJ, 8, 705-708. doi:10.1107/S2052252521007879
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives (Journal article)
Amporndanai, K., Meng, X., Shang, W., Jin, Z., Zhao, Y., Rao, Z., . . . Rogers, M. (2021). Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23313-7
An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures (Journal article)
Rose, S. L., Antonyuk, S. V., Sasaki, D., Yamashita, K., Hirata, K., Ueno, G., . . . Hasnain, S. S. (2021). An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures. SCIENCE ADVANCES, 7(1). doi:10.1126/sciadv.abd8523
Reverse protein engineering of a novel 4-domain copper nitrite reductase reveals functional regulation by protein-protein interaction (Journal article)
Sasaki, D., Watanabe, T. F., Eady, R. R., Garratt, R. C., Antonyuk, S. V., & Hasnain, S. S. (2021). Reverse protein engineering of a novel 4-domain copper nitrite reductase reveals functional regulation by protein-protein interaction. FEBS JOURNAL, 288(1), 262-280. doi:10.1111/febs.15324
2020
Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis (Journal article)
Hough, M. A., Conradie, J., Strange, R. W., Antonyuk, S. V., Eady, R. R., Ghosh, A., & Hasnain, S. S. (n.d.). Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis. Chemical Science. doi:10.1039/d0sc04797j
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis (Journal article)
Amporndanai, K., Rogers, M., Watanabe, S., Yamanaka, K., O'Neill, P. M., & Hasnain, S. S. (2020). Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis. EBIOMEDICINE, 59. doi:10.1016/j.ebiom.2020.102980
Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases (Journal article)
Wright, G. S. A., Watanabe, T. F., Amporndanai, K., Plotkin, S. S., Cashman, N. R., Antonyuk, S. V., & Hasnain, S. S. (2020). Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases. iScience, 23(6). doi:10.1016/j.isci.2020.101159
Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene (Journal article)
Panmanee, J., Antonyuk, S. V., & Hasnain, S. S. (2020). Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 76, 594-607. doi:10.1107/S2059798320006002
Structures of substrate- and product-bound forms of a multi-domain copper nitrite reductase shed light on the role of domain tethering in protein complexes (Journal article)
Sasaki, D., Watanabe, T. F., Eady, R. R., Garratt, R. C., Antonyuk, S. V., & Hasnain, S. S. (2020). Structures of substrate- and product-bound forms of a multi-domain copper nitrite reductase shed light on the role of domain tethering in protein complexes. IUCrJ, 7(3), 557-565. doi:10.1107/s2052252520005230
The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer (Journal article)
Jamali, M. A. M., Gopalasingam, C. C., Johnson, R. M., Tosha, T., Muramoto, K., Muench, S. P., . . . Hasnain, S. S. (2020). The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer. IUCrJ, 7(3), 404-415. doi:10.1107/s2052252520003656
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (vol 6, 29179, 2016) (Journal article)
McPhillie, M., Zhou, Y., El Bissati, K., Dubey, J., Lorenzi, H., Capper, M., . . . McLeod, R. (2020). New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (vol 6, 29179, 2016). SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-62323-1
Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy (Journal article)
Chantadul, V., Wright, G. S. A., Amporndanai, K., Shahid, M., Antonyuk, S. V., Washbourn, G., . . . Hasnain, S. S. (2020). Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-0826-3
2019
The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis. (Journal article)
Wright, G. S. A., Antonyuk, S. V., & Hasnain, S. S. (2019). The biophysics of superoxide dismutase-1 and amyotrophic lateral sclerosis.. Quarterly reviews of biophysics, 52, e12. doi:10.1017/s003358351900012x
Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo–electron microscopy (Journal article)
Gopalasingam, C. C., Johnson, R. M., Chiduza, G. N., Tosha, T., Yamamoto, M., Shiro, Y., . . . Samar Hasnain, S. (2019). Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo–electron microscopy. Science Advances, 5(8). doi:10.1126/sciadv.aax1803
THE SOD1-HCCS MECHANISM INVOLVED IN COPPER HOMEOSTASIS (Conference Paper)
Sala, F. A., Wrigth, G., Antonyuk, S., Garratt, R. C., & Hasnain, S. S. (2019). THE SOD1-HCCS MECHANISM INVOLVED IN COPPER HOMEOSTASIS. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 75 (pp. E71). doi:10.1107/S2053273319094853
Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis (Journal article)
Hedison, T. M., Shenoy, R. T., Iorgu, A. I., Heyes, D. J., Fisher, K., Wright, G. S. A., . . . Scrutton, N. S. (2019). Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis. ACS Catalysis, 9(7), 6087-6099. doi:10.1021/acscatal.9b01266
Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography (Journal article)
Halsted, T. P., Yamashita, K., Gopalasingam, C. C., Shenoy, R. T., Hirata, K., Ago, H., . . . Hasnain, S. S. (2019). Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography. IUCRJ, 6, 761-772. doi:10.1107/S2052252519008285
LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM (Journal article)
Chiduza, G. N., Johnson, R. M., Wright, G. S. A., Antonyuk, S. V., Muench, S. P., & Hasnain, S. S. (2019). LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 75, 660-669. doi:10.1107/S2059798319009094
Synchrotron science in the UK: NINA, the SRS and Diamond (Journal article)
Hasnain, S. S., & Catlow, C. R. A. (2019). Synchrotron science in the UK: NINA, the SRS and Diamond. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 377(2147). doi:10.1098/rsta.2019.0147
Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory ß subunit and quinolone-based compounds (Journal article)
Panmanee, J., Bradley-Clarke, J., Mato, J. M., O'Neill, P. M., Antonyuk, S. V., & Hasnain, S. S. (2019). Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory ß subunit and quinolone-based compounds. The Federation of European Biochemical Societies (FEBS) Journal, 286(11), 2135-2154. doi:10.1111/febs.14790
The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM (Journal article)
Muench, S. P., Antonyuk, S. V., & Hasnain, S. S. (2019). The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM. IUCRJ, 6(2), 167-177. doi:10.1107/S2052252519002422
Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS (Journal article)
Sala, F. A., Wright, G. S. A., Antonyuk, S. V., Garratt, R. C., & Hasnain, S. S. (2019). Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. PLOS BIOLOGY, 17(2). doi:10.1371/journal.pbio.3000141
2018
Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties (Journal article)
David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371
Identification of a tyrosine switch in copper-haem nitrite reductases (Journal article)
Dong, J., Sasaki, D., Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2018). Identification of a tyrosine switch in copper-haem nitrite reductases. IUCrJ, 5(4), 510-518. doi:10.1107/S2052252518008242
Structural studies of human superoxide dismutase (SOD1) with its metallochaperone (Conference Paper)
Sala, F. A., Wright, G. S. A., Antonyuk, S. V., Garratt, R. C., & Hasnain, S. S. (2018). Structural studies of human superoxide dismutase (SOD1) with its metallochaperone. In FEBS OPEN BIO Vol. 8 (pp. 432-433). Retrieved from http://gateway.webofknowledge.com/
Enzyme catalysis captured using multiple structures from one crystal at varying temperatures (Journal article)
Horrell, S., Kekilli, D., Sen, K., Owen, R. U., Dworkowski, F. S. N., Antonyuk, S. V., . . . Hough, M. A. (2018). Enzyme catalysis captured using multiple structures from one crystal at varying temperatures. IUCRJ, 5, 283-292. doi:10.1107/S205225251800386X
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation (Journal article)
Capper, M. J., Wright, G. S. A., Barbieri, L., Luchinat, E., Mercatelli, E., McAlary, L., . . . Hasnain, S. S. (2018). The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04114-x
Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system (Journal article)
Wright, G. S. A., Saeki, A., Hikima, T., Nishizono, Y., Hisano, T., Kamaya, M., . . . Sawai, H. (2018). Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system. SCIENCE SIGNALING, 11(525). doi:10.1126/scisignal.aaq0825
Hiromichi Kamitsubo (1933-2017) obituary (Journal article)
Ishikawa, T., & Hasnain, S. (2018). Hiromichi Kamitsubo (1933-2017) obituary. JOURNAL OF SYNCHROTRON RADIATION, 25, 304-305. doi:10.1107/S1600577518002795
X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery (Journal article)
Amporndanai, K., Johnson, R. M., O'Neill, P., Fishwick, C. W. G., Jamson, A. H., Rawson, S., . . . Hasnain, S. (2018). X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery. IUCrJ, 5(Pt 2), 200-210. doi:10.1107/S2052252518001616
Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme (Journal article)
Gonska, N., Young, D., Yuki, R., Okamoto, T., Hisano, T., Antonyuk, S., . . . Adelroth, P. (2018). Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-21804-0
Characterization of the quinoldependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme (Journal article)
Antonyuk, S. V., Hasnain, S., Gonska, N., Young, D., Yuki, R., Okamoto, T., . . . Ädelroth, P. (n.d.). Characterization of the quinoldependent nitric oxide reductasefrom the pathogen Neisseria meningitidis, an electrogenic enzyme. Scientific Reports. doi:10.1038/s41598-018-21804-0
An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase (Journal article)
Halsted, T. P., Yamashita, K., Hirata, K., Ago, H., Ueno, G., Tosha, T., . . . Hasnain, S. S. (2018). An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase. IUCRJ, 5, 22-31. doi:10.1107/S2052252517016128
2017
MSOX crystallography and simulations to capture redox enzyme catalysis (Conference Paper)
Hough, M. A., Kekilli, D., Horrell, S., Sen, K., Yong, C., Keal, T. W. K., . . . Strange, R. W. (2017). MSOX crystallography and simulations to capture redox enzyme catalysis. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 73 (pp. C651). doi:10.1107/S2053273317089227
Seventy years of publications (Journal article)
Hasnain, S. S. (2017). Seventy years of publications. JOURNAL OF SYNCHROTRON RADIATION, 24, 904-905. doi:10.1107/S1600577517012292
Seventy years of publications (Journal article)
Hasnain, S. S. (2017). Seventy years of publications. IUCRJ, 4, 512-513. doi:10.1107/S205225251701168X
Seventy years of publications (Journal article)
Hasnain, S. S. (2017). Seventy years of publications. ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 73, 652-653. doi:10.1107/S205322961701172X
INTRA- AND INTER-MOLECULAR SIGNAL TRANSDUCTION MECHANISMS OF HEME SENSING SYSTEMS (Conference Paper)
Sawai, H., Wright, G. S. A., Saeki, A., Hikima, T., Yamamoto, M., Antonyuk, S., . . . Shiro, Y. (2017). INTRA- AND INTER-MOLECULAR SIGNAL TRANSDUCTION MECHANISMS OF HEME SENSING SYSTEMS. In AMERICAN JOURNAL OF HEMATOLOGY Vol. 92 (pp. E463). Retrieved from http://gateway.webofknowledge.com/
Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. (Journal article)
Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (n.d.). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.. Scientific Reports, 7. doi:10.1038/srep43580
2016
Impact and influence of crystallography across the sciences (Journal article)
Hasnain, S. (2016). Impact and influence of crystallography across the sciences. IUCRJ, 3, 389-390. doi:10.1107/S2052252516017012
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (Journal article)
McPhillie, M., Zhou, Y., El Bissati, K., Dubey, J., Lorenzi, H., Capper, M., . . . McLeod, R. (2016). New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. SCIENTIFIC REPORTS, 6, 23 pages. doi:10.1038/srep29179
Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal (Journal article)
Horrell, S., Antonyuk, S. V., Eady, R. R., Hasnain, S. S., Hough, M. A., & Strange, R. W. (2016). Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal. IUCrJ, 3(Part 4), 271-281. doi:10.1107/S205225251600823X
A faulty interaction between SOD1 and hCCS in neurodegenerative disease (Journal article)
Wright, G. S. A., Antonyuk, S. V., & Hasnain, S. S. (2016). A faulty interaction between SOD1 and hCCS in neurodegenerative disease. SCIENTIFIC REPORTS, 6. doi:10.1038/srep27691
Fresh insight to functioning of selected enzymes of the nitrogen cycle (Journal article)
Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2016). Fresh insight to functioning of selected enzymes of the nitrogen cycle. CURRENT OPINION IN CHEMICAL BIOLOGY, 31, 103-112. doi:10.1016/j.cbpa.2016.02.009
Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes (Journal article)
Murray, B., Antonyuk, S. V., Marina, A., Lu, S. C., Mato, J. M., Hasnain, S. S., & Rojas, A. L. (2016). Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes. Proceedings of the National Academy of Sciences of USA, 113(8), 2104-2109. doi:10.1073/pnas.1510959113
2015
Crystallography in the 21st century: pure and applied (Journal article)
Hasnain, S. S. (2015). Crystallography in the 21st century: pure and applied. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 48, 1611-1613. doi:10.1107/S1600576715019524
Crystallography in the 21st century (Journal article)
Hasnain, S. S. (2015). Crystallography in the 21st century. JOURNAL OF SYNCHROTRON RADIATION, 22, 1331-1333. doi:10.1107/S1600577515019578
Crystallography in the 21st century (Journal article)
Hasnain, S. S. (2015). Crystallography in the 21st century. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 71, 559-561. doi:10.1107/S2053273315019464
Crystallography in the 21st century (Journal article)
Hasnain, S. S. (2015). Crystallography in the 21st century. IUCrJ, 2, 602-604. doi:10.1107/S2052252515017509
Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential (Journal article)
Blakeley, M. P., Hasnain, S. S., & Antonyuk, S. V. (2015). Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential. IUCRJ, 2, 464-474. doi:10.1107/S2052252515011239
Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 (Journal article)
Capper, M., O'Neill, P., Fisher, N., Strange, R., Moss, D., Ward, S., . . . Antonyuk, S. (2015). Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Proceedings of the National Academy of Sciences of the United States of America, 112(3), 755-760. doi:10.1073/pnas.1416611112
IUCrJ celebrates its first year of publication (Journal article)
Hasnain, S. S. (2015). IUCrJ celebrates its first year of publication. IUCRJ, 2, 1-2. doi:10.1107/S205225251402750X
2014
Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase (Journal article)
Leferink, N. G. H., Antonyuk, S., Houwman, J. A., Scrutton, N., Eady, R. R., & Hasnain, S. S. (2014). Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase. Nature Communications, 5. doi:10.1038/ncomms5395
Acta E transforms from Structure Reports Online to Crystallographic Communications. (Journal article)
Hasnain, S. S. (2014). Acta E transforms from Structure Reports Online to Crystallographic Communications.. Acta crystallographica. Section E, Structure reports online, 70(Pt 7), 1-2. doi:10.1107/s1600536814011775
Structure and function study of the complex that synthesizes S-adenosylmethionine (Journal article)
Murray, B., Antonyuk, S. V., Marina, A., Van Liempd, S. M., Lu, S. C., Mato, J. M., . . . Rojas, A. L. (2014). Structure and function study of the complex that synthesizes S-adenosylmethionine. IUCRJ, 1, 240-249. doi:10.1107/S2052252514012585
Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging (Journal article)
Hasnain, S. (2014). Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging. Nature Communications, 5. doi:10.1038/ncomms4798
Fingerprinting redox and ligand states in haemprotein crystal structures using resonance Raman spectroscopy (Journal article)
Kekilli, D., Dworkowski, F. S. N., Pompidor, G., Fuchs, M. R., Andrew, C. R., Antonyuk, S., . . . Hough, M. A. (2014). Fingerprinting redox and ligand states in haemprotein crystal structures using resonance Raman spectroscopy. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 70, 1289-1296. doi:10.1107/S1399004714004039
Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life (Journal article)
Austin, J. A., Wright, G. S. A., Watanabe, S., Grossmann, J. G., Antonyuk, S. V., Yamanaka, K., & Hasnain. (2014). Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. Proceedings of the National Academy of Sciences of the United States of America, 111(11), 4309-4314. doi:10.1073/pnas.1317317111
Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies (Journal article)
Iram, N., Shah, M. S., Ismat, F., Habib, M., Iqbal, M., Hasnain, S. S., & Rahman, M. (2014). Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 98(4), 1691-1701. doi:10.1007/s00253-013-5043-2
100 years of crystallography: the IUCr launches a comprehensive open-access journal, IUCrJ (Journal article)
Hasnain, S. S. (2014). 100 years of crystallography: the IUCr launches a comprehensive open-access journal, IUCrJ. IUCRJ, 1, 1-2. doi:10.1107/S2052252513033691
Fingerprinting Redox and Ligand States in Haem Protein Crystal Structures using Resonance Raman Spectroscopy (Journal article)
Kekili, D., Dworkowski, F. S. N., Pompidor, G., Fuchs, M. R., Andrew, C. R., Antonyuk, S. V., . . . Hough, M. A. (2014). Fingerprinting Redox and Ligand States in Haem Protein Crystal Structures using Resonance Raman Spectroscopy. ACTA CRYST D: Biological Crystallography, 70, 1289-1296.
Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase (Journal article)
Leferink, N. G. H., Antonyuk, S. V., Houwman, J. A., Scrutton, N. S., Eady, R. R., & Hasnain, S. S. (2014). Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase. Nature Communications.
MSOX crystallography and simulations to capture redox enzyme catalysis (Conference Paper)
Hough, M. A., Kekilli, D., Horrell, S., Sen, K., Yong, C., Keal, T. W. K., . . . Strange, R. W. (2014). MSOX crystallography and simulations to capture redox enzyme catalysis. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 70 (pp. C651). Retrieved from http://gateway.webofknowledge.com/
Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging (Journal article)
Gallagher-Jones, M., Bessho, Y., Kim, S., Park, J., Kim, S., Nam, D., . . . Song, C. (2014). Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging. Nature Communications, 5, 3798.
2013
Transport of gabapentin by LAT1 (SLC7A5) (Journal article)
Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Raedisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). BIOCHEMICAL PHARMACOLOGY, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022
Ligand binding and aggregation of pathogenic SOD1 (Journal article)
Wright, G. S. A., Antonyuk, S. V., Kershaw, N. M., Strange, R. W., & Hasnain, S. S. (2013). Ligand binding and aggregation of pathogenic SOD1. NATURE COMMUNICATIONS, 4. doi:10.1038/ncomms2750
Structures of protein-protein complexes involved in electron transfer (Journal article)
Antonyuk, S. V., Han, C., Eady, R. R., & Hasnain, S. S. (2013). Structures of protein-protein complexes involved in electron transfer. NATURE, 496(7443), 123-127. doi:10.1038/nature11996
Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426 (Journal article)
Padmanabhan, B., Nakamura, Y., Antonyuk, S. V., Strange, R. W., Hasnain, S. S., Yokoyama, S., & Bessho, Y. (2013). Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 69, 342-345. doi:10.1107/S1744309113003369
The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation (Journal article)
Wright, G. S. A., Lee, H. C., Schulze-Briese, C., Grossmann, J. G., Strange, R. W., & Hasnain, S. S. (2013). The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation. JOURNAL OF SYNCHROTRON RADIATION, 20, 383-385. doi:10.1107/S0909049513001866
Transport of gabapentin by LAT1 (SLC7A5) (Journal article)
Dickens,, D., Webb,, S. D., Antonyuk,, S., Giannoudis,, A., Owen,, A., Rädisch,, S., . . . Pirmohamed,, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85, 1672-1683.
X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions (Journal article)
Kershaw, N. M., Wright, G. S. A., Sharma, R., Antonyuk, S. V., Strange, R. W., Berry, N. G., . . . Hasnain, S. S. (2013). X-ray Crystallography and Computational Docking for the Detection and Development of Protein-Ligand Interactions. CURRENT MEDICINAL CHEMISTRY, 20(4), 569-575. Retrieved from http://gateway.webofknowledge.com/
2012
Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase (Journal article)
Strange, R. W., Hough, M. A., Antonyuk, S. V., & Hasnain, S. S. (2012). Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase. PLOS ONE, 7(9). doi:10.1371/journal.pone.0044811
Characterization of a novel copper-haem c dissimilatory nitrite reductase from Ralstonia pickettii (Journal article)
Han, C., Wright, G. S. A., Fisher, K., Rigby, S. E. J., Eady, R. R., & Hasnain, S. S. (2012). Characterization of a novel copper-haem c dissimilatory nitrite reductase from Ralstonia pickettii. BIOCHEMICAL JOURNAL, 444, 219-226. doi:10.1042/BJ20111623
Laser-flash photolysis indicates that internal electron transfer is triggered by proton uptake by Alcaligenes xylosoxidans copper-dependent nitrite reductase (Journal article)
Leferink, N. G. H., Eady, R. R., Hasnain, S. S., & Scrutton, N. S. (2012). Laser-flash photolysis indicates that internal electron transfer is triggered by proton uptake by Alcaligenes xylosoxidans copper-dependent nitrite reductase. FEBS Journal, 279(12), 2174-2181. doi:10.1111/j.1742-4658.2012.08601.x
A Distal Pocket Leu Residue Inhibits the Binding of O2 and NO at the Distal Heme Site of Cytochrome c' (Journal article)
Garton, E. M., Pixton, D. A., Petersen, C. A., Eady, R. R., Hasnain, S. S., & Andrew, C. R. (2012). A Distal Pocket Leu Residue Inhibits the Binding of O2 and NO at the Distal Heme Site of Cytochrome c'. Journal of the American Chemical Society, 134(3), 1461-1463. doi:10.1021/ja209770p
Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography (Journal article)
Doutch, J., Hough, M. A., Hasnain, S. S., & Strange, R. W. (2012). Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography. Journal of Synchrotron Radiation, 19(1), 19-29. doi:10.1107/s0909049511049004
Characterization of a novel copperheme c dissimilatory nitrite reductase from Ralstonia pickettii (Journal article)
Han, C., Wright, G. S. A., Fisher, K., Rigby, S. E. J., Eady, R. R., & Hasnain, S. S. (2012). Characterization of a novel copperheme c dissimilatory nitrite reductase from Ralstonia pickettii. Biochemical Journal, 444, 216-219.
Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase (Journal article)
Leferink, N. G., Pudney, C. R., Brenner, S., Heyes, D. J., Eady, R. R., Hasnain, S. S., . . . Scrutton, N. S. (2012). Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase. FEBS Lett, 586, 578-584.
2011
The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies (Journal article)
Wright, G. S. A., Hasnain, S. S., & Grossmann, J. G. (2011). The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies. BIOCHEMICAL JOURNAL, 439, 39-44. doi:10.1042/BJ20110948
Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins (Journal article)
Antonyuk, S. V., Rustage, N., Petersen, C. A., Arnst, J. L., Heyes, D. J., Sharma, R., . . . Hasnain, S. S. (2011). Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(38), 15780-15785. doi:10.1073/pnas.1109051108
Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase (Journal article)
Leferink, N. G. H., Han, C., Antonyuk, S. V., Heyes, D. J., Rigby, S. E. J., Hough, M. A., . . . Hasnain, S. S. (2011). Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase. BIOCHEMISTRY, 50(19), 4121-4131. doi:10.1021/bi200246f
Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket (Journal article)
Hough, M. A., Antonyuk, S. V., Barbieri, S., Rustage, N., McKay, A. L., Servid, A. E., . . . Hasnain, S. S. (2011). Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket. JOURNAL OF MOLECULAR BIOLOGY, 405(2), 395-409. doi:10.1016/j.jmb.2010.10.035
Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket (Journal article)
Hough, M. A., Antonyuk, S. V., Barbieri, S., Rustage, N., McKay, A. L., Servid, A. E., . . . Hasnain, S. S. (2011). Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket. Journal of Molecular Biology, 405(2), 395-409. doi:10.1016/j.jmb.2010.10.035
Gating Mechanisms for Biological Electron Transfer: Integrating Structure with Biophysics Reveals the Nature of Redox Control in Cytochrome P450 reductase and Copper-Dependent Nitrite Reductase. (Journal article)
Leferink, N. G. H., Pudney, C. R., Brenner, S., Heys, D. J., Eady, R. R., Hasnain, S. S., . . . Scrutton, N. S. (2011). Gating Mechanisms for Biological Electron Transfer: Integrating Structure with Biophysics Reveals the Nature of Redox Control in Cytochrome P450 reductase and Copper-Dependent Nitrite Reductase.. FEBS Letters, 586, 578-584.
Mechanism of Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase (Journal article)
Leferink, N. G. H., Han, C., Antonyuk, S. V., Heyes, D. J., Rigby, S. E. J., Hough, M. A., . . . Hasnain, S. S. (2011). Mechanism of Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase. Biochemistry, 50, 4121-4131. doi:10.1021/bi
2010
Advances in biophysical methods: characterisation and visualization of molecules, cells and organism (Journal article)
Hasnain, S. S., & Wakatsuki, S. (2010). Advances in biophysical methods: characterisation and visualization of molecules, cells and organism. Current Opinion in Structural Biology, 20(5), 584-586. doi:10.1016/j.sbi.2010.09.004
Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli. (Journal article)
Harris, R. L., Barbieri, S., Paraskevopoulos, K., Murphy, L. M., Eady, R. R., Hasnain, S. S., & Sawers, R. G. (2010). Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli.. Journal of molecular microbiology and biotechnology, 18(2), 102-108. doi:10.1159/000287989
Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization (Journal article)
Antonyuk, S., Strange, R. W., & Hasnain, S. S. (2010). Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization. JOURNAL OF MEDICINAL CHEMISTRY, 53(3), 1402-1406. doi:10.1021/jm9017948
Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli (Journal article)
Harris, R. L., Barbieri, S., Paraskevopoulos, K., Murphy, L. M., Eady, R. R., Hasnain, S. S., & Sawers, R. G. (2010). Characterization of cycP gene expression in Achromobacter xylosoxidans NCIMB 11015 and high-level heterologous synthesis of cytochrome c' in Escherichia coli. J Mol Microbiol Biotechnol., 18(2), 102-108.
Structural discovery of small molecule binding sites in SOD1 FALS mutants provides insights for lead optimisation (Journal article)
Antonyuk, S. V., Strange, R. W., & Hasnain, S. S. (2010). Structural discovery of small molecule binding sites in SOD1 FALS mutants provides insights for lead optimisation. Journal of Medicinal Chemistry, 53, 1402-1406.
2009
Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate) (Journal article)
Antonyuk, S. V., Strange, R. W., Ellis, M. J., Bessho, Y., Kuramitsu, S., Inoue, Y., . . . Hasnain, S. S. (2009). Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1209-1213. doi:10.1107/S1744309109044935
Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 angstrom resolution (Journal article)
Antonyuk, S. V., Ellis, M. J., Strange, R. W., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 angstrom resolution. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1204-1208. doi:10.1107/S1744309109043814
Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima (Journal article)
Strange, R. W., Antonyuk, S. V., Ellis, M. J., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of a putative beta-phosphoglucomutase (TM1254) from Thermotoga maritima. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1218-1221. doi:10.1107/S1744309109046302
Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii (Journal article)
Padmanabhan, B., Strange, R. W., Antonyuk, S. V., Ellis, M. J., Hasnain, S. S., Iino, H., . . . Yokoyama, S. (2009). Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1222-1226. doi:10.1107/S174430910904651X
Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophile Methanocaldococcus jannaschii (Journal article)
Malay, A. D., Bessho, Y., Ellis, M. J., Antonyuk, S. V., Strange, R. W., Hasnain, S. S., . . . Yokoyama, S. (2009). Structure of glyceraldehyde-3-phosphate dehydrogenase from the archaeal hyperthermophile Methanocaldococcus jannaschii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1227-1233. doi:10.1107/S1744309109047046
Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii (Journal article)
Antonyuk, S. V., Strange, R. W., Ellis, M. J., Bessho, Y., Kuramitsu, S., Shinkai, A., . . . Hasnain, S. S. (2009). Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1200-1203. doi:10.1107/S1744309109043772
Structure of putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus HB8 (Journal article)
Padmanabhan, B., Bessho, Y., Ebihara, A., Antonyuk, S. V., Ellis, M. J., Strange, R. W., . . . Yokoyama, S. (2009). Structure of putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus HB8. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1234-1239. doi:10.1107/S1744309109050052
The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603) (Journal article)
Strange, R. W., Antonyuk, S. V., Ellis, M. J., Bessho, Y., Kuramitsu, S., Yokoyama, S., & Hasnain, S. S. (2009). The structure of an archaeal ribose-5-phosphate isomerase from Methanocaldococcus jannaschii (MJ1603). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 65, 1214-1217. doi:10.1107/S1744309109044923
Demonstration of Proton-coupled Electron Transfer in the Copper-containing Nitrite Reductases (Journal article)
Brenner, S., Heyes, D. J., Hay, S., Hough, M. A., Eady, R. R., Hasnain, S. S., & Scrutton, N. S. (2009). Demonstration of Proton-coupled Electron Transfer in the Copper-containing Nitrite Reductases. Journal of Biological Chemistry, 284(38), 25973-25983. doi:10.1074/jbc.m109.012245
Digital Ion Trap Mass Spectrometer for Probing the Structure of Biological Macromolecules by Gas Phase X-ray Scattering (Journal article)
McCullough, B. J., Entwistle, A., Konishi, I., Buffey, S., Hasnain, S. S., Brancia, F. L., . . . Gaskell, S. J. (2009). Digital Ion Trap Mass Spectrometer for Probing the Structure of Biological Macromolecules by Gas Phase X-ray Scattering. Analytical Chemistry, 81(9), 3392-3397. doi:10.1021/ac802662d
The Structure of Human Extracellular Copper-Zinc Superoxide Dismutase at 1.7 angstrom Resolution: Insights into Heparin and Collagen Binding (Journal article)
Antonyuk, S. V., Strange, R. W., Marklund, S. L., & Hasnain, S. S. (2009). The Structure of Human Extracellular Copper-Zinc Superoxide Dismutase at 1.7 angstrom Resolution: Insights into Heparin and Collagen Binding. JOURNAL OF MOLECULAR BIOLOGY, 388(2), 310-326. doi:10.1016/j.jmb.2009.03.026
Crystal structure of human prion protein bound to a therapeutic antibody (Journal article)
Antonyuk, S. V., Trevitt, C. R., Strange, R. W., Jackson, G. S., Sangar, D., Batchelor, M., . . . Collinge, J. (2009). Crystal structure of human prion protein bound to a therapeutic antibody. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(8), 2554-2558. doi:10.1073/pnas.0809170106
Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A (Journal article)
Galaleldeen, A., Strange, R. W., Whitson, L. J., Antonyuk, S. V., Narayana, N., Taylor, A. B., . . . Hart, P. J. (2009). Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 492(1-2), 40-47. doi:10.1016/j.abb.2009.09.020
2008
Identification of the Proton Channel to the Active Site Type 2 Cu Center of Nitrite Reductase: Structural and Enzymatic Properties of the His254Phe and Asn90Ser Mutants, (Journal article)
Hough, M. A., Eady, R. R., & Hasnain, S. S. (2008). Identification of the Proton Channel to the Active Site Type 2 Cu Center of Nitrite Reductase: Structural and Enzymatic Properties of the His254Phe and Asn90Ser Mutants,. Biochemistry, 47(51), 13547-13553. doi:10.1021/bi801369y
Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis (Journal article)
Cao, X., Antonyuk, S. V., Seetharaman, S. V., Whitson, L. J., Taylor, A. B., Holloway, S. P., . . . Hart, P. J. (2008). Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(23), 16169-16177. doi:10.1074/jbc.M801522200
Modulation of NO binding to cytochrome c' by distal and proximal haem pocket residues (Journal article)
Barbieri, S., Murphy, L. M., Sawers, R. G., Eady, R. R., & Hasnain, S. S. (2008). Modulation of NO binding to cytochrome c' by distal and proximal haem pocket residues. JBIC Journal of Biological Inorganic Chemistry, 13(4), 531-540. doi:10.1007/s00775-008-0341-3
Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase (Journal article)
Hough, M. A., Antonyuk, S. V., Strange, R. W., Eady, R. R., & Hasnain, S. S. (2008). Crystallography with online optical and X-ray absorption spectroscopies demonstrates an ordered mechanism in copper nitrite reductase. JOURNAL OF MOLECULAR BIOLOGY, 378(2), 353-361. doi:10.1016/j.jmb.2008.01.097
2007
Genomic analysis reveals widespread occurrence of new classes of copper nitrite reductases (Journal article)
Ellis, M. J., Grossmann, J. G., Eady, R. R., & Hasnain, S. S. (2007). Genomic analysis reveals widespread occurrence of new classes of copper nitrite reductases. JBIC Journal of Biological Inorganic Chemistry, 12(8), 1119-1127. doi:10.1007/s00775-007-0282-2
Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase (Journal article)
Strange, R. W., Yong, C. W., Smith, W., & Hasnain, S. S. (2007). Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase. Proceedings of the National Academy of Sciences, 104(24), 10040-10044. doi:10.1073/pnas.0703857104
X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy (Journal article)
Arcovito, A., Benfatto, M., Cianci, M., Hasnain, S. S., Nienhaus, K., Nienhaus, G. U., . . . Della Longa, S. (2007). X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy. Proceedings of the National Academy of Sciences, 104(15), 6211-6216. doi:10.1073/pnas.0608411104
Nitrous oxide reductase (Chapter)
Eady, R. R., Antonyuk, S. V., & Hasnain, S. S. (2007). Nitrous oxide reductase. In A. Messerschmidt (Ed.), Handbook of Metalloproteins (pp. 1). london: John Wiley & Sons.
2006
Insight into catalysis of nitrous oxide reductase from high-resolution structures of resting and inhibitor-bound enzyme from Achromobacter cycloclastes (Journal article)
Paraskevopoulos, K., Antonyuk, S. V., Sawers, R. G., Eady, R. R., & Hasnain, S. S. (2006). Insight into catalysis of nitrous oxide reductase from high-resolution structures of resting and inhibitor-bound enzyme from Achromobacter cycloclastes. JOURNAL OF MOLECULAR BIOLOGY, 362(1), 55-65. doi:10.1016/j.jmb.2006.06.064
Variable metallation of human superoxide dismutase: Atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes (Journal article)
Strange, R. W., Antonyuk, S. V., Hough, M. A., Doucette, P. A., Valentine, J. S., & Hasnain, S. S. (2006). Variable metallation of human superoxide dismutase: Atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes. JOURNAL OF MOLECULAR BIOLOGY, 356(5), 1152-1162. doi:10.1016/j.jmb.2005.11.081
Atomic Resolution Crystal Structures, EXAFS, and Quantum Chemical Studies of Rusticyanin and Its Two Mutants Provide Insight into Its Unusual Properties, (Journal article)
Barrett, M. L., Harvey, I., Sundararajan, M., Surendran, R., Hall, J. F., Ellis, M. J., . . . Hasnain, S. S. (2006). Atomic Resolution Crystal Structures, EXAFS, and Quantum Chemical Studies of Rusticyanin and Its Two Mutants Provide Insight into Its Unusual Properties,. Biochemistry, 45(9), 2927-2939. doi:10.1021/bi052372w
2005
Atomic resolution structures of resting-state, substrate- and product-complexed Cu-nitrite reductase provide insight into catalytic mechanism (Journal article)
Antonyuk, S. V., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2005). Atomic resolution structures of resting-state, substrate- and product-complexed Cu-nitrite reductase provide insight into catalytic mechanism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(34), 12041-12046. doi:10.1073/pnas.0504207102
High resolution structural studies of mutants provide insights into catalysis and electron transfer processes in copper nitrite reductase (Journal article)
Hough, M. A., Ellis, M. J., Antonyuk, S., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2005). High resolution structural studies of mutants provide insights into catalysis and electron transfer processes in copper nitrite reductase. JOURNAL OF MOLECULAR BIOLOGY, 350(2), 300-309. doi:10.1016/j.jmb.2005.04.006
A high-throughput structural biology/proteomics beamline at the SRS on a new multipole wiggler (Conference Paper)
Cianci, M., Antonyuk, S., Bliss, N., Bailey, M. W., Buffey, S. G., Cheung, K. C., . . . Hasnain, S. S. (2005). A high-throughput structural biology/proteomics beamline at the SRS on a new multipole wiggler. In JOURNAL OF SYNCHROTRON RADIATION Vol. 12 (pp. 455-466). doi:10.1107/S0909049505009131
Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg (Journal article)
Antonyuk, S., Elam, J. S., Hough, M. A., Strange, R. W., Doucette, P. A., Rodriguez, J. A., . . . Hasnain, S. S. (2005). Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg. PROTEIN SCIENCE, 14(5), 1201-1213. doi:10.1110/ps.041256705
A high throughput structural biology / proteomics beamline at the SRS on a new multipole wiggler. (Journal article)
Cianci, M., Antonyuk, S., Bliss, N., Buffet, S. G., Cheung, K. C., Clarke, J. A., . . . Hasnain, S. S. (2005). A high throughput structural biology / proteomics beamline at the SRS on a new multipole wiggler.. J. Synchr. Rad., 12, 442-452.
Combined use of XAFS and crystallography for studying protein-ligand interactions in metalloproteins. (Journal article)
Strange, R. W., & Hasnain, S. S. (2005). Combined use of XAFS and crystallography for studying protein-ligand interactions in metalloproteins.. Methods in Molecular Biology, 305, 167-196.
2004
Insights into redox partner interactions and substrate binding in nitrite reductase from Alcaligenes xylosoxidans: Crystal structures of the TrP138His and His313Gln mutants (Journal article)
Barrett, M. L., Harris, R. L., Antonyuk, S., Hough, M. A., Ellis, M. J., Sawers, G., . . . Hasnain, S. S. (2004). Insights into redox partner interactions and substrate binding in nitrite reductase from Alcaligenes xylosoxidans: Crystal structures of the TrP138His and His313Gln mutants. BIOCHEMISTRY, 43(51), 16311-16319. doi:10.1021/bi048682g
Observation of an unprecedented Cu bis-His site: Crystal structure of the H129V mutant of nitrite reductase (Journal article)
Ellis, M. J., Antonyuk, S. V., Strange, R. W., Sawers, G., Eady, R. R., & Hasnain, S. S. (2004). Observation of an unprecedented Cu bis-His site: Crystal structure of the H129V mutant of nitrite reductase. INORGANIC CHEMISTRY, 43(24), 7591-7593. doi:10.1021/ic048966p
Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants (Journal article)
Hough, M. A., Grossmann, J. G., Antonyuk, S. V., Strange, R. W., Doucette, P. A., Rodriguez, J. A., . . . Hasnain, S. S. (2004). Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(16), 5976-5981. doi:10.1073/pnas.0305143101
2003
Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS (Journal article)
Elam, J. S., Taylor, A. B., Strange, R., Antonyuk, S., Doucette, P. A., Rodriguez, J. A., . . . Hart, P. J. (2003). Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. NATURE STRUCTURAL BIOLOGY, 10(6), 461-467. doi:10.1038/nsb935
The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis (Journal article)
Strange, R. W., Antonyuk, S., Hough, M. A., Doucette, P. A., Rodriguez, J. A., Hart, P. J., . . . Hasnain, S. S. (2003). The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis. JOURNAL OF MOLECULAR BIOLOGY, 328(4), 877-891. doi:10.1016/S0022-2836(03)00355-3
The structure of glyceraldehyde 3-phosphate dehydrogenase from Alcaligenes xylosoxidans at 1.7 angstrom resolution (Journal article)
Antonyuk, S. V., Eady, R. R., Strange, R. W., & Hasnain, S. S. (2003). The structure of glyceraldehyde 3-phosphate dehydrogenase from Alcaligenes xylosoxidans at 1.7 angstrom resolution. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 59, 835-842. doi:10.1107/S0907444903041441
2002
Crystal structures of the Met148Leu and Ser86Asp mutants of rusticyanin from Thiobacillus ferrooxidans: Insights into the structural relationship with the cupredoxins and the multi copper proteins (Journal article)
Kanbi, L. D., Antonyuk, S., Hough, M. A., Hall, J. F., Dodd, F. E., & Hasnain, S. S. (2002). Crystal structures of the Met148Leu and Ser86Asp mutants of rusticyanin from Thiobacillus ferrooxidans: Insights into the structural relationship with the cupredoxins and the multi copper proteins. JOURNAL OF MOLECULAR BIOLOGY, 320(2), 263-275. doi:10.1016/S0022-2836(02)00443-6
Resolution improvement from 'in situ annealing' of copper nitrite reductase crystals (Journal article)
Ellis, M. J., Antonyuk, S., & Hasnain, S. S. (2002). Resolution improvement from 'in situ annealing' of copper nitrite reductase crystals. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 58, 456-458. doi:10.1107/S0907444902000136
1986
Iron K-edge EXAFS data on [Fe(o-C6H4(PMe2)2)2Cl2][BF4]n (n = 0-2). The structure of an iron(IV) complex of o-phenylenebis(dimethylphosphine) (Journal article)
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