2023
Zhang, Y., Karamanova, N., Morrow, K. T., Madine, J., Truran, S., Lozoya, M., . . . Migrino, R. Q. (2023). Transcriptomic analyses reveal proinflammatory activation of human brain microvascular endothelial cells by aging-associated peptide medin and reversal by nanoliposomes.. Scientific reports, 13(1), 18802. doi:10.1038/s41598-023-45959-7DOI: 10.1038/s41598-023-45959-7
Medin amyloid may drive arterial aging and disease in the periphery and brain (Journal article)
Madine, J., Davies, H. A., Migrino, R. Q., Ruotsalainen, S. E., Wagner, J., & Neher, J. J. (2023). Medin amyloid may drive arterial aging and disease in the periphery and brain. NATURE AGING. doi:10.1038/s43587-023-00481-3DOI: 10.1038/s43587-023-00481-3
Mesdaghi, S., Price, R. M., Madine, J., & Rigden, D. J. (2023). Deep Learning-based structure modelling illuminates structure and function in uncharted regions of β-solenoid fold space. Journal of Structural Biology, 108010. doi:10.1016/j.jsb.2023.108010DOI: 10.1016/j.jsb.2023.108010
Proietti, R., Rivera-Caravaca, J. M., Harrison, S. L., Buckley, B. J. R., Lopez-Galvez, R., Marin, F., . . . Lip, G. Y. H. (2023). Thoracic aortic aneurysm and atrial fibrillation: clinical associations with the risk of stroke from a global federated health network analysis. INTERNAL AND EMERGENCY MEDICINE. doi:10.1007/s11739-022-03184-6DOI: 10.1007/s11739-022-03184-6
Aging-associated Medin Induces Human Brain Microvascular Endothelial Cell Proinflammatory And Pro-thrombotic Activation Partly Via NFκB (Conference Paper)
Nabaty, N. L., Karamanova, N., Truran, S., Morrow, K., Schafer, R., Nikkhah, M., . . . Migrino, R. Q. (2023). Aging-associated Medin Induces Human Brain Microvascular Endothelial Cell Proinflammatory And Pro-thrombotic Activation Partly Via NFκB. In STROKE Vol. 54. doi:10.1161/str.54.suppl_1.TP222DOI: 10.1161/str.54.suppl_1.TP222
Whitehead, M., Yusoff, S., Ahmad, S., Schmidt, L., Mayr, M., Madine, J., . . . Shanahan, C. M. (2023). Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization. AGING CELL, 22(2). doi:10.1111/acel.13746DOI: 10.1111/acel.13746
2022
Wagner, J., Degenhardt, K., Veit, M., Louros, N., Konstantoulea, K., Skodras, A., . . . Neher, J. J. (2022). Medin co-aggregates with vascular amyloid-β in Alzheimer's disease. NATURE, 612(7938), 123-+. doi:10.1038/s41586-022-05440-3DOI: 10.1038/s41586-022-05440-3
Vio, R., Giordani, A. S., Stefil, M., Madine, J., Fairbairn, T., Themistoclakis, S., . . . Proietti, R. (2022). Arterial stiffness and atrial fibrillation: shared mechanisms, clinical implications and therapeutic options.. Journal of hypertension, 40(9), 1639-1646. doi:10.1097/hjh.0000000000003223DOI: 10.1097/hjh.0000000000003223
Rai, P., Robinson, L., Davies, H. A., Akhtar, R., Field, M., & Madine, J. (n.d.). Is There Enough Evidence to Support the Role of Glycosaminoglycans and Proteoglycans in Thoracic Aortic Aneurysm and Dissection?—A Systematic Review. International Journal of Molecular Sciences, 23(16), 9200. doi:10.3390/ijms23169200DOI: 10.3390/ijms23169200
Fletcher, A. J., Nash, J., Syed, M. B. J., Macaskill, M. G., Tavares, A. A. S., Walker, N., . . . Sellers, S. L. (2022). Microcalcification and Thoracic Aortopathy: A Window Into Disease Severity. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 42(8), 1048-1059. doi:10.1161/ATVBAHA.122.317111DOI: 10.1161/ATVBAHA.122.317111
Soliman, M. G., Davies, H. A., Sharkey, J., Levy, R., & Madine, J. (2022). Development of amyloid beta gold nanorod aggregates as optoacoustic probes. PLOS ONE, 17(3). doi:10.1371/journal.pone.0259608DOI: 10.1371/journal.pone.0259608
Hossack, M., Fisher, R., Torella, F., Madine, J., Field, M., & Akhtar, R. (2022). Micromechanical and Ultrastructural Properties of Abdominal Aortic Aneurysms. Artery Research. doi:10.1007/s44200-022-00011-3DOI: 10.1007/s44200-022-00011-3
Panpho, P., Yang, Y., Davies, H. A., Nawaytou, O., Harky, A., Torella, F., . . . Akhtar, R. (2022). Time-dependent mechanical behaviour of the aortic chronic dissection flap.. Interactive cardiovascular and thoracic surgery. doi:10.1093/icvts/ivac029DOI: 10.1093/icvts/ivac029
Davies, H. A., Caamano-Gutierrez, E., Sarsby, J., Chim, Y. H., Barrett, S., Nawaytou, O., . . . Madine, J. (2022). Rapid evaporative ionization mass spectrometry (intelligent knife) for point-of-care testing in acute aortic dissection surgery. Interactive CardioVascular and Thoracic Surgery. doi:10.1093/icvts/ivac019DOI: 10.1093/icvts/ivac019
2021
Abstract 11596: Amyloidogenic Medin Induces Endothelial Cell Prothrombotic Activation (Journal article)
Karamanova, N., Truran, S., Davies, H., Madine, J., & Migrino, R. Q. (2021). Abstract 11596: Amyloidogenic Medin Induces Endothelial Cell Prothrombotic Activation. Circulation, 144(Suppl_1). doi:10.1161/circ.144.suppl_1.11596DOI: 10.1161/circ.144.suppl_1.11596
Davies, H. A., Caamano-Gutierrez, E., Sarsby, J., Nawaytou, O., Harky, A., Akhtar, R., . . . Madine, J. (n.d.). Exploring the potential of rapid evaporative ionization mass spectrometry (Intelligent Knife) for point-of-care testing in aortic surgery. European Journal of Cardio-Thoracic Surgery. doi:10.1093/ejcts/ezab166DOI: 10.1093/ejcts/ezab166
Nano-Scale Stiffness and Collagen Fibril Deterioration: Probing the Cornea Following Enzymatic Degradation Using Peakforce-QNM AFM (Journal article)
Kazaili, A., Abdul-Amir Al-Hindy, H., Madine, J., & Akhtar, R. (n.d.). Nano-Scale Stiffness and Collagen Fibril Deterioration: Probing the Cornea Following Enzymatic Degradation Using Peakforce-QNM AFM. Sensors, 21(5), 1629. doi:10.3390/s21051629DOI: 10.3390/s21051629
Amyloidogenic Medin Induces Endothelial Cell Prothrombotic Activation (Conference Paper)
Karamanova, N., Truran, S., Davies, H., Madine, J., & Migrino, R. Q. (2021). Amyloidogenic Medin Induces Endothelial Cell Prothrombotic Activation. In CIRCULATION Vol. 144. Retrieved from https://www.webofscience.com/
Kazaili, A., Al-Hindy, H. A. -A., Madine, J., & Akhtar, R. (2021). Nano-Scale Stiffness and Collagen Fibril Deterioration: Probing the Cornea Following Enzymatic Degradation Using Peakforce-QNM AFM.. Sensors, 21, 1629.
2020
Medin amyloid forms age‐associated aggregates in the brain vasculature and may contribute to cerebral β‐amyloidosis (Journal article)
Wagner, J., Degenhardt, K., Wild, K., Obermüller, U., Haesler, L. M., Koppelmann, A. J., . . . Neher, J. J. (2020). Medin amyloid forms age‐associated aggregates in the brain vasculature and may contribute to cerebral β‐amyloidosis. Alzheimer's & Dementia, 16(S2). doi:10.1002/alz.042861DOI: 10.1002/alz.042861
Torpey, J. H., Meade, R. M., Mistry, R., Mason, J. M., & Madine, J. (2020). Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation. FRONTIERS IN NEUROSCIENCE, 14. doi:10.3389/fnins.2020.561462DOI: 10.3389/fnins.2020.561462
Degenhardt, K., Wagner, J., Skodras, A., Candlish, M., Koppelmann, A. J., Wild, K., . . . Neher, J. J. (2020). Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.2011133117DOI: 10.1073/pnas.2011133117
Migrino, R. Q., Karamanova, N., Truran, S., Serrano, G. E., Davies, H. A., Madine, J., & Beach, T. G. (2020). Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia.. Alzheimer's and Dementia, 12(1), e12072. doi:10.1002/dad2.12072DOI: 10.1002/dad2.12072
Torpey, J., Madine, J., Wood, A., & Lian, L. -Y. (2020). Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-66200-9DOI: 10.1038/s41598-020-66200-9
Younger, S., Jang, H., Davies, H. A., Niemiec, M. J., Garcia, J. G. N., Nussinov, R., . . . Arce, F. T. (2020). Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction. BIOPHYSICAL JOURNAL, 118(11), 2769-2782. doi:10.1016/j.bpj.2020.04.026DOI: 10.1016/j.bpj.2020.04.026
Karamanova, N., Truran, S., Serrano, G. E., Beach, T. G., Madine, J., Weissig, V., . . . Migrino, R. Q. (2020). Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside‐Containing Nanoliposomes. Journal of the American Heart Association, 9(2). doi:10.1161/JAHA.119.014810DOI: 10.1161/JAHA.119.014810
2019
2.8 Unique Patterns of Elastin Degradation in Ascending Aortic Aneurysms in Bicuspid Aortic Valve Patients (Journal article)
Chim, Y. H., Davies, H., Nawaytou, O., Field, M., Madine, J., & Akhtar, R. (2019). 2.8 Unique Patterns of Elastin Degradation in Ascending Aortic Aneurysms in Bicuspid Aortic Valve Patients. Artery Research, 25(S1), S19. doi:10.2991/artres.k.191224.013DOI: 10.2991/artres.k.191224.013
P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection (Journal article)
Panpho, P., Davies, H., Field, M., Madine, J., Yang, Y., & Akhtar, R. (2019). P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection. Artery Research, 25(S1), S43. doi:10.2991/artres.k.191224.036DOI: 10.2991/artres.k.191224.036
Chim, Y. H., Davies, H., Mason, D., Nawaytou, O., Field, M., Madine, J., & Akhtar, R. (2019). Bicuspid valve aortopathy is associated with distinct patterns of matrix degradation. The Journal of Thoracic and Cardiovascular Surgery, 160(6), E239-E257. doi:10.1016/j.jtcvs.2019.08.094DOI: 10.1016/j.jtcvs.2019.08.094
Davies, H. A., Caamano-Gutierrez, E., Chim, Y. H., Field, M., Nawaytou, O., Ressel, L., . . . Madine, J. (n.d.). Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid. Amyloid: international journal of experimental and clinical investigation, 26(3), 148-155. doi:10.1080/13506129.2019.1625323DOI: 10.1080/13506129.2019.1625323
Panpho, P., Brendan, G., Chim, Y. H., Davies, H., Field, M., Madine, J., & Akhtar, R. (n.d.). Macro- and Micro-mechanical Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels. Artery Research, 25(1-2), 27-36. doi:10.2991/artres.k.191114.003DOI: 10.2991/artres.k.191114.003
Chim, Y. -H., Caamaño-Gutiérrez, E., Birla, R., Madine, J., Field, M., Akhtar, R., & Davies, H. A. (n.d.). Quality of Reporting in Human Aortic Tissue Research – A Systematic Review. Artery Research. doi:10.2991/artres.k.191106.003DOI: 10.2991/artres.k.191106.003
BAV AORTOPATHY EXHIBITS A UNIQUE PATTERN OF AORTIC DEGRADATION EVEN THOUGH THE CLINICAL RISK OF RUPTURE MIRRORS OTHER ANEURYSMS - A MICROMECHANICAL AND MICROSTRUCTURAL APPROACH (Conference Paper)
Chim, Y. H., Davies, H., Field, M., Madine, J., & Akhtar, R. (2019). BAV AORTOPATHY EXHIBITS A UNIQUE PATTERN OF AORTIC DEGRADATION EVEN THOUGH THE CLINICAL RISK OF RUPTURE MIRRORS OTHER ANEURYSMS - A MICROMECHANICAL AND MICROSTRUCTURAL APPROACH. In HEART Vol. 105 (pp. A162). doi:10.1136/heartjnl-2019-BCS.196DOI: 10.1136/heartjnl-2019-BCS.196
Madine, J. (2019). Cofactor-mediated amyloidogenesis. BIOSCIENCE REPORTS, 39. doi:10.1042/BSR20190327DOI: 10.1042/BSR20190327
Abstract TP557: Endothelial Cell Proinflammatory Priming by Amyloidogenic Medin via NFκB and Inflammasome Pathways and Reversal by Monosialoganglioside Nanoliposomes (Journal article)
Karamanova, N., Truran, S., Madine, J., Davies, H., Zhang, W., Franco, D., . . . Migrino, R. Q. (2019). Abstract TP557: Endothelial Cell Proinflammatory Priming by Amyloidogenic Medin via NFκB and Inflammasome Pathways and Reversal by Monosialoganglioside Nanoliposomes. Stroke, 50(Suppl_1). doi:10.1161/str.50.suppl_1.tp557DOI: 10.1161/str.50.suppl_1.tp557
Abstract WMP73: Discerning How Vascular Inflammation Modulates Neuroinflammation Using Novel Vascular Brain Organ-On-A-Chip: Proof-of-Concept Study (Journal article)
Veldhuizen, J., Truran, S., Madine, J., Davies, H., Karamanova, N., Nikkhah, M., & Migrino, R. Q. (2019). Abstract WMP73: Discerning How Vascular Inflammation Modulates Neuroinflammation Using Novel Vascular Brain Organ-On-A-Chip: Proof-of-Concept Study. Stroke, 50(Suppl_1). doi:10.1161/str.50.suppl_1.wmp73DOI: 10.1161/str.50.suppl_1.wmp73
Panpho, P., Al-Matari, M., Field, M., Madine, J., & Akhtar, R. (2019). Elastic, Viscoelastic and Dissection Resistance Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels.
Biochemical Characteristics of the Aortic True Lumen Wall, False Lumen Wall and Flap During the Acute Phases of Type A Aortic Dissection in Humans (Conference Paper)
Harky, A., Chim, Y. H., Davies, H. A., Field, M., Nawaytou, O., Akhtar, R., & Madine, J. (2019). Biochemical Characteristics of the Aortic True Lumen Wall, False Lumen Wall and Flap During the Acute Phases of Type A Aortic Dissection in Humans. In CIRCULATION Vol. 140. Retrieved from https://www.webofscience.com/
Discerning How Vascular Inflammation Modulates Neuroinflammation Using Novel Vascular Brain Organ-On-A-Chip: Proof-of-Concept Study. (Conference Paper)
Veldhuizen, J., Truran, S., Madine, J., Davies, H., Karamanova, N., Nikkhah, M., & Migrino, R. Q. (2019). Discerning How Vascular Inflammation Modulates Neuroinflammation Using Novel Vascular Brain Organ-On-A-Chip: Proof-of-Concept Study.. In STROKE Vol. 50. Retrieved from https://www.webofscience.com/
Endothelial Cell Proinflammatory Priming by Amyloidogenic Medin via NF[kappa]B and Inflammasome Pathways and Reversal by Monosialoganglioside Nanoliposomes (Conference Paper)
Karamanova, N., Truran, S., Madine, J., Davies, H., Zhang, W., Franco, D., . . . Migrino, R. Q. (2019). Endothelial Cell Proinflammatory Priming by Amyloidogenic Medin via NF[kappa]B and Inflammasome Pathways and Reversal by Monosialoganglioside Nanoliposomes. In STROKE Vol. 50. Retrieved from https://www.webofscience.com/
2018
Hand, K., Wilkinson, M., & Madine, J. (2018). Isolation and purification of recombinant immunoglobulin light chain variable domains from the periplasmic space of Escherichia coli. PLoS One, 13(10). doi:10.1371/journal.pone.0206167DOI: 10.1371/journal.pone.0206167
Truran, S., Karamanova, N., Serrano, G., Madine, J., Davies, H., Beach, T., & Migrino, R. Q. (2018). Peripheral Adipose Arteriole Dilator Response to Amyloid Proteins and Palmitic Acid Recapitulates Central Leptomeningeal Arteriole Response: Validation of a Novel Human Tissue Model. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/
Migrino, R. Q., Truran, S., Karamanova, N., Davies, H., Madine, J., Reaven, P., & Beach, T. G. (2018). Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia. American Journal of Physiology: Heart and Circulatory Physiology, 315(2), H284-H290. doi:10.1152/ajpheart.00206.2018DOI: 10.1152/ajpheart.00206.2018
Davies, H., Lee, C. F., Miller, L., Liu, L., & Madine, J. (2018). Insights into the Origin of Distinct Medin FibrilMorphologies Induced by Incubation Conditionsand Seeding. International Journal of Molecular Sciences, 19(5), 1-15. doi:10.3390/ijms19051357DOI: 10.3390/ijms19051357
Amyloidogenic Medin Impairs Endothelial Cell Autophagy and Viability that is Reversed by Monosialoganglioside Nanoliposomes (Journal article)
Karamanova, N., Truran, S., Weissig, V., Madine, J., Davies, H., Guzman‐Villanueva, D., & Migrino, R. (2018). Amyloidogenic Medin Impairs Endothelial Cell Autophagy and Viability that is Reversed by Monosialoganglioside Nanoliposomes. The FASEB Journal, 32(S1). doi:10.1096/fasebj.2018.32.1_supplement.846.16DOI: 10.1096/fasebj.2018.32.1_supplement.846.16
Peripheral Adipose Arteriole Dilator Response to Amyloid Proteins and Palmitic Acid Recapitulates Central Leptomeningeal Arteriole Response: Validation of a Novel Human Tissue Model (Journal article)
Truran, S., Karamanova, N., Serrano, G., Madine, J., Davies, H., Beach, T., & Migrino, R. Q. (2018). Peripheral Adipose Arteriole Dilator Response to Amyloid Proteins and Palmitic Acid Recapitulates Central Leptomeningeal Arteriole Response: Validation of a Novel Human Tissue Model. The FASEB Journal, 32(S1). doi:10.1096/fasebj.2018.32.1_supplement.712.6DOI: 10.1096/fasebj.2018.32.1_supplement.712.6
Cumberbatch, N., Madine, J., & Arnolds, H. (2018). Monitoring Native and Aggregate Structure of Amino Acids and Human Insulin with Blue Autofluorescence. In BIOPHYSICAL JOURNAL Vol. 114 (pp. 172A). doi:10.1016/j.bpj.2017.11.959
Abstract WP416: Comparison of Ex-vivo Human Leptomeningeal Arteriole Function in Cognitively Normal and Dementia Disorders From Rapid Autopsy Brain Donors (Journal article)
Madrigal, C., Truran, S., Karamanova, N., Serrano, G., Madine, J., Davies, H., . . . Migrino, R. Q. (2018). Abstract WP416: Comparison of Ex-vivo Human Leptomeningeal Arteriole Function in Cognitively Normal and Dementia Disorders From Rapid Autopsy Brain Donors. Stroke, 49(Suppl_1). doi:10.1161/str.49.suppl_1.wp416DOI: 10.1161/str.49.suppl_1.wp416
Karamanova, N., Truran, S., Weissig, V., Madine, J., Davies, H., Guzman-Villanueva, D., & Migrino, R. (2018). Amyloidogenic Medin Impairs Endothelial Cell Autophagy and Viability that is Reversed by Monosialoganglioside Nanoliposomes. In FASEB JOURNAL Vol. 32. Retrieved from https://www.webofscience.com/
Madrigal, C., Truran, S., Karamanova, N., Serrano, G., Madine, J., Davies, H., . . . Migrino, R. Q. (2018). Comparison of Ex-vivo Human Leptomeningeal Arteriole Function in Cognitively Normal and Dementia Disorders From Rapid Autopsy Brain Donors. In STROKE Vol. 49. Retrieved from https://www.webofscience.com/
2017
Phelan, M. M., Caamaño-Gutiérrez, E., Gant, M. S., Grosman, R. X., & Madine, J. (2017). Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein. Metabolomics, 13(12). doi:10.1007/s11306-017-1289-5DOI: 10.1007/s11306-017-1289-5
Mukherjee, S., Pondaven, S. P., Hand, K., Madine, J., & Jaroniec, C. P. (2017). Effect of amino acid mutations on the conformational dynamics of amyloidogenic immunoglobulin light-chains: A combined NMR and in silico study. Scientific Reports, 7. doi:10.1038/s41598-017-10906-wDOI: 10.1038/s41598-017-10906-w
Migrino, M., Davies, H. A., Truran, S., Karamanova, N., Franco, D. A., Beach, T. G., . . . Madine, J. (2017). Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation through the Receptor for Advanced Glycation Endproducts. Cardiovascular Research, 113(11), 1389-1402. doi:10.1093/cvr/cvx135DOI: 10.1093/cvr/cvx135
Migrino, R. Q., Davies, H., Truran, S., Karamanova, N., Franco, D. A., Serrano, G., . . . Madine, J. (2017). Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation Through the Receptor for Advanced Glycation Endproducts. In FASEB JOURNAL Vol. 31. Retrieved from https://www.webofscience.com/
Davies, H. A., Rigden, D. J., Phelan, M. M., & Madine, J. (2017). Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics. Scientific Reports, 7. doi:10.1038/srep45224DOI: 10.1038/srep45224
Townsend, D., Hughes, E., Hussain, R., Siligardi, G., Baldock, S. J., Madine, J., & Middleton, D. A. (2017). Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising α-helical and β-sheet structures.. Biochemistry, 56(11), 1632-1644. doi:10.1021/acs.biochem.6b01120DOI: 10.1021/acs.biochem.6b01120
Truran, S., Karamanova, N., Madine, J., Davies, H., Guzman-Villanueva, D., Serrano, G., . . . Migrino, R. Q. (2017). Medin Amyloid Protein-Induced Human Leptomeningeal Arteriole Endothelial Dysfunction and Pro-Inflammatory Signaling are Reversed by Monosialoganglioside Nanoliposomes. In CIRCULATION Vol. 136. Retrieved from https://www.webofscience.com/
Karamanova, N., Truran, S., Madine, J., Davies, H., Anderson, J., Franco, D. A., . . . Migrino, R. Q. (2017). Medin Amyloid, but Not β-amyloid, Induces Pro-Inflammatory Signaling in Endothelial Cells That is Synergistic With Palmitic Acid. In CIRCULATION Vol. 136. Retrieved from https://www.webofscience.com/
2016
Migrino, R. Q., Truran, S., Karamanova, N., Franco, D., Davies, H. A., Burciu, C., & Madine, J. (2016). HUMAN MICROVASCULAR ENDOTHELIAL DYSFUNCTION INDUCED BY AMYLOIDOGENIC MEDIN PROTEIN. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 67 (pp. 2310). doi:10.1016/S0735-1097(16)32311-7
Davies, H. A., Phelan, M. M., & Madine, J. (2016). <SUP>1</SUP>H, <SUP>15</SUP>N and <SUP>13</SUP>C assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques. BIOMOLECULAR NMR ASSIGNMENTS, 10(1), 75-77. doi:10.1007/s12104-015-9641-zDOI: 10.1007/s12104-015-9641-z
Truran, S., Weissig, V., Madine, J., Davies, H. A., Guzman-Villanueva, D., Franco, D. A., . . . Migrino, R. Q. (2016). Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36(2), 405-412. doi:10.1177/0271678X15610134DOI: 10.1177/0271678X15610134
2015
Davies, H., Phelan, M., Wilkinson, M., Migrino, R., Truran, S., Franco, D. A., . . . Madine, J. (2015). Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid. Biophysical Journal, 109(11), 2363-2370. doi:10.1016/j.bpj.2015.10.034DOI: 10.1016/j.bpj.2015.10.034
β-amyloid Peptide-Induced Human Arteriole Endothelial Dysfunction is Attenuated by Nanoliposomes (Conference Paper)
Guzman-Villanueva, D., Madine, J., Truran, S., Davies, H., Burciu, C., Franco, D., . . . Migrino, R. (2015). β-amyloid Peptide-Induced Human Arteriole Endothelial Dysfunction is Attenuated by Nanoliposomes. In FASEB JOURNAL Vol. 29. Retrieved from https://www.webofscience.com/
Comparison with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid polypeptide medin (Journal article)
Davies, H., Madine, J., & Middleton, D. (2015). Comparison with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid polypeptide medin. The Journal of Biological Chemistry, 290, 7791-7803. doi:10.1074/jbc.M114.602177DOI: 10.1074/jbc.M114.602177
2013
Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity (Journal article)
Madine, J., Davies, H. A., Hughes, E., & Middleton, D. A. (2013). Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity. BIOCHEMISTRY, 52(50), 8984-8992. doi:10.1021/bi401231uDOI: 10.1021/bi401231u
Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample (Journal article)
Middleton, D. A., Madine, J., Castelletto, V., & Hamley, I. W. (2013). Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(40), 10537-10540. doi:10.1002/anie.201301960DOI: 10.1002/anie.201301960
Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid‐State NMR Spectroscopic Measurements on an Aligned Sample (Journal article)
Middleton, D. A., Madine, J., Castelletto, V., & Hamley, I. W. (2013). Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid‐State NMR Spectroscopic Measurements on an Aligned Sample. Angewandte Chemie, 125(40), 10731-10734. doi:10.1002/ange.201301960DOI: 10.1002/ange.201301960
2012
Site-Specific Identification of an Aß Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy (Journal article)
Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Site-Specific Identification of an Aß Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(52), 13140-13143. doi:10.1002/anie.201204459DOI: 10.1002/anie.201204459
Site‐Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid‐State NMR Spectroscopy (Journal article)
Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Site‐Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid‐State NMR Spectroscopy. Angewandte Chemie, 124(52), 13317-13320. doi:10.1002/ange.201204459DOI: 10.1002/ange.201204459
Insights into the aggregation pathway of α-synuclein (Chapter)
Madine, J. (2012). Insights into the aggregation pathway of α-synuclein. In Amyloids: Composition, Functions and Pathology (pp. 149-162).
Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks (Journal article)
Madine, J., Davies, H. A., Shaw, C., Hamley, I. W., & Middleton, D. A. (2012). Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks. CHEMICAL COMMUNICATIONS, 48(24), 2976-2978. doi:10.1039/c2cc17118jDOI: 10.1039/c2cc17118j
Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin (Journal article)
Davies, H. A., Madine, J., & Middleton, D. A. (2012). Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin. JOURNAL OF PEPTIDE SCIENCE, 18(1), 65-72. doi:10.1002/psc.1418DOI: 10.1002/psc.1418
2011
Insights into the aggregation pathway of a-synuclein (Chapter)
Madine, J. (2011). Insights into the aggregation pathway of a-synuclein. In Amyloids: Composition, Functions and Pathology (pp. in press). New York: Nova Science Publishers.
2010
Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor site (Journal article)
Edwards, R., Madine, J., Fielding, L., & Middleton, D. A. (2010). Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor site. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 12(42), 13999-14008. doi:10.1039/c0cp00326cDOI: 10.1039/c0cp00326c
Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin (Journal article)
Madine, J., & Middleton, D. A. (2010). Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 39(9), 1281-1288. doi:10.1007/s00249-010-0581-3DOI: 10.1007/s00249-010-0581-3
2009
Evaluation of β-Alanine- and GABA-Substituted Peptides as Inhibitors of Disease-Linked Protein Aggregation (Journal article)
Madine, J., Wang, X., Brown, D. R., & Middleton, D. A. (2009). Evaluation of β-Alanine- and GABA-Substituted Peptides as Inhibitors of Disease-Linked Protein Aggregation. CHEMBIOCHEM, 10(12), 1982-1987. doi:10.1002/cbic.200900219DOI: 10.1002/cbic.200900219
Inhibitors of protein aggregation and toxicity (Journal article)
Amijee, H., Madine, J., Middleton, D. A., & Doig, A. J. (2009). Inhibitors of protein aggregation and toxicity. BIOCHEMICAL SOCIETY TRANSACTIONS, 37, 692-696. doi:10.1042/BST0370692DOI: 10.1042/BST0370692
Exploiting a <SUP>13</SUP>C-labelled heparin analogue for <i>in situ</i> solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils (Journal article)
Madine, J., Clayton, J. C., Yates, E. A., & Middleton, D. A. (2009). Exploiting a <SUP>13</SUP>C-labelled heparin analogue for <i>in situ</i> solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2414-2420. doi:10.1039/b820808eDOI: 10.1039/b820808e
Cross-β Spine Architecture of Fibrils Formed by the Amyloidogenic Segment NFGSVQFV of Medin from Solid-State NMR and X-ray Fiber Diffraction Measurements (Journal article)
Madine, J., Copland, A., Serpell, L. C., & Middleton, D. A. (2009). Cross-β Spine Architecture of Fibrils Formed by the Amyloidogenic Segment NFGSVQFV of Medin from Solid-State NMR and X-ray Fiber Diffraction Measurements. BIOCHEMISTRY, 48(14), 3089-3099. doi:10.1021/bi802164eDOI: 10.1021/bi802164e
TARGETING α-SYNUCLEIN AGGREGATION FOR PARKINSON'S DISEASE TREATMENT (Journal article)
Madine, J., & Middleton, D. A. (2009). TARGETING α-SYNUCLEIN AGGREGATION FOR PARKINSON'S DISEASE TREATMENT. DRUGS OF THE FUTURE, 34(8), 655-663. doi:10.1358/dof.2009.034.08.1391472DOI: 10.1358/dof.2009.034.08.1391472
Targeting alpha-synuclein aggregation for Parkinson's disease treatement (Journal article)
Madine, J., & Middleton, D. A. (2009). Targeting alpha-synuclein aggregation for Parkinson's disease treatement. Drugs of the Future, 34(8), 655. doi:10.1358/dof.2009.034.08.1391472DOI: 10.1358/dof.2009.034.08.1391472
Targeting alpha-synuclein aggregation for Parkinson's disease treatement (Journal article)
Madine, J., & Middleton, D. A. (2009). Targeting alpha-synuclein aggregation for Parkinson's disease treatement. Drugs of the Future, 34(8), 655. doi:10.1358/dof.2009.34.8.1391472DOI: 10.1358/dof.2009.34.8.1391472
2008
Structural Insights into the Polymorphism of Amyloid-Like Fibrils Formed by Region 20-29 of Amylin Revealed by Solid-State NMR and X-ray Fiber Diffraction (Journal article)
Madine, J., Jack, E., Stockley, P. G., Radford, S. E., Serpell, L. C., & Middleton, D. A. (2008). Structural Insights into the Polymorphism of Amyloid-Like Fibrils Formed by Region 20-29 of Amylin Revealed by Solid-State NMR and X-ray Fiber Diffraction. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(45), 14990-15001. doi:10.1021/ja802483dDOI: 10.1021/ja802483d
The effects of -synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy (Journal article)
Madine, J., Hughes, E., Doig, A. J., & Middleton, D. A. (2008). The effects of -synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy. MOLECULAR MEMBRANE BIOLOGY, 25(6-7), 518-527. doi:10.1080/09687680802467977DOI: 10.1080/09687680802467977
Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR (Journal article)
Madine, J., Doig, A. J., & Middleton, D. A. (2008). Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR. J. Am. Chem. Soc., 130(7873-7).
Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues (Journal article)
Jack, E. R., Madine, J., Lian, L. -Y., & Middleton, D. A. (2008). Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues. MOLECULAR MEMBRANE BIOLOGY, 25(1), 14-22. doi:10.1080/09687680701494007DOI: 10.1080/09687680701494007
2006
An NMR strategy for obtaining multiple conformational constraints for <SUP>15</SUP>N-<SUP>13</SUP>C spin-pair labelled organic solids (Journal article)
Madine, J., & Middleton, D. A. (2006). An NMR strategy for obtaining multiple conformational constraints for <SUP>15</SUP>N-<SUP>13</SUP>C spin-pair labelled organic solids. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 8(44), 5223-5228. doi:10.1039/b610014gDOI: 10.1039/b610014g
A study of the regional effects of α-synuclein on the organization and stability of phospholipid bilayers (Journal article)
Madine, J., Doig, A. J., & Middleton, D. A. (2006). A study of the regional effects of α-synuclein on the organization and stability of phospholipid bilayers. BIOCHEMISTRY, 45(18), 5783-5792. doi:10.1021/bi052151qDOI: 10.1021/bi052151q
2005
Studies of the aggregation of an amyloidogenic α-synuclein peptide fragment (Journal article)
Madine, J., Doig, A. J., Kitmitto, A., & Middleton, D. A. (2005). Studies of the aggregation of an amyloidogenic α-synuclein peptide fragment. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 1113-1115. doi:10.1042/BST0331113DOI: 10.1042/BST0331113
Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment. (Journal article)
Madine, J., Doig, A. J., Kitmitto, A., & Middleton, D. A. (2005). Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment.. Biochemical Society transactions, 33(Pt 5), 1113-1115. doi:10.1042/bst20051113DOI: 10.1042/bst20051113
2004
The aggregation and membrane-binding properties of an α-synuclein peptide fragment (Journal article)
Madine, J., Doig, A. J., & Middleton, D. A. (2004). The aggregation and membrane-binding properties of an α-synuclein peptide fragment. BIOCHEMICAL SOCIETY TRANSACTIONS, 32, 1127-1129. doi:10.1042/BST0321127DOI: 10.1042/BST0321127
Screening molecular associations with lipid membranes using natural abundance 13C cross-polarization magic-angle spinning NMR and principal component analysis. (Journal article)
Middleton, D. A., Hughes, E., & Madine, J. (2004). Screening molecular associations with lipid membranes using natural abundance 13C cross-polarization magic-angle spinning NMR and principal component analysis.. Journal of the American Chemical Society, 126(31), 9478-9479. doi:10.1021/ja048226fDOI: 10.1021/ja048226f
Screening molecular associations with lipid membranes using natural abundance <SUP>13</SUP>C cross-polarization magic-angle spinning NMR and principal component analysis (Journal article)
Middleton, D. A., Hughes, E., & Madine, J. (2004). Screening molecular associations with lipid membranes using natural abundance <SUP>13</SUP>C cross-polarization magic-angle spinning NMR and principal component analysis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(31), 9478-9479. doi:10.1021/ja048226fDOI: 10.1021/ja048226f
