Dr David Dickens

Selected Publications

1. Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. (Journal article - 2021)
2. Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process (Journal article - 2018)
3. Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. (Journal article - 2017)
4. Chapter 5. Drug Transporters at the Blood–Brain Barrier (Chapter - 2016)
5. Transport of gabapentin by LAT1 (SLC7A5) (Journal article - 2013)
6. A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp (Journal article - 2013)

Filter the publication list

2021

The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active ß1-integrin in adult tendon cells (Journal article)

Ide, K., Takahashi, S., Sakai, K., Taga, Y., Ueno, T., Dickens, D., . . . Sakai, T. (2021). The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active ß1-integrin in adult tendon cells. Journal of Biological Chemistry, 100819. doi:10.1016/j.jbc.2021.100819

DOI: 10.1016/j.jbc.2021.100819

Inflammatory Bowel Disease: A Personalized Approach. (Journal article)

Konidari, A., Dickens, D., & Pirmohamed, M. (2021). Inflammatory Bowel Disease: A Personalized Approach.. Frontiers in Pediatrics, 8, 620545. doi:10.3389/fped.2020.620545

DOI: 10.3389/fped.2020.620545

Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. (Journal article)

Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., . . . Dickens, D. (2021). Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. MOLECULAR PHARMACEUTICS, 18(1), 113-123. doi:10.1021/acs.molpharmaceut.0c00727

DOI: 10.1021/acs.molpharmaceut.0c00727

2020

Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants (Journal article)

Gutbier, S., Kyriakou, S., Schildknecht, S., Ueckert, A. -K., Bruell, M., Lewis, F., . . . Pienaar, I. S. (2020). Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants. ARCHIVES OF TOXICOLOGY, 94(9), 3105-3123. doi:10.1007/s00204-020-02826-y

DOI: 10.1007/s00204-020-02826-y

2018

Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process (Journal article)

Dickens, D., Rädisch, S., Chiduza, G. N., Giannoudis, A., Cross, M. J., Malik, H., . . . Nies, A. T. (2018). Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. Molecular Pharmaceutics, 15(8), 3557-3572. doi:10.1021/acs.molpharmaceut.8b00547

DOI: 10.1021/acs.molpharmaceut.8b00547

2017

In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line (Journal article)

Curley, P., Giardiello, M., Liptrott, N. J., Dickens, D., Moss, D. M., Hobson, J. J., . . . Owen, A. (2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine, 2(3), 157-169. doi:10.1002/jin2.32

DOI: 10.1002/jin2.32

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. (Journal article)

Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (n.d.). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.. Scientific Reports, 7. doi:10.1038/srep43580

DOI: 10.1038/srep43580

2016

Chapter 5. Drug Transporters at the Blood–Brain Barrier (Chapter)

Dickens, D., Radisch, S., & Pirmohamed, M. (n.d.). Chapter 5. Drug Transporters at the Blood–Brain Barrier. In Drug Transporters : Role and Importance in ADME and Drug Development (pp. 151-183). Royal Society of Chemistry. doi:10.1039/9781782623793-00151

DOI: 10.1039/9781782623793-00151

2015

Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography (Journal article)

Sander, K., Galante, E., Gendron, T., Yiannaki, E., Patel, N., Kalber, T. L., . . . Arstad, E. (2015). Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography. JOURNAL OF MEDICINAL CHEMISTRY, 58(15), 6058-6080. doi:10.1021/acs.jmedchem.5b00652

DOI: 10.1021/acs.jmedchem.5b00652

Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry (Journal article)

Alfirevic, A., Durocher, J., Elati, A., Leon, W., Dickens, D., Raedisch, S., . . . Winikoff, B. (2015). Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry. PHARMACOGENOMICS, 16(9), 919-928. doi:10.2217/pgs.15.53

DOI: 10.2217/pgs.15.53

2014

A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine (Journal article)

Raedisch, S., Dickens, D., Lang, T., Bonnett, L., Arlanov, R., Johnson, M. R., . . . Pirmohamed, M. (2014). A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine. PHARMACOGENOMICS JOURNAL, 14(5), 481-487. doi:10.1038/tpj.2014.5

DOI: 10.1038/tpj.2014.5

2013

ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein (Journal article)

Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein. PHARMACOGENETICS AND GENOMICS, 23(6), 314-323. doi:10.1097/FPC.0b013e328360d10c

DOI: 10.1097/FPC.0b013e328360d10c

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Rädisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI: 10.1016/j.bcp.2013.03.022

A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp (Journal article)

Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLOS ONE, 8(5). doi:10.1371/journal.pone.0064854

DOI: 10.1371/journal.pone.0064854

2012

Lamotrigine is a substrate for OCT1 in brain endothelial cells (Journal article)

Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B., . . . Pirmohamed, M. (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. BIOCHEMICAL PHARMACOLOGY, 83(6), 805-814. doi:10.1016/j.bcp.2011.12.032

DOI: 10.1016/j.bcp.2011.12.032

2011

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein (Journal article)

Vogler, M., Dickens, D., Dyer, M. J. S., Owen, A., Pirmohamed, M., & Cohen, G. M. (2011). The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 408(2), 344-349. doi:10.1016/j.bbrc.2011.04.043

DOI: 10.1016/j.bbrc.2011.04.043

2009

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins (Journal article)

Lam, D., Dickens, D., Reid, E. B., Loh, S. H. Y., Moisoi, N., & Martins, L. M. (2009). MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(29), 11978-11983. doi:10.1073/pnas.0900608106

DOI: 10.1073/pnas.0900608106