Photo of Professor Lu-Gang Yu

Professor Lu-Gang Yu PhD

Professor of Glyco-oncology Biochemistry & Systems Biology

Research

Galectins in cancer development, progression and metastasis

Developing galectin-targeted therapeutic agents for treatment of cancer and metastasis

Alteration of cell glycosylation in cancer development and progression

Research Grants

Investigating the impact of protein O-glycosylation changes on EGFR activation, signalling and EGFRtargeted cancer therapies

ROYAL SOCIETY

March 2021 - March 2023

Research Support Fees for Muhammed Negedu

TERTIARY EDUCATION TRUST FUND (NIGERIA)

December 2019 - November 2023

The role of MUC1 in anoikis (suspension-induced apoptosis) of human epithelial calls. Biomedical vacation scholarship for Tony Lu. Vacation Scholarship

WELLCOME TRUST (UK)

June 2016 - July 2016

A pilot IBD biomarker study: analysis of serum levels of four proteins in IBD patients and healthy people

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

April 2015 - March 2016

Mucosa-associated bacteria and human colon cancer.

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

October 2005 - September 2007

Studies to characterise the intracellular ligands for the anti-proliferative mushroom lectin in colon cancer cells.

NORTH WEST CANCER RESEARCH FUND

June 1999 - June 2002

Characterization of the endothelial cell surface molecule(s) responsible for galectin-3-induced secretion of metastasis-promoting cytokines

NORTH WEST CANCER RESEARCH FUND, NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH - NWCR (UK)

July 2014 - March 2017

Identification and functional characterization of the jacalin-binding cell membrane protein that regulates tyrosine phosphorylation of tumour suppressor PHAPI/pp32.

NORTH WEST CANCER RESEARCH FUND

October 2006 - September 2009

The role of galectin-3-MUC1 interaction in epithelial cancer cell adhesion.

ROYAL SOCIETY (CHARITABLE)

September 2006 - August 2007

In vitro characterization of circulating galectin-3-induced cancer cell adhesion to endothelium.

CANCER RESEARCH UK (CRUK) (UK)

September 2006 - August 2010

Screening the NIH small molecule repository for galectin-3 inhibitors: A pilot study for identification of novel therapeutic leads for cancer treatment

CANCER RESEARCH UK (CRUK) (UK)

July 2010 - June 2011

Investigation into the mechanisms by which the galactose-binding lectin in mushrooms affects proliferation in colon cancer cells.

WORLD CANCER RESEARCH FUND (UK)

December 1999 - November 2002

Tumour suppressing activity of Sclerotium rolfsii lectin on colon cancer

UK-INDIA EDUCATION AND RESEARCH INITIATIVE (UK)

January 2009 - December 2012

The cancer-associated MUC1 and MUC1-galectin interactions in cancer endothelial adhesion and extra-vasation

NORTH WEST CANCER RESEARCH FUND

February 2008 - January 2011

Research Collaborations

Professor Jonathan Rhodes

Internal

GI cancer

Professor Mark Pritchard

Internal

animal models, joint PhD supervision

Dr. Carrie Duckworth

Internal

joint PhD supervision

Dr Sreedhar Subramanian

Internal

IBD

Dr. Mark Morgan

Internal

Joint PhD supervision

Dr. John Hilkens

External: Netherlands Cancer Institute

MUC1 and cancer

Professor Lu-Yun Lian

Internal

Structural biology

Professor Jeremy Turnbull

Internal

Heparin

Professor Hans Wandall

External: University of Copenhagen

Glycan analysis

Dr. Edwin Yates

Internal

Joint PhD supervision

Professor Shashikala Inamdar

External: Karnatak University, India

Joint UK-India Education and Research Initiative (UKIERI) award

Dr. Joseph Barchi

External: National Institute of Health

TF-nanoparticles

Professor Gerard Nash

External: University of Birmingham

Cell adhesion under flow