2023
MacEwan, D. (n.d.). Tumour necrosis factor (TNF) receptor family in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023(1). doi:10.2218/gtopdb/f334/2023.1DOI: 10.2218/gtopdb/f334/2023.1
Almutairi, M., Lister, A., Zhao, Q., Line, J., Adair, K., Tailor, A., . . . Naisbitt, D. J. (2023). Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides.. Journal of immunology (Baltimore, Md. : 1950), 210(8), 1031-1042. doi:10.4049/jimmunol.2200531DOI: 10.4049/jimmunol.2200531
NRAS contributes to drug-resistant acute myeloid leukaemia (Conference Paper)
Healy, F. M., Marensi, V., Woolley, J. F., & MacEwan, D. J. (2023). NRAS contributes to drug-resistant acute myeloid leukaemia. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 180 (pp. 492). Retrieved from https://www.webofscience.com/
NRAS mutations contribute to drug resistance in acute myeloid Leukaemia (Conference Paper)
Healy, F., Marensi, V., Woolley, J. F., & MacEwan, D. J. (2023). NRAS mutations contribute to drug resistance in acute myeloid Leukaemia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 201 (pp. 32-33). Retrieved from https://www.webofscience.com/
2022
Healy, F. M., Prior, I. A., & MacEwan, D. J. (2022). The importance of Ras in drug resistance in cancer. BRITISH JOURNAL OF PHARMACOLOGY, 179(12), 2844-2867. doi:10.1111/bph.15420DOI: 10.1111/bph.15420
Themed issue: 'New avenues in cancer prevention and treatment' (Journal article)
Stefanska, B., Tucker, S. J., & MacEwan, D. J. (2022). Themed issue: 'New avenues in cancer prevention and treatment'. BRITISH JOURNAL OF PHARMACOLOGY, 179(12), 2789-2794. doi:10.1111/bph.15715DOI: 10.1111/bph.15715
2021
Kilfoil, P., Feng, S. L., Bassyouni, A., Lee, T., Leishman, D., Li, D., . . . Jenkinson, S. (2021). Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters. European Journal of Pharmacology, 174584. doi:10.1016/j.ejphar.2021.174584DOI: 10.1016/j.ejphar.2021.174584
Linley, A. J., Karydis, L. I., Mondru, A. K., D'Avola, A., Al Shmrany, H., Cicconi, S., . . . Slupsky, J. R. (2021). Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells. CLINICAL CANCER RESEARCH, 27(20), 5647-5659. doi:10.1158/1078-0432.CCR-21-0161DOI: 10.1158/1078-0432.CCR-21-0161
Zhao, Q., Almutairi, M., Tailor, A., Lister, A., Harper, N., Line, J., . . . Naisbitt, D. J. (2021). HLA Class-II. Restricted CD8<SUP>+</SUP> T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2412-+. doi:10.1016/j.jid.2021.03.014DOI: 10.1016/j.jid.2021.03.014
Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., . . . Waldman, S. A. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors. BRITISH JOURNAL OF PHARMACOLOGY, 178, S264-S312. doi:10.1111/bph.15541DOI: 10.1111/bph.15541
Tumour necrosis factor (TNF) receptor family in GtoPdb v.2021.3 (Journal article)
MacEwan, D. (n.d.). Tumour necrosis factor (TNF) receptor family in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE, 2021(3). doi:10.2218/gtopdb/f334/2021.3DOI: 10.2218/gtopdb/f334/2021.3
Healy, F., Marensi, V., Woolley, J. F., & MacEwan, D. J. (2021). NRAS Mutations in Acute Myeloid Leukaemia Confer Increased Leukaemogenic Potential and Contribute to Drug Resistance. BRITISH JOURNAL OF PHARMACOLOGY, 180, 1161-1162. doi:10.1111/bph.15420DOI: 10.1111/bph.15420
NRAS mutations arise in resistance to FLT3 inhibitors in acute myeloid leukaemia (Conference Paper)
Healy, F., Marensi, V., Maerken, M., Anyfantis, G., Woolley, J., & MacEwan, D. (2021). NRAS mutations arise in resistance to FLT3 inhibitors in acute myeloid leukaemia. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 4949-4950). Retrieved from https://www.webofscience.com/
Marensi, V., Keeshan, K. R., & MacEwan, D. J. (2021). Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors. BIOCHEMICAL PHARMACOLOGY, 183. doi:10.1016/j.bcp.2020.114348DOI: 10.1016/j.bcp.2020.114348
2020
Poh, J., Ponsford, A. H., Boyd, J., Woodsmith, J., Stelzl, U., Wanker, E., . . . Sanderson, C. M. (2020). A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation. Redox Biology, 37. doi:10.1016/j.redox.2020.101686DOI: 10.1016/j.redox.2020.101686
2019
Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., . . . CGTP Collaborators. (2019). THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors.. British journal of pharmacology, 176 Suppl 1, S247-S296. doi:10.1111/bph.14751DOI: 10.1111/bph.14751
Apoptosis of Leukemia Cells by <i>Ocimum</i> <i>basilicum</i> Fractions Following TNF alpha Induced Activation of JNK and Caspase 3 (Journal article)
Rehan, T., MacEwan, D., Shah, N., Rehan, T., Tahira, R., Murad, S., . . . Sultan, A. (2019). Apoptosis of Leukemia Cells by <i>Ocimum</i> <i>basilicum</i> Fractions Following TNF alpha Induced Activation of JNK and Caspase 3. CURRENT PHARMACEUTICAL DESIGN, 25(34), 3681-3691. doi:10.2174/1381612825666191011100826DOI: 10.2174/1381612825666191011100826
MacEwan, D. (n.d.). Tumour necrosis factor (TNF) receptor family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi:10.2218/gtopdb/f334/2019.4DOI: 10.2218/gtopdb/f334/2019.4
2018
Curtis, M. J., Alexander, S., Cirino, G., Docherty, J. R., George, C. H., Giembycz, M. A., . . . Ahluwalia, A. (2018). Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. BRITISH JOURNAL OF PHARMACOLOGY, 175(7), 987-993. doi:10.1111/bph.14153DOI: 10.1111/bph.14153
Alexander, S. P. H., Roberts, R. E., Broughton, B. R. S., Sobey, C. G., George, C. H., Stanford, S. C., . . . Ahluwalia, A. (2018). Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology. BRITISH JOURNAL OF PHARMACOLOGY, 175(3), 407-411. doi:10.1111/bph.14112DOI: 10.1111/bph.14112
Wilson, L. J., Linley, A., Hammond, D. E., Hood, F. E., Coulson, J. M., MacEwan, D. J., . . . Prior, I. A. (2018). New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome. CANCER RESEARCH, 78(1), 15-29. doi:10.1158/0008-5472.CAN-17-2291DOI: 10.1158/0008-5472.CAN-17-2291
2017
Alexander, S. P. H., Fabbro, D., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., . . . Davies, J. A. (2017). THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes. BRITISH JOURNAL OF PHARMACOLOGY, 174, S272-S359. doi:10.1111/bph.13877DOI: 10.1111/bph.13877
Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., . . . Zajac, J. M. (2017). THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. BRITISH JOURNAL OF PHARMACOLOGY, 174, S1-S16. doi:10.1111/bph.13882DOI: 10.1111/bph.13882/full
Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases (Book)
Stefanska, B., & MacEwan, D. J. (Eds.) (2017). Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases. Springer New York. doi:10.1007/978-1-4939-6743-8DOI: 10.1007/978-1-4939-6743-8
Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases Preface (Chapter)
Stefanska, B., & MacEwan, D. J. (2017). Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases Preface. In EPIGENETICS AND GENE EXPRESSION IN CANCER, INFLAMMATORY AND IMMUNE DISEASES (pp. V-VII). Retrieved from https://www.webofscience.com/
MicroRNAs in Therapy and Toxicity (Chapter)
MacEwan, D. J., Shah, N. M., & Antoine, D. J. (2017). MicroRNAs in Therapy and Toxicity. In EPIGENETICS AND GENE EXPRESSION IN CANCER, INFLAMMATORY AND IMMUNE DISEASES (pp. 155-167). doi:10.1007/978-1-4939-6743-8_10DOI: 10.1007/978-1-4939-6743-8_10
Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts (Journal article)
George, C. H., Stanford, S. C., Alexander, S., Cirino, G., Docherty, J. R., Giembycz, M. A., . . . Ahluwalia, A. (2017). Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts. BRITISH JOURNAL OF PHARMACOLOGY, 174(17), 2801-2804. doi:10.1111/bph.13925DOI: 10.1111/bph.13925
2015
Alexander, S. P., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., . . . CGTP Collaborators. (2015). The Concise Guide to PHARMACOLOGY 2015/16: Overview.. British journal of pharmacology, 172(24), 5729-5743. doi:10.1111/bph.13347DOI: 10.1111/bph.13347
Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia (Journal article)
Pillinger, G., Abdul-Aziz, A., Zaitseva, L., Lawes, M., MacEwan, D., Bowles, K. M., & Rushworth, S. A. (2015). Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia. Scientific Reports, 5. doi:10.1038/srep12949DOI: 10.1038/srep12949
TWEAKing for a fight with GVHD (Journal article)
MacEwan, D. J. (2015). TWEAKing for a fight with GVHD. BLOOD, 126(4), 429-430. doi:10.1182/blood-2015-06-649517DOI: 10.1182/blood-2015-06-649517
Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma (Journal article)
Murray, M. Y., Zaitseva, L., Auger, M. J., Craig, J. I. O., MacEwan, D., Rushworth, S. A., & Bowles, K. M. (2015). Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma. Cell Cycle, 14(14), 2367-2375. doi:10.1080/15384101.2014.998067DOI: 10.1080/15384101.2014.998067
Experimental design and analysis and their reporting: new guidance for publication in BJP (Journal article)
Curtis, M. J., Bond, R. A., Spina, D., Ahluwalia, A., Alexander, S. P. A., Giembycz, M. A., . . . McGrath, J. C. (2015). Experimental design and analysis and their reporting: new guidance for publication in BJP. BRITISH JOURNAL OF PHARMACOLOGY, 172(14), 3461-3471. doi:10.1111/bph.12856DOI: 10.1111/bph.12856
Epigenetics and pharmacology (Journal article)
Stefanska, B., & MacEwan, D. J. (2015). Epigenetics and pharmacology. BRITISH JOURNAL OF PHARMACOLOGY, 172(11), 2701-2704. doi:10.1111/bph.13136DOI: 10.1111/bph.13136
Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells (Journal article)
Rushworth, S. A., Pillinger, G., Abdul-Aziz, A., Piddock, R., Shafat, M. S., Murray, M. Y., . . . Bowles, K. M. (2015). Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells. The Lancet Haematology, 2(5), E204-E211. doi:10.1016/S2352-3026(15)00046-0DOI: 10.1016/S2352-3026(15)00046-0
Shah, N. M., Zaitseva, L., Bowles, K. M., MacEwan, D., & Rushworth, S. A. (2015). NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival. Cell Death and Differentiation, 22(4), 654-664. doi:10.1038/cdd.2014.152DOI: 10.1038/cdd.2014.152
Oxidative Stress Responses and NRF2 in Human Leukaemia (Journal article)
Abdul-Aziz, A., MacEwan, D. J., Bowles, K. M., & Rushworth, S. A. (2015). Oxidative Stress Responses and NRF2 in Human Leukaemia. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015. doi:10.1155/2015/454659DOI: 10.1155/2015/454659
2014
Zaitseva, L., Murray, M. Y., Shafat, M. S., Lawes, M. J., MacEwan, D. J., Bowles, K. M., & Rushworth, S. A. (2014). Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML. Oncotarget, 5(20), 9930-9938. doi:10.18632/oncotarget.2479DOI: 10.18632/oncotarget.2479
MacEwan, D. J., Barrera, L. N., Keadsanti, S., Rushworth, S. A., Shah, N. M., Yuan, T., & Zaitseva, L. (2014). Understanding life and death decisions in human leukaemias. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 747-751. doi:10.1042/BST20140127DOI: 10.1042/BST20140127
Rushworth, S. A., Murray, M. Y., Zaitseva, L., Bowles, K. M., & MacEwan, D. (2014). Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia. Blood, 123(8), 1229-1238. doi:10.1182/blood-2013-06-511154DOI: 10.1182/blood-2013-06-511154
The BTK Inhibitor Ibrutinib Blocks SDF1/CXCR4 Mediated Migration of Acute Myeloid Leukemia Cells (Conference Paper)
Rushworth, S. A., Zaitseva, L., Murray, M. Y., Lawes, M. J., MacEwan, D. J., & Bowles, K. M. (2014). The BTK Inhibitor Ibrutinib Blocks SDF1/CXCR4 Mediated Migration of Acute Myeloid Leukemia Cells. In BLOOD Vol. 124. Retrieved from https://www.webofscience.com/
2013
The Concise Guide to PHARMACOLOGY 2013/14: Overview (Journal article)
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., McGrath, J. C., . . . Harmar, A. J. (2013). The Concise Guide to PHARMACOLOGY 2013/14: Overview. British Journal of Pharmacology, 170(8), 1449-1458. doi:10.1111/bph.12444DOI: 10.1111/bph.12444
Ibrutinib in Relapsed Chronic Lymphocytic Leukemia (Journal article)
Neffendorf, J. E., Gout, I., & Hildebrand, G. D. (2013). Ibrutinib in Relapsed Chronic Lymphocytic Leukemia. NEW ENGLAND JOURNAL OF MEDICINE, 369(13), 1277. doi:10.1056/NEJMc1309710DOI: 10.1056/NEJMc1309710
Ibrutinib in Relapsed Chronic Lymphocytic Leukemia REPLY (Journal article)
Byrd, J. C., O'Brien, S., & James, D. F. (2013). Ibrutinib in Relapsed Chronic Lymphocytic Leukemia REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 369(13), 1278-1279. Retrieved from https://www.webofscience.com/
Understanding the role of NRF2-regulated miRNAs in human malignancies (Journal article)
Shah, N. M., Rushworth, S. A., Murray, M. Y., Bowles, K. M., & MacEwan, D. J. (2013). Understanding the role of NRF2-regulated miRNAs in human malignancies. ONCOTARGET, 4(8), 1130-1142. doi:10.18632/oncotarget.1181DOI: 10.18632/oncotarget.1181
Emerging therapeutic aspects in oncology (Journal article)
MacEwan, D. J. (2013). Emerging therapeutic aspects in oncology. BRITISH JOURNAL OF PHARMACOLOGY, 169(8), 1647-1651. doi:10.1111/bph.12304DOI: 10.1111/bph.12304
Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression (Journal article)
Murray, M. Y., Rushworth, S. A., Zaitseva, L., Bowles, K. M., & MacEwan, D. J. (2013). Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression. CELL CYCLE, 12(13), 2144-2153. doi:10.4161/cc.25251DOI: 10.4161/cc.25251
BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB (Journal article)
Rushworth, S. A., Bowles, K. M., Barrera, L. N., Murray, M. Y., Zaitseva, L., & MacEwan, D. J. (2013). BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB. CELLULAR SIGNALLING, 25(1), 106-112. doi:10.1016/j.cellsig.2012.09.008DOI: 10.1016/j.cellsig.2012.09.008
EMERGING THERAPY TARGETING TYROSINE-PROTEIN KINASE BTK: POTENTIAL FOR IBRUTINIB AND OTHER BTK INHIBITORS (Journal article)
MacEwan, D. J., Bowles, K. M., & Rushworth, S. A. (2013). EMERGING THERAPY TARGETING TYROSINE-PROTEIN KINASE BTK: POTENTIAL FOR IBRUTINIB AND OTHER BTK INHIBITORS. DRUGS OF THE FUTURE, 38(8), 569-573. doi:10.1358/dof.2013.38.8.1998163DOI: 10.1358/dof.2013.38.8.1998163
Emerging therapy targeting tyrosine-protein kinase BTK: potential for ibrutinib and other BTK inhibitors (Journal article)
MacEwan, D. J., Bowles, K. M., & Rushworth, S. A. (2013). Emerging therapy targeting tyrosine-protein kinase BTK: potential for ibrutinib and other BTK inhibitors. Drugs of the Future, 38(8), 569. doi:10.1358/dof.2013.038.08.1998163DOI: 10.1358/dof.2013.038.08.1998163
2012
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance (Journal article)
Rushworth, S. A., Zaitseva, L., Murray, M. Y., Shah, N. M., Bowles, K. M., & MacEwan, D. J. (2012). The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance. BLOOD, 120(26), 5188-5198. doi:10.1182/blood-2012-04-422121DOI: 10.1182/blood-2012-04-422121
Bortezomib induces heme oxygenase-1 expression in multiple myeloma (Journal article)
Barrera, L. N., Rushworth, S. A., Bowles, K. M., & MacEwan, D. J. (2012). Bortezomib induces heme oxygenase-1 expression in multiple myeloma. CELL CYCLE, 11(12), 2248-2252. doi:10.4161/cc.20343DOI: 10.4161/cc.20343
Micro RNAs as a new therapeutic target towards leukaemia signalling (Journal article)
Murray, M. Y., Rushworth, S. A., & MacEwan, D. J. (2012). Micro RNAs as a new therapeutic target towards leukaemia signalling. CELLULAR SIGNALLING, 24(2), 363-368. doi:10.1016/j.cellsig.2011.09.021DOI: 10.1016/j.cellsig.2011.09.021
Understanding the role of miRNA in regulating NF-κB in blood cancer (Journal article)
Rushworth, S. A., Murray, M. Y., Barrera, L. N., Heasman, S. -A., Zaitseva, L., & MacEwan, D. J. (2012). Understanding the role of miRNA in regulating NF-κB in blood cancer. American Journal of Cancer Research, 2(1), 65-74.
2011
TNF mediates the sustained activation of Nrf2 in human monocytes (vol 187, pg 702, 2011) (Journal article)
Rushworth, S. A., Shah, S., & MacEwan, D. J. (2011). TNF mediates the sustained activation of Nrf2 in human monocytes (vol 187, pg 702, 2011). JOURNAL OF IMMUNOLOGY, 187(11), 6160. doi:10.4049/jimmunol.1190072DOI: 10.4049/jimmunol.1190072
Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 (Journal article)
Heasman, S. -A., Zaitseva, L., Bowles, K. M., Rushworth, S. A., & MacEwan, D. J. (2011). Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1. ONCOTARGET, 2(9), 658-668. doi:10.18632/oncotarget.321DOI: 10.18632/oncotarget.321
TNF Mediates the Sustained Activation of Nrf2 in Human Monocytes (Journal article)
Rushworth, S. A., Shah, S., & MacEwan, D. J. (2011). TNF Mediates the Sustained Activation of Nrf2 in Human Monocytes. JOURNAL OF IMMUNOLOGY, 187(2), 702-707. doi:10.4049/jimmunol.1004117DOI: 10.4049/jimmunol.1004117
Silencing FLIP<sub>L</sub> modifies TNF-induced apoptotic protein expression (Journal article)
Zaitseva, L., Rushworth, S. A., & MacEwan, D. J. (2011). Silencing FLIP<sub>L</sub> modifies TNF-induced apoptotic protein expression. CELL CYCLE, 10(7), 1067-1072. doi:10.4161/cc.10.7.15247DOI: 10.4161/cc.10.7.15247
Rushworth, S. A., & Macewan, D. J. (2011). The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells.. Cancers, 3(2), 1605-1621. doi:10.3390/cancers3021605DOI: 10.3390/cancers3021605
High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors (Journal article)
Rushworth, S. A., Bowles, K. M., & MacEwan, D. J. (2011). High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors. CANCER RESEARCH, 71(5), 1999-2009. doi:10.1158/0008-5472.CAN-10-3018DOI: 10.1158/0008-5472.CAN-10-3018
Differential role of FLIP isoforms in TNF-induced cell life and death responses (Chapter)
Langa, S., & MacEwan, D. J. (2011). Differential role of FLIP isoforms in TNF-induced cell life and death responses. In D. Wallach, A. Kovalenko, & M. Feldman (Eds.), Advances in TNF Family Research (Vol. 691, pp. 814).
Elevated Nrf2 levels in acute myeloid leukaemia reduces sensitivity towards proteasome inhibitors (Journal article)
Rushworth, S. A., Bowles, K. M., & MacEwan, D. J. (2011). Elevated Nrf2 levels in acute myeloid leukaemia reduces sensitivity towards proteasome inhibitors. Basic & Clinical Pharmacology & Toxicology, 109, 31.
FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism (Journal article)
Rushworth, S. A., Zaitseva, L., Langa, S., Bowles, K. M., & MacEwan, D. J. (2011). FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism. Oncotarget, 1(5), 359-366.
Heme oxygenase-1 protects acute myeloid leukaemia cells from front line chemotherapeutic drugs (Journal article)
Heasman, S. A., Zaitseva, L., Bowles, K., Rushworth, S. A., & MacEwan, D. J. (2011). Heme oxygenase-1 protects acute myeloid leukaemia cells from front line chemotherapeutic drugs. Basic & Clinical Pharmacology & Toxicology, 109, 96.
Regulation of apoptotic signaling by FLIP modulatory proteins (Journal article)
Zaitseva, L. G., Rushworth, S. A., & MacEwan, D. J. (2011). Regulation of apoptotic signaling by FLIP modulatory proteins. Basic & Clinical Pharmacology & Toxicology, 109, 58.
Regulation of heme oxygenase-1 (HO-1) by gene promoter methylation in acute myeloid leukaemia (Journal article)
Barrera, L. N., Rushworth, S. A., & MacEwan, D. J. (2011). Regulation of heme oxygenase-1 (HO-1) by gene promoter methylation in acute myeloid leukaemia. Basic & Clinical Pharmacology & Toxicology, 109, 96.
Targeted treatments of chronic myeloid leukaemia (Journal article)
Heasman, S. A., Small, M., & MacEwan, D. J. (2011). Targeted treatments of chronic myeloid leukaemia. British Oncology Pharmacy Association, (3), 11-15.
The interrelationship between NF-kB, Nrf2 and Keap1 in controlling TNF induced inflammatory responses (Chapter)
Rushworth, S. A., & MacEwan, D. J. (2011). The interrelationship between NF-kB, Nrf2 and Keap1 in controlling TNF induced inflammatory responses. In Advances in TNF Family Research (Vol. 691, pp. 666-667).
2010
FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism (Journal article)
Rushworth, S. A., Zaitseva, L., Langa, S., Bowles, K. M., & MacEwan, D. J. (2010). FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism. ONCOTARGET, 1(5), 359-366. Retrieved from https://www.webofscience.com/
NF-kB-Inhibited Acute Myeloid Leukemia Cells Are Rescued from Apoptosis by Heme Oxygenase-1 Induction (Journal article)
Rushworth, S. A., Bowles, K. M., Raninga, P., & MacEwan, D. J. (2010). NF-kB-Inhibited Acute Myeloid Leukemia Cells Are Rescued from Apoptosis by Heme Oxygenase-1 Induction. CANCER RESEARCH, 70(7), 2973-2983. doi:10.1158/0008-5472.CAN-09-3407DOI: 10.1158/0008-5472.CAN-09-3407
2008
Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes (Journal article)
Rushworth, S. A., MacEwan, D. J., & O'Connell, M. A. (2008). Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes. JOURNAL OF IMMUNOLOGY, 181(10), 6730-6737. doi:10.4049/jimmunol.181.10.6730DOI: 10.4049/jimmunol.181.10.6730
HO-1 underlies resistance of AML cells to TNF-induced apoptosis (Journal article)
Rushworth, S. A., & MacEwan, D. J. (2008). HO-1 underlies resistance of AML cells to TNF-induced apoptosis. BLOOD, 111(7), 3793-3801. doi:10.1182/blood-2007-07-104042DOI: 10.1182/blood-2007-07-104042
Interactions between TNF and GnRH (Journal article)
MacEwan, D. J. (2008). Interactions between TNF and GnRH. NEUROCHEMICAL RESEARCH, 33(4), 678-682. doi:10.1007/s11064-007-9505-8DOI: 10.1007/s11064-007-9505-8
TNF signaling gets FLIPped off - TNF-induced regulation of FLIP (Journal article)
Rushworth, S. A., Taylor, A., Langa, S., & MacEwan, D. J. (2008). TNF signaling gets FLIPped off - TNF-induced regulation of FLIP. CELL CYCLE, 7(2), 194-199. doi:10.4161/cc.7.2.5159DOI: 10.4161/cc.7.2.5159
2007
Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes:: reduction by salicylate allows TNF-induced apoptosis (Journal article)
Rae, C., Langa, S., Tucker, S. J., & MacEwan, D. J. (2007). Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes:: reduction by salicylate allows TNF-induced apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(31), 12790-12795. doi:10.1073/pnas.0701437104DOI: 10.1073/pnas.0701437104
TNFR1-induced NF-κB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells (Journal article)
Zhou, Z., Connell, M. C., & MacEwan, D. J. (2007). TNFR1-induced NF-κB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells. CELLULAR SIGNALLING, 19(6), 1238-1248. doi:10.1016/j.cellsig.2006.12.013DOI: 10.1016/j.cellsig.2006.12.013
2006
Influx of extracellular Ca<SUP>2+</SUP> is necessary for electrotaxis in <i>Dictyostelium</i> (Journal article)
Shanley, L. J., Walczysko, P., Bain, M., MacEwan, D. J., & Zhao, M. (2006). Influx of extracellular Ca<SUP>2+</SUP> is necessary for electrotaxis in <i>Dictyostelium</i>. JOURNAL OF CELL SCIENCE, 119(22), 4741-4748. doi:10.1242/jcs.03248DOI: 10.1242/jcs.03248
Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA (Journal article)
McLaggan, D., Adjimatera, N., Sepcic, K., Jaspars, M., MacEwan, D. J., Blagbrough, I. S., & Scott, R. H. (2006). Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA. BMC BIOTECHNOLOGY, 6. doi:10.1186/1472-6750-6-6DOI: 10.1186/1472-6750-6-6
2004
Granulocyte macrophage-colony stimulating factor and interleukin-3 increase expression of type II tumour necrosis factor receptor, increasing susceptibility to tumour necrosis factor-induced apoptosis. Control of leukaemia cell life/death switching (Journal article)
Rae, C., & MacEwan, D. J. (2004). Granulocyte macrophage-colony stimulating factor and interleukin-3 increase expression of type II tumour necrosis factor receptor, increasing susceptibility to tumour necrosis factor-induced apoptosis. Control of leukaemia cell life/death switching. CELL DEATH AND DIFFERENTIATION, 11, S162-S171. doi:10.1038/sj.cdd.4401494DOI: 10.1038/sj.cdd.4401494
Switching leukemia cell phenotype between life and death (Journal article)
Tucker, S. J., Rae, C., Littlejohn, A. F., Paul, A., & MacEwan, D. J. (2004). Switching leukemia cell phenotype between life and death. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(35), 12940-12945. doi:10.1073/pnas.0400949101DOI: 10.1073/pnas.0400949101
2003
Distinct regulation of cytosolic phospholipase A<sub>2</sub> phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes (Journal article)
Jupp, O. J., Vandenabeele, P., & MacEwan, D. J. (2003). Distinct regulation of cytosolic phospholipase A<sub>2</sub> phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes. BIOCHEMICAL JOURNAL, 374, 453-461. doi:10.1042/BJ20030705DOI: 10.1042/BJ20030705
The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells (Journal article)
Tucker, S. J., McClelland, D., Jaspars, M., Sepcic, K., MacEwan, D. J., & Scott, R. H. (2003). The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1614(2), 171-181. doi:10.1016/S0005-2736(03)00175-5DOI: 10.1016/S0005-2736(03)00175-5
Tumor necrosis factor-α-induced activation of RhoA in airway smooth muscle cells:: Role in the Ca<SUP>2+</SUP> sensitization of myosin light chain<sub>20</sub> phosphorylation (Journal article)
Hunter, I., Cobban, H. J., Vandenabeele, P., MacEwan, D. J., & Nixon, G. F. (2003). Tumor necrosis factor-α-induced activation of RhoA in airway smooth muscle cells:: Role in the Ca<SUP>2+</SUP> sensitization of myosin light chain<sub>20</sub> phosphorylation. MOLECULAR PHARMACOLOGY, 63(3), 714-721. doi:10.1124/mol.63.3.714DOI: 10.1124/mol.63.3.714
Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-κB signaling (Journal article)
Littlejohn, A. F., Tucker, S. J., Mohamed, A. A. A., McKay, S., Helms, M. J., Vandenabeele, P., & MacEwan, D. J. (2003). Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-κB signaling. BIOCHEMICAL PHARMACOLOGY, 65(1), 91-99. doi:10.1016/S0006-2952(02)01443-0DOI: 10.1016/S0006-2952(02)01443-0
2002
Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not (Journal article)
Mohamed, A. A. A., Jupp, O. J., Anderson, H. M., Littlejohn, A. F., Vandenabeele, P., & MacEwan, D. J. (2002). Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not. BIOCHEMICAL JOURNAL, 366, 145-155. doi:10.1042/BJ20020527DOI: 10.1042/BJ20020527
Differential activation of nuclear factor-κB by tumour necrosis factor receptor subtypes.: TNFR1 predominates whereas TNFR2 activates transcription poorly (Journal article)
McFarlane, S. M., Pashmi, G., Connell, M. C., Littlejohn, A. F., Tucker, S. J., Vandenabeele, P., & MacEwan, D. J. (2002). Differential activation of nuclear factor-κB by tumour necrosis factor receptor subtypes.: TNFR1 predominates whereas TNFR2 activates transcription poorly. FEBS LETTERS, 515(1-3), 119-126. doi:10.1016/S0014-5793(02)02450-XDOI: 10.1016/S0014-5793(02)02450-X
TNF receptor subtype signalling: Differences and cellular consequences (Journal article)
MacEwan, D. J. (2002). TNF receptor subtype signalling: Differences and cellular consequences. CELLULAR SIGNALLING, 14(6), 477-492. doi:10.1016/S0898-6568(01)00262-5DOI: 10.1016/S0898-6568(01)00262-5
TNF-α receptors simultaneously activate Ca<SUP>2+</SUP> mobilisation and stress kinases in cultured sensory neurones (Journal article)
Pollock, J., McFarlane, S. M., Connell, M. C., Zehavi, U., Vandenabeele, P., MacEwan, D. J., & Scott, R. H. (2002). TNF-α receptors simultaneously activate Ca<SUP>2+</SUP> mobilisation and stress kinases in cultured sensory neurones. NEUROPHARMACOLOGY, 42(1), 93-106. doi:10.1016/S0028-3908(01)00163-0DOI: 10.1016/S0028-3908(01)00163-0
TNF ligands and receptors - a matter of life and death (Journal article)
MacEwan, D. J. (2002). TNF ligands and receptors - a matter of life and death. BRITISH JOURNAL OF PHARMACOLOGY, 135(4), 855-875. doi:10.1038/sj.bjp.0704549DOI: 10.1038/sj.bjp.0704549
2001
Type II tumour necrosis factor-α receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAR pathways (Journal article)
Jupp, O. J., McFarlane, S. M., Anderson, H. M., Littlejohn, A. F., Mohamed, A. A. A., MacKay, R. H., . . . MacEwan, D. J. (2001). Type II tumour necrosis factor-α receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAR pathways. BIOCHEMICAL JOURNAL, 359, 525-535. doi:10.1042/0264-6021:3590525DOI: 10.1042/0264-6021:3590525
Modulated kinase activities, in cells undergoing tumour necrosis, factor-induced apoptotic cell death (Journal article)
Helms, M. L., Mohamed, A. A. A., & MacEwan, D. J. (2001). Modulated kinase activities, in cells undergoing tumour necrosis, factor-induced apoptotic cell death. FEBS LETTERS, 505(1), 68-74. doi:10.1016/S0014-5793(01)02779-XDOI: 10.1016/S0014-5793(01)02779-X
Agonist-induced internalization and trafficking of cannabinoid CB<sub>1</sub> receptors in hippocampal neurons (Journal article)
Coutts, A. A., Anavi-Goffer, S., Ross, R. A., MacEwan, D. J., Mackie, K., Pertwee, R. G., & Irving, A. J. (2001). Agonist-induced internalization and trafficking of cannabinoid CB<sub>1</sub> receptors in hippocampal neurons. JOURNAL OF NEUROSCIENCE, 21(7), 2425-2433. Retrieved from https://www.webofscience.com/
Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle (Journal article)
McFarlane, S. M., Jupp, O. J., Cobban, H. J., Hunter, I., Anderson, H. M., Vandenabeele, P., . . . MacEwan, D. J. (2001). Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle. BIOCHEMICAL PHARMACOLOGY, 61(6), 749-759. doi:10.1016/S0006-2952(01)00530-5DOI: 10.1016/S0006-2952(01)00530-5
Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception (Journal article)
Ross, R. A., Coutts, A. A., McFarlane, S. M., Anavi-Goffer, S., Irving, A. J., Pertwee, R. G., . . . Scott, R. H. (2001). Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception. NEUROPHARMACOLOGY, 40(2), 221-232. doi:10.1016/S0028-3908(00)00135-0DOI: 10.1016/S0028-3908(00)00135-0
Tumour necrosis factor-alpha increases the Ca2+ sensitivity of myosin light chain(20) phosphorylation in cultured airway smooth muscle cells via a rho-activated pathway (Journal article)
Hunter, I., Cobban, H. J., MacEwan, D. J., & Nixon, G. F. (2001). Tumour necrosis factor-alpha increases the Ca2+ sensitivity of myosin light chain(20) phosphorylation in cultured airway smooth muscle cells via a rho-activated pathway. FASEB Journal, 15(4), A163.
2000
Selective down-regulation of the G<sub>q</sub>α/G<sub>11</sub>α G-protein family in tumour necrosis factor-α induced cell death (Journal article)
Pollock, V. P., Lofthouse, E. J., Jupp, O. J., Gauld, S. B., Anderson, H. M., & MacEwan, D. J. (2000). Selective down-regulation of the G<sub>q</sub>α/G<sub>11</sub>α G-protein family in tumour necrosis factor-α induced cell death. MOLECULAR AND CELLULAR BIOCHEMISTRY, 206(1-2), 67-74. doi:10.1023/A:1007066409645DOI: 10.1023/A:1007066409645
Tumour necrosis factor receptor activation mobilizes Ca2+from intracellular stores of neonatal rat cultured sensory neurones (Journal article)
Pollock, J., McFarlane, S. M., Vandenabeele, P., MacEwan, D. J., & Scott, R. H. (2000). Tumour necrosis factor receptor activation mobilizes Ca2+from intracellular stores of neonatal rat cultured sensory neurones. Journal of Physiology-London, 528P, 57P-58P.
Tumour necrosis factor-alpha increases the Ca2+ sensitivity of myosin light chain20 phosphorylation in cultured guinea-pig airway smooth muscle cells (Journal article)
Cobban, H. J., MacEwan, D. J., & Nixon, G. F. (2000). Tumour necrosis factor-alpha increases the Ca2+ sensitivity of myosin light chain20 phosphorylation in cultured guinea-pig airway smooth muscle cells. Journal of Physiology-London, 528P, 7P.
Tumour necrosis factor-alpha receptor subtypes in guinea-pig cultured airway smooth muscle cells stimulate stress-activated, but not mitogen-activated, protein kinases (Journal article)
McFarlane, S. M., Jupp, O. J., Cobban, H. J., Nixon, G. F., & MacEwan, D. J. (2000). Tumour necrosis factor-alpha receptor subtypes in guinea-pig cultured airway smooth muscle cells stimulate stress-activated, but not mitogen-activated, protein kinases. Journal of Physiology-London, 528P, 10P.
Unmodified calcium concentrations in tumour necrosis factor receptor subtype-mediated apoptotic cell death (Journal article)
McFarlane, S. M., Anderson, H. M., Tucker, S. J., Jupp, O. J., & McEwan, D. J. (2000). Unmodified calcium concentrations in tumour necrosis factor receptor subtype-mediated apoptotic cell death. MOLECULAR AND CELLULAR BIOCHEMISTRY, 211(1-2), 19-26. doi:10.1023/A:1007189911897DOI: 10.1023/A:1007189911897
1999
Tumour necrosis factor-α activates a calcium sensitization pathway in guinea-pig bronchial smooth muscle (Journal article)
Parris, J. R. M., Cooban, H. J., Littlejohn, A. F., MacEwan, D. J., & Nixon, G. F. (1999). Tumour necrosis factor-α activates a calcium sensitization pathway in guinea-pig bronchial smooth muscle. JOURNAL OF PHYSIOLOGY-LONDON, 518(2), 561-569. doi:10.1111/j.1469-7793.1999.0561p.xDOI: 10.1111/j.1469-7793.1999.0561p.x
Tumor necrosis factor-α mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression (Journal article)
Baxter, G. T., Kuo, R. C., Jupp, O. J., Vandenabeele, P., & MacEwan, D. J. (1999). Tumor necrosis factor-α mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(14), 9539-9547. doi:10.1074/jbc.274.14.9539DOI: 10.1074/jbc.274.14.9539
Evidence for cannabinoid receptor-mediated inhibition of voltage-activated Ca2+ currents in neonatal rat cultured DAG neurones (Journal article)
Ross, R. A., Coutts, A. A., McFarlane, S. M., Irving, A. J., Pertwee, R. G., MacEwan, D. J., & Scott, R. H. (1999). Evidence for cannabinoid receptor-mediated inhibition of voltage-activated Ca2+ currents in neonatal rat cultured DAG neurones. British Journal of Pharmacology, 128, U12.
Protein kinase C isoforms in pituitary cells displaying differential sensitivity to phorbol ester (Journal article)
MacEwan, D. J., Johnson, M. S., & Mitchell, R. (1999). Protein kinase C isoforms in pituitary cells displaying differential sensitivity to phorbol ester. MOLECULAR AND CELLULAR BIOCHEMISTRY, 202(1-2), 85-90. doi:10.1023/A:1007090718274DOI: 10.1023/A:1007090718274
1998
Tumor necrosis factor-alpha (TNF) activates a novel calcium sensitization pathway in bronchial smooth muscle (Journal article)
Parris, J. R. M., MacEwan, D. J., & Nixon, G. F. (1998). Tumor necrosis factor-alpha (TNF) activates a novel calcium sensitization pathway in bronchial smooth muscle. Biophysical Journal, 74(2), A380.
Tumour necrosis factor-alpha (TNF-alpha) enhances guinea-pig airways smooth muscle contractility via a calcium sensitization pathway (Journal article)
Parris, J. R. M., MacEwan, D. J., & Nixon, G. F. (1998). Tumour necrosis factor-alpha (TNF-alpha) enhances guinea-pig airways smooth muscle contractility via a calcium sensitization pathway. British Journal of Pharmacology, 123, U106.
1997
Inverse agonism at adrenergic and opioid receptors: studies with wild type and constitutively active mutant receptors. (Journal article)
Milligan, G., MacEwan, D. J., Mercouris, M., & Mullaney, I. (1997). Inverse agonism at adrenergic and opioid receptors: studies with wild type and constitutively active mutant receptors.. Receptors & channels, 5(3-4), 209-213.
Mini-review - Inverse agonism at adrenergic and opioid receptors: Studies with wild type and constitutively active mutant receptors. (Journal article)
Milligan, G., MacEwan, D. J., Mercouris, M., & Mullaney, I. (1997). Mini-review - Inverse agonism at adrenergic and opioid receptors: Studies with wild type and constitutively active mutant receptors.. RECEPTORS & CHANNELS, 5(3-4), 209-213. Retrieved from https://www.webofscience.com/
Regulation of the stoichiometry of protein components of the stimulatory adenylyl cyclase cascade. (Journal article)
Milligan, G., Mullaney, I., Kim, G. D., & MacEwan, D. (1998). Regulation of the stoichiometry of protein components of the stimulatory adenylyl cyclase cascade.. Advances in pharmacology (San Diego, Calif.), 42, 462-465. doi:10.1016/s1054-3589(08)60788-7DOI: 10.1016/s1054-3589(08)60788-7
1996
Up-regulation of a constitutively active form of the beta(2)-adrenoceptor by sustained treatment with inverse agonists but not antagonists (Journal article)
MacEwan, D. J., & Milligan, G. (1996). Up-regulation of a constitutively active form of the beta(2)-adrenoceptor by sustained treatment with inverse agonists but not antagonists. FEBS LETTERS, 399(1-2), 108-112. doi:10.1016/S0014-5793(96)01300-2DOI: 10.1016/S0014-5793(96)01300-2
Inverse agonist-induced up-regulation of the human beta(2)-adrenoceptor in transfected neuroblastoma X glioma hybrid cells (Journal article)
MacEwan, D. J., & Milligan, G. (1996). Inverse agonist-induced up-regulation of the human beta(2)-adrenoceptor in transfected neuroblastoma X glioma hybrid cells. MOLECULAR PHARMACOLOGY, 50(6), 1479-1486. Retrieved from https://www.webofscience.com/
Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta(2)-adrenoceptor - Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity (Journal article)
MacEwan, D. J., Kim, G. D., & Milligan, G. (1996). Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta(2)-adrenoceptor - Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity. BIOCHEMICAL JOURNAL, 318, 1033-1039. doi:10.1042/bj3181033DOI: 10.1042/bj3181033
Elevated cPLA(2) levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis (Journal article)
MacEwan, D. J. (1996). Elevated cPLA(2) levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis. FEBS LETTERS, 379(1), 77-81. doi:10.1016/0014-5793(95)01495-0DOI: 10.1016/0014-5793(95)01495-0
Mechanism of gonadotrophin releasing hormone receptor mediated regulation of G-proteins in clonal pituitary gonadotrophs (Book)
Shah, B. H., MacEwan, D. J., & Milligan, G. (1996). Mechanism of gonadotrophin releasing hormone receptor mediated regulation of G-proteins in clonal pituitary gonadotrophs. Z. H. Zaidi, & D. L. Smith (Eds.).
Regulation of mammalian G-protein function (Journal article)
MacEwan, D. J., & Milligan, G. (1996). Regulation of mammalian G-protein function. Journal of Experimental Botany, 47(SUPPL.), 2.
1995
G-PROTEIN PALMITOYLATION - REGULATION AND FUNCTIONAL-SIGNIFICANCE (Journal article)
MILLIGAN, G., GRASSIE, M. A., WISE, A., MACEWAN, D. J., MAGEE, A. I., & PARENTI, M. (1995). G-PROTEIN PALMITOYLATION - REGULATION AND FUNCTIONAL-SIGNIFICANCE. BIOCHEMICAL SOCIETY TRANSACTIONS, 23(3), 583-587. doi:10.1042/bst0230583DOI: 10.1042/bst0230583
DEGRADATION OF G(11)ALPHA/G(Q)ALPHA IS ACCELERATED BY AGONIST OCCUPANCY OF ALPHA(1A/D), ALPHA(1B), AND ALPHA(1C) ADRENERGIC-RECEPTORS (Journal article)
WISE, A., LEE, T. W., MACEWAN, D. J., & MILLIGAN, G. (1995). DEGRADATION OF G(11)ALPHA/G(Q)ALPHA IS ACCELERATED BY AGONIST OCCUPANCY OF ALPHA(1A/D), ALPHA(1B), AND ALPHA(1C) ADRENERGIC-RECEPTORS. JOURNAL OF BIOLOGICAL CHEMISTRY, 270(29), 17196-17203. doi:10.1074/jbc.270.29.17196DOI: 10.1074/jbc.270.29.17196
Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter. Involvement of nuclear factor of activated T cell-related factors in interleukin-5 expression. (Journal article)
Lee, H. J., Masuda, E. S., Arai, N., Arai, K., & Yokota, T. (1995). Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter. Involvement of nuclear factor of activated T cell-related factors in interleukin-5 expression.. The Journal of biological chemistry, 270(29), 17541-17550. doi:10.1074/jbc.270.29.17541DOI: 10.1074/jbc.270.29.17541
PHORBOL ESTER AND DIACYLGLYCEROL ACTIVATION OF NATIVE PROTEIN-KINASE-C SPECIES FROM VARIOUS TISSUES (Journal article)
JOHNSON, M. S., SIMPSON, J., MACEWAN, D. J., ISON, A., CLEGG, R. A., CONNOR, K., & MITCHELL, R. (1995). PHORBOL ESTER AND DIACYLGLYCEROL ACTIVATION OF NATIVE PROTEIN-KINASE-C SPECIES FROM VARIOUS TISSUES. MOLECULAR AND CELLULAR BIOCHEMISTRY, 146(2), 127-137. doi:10.1007/BF00944605DOI: 10.1007/BF00944605
GONADOTROPIN-RELEASING-HORMONE RECEPTOR AGONIST-MEDIATED DOWN-REGULATION OF G(Q)ALPHA/G(11)ALPHA (PERTUSSIS TOXIN-INSENSITIVE) G-PROTEINS IN ALPHA-T3-1 GONADOTROPH CELLS REFLECTS INCREASED G-PROTEIN TURNOVER BUT NOT ALTERATIONS IN MESSENGER-RNA LEVELS (Journal article)
SHAH, B. H., MACEWAN, D. J., & MILLIGAN, G. (1995). GONADOTROPIN-RELEASING-HORMONE RECEPTOR AGONIST-MEDIATED DOWN-REGULATION OF G(Q)ALPHA/G(11)ALPHA (PERTUSSIS TOXIN-INSENSITIVE) G-PROTEINS IN ALPHA-T3-1 GONADOTROPH CELLS REFLECTS INCREASED G-PROTEIN TURNOVER BUT NOT ALTERATIONS IN MESSENGER-RNA LEVELS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 92(6), 1886-1890. doi:10.1073/pnas.92.6.1886DOI: 10.1073/pnas.92.6.1886
MECHANISMS OF AGONIST-INDUCED G-PROTEIN ELIMINATION (Journal article)
MILLIGAN, G., WISE, A., MACEWAN, D. J., GRASSIE, M. A., KENNEDY, F. R., LEE, T. W., . . . MULLANEY, I. (1995). MECHANISMS OF AGONIST-INDUCED G-PROTEIN ELIMINATION. BIOCHEMICAL SOCIETY TRANSACTIONS, 23(1), 166-170. doi:10.1042/bst0230166DOI: 10.1042/bst0230166
ANALYSIS OF THE ROLE OF RECEPTOR NUMBER IN DEFINING THE INTRINSIC ACTIVITY AND POTENCY OF PARTIAL AGONISTS IN NEUROBLASTOMA X GLIOMA HYBRID NG108-15 CELLS TRANSFECTED TO EXPRESS DIFFERING LEVELS OF THE HUMAN BETA(2)-ADRENOCEPTOR (Journal article)
MACEWAN, D. J., KIM, G. D., & MILLIGAN, G. (1995). ANALYSIS OF THE ROLE OF RECEPTOR NUMBER IN DEFINING THE INTRINSIC ACTIVITY AND POTENCY OF PARTIAL AGONISTS IN NEUROBLASTOMA X GLIOMA HYBRID NG108-15 CELLS TRANSFECTED TO EXPRESS DIFFERING LEVELS OF THE HUMAN BETA(2)-ADRENOCEPTOR. MOLECULAR PHARMACOLOGY, 48(2), 316-325. Retrieved from https://www.webofscience.com/
INVOLVEMENT OF MULTIPLE PROTEIN-KINASE-C ISOZYMES IN THE ACTH SECRETORY PATHWAY OF ATT-20 CELLS (Journal article)
MCFERRAN, B. W., MACEWAN, D. J., & GUILD, S. B. (1995). INVOLVEMENT OF MULTIPLE PROTEIN-KINASE-C ISOZYMES IN THE ACTH SECRETORY PATHWAY OF ATT-20 CELLS. BRITISH JOURNAL OF PHARMACOLOGY, 115(2), 307-315. doi:10.1111/j.1476-5381.1995.tb15878.xDOI: 10.1111/j.1476-5381.1995.tb15878.x
1994
Cell cycle dependency of TNF-alpha effects on TF-1 cells: A role for the TNFR II in mediating apoptosis (Journal article)
Kuo, R. C., MacEwan, D. J., & Baxter, G. T. (1994). Cell cycle dependency of TNF-alpha effects on TF-1 cells: A role for the TNFR II in mediating apoptosis. Molecular Biology of the Cell, 5(SUPPL.), 26A.
Interferon-alpha induces PKC-epsilon gene-expression as well as a novel PKC-epsilon-related transcript (Journal article)
Pfeffer, L. M., Constantinescu, S. N., MacEwan, D. J., Parker, P. J., & Wang, C. (1994). Interferon-alpha induces PKC-epsilon gene-expression as well as a novel PKC-epsilon-related transcript. Journal of Cellular Biochemistry, 87.
1993
Biochemical characterisation of an apparently novel isoform of protein kinase C in pituitary. (Journal article)
Ison, A. J., Johnson, M. S., MacEwan, D. J., Simpson, J., Clegg, R. A., Connor, K., & Mitchell, R. (1993). Biochemical characterisation of an apparently novel isoform of protein kinase C in pituitary.. Biochemical Society transactions, 21(4), 386S. doi:10.1042/bst021386sDOI: 10.1042/bst021386s
CHARACTERIZATION OF PROTEIN-KINASE-C ISOFORMS AND ENZYMATIC-ACTIVITY FROM THE ALPHA-T3-1 GONADOTROPH-DERIVED CELL-LINE (Journal article)
JOHNSON, M. S., MACEWAN, D. J., SIMPSON, J., & MITCHELL, R. (1993). CHARACTERIZATION OF PROTEIN-KINASE-C ISOFORMS AND ENZYMATIC-ACTIVITY FROM THE ALPHA-T3-1 GONADOTROPH-DERIVED CELL-LINE. FEBS LETTERS, 333(1-2), 67-72. doi:10.1016/0014-5793(93)80376-6DOI: 10.1016/0014-5793(93)80376-6
EVIDENCE FOR A DISTINCT H7-RESISTANT FORM OF PROTEIN-KINASE-C IN RAT ANTERIOR-PITUITARY GLAND (Journal article)
ISON, A. J., MACEWAN, D. J., JOHNSON, M. S., CLEGG, R. A., CONNOR, K., & MITCHELL, R. (1993). EVIDENCE FOR A DISTINCT H7-RESISTANT FORM OF PROTEIN-KINASE-C IN RAT ANTERIOR-PITUITARY GLAND. FEBS LETTERS, 329(1-2), 199-204. doi:10.1016/0014-5793(93)80221-FDOI: 10.1016/0014-5793(93)80221-F
INTERFERON-ALPHA INDUCES PROTEIN-KINASE C-EPSILON (PKC-EPSILON) GENE-EXPRESSION AND A 4.7-KB PKC-EPSILON-RELATED TRANSCRIPT (Journal article)
WANG, C., CONSTANTINESCU, S. N., MACEWAN, D. J., STRULOVICI, B., DEKKER, L. V., PARKER, P. J., & PFEFFER, L. M. (1993). INTERFERON-ALPHA INDUCES PROTEIN-KINASE C-EPSILON (PKC-EPSILON) GENE-EXPRESSION AND A 4.7-KB PKC-EPSILON-RELATED TRANSCRIPT. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 90(15), 6944-6948. doi:10.1073/pnas.90.15.6944DOI: 10.1073/pnas.90.15.6944
EVIDENCE THAT PROTEIN KINASE-C-ALPHA HAS REDUCED AFFINITY TOWARDS 1,2-DIOCTANOYL-SN-GLYCEROL - THE EFFECTS OF LIPID ACTIVATORS ON PHORBOL ESTER BINDING AND KINASE-ACTIVITY (Journal article)
MACEWAN, D. J., MITCHELL, R., JOHNSON, M. S., THOMSON, F. J., LUTZ, E. M., CLEGG, R. A., & CONNOR, K. (1993). EVIDENCE THAT PROTEIN KINASE-C-ALPHA HAS REDUCED AFFINITY TOWARDS 1,2-DIOCTANOYL-SN-GLYCEROL - THE EFFECTS OF LIPID ACTIVATORS ON PHORBOL ESTER BINDING AND KINASE-ACTIVITY. EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 246(1), 9-18. doi:10.1016/0922-4106(93)90003-RDOI: 10.1016/0922-4106(93)90003-R
FUNCTIONAL EXPRESSION OF 5-HT1C RECEPTOR CDNA IN COS 7-CELLS AND ITS INFLUENCE ON PROTEIN-KINASE-C (Journal article)
LUTZ, E. M., MITCHELL, R., JOHNSON, M. S., & MACEWAN, D. (1993). FUNCTIONAL EXPRESSION OF 5-HT1C RECEPTOR CDNA IN COS 7-CELLS AND ITS INFLUENCE ON PROTEIN-KINASE-C. FEBS LETTERS, 316(3), 228-232. doi:10.1016/0014-5793(93)81298-EDOI: 10.1016/0014-5793(93)81298-E
ESTRADIOL-17-BETA MODULATES THE ACTIONS OF PHARMACOLOGICALLY DISTINCT FORMS OF PROTEIN-KINASE-C IN RAT ANTERIOR-PITUITARY-CELLS (Journal article)
THOMSON, F. J., JOHNSON, M. S., MACEWAN, D. J., & MITCHELL, R. (1993). ESTRADIOL-17-BETA MODULATES THE ACTIONS OF PHARMACOLOGICALLY DISTINCT FORMS OF PROTEIN-KINASE-C IN RAT ANTERIOR-PITUITARY-CELLS. JOURNAL OF ENDOCRINOLOGY, 136(1), 105-117. doi:10.1677/joe.0.1360105DOI: 10.1677/joe.0.1360105
THE DIFFERENTIAL-EFFECTS OF PROTEIN-KINASE-C ACTIVATORS AND INHIBITORS ON RAT ANTERIOR-PITUITARY HORMONE-RELEASE (Journal article)
THOMSON, F. J., JOHNSON, M. S., MITCHELL, R., WOLBERS, W. B., ISON, A. J., & MACEWAN, D. J. (1993). THE DIFFERENTIAL-EFFECTS OF PROTEIN-KINASE-C ACTIVATORS AND INHIBITORS ON RAT ANTERIOR-PITUITARY HORMONE-RELEASE. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 94(2), 223-234. doi:10.1016/0303-7207(93)90171-FDOI: 10.1016/0303-7207(93)90171-F
THE INVOLVEMENT OF DIHYDROPYRIDINE-SENSITIVE CALCIUM CHANNELS IN PHORBOL ESTER-INDUCED LUTEINIZING-HORMONE AND GROWTH-HORMONE RELEASE (Journal article)
JOHNSON, M. S., THOMSON, F. J., MACEWAN, D. J., & MITCHELL, R. (1993). THE INVOLVEMENT OF DIHYDROPYRIDINE-SENSITIVE CALCIUM CHANNELS IN PHORBOL ESTER-INDUCED LUTEINIZING-HORMONE AND GROWTH-HORMONE RELEASE. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 95(1-2), 31-41. doi:10.1016/0303-7207(93)90026-GDOI: 10.1016/0303-7207(93)90026-G
The protein kinase C isoform content of rat pituitary tissue (Journal article)
MacEwan, D. J. (1993). The protein kinase C isoform content of rat pituitary tissue. FASEB Journal, 7(4), A601.
1992
Properties and [32P] phosphorylation targets of a novel form of protein kinase C in pituitary. (Journal article)
MacEwan, D. J., Simpson, J., Mitchell, R., Johnson, M. S., Thomson, F. J., & Fink, G. (1992). Properties and [32P] phosphorylation targets of a novel form of protein kinase C in pituitary.. Biochemical Society transactions, 20(2), 133S. doi:10.1042/bst020133sDOI: 10.1042/bst020133s
PROTEIN-KINASE-C MAY BE REQUIRED TO MAINTAIN ACTIVITY OF NIMODIPINE-SENSITIVE CA2+ CHANNELS IN RAT ANTERIOR-PITUITARY-CELLS INVITRO (Journal article)
MACEWAN, D. J., JOHNSON, M. S., THOMSON, F. J., & MITCHELL, R. (1992). PROTEIN-KINASE-C MAY BE REQUIRED TO MAINTAIN ACTIVITY OF NIMODIPINE-SENSITIVE CA2+ CHANNELS IN RAT ANTERIOR-PITUITARY-CELLS INVITRO. JOURNAL OF PHYSIOLOGY-LONDON, 446, P282. Retrieved from https://www.webofscience.com/
DIFFERENTIAL ACTIONS OF PROTEIN-KINASE-C MODULATORS ON THE RELEASE OF HORMONES FROM RAT ANTERIOR-PITUITARY TISSUE INVITRO (Journal article)
JOHNSON, M. S., THOMSON, F. J., AVERY, J. L., MACEWAN, D. J., & MITCHELL, P. R. (1992). DIFFERENTIAL ACTIONS OF PROTEIN-KINASE-C MODULATORS ON THE RELEASE OF HORMONES FROM RAT ANTERIOR-PITUITARY TISSUE INVITRO. JOURNAL OF PHYSIOLOGY-LONDON, 446, P283. Retrieved from https://www.webofscience.com/
1991
CALCIUM INFLUX THROUGH L-TYPE CHANNELS INTO RAT ANTERIOR-PITUITARY-CELLS CAN BE MODULATED IN 2 WAYS BY PROTEIN-KINASE-C - (PKC-ISOFORM SELECTIVITY OF 1,2-DIOCTANOYL SN-GLYCEROL) (Journal article)
MACEWAN, D. J., & MITCHELL, R. (1991). CALCIUM INFLUX THROUGH L-TYPE CHANNELS INTO RAT ANTERIOR-PITUITARY-CELLS CAN BE MODULATED IN 2 WAYS BY PROTEIN-KINASE-C - (PKC-ISOFORM SELECTIVITY OF 1,2-DIOCTANOYL SN-GLYCEROL). FEBS LETTERS, 291(1), 79-83. doi:10.1016/0014-5793(91)81108-KDOI: 10.1016/0014-5793(91)81108-K
INHIBITION OF DEPOLARIZATION-INDUCED CALCIUM INFLUX INTO GH3 CELLS BY ARACHIDONIC-ACID - THE INVOLVEMENT OF PROTEIN-KINASE-C (Journal article)
MACEWAN, D. J., MITCHELL, R., THOMSON, F. J., & JOHNSON, M. S. (1991). INHIBITION OF DEPOLARIZATION-INDUCED CALCIUM INFLUX INTO GH3 CELLS BY ARACHIDONIC-ACID - THE INVOLVEMENT OF PROTEIN-KINASE-C. BIOCHIMICA ET BIOPHYSICA ACTA, 1094(3), 346-354. doi:10.1016/0167-4889(91)90096-GDOI: 10.1016/0167-4889(91)90096-G
DIFFERENTIAL ACTIVATION OF PHOSPHOLIPASE-A2 BY PROTEIN-KINASE-C IN PITUITARY-CELLS (Journal article)
THOMSON, F. J., MITCHELL, R., JOHNSON, M. S., & MACEWAN, D. J. (1991). DIFFERENTIAL ACTIVATION OF PHOSPHOLIPASE-A2 BY PROTEIN-KINASE-C IN PITUITARY-CELLS. BIOCHEMICAL SOCIETY TRANSACTIONS, 19(2), S117. doi:10.1042/bst019117sDOI: 10.1042/bst019117s
Does inositol hexakisphosphate induce Ca2+ entry into GH3 cells? (Conference Paper)
Mitchell, R., MacEwan, D., Dougan, L., Johnson, M., & Thomson, F. (1991). Does inositol hexakisphosphate induce Ca2+ entry into GH3 cells?. In Biochemical Society transactions Vol. 19 (pp. 116S). doi:10.1042/bst019116sDOI: 10.1042/bst019116s
Protein kinase C-dependent and -independent actions of arachidonic acid in GH3 cells. (Journal article)
MacEwan, D. J., Mitchell, R., Johnson, M. S., & Thomson, F. J. (1991). Protein kinase C-dependent and -independent actions of arachidonic acid in GH3 cells.. Biochemical Society transactions, 19(2), 115S. doi:10.1042/bst019115sDOI: 10.1042/bst019115s
A POSSIBLE ROLE FOR PHOSPHOLIPASE-A2 IN PHORBOL ESTER-INDUCED RELEASE OF HORMONES FROM RAT ANTERIOR-PITUITARY TISSUE INVITRO (Journal article)
THOMSON, F. J., MITCHELL, R., JOHNSON, M. S., & MACEWAN, D. J. (1991). A POSSIBLE ROLE FOR PHOSPHOLIPASE-A2 IN PHORBOL ESTER-INDUCED RELEASE OF HORMONES FROM RAT ANTERIOR-PITUITARY TISSUE INVITRO. JOURNAL OF PHYSIOLOGY-LONDON, 434, P97. Retrieved from https://www.webofscience.com/
Cellular actions of pharmacologically distinct forms of protein kinase C (Journal article)
Thomson, F. J., Johnson, M. S., MacEwan, D. J., Fink, G., & Mitchell, R. (1991). Cellular actions of pharmacologically distinct forms of protein kinase C. Society for Neuroscience Abstracts, 17(1-2), 604.
Characterisation of tritiated dimethylstuarosporine binding sites by displacement studies using protein kinase C inhibitors (Journal article)
Thomson, F. J., Mitchell, R., MacEwan, D. J., Harvey, J., & Johnson, M. S. (1991). Characterisation of tritiated dimethylstuarosporine binding sites by displacement studies using protein kinase C inhibitors. British Journal of Pharmacology, 104(PROC.), 452P-ABSTRACT 452P.
Cholecystokinin-octapeptide stimulates ACTH release from AtT-20 tumour cells through a mechanism independent of polyphosphoinositide hydrolysis (Journal article)
MacEwan, D. J., & Guild, S. (1991). Cholecystokinin-octapeptide stimulates ACTH release from AtT-20 tumour cells through a mechanism independent of polyphosphoinositide hydrolysis. British Journal of Pharmacology, 104(PROC.), 451P-ABSTRACT 451P.
MODULATION BY PHORBOL 12,13-DIBUTYRATE OF DIHYDROPYRIDINE-SENSITIVE HORMONE-RELEASE FROM RAT ANTERIOR-PITUITARY TISSUE INVITRO (Journal article)
JOHNSON, M. S., MITCHELL, R., MACEWAN, D. J., & THOMSON, F. J. (1991). MODULATION BY PHORBOL 12,13-DIBUTYRATE OF DIHYDROPYRIDINE-SENSITIVE HORMONE-RELEASE FROM RAT ANTERIOR-PITUITARY TISSUE INVITRO. JOURNAL OF PHYSIOLOGY-LONDON, 434, P96. Retrieved from https://www.webofscience.com/
Regional differences in the affinity of diacylglycerol analogues for tritiated phorbol 12,13-dibutyrate binding sites (Journal article)
MacEwan, D. J., Mitchell, R., Johnson, M. S., & Thomson, F. J. (1991). Regional differences in the affinity of diacylglycerol analogues for tritiated phorbol 12,13-dibutyrate binding sites. British Journal of Pharmacology, 104(PROC.), 454P-ABSTRACT 454P.
The effects of different class of activators of protein kinase C on rat midbrain (Journal article)
Mitchell, R., Johnson, M. S., Avery, J. L., MacEwan, D. J., & Thomson, F. J. (1991). The effects of different class of activators of protein kinase C on rat midbrain. British Journal of Pharmacology, 104(PROC.), 453P-ABSTRACT 453P.
1990
ARACHIDONIC-ACID ACTS THROUGH PROTEIN KINASE-C TO INHIBIT DEPOLARIZATION-INDUCED CA-2+(45) INFLUX (Conference Paper)
MACEWAN, D., & MITCHELL, R. (1990). ARACHIDONIC-ACID ACTS THROUGH PROTEIN KINASE-C TO INHIBIT DEPOLARIZATION-INDUCED CA-2+(45) INFLUX. In BIOCHEMICAL SOCIETY TRANSACTIONS Vol. 18 (pp. 432-433). Retrieved from https://www.webofscience.com/
BIOLOGICAL-ACTIVITY OF SOME THYROTROPIN-RELEASING-HORMONE ANALOGS SUBSTITUTED AT THE 2-POSITION (Conference Paper)
MITCHELL, R., MACEWAN, D., JOHNSON, M., DOUGAN, L., & BLADON, C. (1990). BIOLOGICAL-ACTIVITY OF SOME THYROTROPIN-RELEASING-HORMONE ANALOGS SUBSTITUTED AT THE 2-POSITION. In BIOCHEMICAL SOCIETY TRANSACTIONS Vol. 18 (pp. 433-434). doi:10.1042/bst0180433DOI: 10.1042/bst0180433
Effects of calmodulin antagonists on neurohormone-induced <sup>45</sup>Ca<sup>2+</sup> influx into rat anterior pituitary tissue in vitro (Journal article)
Johnson, M. S., MacEwan, D. J., Mitchell, R., & Thomson, F. J. (1990). Effects of calmodulin antagonists on neurohormone-induced <sup>45</sup>Ca<sup>2+</sup> influx into rat anterior pituitary tissue in vitro. Journal of Physiology, 424.
Inhibition of depolarization-induced calcium influx into GH<inf>3</inf> cels by arachidonic acid may involve direct activation of protein kinase C (Journal article)
MacEwan, D. J., & Mitchell, R. (1990). Inhibition of depolarization-induced calcium influx into GH<inf>3</inf> cels by arachidonic acid may involve direct activation of protein kinase C. Journal of Physiology, 424.
PHARMACOLOGY AND CELLULAR ACTIONS OF PROTEIN-KINASE-C ISOFORMS (Conference Paper)
MITCHELL, R., MACEWAN, D., JOHNSON, M., & THOMSON, F. (1990). PHARMACOLOGY AND CELLULAR ACTIONS OF PROTEIN-KINASE-C ISOFORMS. In EUROPEAN JOURNAL OF PHARMACOLOGY Vol. 183 (pp. 750-751). doi:10.1016/0014-2999(90)92552-TDOI: 10.1016/0014-2999(90)92552-T
Selectivity of protein kinase C activators in the regulation of calcium channels in rat anterior pituitary cells (Journal article)
MacEwan, D. J., Mitchell, R., Johnson, M. S., & Thomason, F. J. (1990). Selectivity of protein kinase C activators in the regulation of calcium channels in rat anterior pituitary cells. Journal of Endocrinology, 124(SUPPL).
1989
Depolarization-induced Ca-45(2+) influx into rat anterior-pituitary cells in vitro can be modulated in 2 ways by protein kinase C (Journal article)
Johnson, M. S., MacEwan, D. J., & Mitchell, R. (1989). Depolarization-induced Ca-45(2+) influx into rat anterior-pituitary cells in vitro can be modulated in 2 ways by protein kinase C. Journal of Physiology-London, 418, P186.
Lithium enhances the inhibitory effect of protein kinase C on LHRH-induced Ca-45(2+) influx into rat anterior-pituitary tissue in vitro (Journal article)
Johnson, M. S., MacEwan, D. J., Mitchell, R., & Thomson, F. J. (1989). Lithium enhances the inhibitory effect of protein kinase C on LHRH-induced Ca-45(2+) influx into rat anterior-pituitary tissue in vitro. Journal of Physiology-London, 418, P185.
