Photo of Dr Natasha Savage

Dr Natasha Savage Dr.

Lecturer Biochemistry & Systems Biology

    Publications

    2020

    Describing the movement of molecules in reduced-dimension models (Internet publication)

    Savage, N. S. (n.d.). Describing the movement of molecules in reduced-dimension models. Retrieved from http://arxiv.org/abs/2011.01069v3

    2016

    Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast (Journal article)

    Woods, B., Lai, H., Wu, C. -F., Zyla, T. R., Savage, N. S., & Lew, D. J. (2016). Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast. Current Biology, 26(16), 2114-2126. doi:10.1016/j.cub.2016.06.047

    DOI: 10.1016/j.cub.2016.06.047

    2015

    Superresolution microscopy reveals a dynamic picture of cell polarity maintenance during directional growth (Journal article)

    Ishitsuka, Y., Savage, N., Yiming, L., Bergs, A., Grun, N., Kolher, D., . . . Takeshita, N. (2015). Superresolution microscopy reveals a dynamic picture of cell polarity maintenance during directional growth. Science advances, 1(10). doi:10.1126/sciadv.1500947

    DOI: 10.1126/sciadv.1500947

    Role of competition between polarity sites in establishing a unique front (Journal article)

    Wu, C. -F., Chiou, J. -G., Minakova, M., Woods, B., Tsygankov, D., Zyla, T., . . . Lew, D. (2015). Role of competition between polarity sites in establishing a unique front. eLIFE, 4, 33 pages. doi:10.7554/eLife.11611

    DOI: 10.7554/eLife.11611

    2014

    UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity (Journal article)

    Wang, Z., Linden, L. M., Naegeli, K. M., Ziel, J. W., Chi, Q., Hagedorn, E. J., . . . Sherwood, D. R. (2014). UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. Journal of Cell Biology, 206(5), 619-633. doi:10.1083/jcb.201405026

    DOI: 10.1083/jcb.201405026

    Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit (Journal article)

    Kuo, C. -C., Savage, N. S., Chen, H., Wu, C. -F., Zyla, T. R., & Lew, D. J. (2014). Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit. Current Biology, 24(7), 753-759. doi:10.1016/j.cub.2014.02.024

    DOI: 10.1016/j.cub.2014.02.024

    2013

    Positional signaling and expression of ENHANCER OF TRY AND CPC1 are tuned to increase root hair density in response to phosphate deficiency in Arabidopsis thaliana. (Journal article)

    Savage, N., Yang, T. J. W., Chen, C. Y., Lin, K. -L., Monk, N. A. M., & Schmidt, W. (2013). Positional signaling and expression of ENHANCER OF TRY AND CPC1 are tuned to increase root hair density in response to phosphate deficiency in Arabidopsis thaliana.. PloS one, 8(10), e75452. doi:10.1371/journal.pone.0075452

    DOI: 10.1371/journal.pone.0075452

    Daughter Cell Identity Emerges from the Interplay of Cdc42, Septins, and Exocytosis (Journal article)

    Okada, S., Leda, M., Hanna, J., Savage, N. S., Bi, E., & Goryachev, A. B. (2013). Daughter Cell Identity Emerges from the Interplay of Cdc42, Septins, and Exocytosis. Developmental Cell, 26, 148-161.

    Interaction between bud-site selection and polarity-establishment machineries in budding yeast (Journal article)

    Wu, C. -F., Savage, N. S., & Lew, D. J. (2013). Interaction between bud-site selection and polarity-establishment machineries in budding yeast. Philosophical Transactions of The Royal Society B, 368(1629).

    Tracking Shallow Chemical Gradients by Actin-Driven Wandering of the Polarization Site (Journal article)

    Dyer, J. M., Savage, N. S., Jin, M., Zyla, T. R., Elston, T. C., & Lew, D. J. (2013). Tracking Shallow Chemical Gradients by Actin-Driven Wandering of the Polarization Site. Current Biology, 23(1), 32-41. doi:10.1016/j.cub.2012.11.014

    DOI: 10.1016/j.cub.2012.11.014

    2012

    Mechanistic mathematical model of polarity in yeast (Journal article)

    Savage, N. S., Layton, A. T., & Lew, D. J. (2012). Mechanistic mathematical model of polarity in yeast. Molecular Biology of the Cell, 23(10), 1998-2013.

    2011

    Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment (Journal article)

    Layton, A. T., Savage, N. S., Howell, A. S., Carroll, S. Y., Drubin, D. G., & Lew, D. J. (2011). Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment. Current Biology, 21(3), 184-194.

    2009

    Singularity in Polarization: Rewiring Yeast Cells to Make Two Buds (Journal article)

    Howell, A. S., Savage, N. S., Johnson, S. A., Bose, I., Wagner, A. W., Zyla, T. R., . . . Lew, D. J. (2009). Singularity in Polarization: Rewiring Yeast Cells to Make Two Buds. Cell, 139(4), 731-743. doi:10.1016/j.cell.2009.10.024

    DOI: 10.1016/j.cell.2009.10.024

    2008

    A Mutual Support Mechanism through Intercellular Movement of CAPRICE and GLABRA3 Can Pattern the Arabidopsis Root Epidermis (Journal article)

    Savage, N. S., Walker, T., Wieckowski, Y., Schiefelbein, J., Dolan, L., & Monk, N. A. M. (n.d.). A Mutual Support Mechanism through Intercellular Movement of CAPRICE and GLABRA3 Can Pattern the Arabidopsis Root Epidermis. PLoS Biology, 6(9), e235. doi:10.1371/journal.pbio.0060235

    DOI: 10.1371/journal.pbio.0060235

    2007

    From priming to plasticity: the changing fate of rhizodermic cells (Journal article)

    Savage, N. S., & Schmidt, W. (2007). From priming to plasticity: the changing fate of rhizodermic cells. Bioessays, 30(1), 75-81.

    2005

    The Effects of State Dependent and State Independent Probabilistic Updating on Boolean Network Dynamics. (Thesis / Dissertation)

    Savage, N. (2005, January 3). The Effects of State Dependent and State Independent Probabilistic Updating on Boolean Network Dynamics.. (University of Manchester).