2022
Bourque, M., Gregoire, L., Patel, W., Dickens, D., Snodgrass, R., & Di Paolo, T. (2022). AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys. CELLS, 11(22). doi:10.3390/cells11223530DOI: 10.3390/cells11223530
Cappoli, N., Jenkinson, M. D., Dello Russo, C., & Dickens, D. (2022). LAT1, a novel pharmacological target for the treatment of glioblastoma. BIOCHEMICAL PHARMACOLOGY, 201. doi:10.1016/j.bcp.2022.115103DOI: 10.1016/j.bcp.2022.115103
2021
Ide, K., Takahashi, S., Sakai, K., Taga, Y., Ueno, T., Dickens, D., . . . Sakai, T. (2021). The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells. Journal of Biological Chemistry, 100819. doi:10.1016/j.jbc.2021.100819DOI: 10.1016/j.jbc.2021.100819
Konidari, A., Dickens, D., & Pirmohamed, M. (2021). Inflammatory Bowel Disease: A Personalized Approach.. Frontiers in Pediatrics, 8, 620545. doi:10.3389/fped.2020.620545DOI: 10.3389/fped.2020.620545
Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., . . . Dickens, D. (2021). Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. MOLECULAR PHARMACEUTICS, 18(1), 113-123. doi:10.1021/acs.molpharmaceut.0c00727DOI: 10.1021/acs.molpharmaceut.0c00727
2020
Gutbier, S., Kyriakou, S., Schildknecht, S., Ueckert, A. -K., Bruell, M., Lewis, F., . . . Pienaar, I. S. (2020). Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants. ARCHIVES OF TOXICOLOGY, 94(9), 3105-3123. doi:10.1007/s00204-020-02826-yDOI: 10.1007/s00204-020-02826-y
2018
Dickens, D., Rädisch, S., Chiduza, G. N., Giannoudis, A., Cross, M. J., Malik, H., . . . Nies, A. T. (2018). Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. Molecular Pharmaceutics, 15(8), 3557-3572. doi:10.1021/acs.molpharmaceut.8b00547DOI: 10.1021/acs.molpharmaceut.8b00547
2017
Curley, P., Giardiello, M., Liptrott, N. J., Dickens, D., Moss, D. M., Hobson, J. J., . . . Owen, A. (2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine, 2(3), 157-169. doi:10.1002/jin2.32DOI: 10.1002/jin2.32
Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (n.d.). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.. Scientific Reports, 7. doi:10.1038/srep43580DOI: 10.1038/srep43580
2016
Drug Transporters at the Blood-Brain Barrier (Chapter)
Dickens, D., Radisch, S., & Pirmohamed, M. (2016). Drug Transporters at the Blood-Brain Barrier. In DRUG TRANSPORTERS: VOL 1: ROLE AND IMPORTANCE IN ADME AND DRUG DEVELOPMENT (Vol. 54, pp. 151-183). Retrieved from https://www.webofscience.com/
2015
Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography (Journal article)
Sander, K., Galante, E., Gendron, T., Yiannaki, E., Patel, N., Kalber, T. L., . . . Arstad, E. (2015). Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography. JOURNAL OF MEDICINAL CHEMISTRY, 58(15), 6058-6080. doi:10.1021/acs.jmedchem.5b00652DOI: 10.1021/acs.jmedchem.5b00652
Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry (Journal article)
Alfirevic, A., Durocher, J., Elati, A., Leon, W., Dickens, D., Raedisch, S., . . . Winikoff, B. (2015). Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry. PHARMACOGENOMICS, 16(9), 919-928. doi:10.2217/pgs.15.53DOI: 10.2217/pgs.15.53
2014
A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine (Journal article)
Raedisch, S., Dickens, D., Lang, T., Bonnett, L., Arlanov, R., Johnson, M. R., . . . Pirmohamed, M. (2014). A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine. PHARMACOGENOMICS JOURNAL, 14(5), 481-487. doi:10.1038/tpj.2014.5DOI: 10.1038/tpj.2014.5
2013
ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein (Journal article)
Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein. PHARMACOGENETICS AND GENOMICS, 23(6), 314-323. doi:10.1097/FPC.0b013e328360d10cDOI: 10.1097/FPC.0b013e328360d10c
Transport of gabapentin by LAT1 (SLC7A5) (Journal article)
Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Rädisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022DOI: 10.1016/j.bcp.2013.03.022
A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp (Journal article)
Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLOS ONE, 8(5). doi:10.1371/journal.pone.0064854DOI: 10.1371/journal.pone.0064854
2012
Lamotrigine is a substrate for OCT1 in brain endothelial cells (Journal article)
Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B., . . . Pirmohamed, M. (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. BIOCHEMICAL PHARMACOLOGY, 83(6), 805-814. doi:10.1016/j.bcp.2011.12.032DOI: 10.1016/j.bcp.2011.12.032
2011
The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein (Journal article)
Vogler, M., Dickens, D., Dyer, M. J. S., Owen, A., Pirmohamed, M., & Cohen, G. M. (2011). The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 408(2), 344-349. doi:10.1016/j.bbrc.2011.04.043DOI: 10.1016/j.bbrc.2011.04.043
2009
MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins (Journal article)
Lam, D., Dickens, D., Reid, E. B., Loh, S. H. Y., Moisoi, N., & Martins, L. M. (2009). MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(29), 11978-11983. doi:10.1073/pnas.0900608106DOI: 10.1073/pnas.0900608106
