2024
Incorporating Transgender and nonbinary Participants in Phase 1 Clinical Drug Trials: Current Knowledge Gaps and Considerations for Phase 1 Studies (Preprint)
DOI: 10.22541/au.171126582.28610664/v1
Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee. (Journal article)
Hilmer, S. N., Schwartz, J., Petrovic, M., Walker, L. E., Thürmann, P., & Le Couteur, D. G. (2024). Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee.. Journal of the American Geriatrics Society. doi:10.1111/jgs.18826DOI: 10.1111/jgs.18826
Asiimwe, I. G., Walker, L., Sofat, R., Jorgensen, A. L., Pirmohamed, M., & Multimorbidity Mechanism and Therapeutic Research Collaborative (MMTRC). (2024). Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.. Clinical pharmacology and therapeutics. doi:10.1002/cpt.3229DOI: 10.1002/cpt.3229
Walker, L. E., & Pirmohamed, M. (2024). The status of drug evaluation in older adults in the United Kingdom: Bridging the representation gap.. Journal of the American Geriatrics Society. doi:10.1111/jgs.18817DOI: 10.1111/jgs.18817
Public Attitudes Towards Access to Health Data for Research Purposes Through Citizens' Jury in Uganda. (Journal article)
Walker, L. E., Nakyeyune, L., Ashaba, A., Ahebwa, S., Nakijoba, R., Asiimwe, S. P., . . . Waitt, C. (2024). Public Attitudes Towards Access to Health Data for Research Purposes Through Citizens' Jury in Uganda.. Studies in health technology and informatics, 310, 129-133. doi:10.3233/shti230941DOI: 10.3233/shti230941
2023
Immunomodulatory interventions for focal epilepsy. (Journal article)
Panebianco, M., Walker, L., & Marson, A. G. (2023). Immunomodulatory interventions for focal epilepsy.. The Cochrane database of systematic reviews, 10, CD009945. doi:10.1002/14651858.cd009945.pub3DOI: 10.1002/14651858.cd009945.pub3
Braithwaite, E., Todd, O. M., Atkin, A., Hulatt, R., Tadrous, R., Alldred, D. P., . . . Clegg, A. (2023). Interventions for reducing anticholinergic medication burden in older adults-a systematic review and meta-analysis. AGE AND AGEING, 52(9). doi:10.1093/ageing/afad176DOI: 10.1093/ageing/afad176
Challenger, E., Penchala, S. D., Hale, C., Fitzgerald, R., Walker, L., Reynolds, H., . . . Else, L. (2023). Development and validation of an LC-MS/MS method for quantification of favipiravir in human plasma. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 233. doi:10.1016/j.jpba.2023.115436DOI: 10.1016/j.jpba.2023.115436
Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide? (Journal article)
Walker, L. E., & Pirmohamed, M. (2023). Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide?. Drug and therapeutics bulletin, 61(6), 87-91. doi:10.1136/dtb.2022.000050DOI: 10.1136/dtb.2022.000050
Woodall, A., Prosser, A., Griffiths, M., Shooter, B., Garfitt, J., Walker, L., & Buchan, I. (2023). Cardiovascular risk estimation in rural psychiatric inpatient populations: Cross-sectional preliminary study.. Psychiatry research communications, 3(1), 100103. doi:10.1016/j.psycom.2023.100103DOI: 10.1016/j.psycom.2023.100103
Fahmi, A., Wong, D., Walker, L., Buchan, I., Pirmohamed, M., Sharma, A., . . . van Staa, T. P. (2023). Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.. PloS one, 18(2), e0281466. doi:10.1371/journal.pone.0281466DOI: 10.1371/journal.pone.0281466
Kuan, V., Denaxas, S., Patalay, P., Nitsch, D., Mathur, R., Gonzalez-Izquierdo, A., . . . MMTRC. (2023). Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study. LANCET DIGITAL HEALTH, 5(1), E16-E27. doi:10.1016/S2589-7500(22)00187-XDOI: 10.1016/S2589-7500(22)00187-X
2022
Donovan-Banfield, I., Penrice-Randal, R., Goldswain, H., Rzeszutek, A. M., Pilgrim, J., Bullock, K., . . . Fletcher, T. (2022). Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34839-9DOI: 10.1038/s41467-022-34839-9
Khoo, S. H., FitzGerald, R., Saunders, G., Middleton, C., Ahmad, S., Edwards, C. J., . . . Vyas, A. (2022). Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. The Lancet Infectious Diseases. doi:10.1016/s1473-3099(22)00644-2DOI: 10.1016/s1473-3099(22)00644-2
Essa, H., Walker, L., Mohee, K., Oguguo, C., Douglas, H., Kahn, M., . . . Sankaranarayanan, R. (2022). Multispecialty multidisciplinary input into comorbidities along with treatment optimisation in heart failure reduces hospitalisation and clinic attendance. OPEN HEART, 9(2). doi:10.1136/openhrt-2022-001979DOI: 10.1136/openhrt-2022-001979
Osanlou, R., Walker, L., Hughes, D. A., Burnside, G., & Pirmohamed, M. (2022). Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions. BMJ OPEN, 12(7). doi:10.1136/bmjopen-2021-055551DOI: 10.1136/bmjopen-2021-055551
Moss, J. G., Young, D., Rashed, A. N., Walker, L. E., & Hawcutt, D. B. (2023). Paediatric polypharmacy and deprescribing: the views of UK healthcare professionals. ARCHIVES OF DISEASE IN CHILDHOOD, 108(1), 72-73. doi:10.1136/archdischild-2022-323827DOI: 10.1136/archdischild-2022-323827
Sodium-glucose co-transporter-2 inhibitors in the non-diabetic heart failure patient (Journal article)
Essa, H., Walker, L., & Sankaranarayanan, R. (2022). Sodium-glucose co-transporter-2 inhibitors in the non-diabetic heart failure patient. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(6), 2566-2570. doi:10.1111/bcp.15085DOI: 10.1111/bcp.15085
Green, T. J., Walker, L. E., & Turner, R. M. (2022). A European cross-sectional survey to investigate how involved doctors training in clinical pharmacology are in drug concentration monitoring. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1007/s00228-022-03316-zDOI: 10.1007/s00228-022-03316-z
FitzGerald, R., Dickinson, L., Else, L., Fletcher, T., Hale, C., Amara, A., . . . Khoo, S. (2022). Pharmacokinetics of ss-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. CLINICAL INFECTIOUS DISEASES. doi:10.1093/cid/ciac199DOI: 10.1093/cid/ciac199
Walker, L. E., FitzGerald, R., Saunders, G., Lyon, R., Fisher, M., Martin, K., . . . Fletcher, T. E. (2022). An Open Label, Adaptive, Phase 1 Trial of High-Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS-CoV-2. CLINICAL PHARMACOLOGY & THERAPEUTICS, 111(3), 585-594. doi:10.1002/cpt.2463DOI: 10.1002/cpt.2463
Triple antithrombotic therapy and dual therapy - What is the evidence base? (Journal article)
Essa, H., Sankaranarayanan, R., & Walker, L. (2022). Triple antithrombotic therapy and dual therapy - What is the evidence base?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15257DOI: 10.1111/bcp.15257
Stefil, M., Dixon, M., Bahar, J., Saied, S., Mashida, K., Heron, O., . . . Sankaranarayanan, R. (2022). Polypharmacy in Older People With Heart Failure: Roles of the Geriatrician and Pharmacist.. Cardiac failure review, 8, e34. doi:10.15420/cfr.2022.14DOI: 10.15420/cfr.2022.14
Walker, L. E., Abuzour, A. S., Bollegala, D., Clegg, A., Gabbay, M., Griffiths, A., . . . Buchan, I. (2022). The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity.. Journal of multimorbidity and comorbidity, 12, 26335565221145493. doi:10.1177/26335565221145493DOI: 10.1177/26335565221145493
2021
Concise advice: Introducing a new clinically focused BJCP series on evidence-based (de)prescribing in challenging situations (Journal article)
Walker, L. E., & Cremers, S. (2021). Concise advice: Introducing a new clinically focused BJCP series on evidence-based (de)prescribing in challenging situations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4484-4487. doi:10.1111/bcp.15093DOI: 10.1111/bcp.15093
Long-term bisphosphonate therapy and atypical femoral fracture: Can you have too much of a good thing? (Journal article)
Walker, L. E., & Cooper, C. (2021). Long-term bisphosphonate therapy and atypical femoral fracture: Can you have too much of a good thing?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4877-4879. doi:10.1111/bcp.15110DOI: 10.1111/bcp.15110
Amara, A., Penchala, S. D., Else, L., Hale, C., FitzGerald, R., Walker, L., . . . Khoo, S. (2021). The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite β-d-N4-hydroxycytidine in human plasma and saliva. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 206. doi:10.1016/j.jpba.2021.114356DOI: 10.1016/j.jpba.2021.114356
Khoo, S. H., Fitzgerald, R., Fletcher, T., Ewings, S., Jaki, T., Lyon, R., . . . Griffiths, G. (2021). Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 76(12), 3286-3295. doi:10.1093/jac/dkab318DOI: 10.1093/jac/dkab318
Walker, L. E., Sills, G. J., Jorgensen, A., Alapirtti, T., Peltola, J., Brodie, M. J., . . . Pirmohamed, M. (2021). High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study. EPILEPSIA. doi:10.1111/epi.17116DOI: 10.1111/epi.17116
Griffiths, G. O., FitzGerald, R., Jaki, T., Corkhill, A., Reynolds, H., Ewings, S., . . . Khoo, S. (2021). AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter. TRIALS, 22(1). doi:10.1186/s13063-021-05458-4DOI: 10.1186/s13063-021-05458-4
Walker, L. E., & Mangoni, A. A. (2021). Avoiding harm from overprescribing: What are the challenges and how do we overcome them?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(1), 6-8. doi:10.1111/bcp.14696DOI: 10.1111/bcp.14696
Vincent-Paulraj, A., Burnside, G., Coenen, F., Pirmohamed, M., & Walker, L. (2021). Sequential Association Rule Mining Revisited: A Study Directed at Relational Pattern Mining for Multi-morbidity. In ARTIFICIAL INTELLIGENCE XXXVIII Vol. 13101 (pp. 241-253). doi:10.1007/978-3-030-91100-3_20DOI: 10.1007/978-3-030-91100-3_20
2020
Doherty, A. J., Boland, P., Reed, J., Clegg, A. J., Stephani, A., Williams, N. H., . . . Walker, L. (2020). Barriers and facilitators to deprescribing in primary care: a systematic review. BJGP Open, 4(3), 0. doi:10.3399/bjgpopen20X101096DOI: 10.3399/bjgpopen20X101096
Griffiths, G., Fitzgerald, R., Jaki, T., Corkhill, A., Marwood, E., Reynolds, H., . . . Khoo, S. (2020). AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial. TRIALS, 21(1). doi:10.1186/s13063-020-04473-1DOI: 10.1186/s13063-020-04473-1
2019
Strategies to safely reduce polypharmacy in older people: a systematic review of barriers and facilitators to effective intervention (Other)
Hill, R. A., Walker, L., Osanlou, O., Williams, N., & Khedmati Morasae, E. (2019). Strategies to safely reduce polypharmacy in older people: a systematic review of barriers and facilitators to effective intervention. Retrieved from http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019121848
2018
TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers. (Journal article)
Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A. L., Park, B. K., . . . Antoine, D. J. (2018). TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.. Journal of hepatology, S0168-8278(18)32042-7. doi:10.1016/j.jhep.2018.04.024DOI: 10.1016/j.jhep.2018.04.024
2017
Auvin, S., Walker, L. E., Gallentine, W., Jozwiak, S., Tombini, M., & Sills, G. J. (2017). Prospective clinical trials to investigate clinical and molecular biomarkers. EPILEPSIA, 58(S3), 20-26. doi:10.1111/epi.13782DOI: 10.1111/epi.13782
Stroke Pharmacogenetics (Chapter)
Walker, L. E., Stewart, A., & Pirmohamed, S. M. (2017). Stroke Pharmacogenetics. In P. Sharma, & J. F. Meschia (Eds.), Stroke Genetics (pp. 327-410). Springer. doi:10.1007/978-3-319-56210-0_17DOI: 10.1007/978-3-319-56210-0_17
2016
A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease (Journal article)
Walker, L., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2016). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003DOI: 10.1080/1354750X.2016.1265003
Walker, L. E., Janigro, D., Heinemann, U., Riikonen, R., Bernard, C., & Patel, M. (2016). WONOEP appraisal: Molecular and cellular biomarkers for epilepsy. EPILEPSIA, 57(9), 1354-1362. doi:10.1111/epi.13460DOI: 10.1111/epi.13460
2015
Personalized medicine approaches in epilepsy (Journal article)
Walker, L. E., Mirza, N., Yip, V. L. M., Marson, A. G., & Pirmohamed, M. (2015). Personalized medicine approaches in epilepsy. JOURNAL OF INTERNAL MEDICINE, 277(2), 218-234. doi:10.1111/joim.12322DOI: 10.1111/joim.12322
2014
Adverse Drug Reactions (Chapter)
Walker, L., Yip, V., & Pirmohamed, M. (2014). Adverse Drug Reactions. In Handbook of Pharmacogenomics and Stratified Medicine (pp. 405-435). Elsevier. doi:10.1016/b978-0-12-386882-4.00020-7DOI: 10.1016/b978-0-12-386882-4.00020-7
2013
Immunomodulatory interventions for focal epilepsy syndromes (Journal article)
Walker, L., Pirmohamed, M., & Marson, A. G. (2013). Immunomodulatory interventions for focal epilepsy syndromes. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (6). doi:10.1002/14651858.CD009945.pub2DOI: 10.1002/14651858.CD009945.pub2
Stroke Pharmacogenetics (Chapter)
Walker, L. E., Stewart, A., & Pirmohamed, M. (2013). Stroke Pharmacogenetics. In Stroke Genetics (pp. 223-297). Springer London. doi:10.1007/978-0-85729-209-4_14DOI: 10.1007/978-0-85729-209-4_14
2012
Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy? (Journal article)
Walker, L., & Sills, G. J. (2012). Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?. EPILEPSY CURRENTS, 12(1), 8-12. doi:10.5698/1535-7511-12.1.8DOI: 10.5698/1535-7511-12.1.8
2011
'Septrin psychosis' among renal transplant patients with <i>Pneumocystis jirovecii</i> pneumonia (Journal article)
Walker, L. E., Thomas, S., McBride, C., Howse, M., Turtle, L. C. W., Vivancos, R., . . . Beadsworth, M. B. J. (2011). 'Septrin psychosis' among renal transplant patients with <i>Pneumocystis jirovecii</i> pneumonia. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 66(5), 1117-1119. doi:10.1093/jac/dkr050DOI: 10.1093/jac/dkr050
2009
Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin (Journal article)
Ganguli, A., Walker, L., FitzGerald, R. J., & Pirmohamed, M. (2009). Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin. ANNALS OF PHARMACOTHERAPY, 43(9), 1528-1531. doi:10.1345/aph.1L542DOI: 10.1345/aph.1L542
SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer (Journal article)
Moss, A. C., Jacobson, G. M., Walker, L. E., Blake, N. W., Marshall, E., & Coulson, J. M. (2009). SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer. CLINICAL CANCER RESEARCH, 15(1), 274-283. doi:10.1158/1078-0432.CCR-08-1163DOI: 10.1158/1078-0432.CCR-08-1163