2023
A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity. (Journal article)
Gall, L., Jardi, F., Lammens, L., Piñero, J., Souza, T. M., Rodrigues, D., . . . Pin, C. (2023). A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity. . CPT: pharmacometrics & systems pharmacology. doi:10.1002/psp4.13029DOI: 10.1002/psp4.13029
Wan, Y., Adair, K., Herrmann, A., Shan, X., Xia, L., Duckworth, C. A., & Yu, L. -G. (2023). C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression.. Cell death & disease, 14(8), 547. doi:10.1038/s41419-023-06082-7DOI: 10.1038/s41419-023-06082-7
Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants (Journal article)
Jardi, F., Kelly, C., Teague, C., Fowler-Williams, H., Sevin, D. C., Rodrigues, D., . . . Pritchard, D. M. (2023). Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants. ARCHIVES OF TOXICOLOGY, 97(1), 235-254. doi:10.1007/s00204-022-03374-3DOI: 10.1007/s00204-022-03374-3
2022
Papoutsopoulou, S., Tang, J., Elramli, A. H., Williams, J. M., Gupta, N., Ikuomola, F. I., . . . Pritchard, D. M. (2022). Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 323(4), G306-G317. doi:10.1152/ajpgi.00037.2022DOI: 10.1152/ajpgi.00037.2022
Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo. (Journal article)
Papoutsopoulou, S., Pollock, L., Williams, J. M., Abdul-Mahdi, M. M. L. F., Dobbash, R., Duckworth, C. A., & Campbell, B. J. (2022). Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo.. Biology, 11(10), 1377. doi:10.3390/biology11101377DOI: 10.3390/biology11101377
2021
Simpson, H. L., Roberts, C. L., Thompson, L. M., Leiper, C. R., Gittens, N., Trotter, E., . . . Campbell, B. J. (2021). Soluble Non-Starch Polysaccharides From Plantain (Musa x paradisiaca L.) Diminish Epithelial Impact of Clostridioides difficile. FRONTIERS IN PHARMACOLOGY, 12. doi:10.3389/fphar.2021.766293DOI: 10.3389/fphar.2021.766293
Duckworth, C. A. (2021). Identifying key regulators of the intestinal stem cell niche. BIOCHEMICAL SOCIETY TRANSACTIONS, 49(5), 2163-2176. doi:10.1042/BST20210223DOI: 10.1042/BST20210223
Wang, W., Sindrewicz-Goral, P., Chen, C., Duckworth, C. A., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2021). Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines. CARCINOGENESIS, 42(8), 1079-1088. doi:10.1093/carcin/bgab059DOI: 10.1093/carcin/bgab059
Exarchou, K., Moore, A. R., Smart, H. L., Duckworth, C. A., Howes, N., & Pritchard, D. M. (2021). A "Watch and Wait" Strategy Involving Regular Endoscopic Surveillance Is Safe for Many Patients with Small, Sporadic, Grade 1, Non-Ampullary, Non-Functioning Duodenal Neuroendocrine Tumours. NEUROENDOCRINOLOGY, 111(8), 764-774. doi:10.1159/000511613DOI: 10.1159/000511613
Howell, L., Jenkins, R. E., Lynch, S., Duckworth, C., Kevin Park, B., & Goldring, C. (2021). Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification. ARCHIVES OF TOXICOLOGY, 95(7), 2413-2430. doi:10.1007/s00204-021-03075-3DOI: 10.1007/s00204-021-03075-3
Oliveira, R. G. D., Damazo, A. S., Antonielli, L. F., Miyajima, F., Pavan, E., Duckworth, C. A., . . . Martins, D. T. D. O. (2021). Dilodendron bipinnatum Radlk. extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-α and IL-1β concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant effect.. Journal of Ethnopharmacology, 269, 113735. doi:10.1016/j.jep.2020.113735DOI: 10.1016/j.jep.2020.113735
Arunachalam, K., Damazo, A. S., Macho, A., Matchado, M. S., Pavan, E., Figueiredo, F. D. F., . . . de Oliveira Martins, D. T. (2021). Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach. BIOCHEMICAL PHARMACOLOGY, 186. doi:10.1016/j.bcp.2021.114490DOI: 10.1016/j.bcp.2021.114490
Mahalhal, A., Burkitt, M. D., Duckworth, C. A., Hold, G. L., Campbell, B. J., Pritchard, D. M., & Probert, C. S. (2021). Long-Term Iron Deficiency and Dietary Iron Excess Exacerbate Acute Dextran Sodium Sulphate-Induced Colitis and Are Associated with Significant Dysbiosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(7). doi:10.3390/ijms22073646DOI: 10.3390/ijms22073646
IRINOTECAN INDUCES A RAPID INCREASE IN ENTEROID PERMEABILITY (Conference Paper)
Turnbull, J. L., Lynch, S., Pritchard, D. M., Goldring, C. E. P., & Duckworth, C. A. (2021). IRINOTECAN INDUCES A RAPID INCREASE IN ENTEROID PERMEABILITY. In GUT Vol. 70 (pp. A177-A178). doi:10.1136/gutjnl-2020-bsgcampus.337DOI: 10.1136/gutjnl-2020-bsgcampus.337
2020
Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease (Journal article)
Lloyd, K., Papoutsopoulou, S., Smith, E., Stegmaier, P., Bergey, F., Morris, L., . . . Burkitt, M. D. (2020). Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease. DISEASE MODELS & MECHANISMS, 13(11). doi:10.1242/dmm.044040DOI: 10.1242/dmm.044040
IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (vol 458C, pg 29, 2019) (Journal article)
Mihajluk, K., Simms, C., Reay, M., Madureira, P. A., Howarth, A., Murray, P., . . . Hill, R. (2020). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas (vol 458C, pg 29, 2019). CANCER LETTERS, 469, 524-525. doi:10.1016/j.canlet.2019.10.002DOI: 10.1016/j.canlet.2019.10.002
Lloyd, K. A., Parsons, B. N., Burkitt, M. D., Moore, A. R., Papoutsopoulou, S., Boyce, M., . . . Pritchard, D. M. (2020). Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 10(1), 113-132. doi:10.1016/j.jcmgh.2020.01.010DOI: 10.1016/j.jcmgh.2020.01.010
2019
Evans, J. P., Winiarski, B. K., Sutton, P. A., Ressel, L., Duckworth, C. A., Pritchard, D. M., . . . Kitteringham, N. R. (2019). Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research. LABORATORY ANIMALS, 53(6), 598-609. doi:10.1177/0023677219826165DOI: 10.1177/0023677219826165
Jones, L. G., Vaida, A., Thompson, L. M., Ikuomola, F. I., Caamaño, J. H., Burkitt, M. D., . . . Duckworth, C. A. (2019). NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells. Cell Death and Disease, 10. doi:10.1038/s41419-019-2129-5DOI: 10.1038/s41419-019-2129-5
Luu, L., Johnston, L. J., Derricott, H., Armstrong, S. D., Randle, N., Hartley, C. S., . . . Coombes, J. L. (2019). An Open-Format Enteroid Culture System for Interrogation of Interactions Between Toxoplasma gondii and the Intestinal Epithelium. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 9. doi:10.3389/fcimb.2019.00300DOI: 10.3389/fcimb.2019.00300
Duckworth, C. A., Pritchard, D. M., Mihailuk, K., Simms, C., Reay, M., Madureira, P., . . . Hill, R. (2019). IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas. Cancer Letters. doi:10.1016/j.canlet.2019.05.028DOI: 10.1016/j.canlet.2019.05.028
Frau, A., Kenny, J. G., Lenzi, L., Campbell, B. J., Ijaz, U. Z., Duckworth, C. A., . . . Probert, C. S. J. (2019). DNA extraction and amplicon production strategies deeply influence the outcome of gut mycobiome studies. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-44974-xDOI: 10.1038/s41598-019-44974-x
Tawfik, A., Knight, P., Duckworth, C. A., Pritchard, D. M., Rhodes, J. M., & Campbell, B. J. (2019). Replication of Crohn's Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation. PATHOGENS, 8(2). doi:10.3390/pathogens8020074DOI: 10.3390/pathogens8020074
Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., Duckworth, C. A., & Pritchard, D. M. (2019). Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (vol 8, e2939, 2017). CELL DEATH & DISEASE, 10. doi:10.1038/s41419-019-1534-0DOI: 10.1038/s41419-019-1534-0
Stem cell models as an in vitro model for predictive toxicology (Journal article)
Lynch, S., Pridgeon, C. S., Duckworth, C. A., Sharma, P., Park, B. K., & Goldring, C. E. P. (2019). Stem cell models as an in vitro model for predictive toxicology. BIOCHEMICAL JOURNAL, 476, 1149-1158. doi:10.1042/BCJ20170780DOI: 10.1042/BCJ20170780
Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice (Journal article)
Reade, S., Williams, J. M., Aggio, R., Duckworth, C. A., Mahalhal, A., Hough, R., . . . Probert, C. S. (2019). Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice. FASEB JOURNAL, 33(3), 3129-3136. doi:10.1096/fj.201800076RRDOI: 10.1096/fj.201800076RR
Derricott, H., Luu, L., Fong, W. Y., Hartley, C. S., Johnston, L. J., Armstrong, S. D., . . . Coombes, J. L. (2019). Developing a 3D intestinal epithelium model for livestock species. Cell and Tissue Research, 375(02), 409-424. doi:10.1007/s00441-018-2924-9DOI: 10.1007/s00441-018-2924-9
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2019). Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.. Oncotarget, 10(6), 685. doi:10.18632/oncotarget.26625DOI: 10.18632/oncotarget.26625
Endoscopic Surveillance Is a Viable Alternative Management Strategy for Patients with Localised Small Non-Functional Low Grade Duodenal Neuroendocrine Tumours (dNETs) (Conference Paper)
Exarchou, K., Howes, N., Moore, A., Duckworth, C. A., & Pritchard, D. M. (2019). Endoscopic Surveillance Is a Viable Alternative Management Strategy for Patients with Localised Small Non-Functional Low Grade Duodenal Neuroendocrine Tumours (dNETs). In NEUROENDOCRINOLOGY Vol. 108 (pp. 56). Retrieved from https://www.webofscience.com/
Endoscopic surveillance is a viable alternative management strategy for patients with localised small non-functional low grade duodenal neuroendocrine tumours (dNETs) (Conference Paper)
Exarchou, K., Howes, N., Moore, A., Duckworth, C. A., & Pritchard, D. M. (2019). Endoscopic surveillance is a viable alternative management strategy for patients with localised small non-functional low grade duodenal neuroendocrine tumours (dNETs). In BRITISH JOURNAL OF SURGERY Vol. 106 (pp. 74). Retrieved from https://www.webofscience.com/
2018
Mahalhal, A., Williams, J. M., Johnson, S., Ellaby, N., Duckworth, C. A., Burkitt, M. D., . . . Probert, C. S. (2018). Oral iron exacerbates colitis and influences the intestinal microbiome. PLOS ONE, 13(10). doi:10.1371/journal.pone.0202460DOI: 10.1371/journal.pone.0202460
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget, 9(43), 27104-27116. doi:10.18632/oncotarget.25497DOI: 10.18632/oncotarget.25497
GLIADIN PEPTIDE P56-68 ENHANCES EPITHELIAL PERMEABILITY IN A 3D ENTEROID MODEL (Conference Paper)
Thompson, L., Vaida, A., Campbell, B., & Duckworth, C. (2018). GLIADIN PEPTIDE P56-68 ENHANCES EPITHELIAL PERMEABILITY IN A 3D ENTEROID MODEL. In GUT Vol. 67 (pp. A163). doi:10.1136/gutjnl-2018-BSGAbstracts.323DOI: 10.1136/gutjnl-2018-BSGAbstracts.323
2017
parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison Of The Human Gastric Microbiota In Hypochlorhydric States Arising As A Result Of Helicobacter pylori-Induced Atrophic Gastritis, Autoimmune Atrophic Gastritis And Proton Pump Inhibitor Use. PLoS Pathogens. doi:10.1101/144907DOI: 10.1101/144907
Parsons, B. N., Ijaz, U. Z., D'Amore, R., Burkitt, M. D., Eccles, R., Lenzi, L., . . . Pritchard, D. M. (2017). Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use. PLoS Pathogens, 13(11). doi:10.1371/journal.ppat.1006653DOI: 10.1371/journal.ppat.1006653
Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., & Pritchard, D. M. (2017). Mice lacking NF-kappa B1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration. CELL DEATH & DISEASE, 8. doi:10.1038/cddis.2017.332DOI: 10.1038/cddis.2017.332
Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. doi:10.1016/j.pharmthera.2017.01.002DOI: 10.1016/j.pharmthera.2017.01.002
Burkitt, M. D., Duckworth, C. A., Williams, J. M., & Pritchard, D. M. (2017). Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. DISEASE MODELS & MECHANISMS, 10(2), 89-104. doi:10.1242/dmm.027649DOI: 10.1242/dmm.027649
2016
Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression (Journal article)
Duckworth, C., Zhang, L., Carroll, S. L., Ethier, S. P., & Cheung, H. W. (2016). Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression. ONCOGENE, 35(31), 4036-4047. doi:10.1038/onc.2015.472DOI: 10.1038/onc.2015.472
Elramli, A. H., Duckworth, C. A., Campbell, B. J., & Pritchard, D. M. (2016). ANTI-CD3 ANTIBODY INDUCES T-CELL MEDIATED APOPTOSIS AND SHEDDING OF MURINE SMALL INTESTINAL EPITHELIAL CELLS. In GUT Vol. 65 (pp. A75). doi:10.1136/gutjnl-2016-312388.134DOI: 10.1136/gutjnl-2016-312388.134
Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis (Journal article)
Merga, Y. J., O Hara, A., Burkitt, M. D., Duckworth, C. A., Probert, C. S., Campbell, B. J., & Pritchard, D. M. (2016). Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 310(11), G1081-G1090. doi:10.1152/ajpgi.00026.2016DOI: 10.1152/ajpgi.00026.2016
Williams, J. M., Duckworth, C. A., Vowell, K., Burkitt, M. D., & Pritchard, D. M. (2016). Intestinal Preparation Techniques for Histological Analysis in the Mouse.. Current protocols in mouse biology, 6(2), 148-168. doi:10.1002/cpmo.2DOI: 10.1002/cpmo.2
2015
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409DOI: 10.18632/oncotarget.4409
bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice (Journal article)
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., Williams, J. M., O'Reilly, L. A., & Pritchard, D. M. (2015). bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(6), G420-G430. doi:10.1152/ajpgi.00404.2014DOI: 10.1152/ajpgi.00404.2014
NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice (Journal article)
Burkitt, M., Hanedi, A. F., Duckworth, C., Williams, J. M., Tang, J. M., O'Reilly, L. A., . . . Pritchard, M. (2015). NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. The Journal of Pathology, 236(3), 326-336. doi:10.1002/path.4527DOI: 10.1002/path.4527
Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer. (Journal article)
Duckworth, C. A., Burkitt, M. D., Williams, J. M., Parsons, B. N., Tang, J. M. F., & Pritchard, D. M. (2015). Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.. Current protocols in pharmacology, 69, 14.34.1-14.34.35. doi:10.1002/0471141755.ph1434s69DOI: 10.1002/0471141755.ph1434s69
TAMOXIFEN INDUCED GASTRIC ATROPHY IS REGULATED BY THE NF-B SUBUNIT NFKB1 (Conference Paper)
Williams, J. M., Norman, R., Tang, J. M., Duckworth, C. A., Caamano, J., Pritchard, D. M., & Burkitt, M. D. (2015). TAMOXIFEN INDUCED GASTRIC ATROPHY IS REGULATED BY THE NF-B SUBUNIT NFKB1. In GUT Vol. 64 (pp. A482). doi:10.1136/gutjnl-2015-309861.1056DOI: 10.1136/gutjnl-2015-309861.1056
Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip (Journal article)
Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., & Pritchard, D. M. (2015). Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip. VETERINARY PATHOLOGY, 52(3), 445-455. doi:10.1177/0300985814559404DOI: 10.1177/0300985814559404
Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis (Conference Paper)
Bharucha, S., Geraghty, J., Duckworth, C. A., Armstrong, J., Szatmary, P., Winn, S. A., . . . Sutton, R. (2015). Confocal Endomicroscopy Demonstrates Increased Intestinal Permeability and Gut Dysfunction in Patients With Acute and Chronic Pancreatitis. In GASTROENTEROLOGY Vol. 148 (pp. S145). Retrieved from https://www.webofscience.com/
Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System (Conference Paper)
Burkitt, M. D., Jones, L. G., Caamano, J., Pritchard, D. M., & Duckworth, C. A. (2015). Intestinal Epithelial Cell Specific Deletion of Nfkb2 Protects Against Immune Cell Derived Damage-Inducing Factors in an Enteroid and Bone Marrow Derived Dendritic Cell Co-Culture System. In GASTROENTEROLOGY Vol. 148 (pp. S8-S9). Retrieved from https://www.webofscience.com/
NFKB1 DEFICIENCY ALTERS SUSCEPTIBILITY TO HELICOBACTER SPP. INDUCED IL-1 SECRETION IN BONE MARROW DERIVED DENDRITIC CELLS (Conference Paper)
Tang, J. M., Pritchard, D. M., Duckworth, C. A., Caamano, J., & Burkitt, M. D. (2015). NFKB1 DEFICIENCY ALTERS SUSCEPTIBILITY TO HELICOBACTER SPP. INDUCED IL-1 SECRETION IN BONE MARROW DERIVED DENDRITIC CELLS. In GUT Vol. 64 (pp. A22-A23). Retrieved from https://www.webofscience.com/
NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1 beta Secretion in Bone Marrow Derived Dendritic Cells (Conference Paper)
Tang, J. M., Duckworth, C. A., Pritchard, D. M., Caamano, J., & Burkitt, M. D. (2015). NFKB1 Deficiency Alters Susceptibility to Helicobacter spp. Induced IL-1 beta Secretion in Bone Marrow Derived Dendritic Cells. In GASTROENTEROLOGY Vol. 148 (pp. S118). Retrieved from https://www.webofscience.com/
Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-kappa B Subunit NFKB1 (Conference Paper)
Williams, J. M., Norman, R., Tang, J. M., Caamano, J., Duckworth, C. A., Pritchard, D. M., & Burkitt, M. D. (2015). Tamoxifen Induced Gastric Atrophy Is Regulated by the NF-kappa B Subunit NFKB1. In GASTROENTEROLOGY Vol. 148 (pp. S565). Retrieved from https://www.webofscience.com/
2014
Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1 (Journal article)
Zhao, Q., Duckworth, C. A., Wang, W. K., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galactin-3 to promote metastasis by interaction with cancer-associated MUC1. Carcinogenesis, 35(12), 2815-2821. doi:10.1093/carcin/bgu216DOI: 10.1093/carcin/bgu216
Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1 (Journal article)
Zhao, Q., Duckworth, C. A., Wang, W., Guo, X., Barrow, H., Pritchard, D. M., . . . Yu, L. -G. (2014). Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1. Carcinogenesis, 35(12), 2815-2821. doi:10.1093/carcin/bgu216DOI: 10.1093/carcin/bgu216
A METABOLOMIC PROFILING STUDY OF A CHEMICALLY-INDUCED MOUSE MODEL OF INTESTINAL INFLAMMATION (Conference Paper)
Reade, S., Duckworth, C. A., Khalid, T., Mayor, A., Aggio, R., Pritchard, D. M., & Probert, C. S. (2014). A METABOLOMIC PROFILING STUDY OF A CHEMICALLY-INDUCED MOUSE MODEL OF INTESTINAL INFLAMMATION. In GUT Vol. 63 (pp. A172). doi:10.1136/gutjnl-2014-307263.369DOI: 10.1136/gutjnl-2014-307263.369
Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis (Journal article)
Chen, C., Duckworth, C. A., Fu, B., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2014). Circulating galectins-2,-4 and-8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis. BRITISH JOURNAL OF CANCER, 110(3), 741-752. doi:10.1038/bjc.2013.793DOI: 10.1038/bjc.2013.793
Deletion of specific NF-κB proteins regulates susceptibility to colitis associated adenoma development in C57BL/6 mice as a result of altered inflammatory and DNA damage responses (Journal article)
Burkitt, M. D., Hanedi, A., Duckworth, C. A., Williams, J. M., Dimaline, R., Caamano, J., & Pritchard, D. M. (2014). Deletion of specific NF-κB proteins regulates susceptibility to colitis associated adenoma development in C57BL/6 mice as a result of altered inflammatory and DNA damage responses. PLOS Genetics.
PWE-109 A Metabolomic Profiling Study Of A Chemically-induced Mouse Model Of Intestinal Inflammation (Conference Paper)
Reade, S., Duckworth, C. A., Khalid, T., Mayor, A., Aggio, R., Pritchard, D. M., & Probert, C. S. (2014). PWE-109 A Metabolomic Profiling Study Of A Chemically-induced Mouse Model Of Intestinal Inflammation. In Gut Vol. 63 (pp. A172).
2013
Signaling mediated by the NF-kappa B sub-units NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice (Journal article)
Burkitt, M. D., Williams, J. M., Duckworth, C. A., O'Hara, A., Hanedi, A., Varro, A., . . . Pritchard, D. M. (2013). Signaling mediated by the NF-kappa B sub-units NF-kappa B1, NF-kappa B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. ONCOGENE, 32(50), 5563-5573. doi:10.1038/onc.2013.334DOI: 10.1038/onc.2013.334
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide (Journal article)
Williams, J. M., Duckworth, C. A., Watson, A. J. M., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. DISEASE MODELS & MECHANISMS, 6(6), 1388-1399. doi:10.1242/dmm.013284DOI: 10.1242/dmm.013284
Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium (Journal article)
Chen, C., Duckworth, C. A., Zhao, Q., Pritchard, D. M., Rhodes, J. M., & Yu, L. -G. (2013). Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium. CLINICAL CANCER RESEARCH, 19(7), 1693-1704. doi:10.1158/1078-0432.CCR-12-2940DOI: 10.1158/1078-0432.CCR-12-2940
Suppression of Core 1 Gal-Transferase Is Associated with Reduction of TF and Reciprocal Increase of Tn, sialyl-Tn and Core 3 Glycans in Human Colon Cancer Cells (Journal article)
Barrow, H., Tam, B., Duckworth, C. A., Rhodes, J. M., & Yu, L. -G. (2013). Suppression of Core 1 Gal-Transferase Is Associated with Reduction of TF and Reciprocal Increase of Tn, sialyl-Tn and Core 3 Glycans in Human Colon Cancer Cells. PLOS ONE, 8(3). doi:10.1371/journal.pone.0059792DOI: 10.1371/journal.pone.0059792
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide (Journal article)
Williams, J. M., Duckworth, C. A., Watson, A. J. M., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, M. D. (2013). A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. Disease Models & Mechanisms.
Deletion of Specific NF kappa B Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses (Journal article)
Hanedi, A., Burkitt, M. D., Williams, J. M., Duckworth, C. A., Caamano, J., & Pritchard, D. M. (2013). Deletion of Specific NF kappa B Proteins Regulates Susceptibility to Developing Colitis Associated Cancer in C57BL/6 Mice As a Result of Altered Inflammatory and DNA Damage Responses. GASTROENTEROLOGY, 144(5), S136. Retrieved from https://www.webofscience.com/
Galectins in the blood circulation: potential therapeutic targets of cancer metastasis (Journal article)
Duckworth, C. A., & Yu, L. G. (2013). Galectins in the blood circulation: potential therapeutic targets of cancer metastasis. ACS, 115, 310-322.
Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NF kappa B Signalling (Journal article)
Williams, J. M., Duckworth, C. A., Campbell, B. J., Frey, M. R., Miguel, J. C., Burkitt, M. D., . . . Pritchard, D. M. (2013). Lipopolysaccharide Induces Small Intestinal Epithelial Cell Apoptosis and Shedding by a TLR4 and TNFR1 Dependent Mechanism, Which Is Regulated by NF kappa B Signalling. GASTROENTEROLOGY, 144(5), S668. Retrieved from https://www.webofscience.com/
Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice (Journal article)
Duckworth, C. A., Clyde, D., Worthley, D. L., Wang, T. C., Varro, A., & Pritchard, D. M. (2013). Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice. GASTROENTEROLOGY, 145(1), 197-+. doi:10.1053/j.gastro.2013.03.012DOI: 10.1053/j.gastro.2013.03.012
2012
Galectins in the Blood Circulation: Potential Therapeutic Targets of Cancer Metastasis (Chapter)
Duckworth, C. A., & Yu, L. -G. (2012). Galectins in the Blood Circulation: Potential Therapeutic Targets of Cancer Metastasis. In Unknown Book (Vol. 1115, pp. 309-+). Retrieved from https://www.webofscience.com/
CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach (Journal article)
Duckworth, C. A., Clyde, D., & Pritchard, D. M. (2012). CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 303(8), G915-G926. doi:10.1152/ajpgi.00068.2012DOI: 10.1152/ajpgi.00068.2012
Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease (Journal article)
Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., . . . Watson, A. J. M. (2012). Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut, 61(8), 1146-1153. doi:10.1136/gutjnl-2011-300695DOI: 10.1136/gutjnl-2011-300695
Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease (Journal article)
Kiesslich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., . . . Watson, A. J. M. (2012). Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. GUT, 61(8), 1146-1153. doi:10.1136/gutjnl-2011-300695DOI: 10.1136/gutjnl-2011-300695
ALTERED TRAIL, CASPASE12, BAK AND FAS-L EXPRESSIONS ARE ASSOCIATED WITH INCREASED SUSCEPTIBILITY TO RADIATION INDUCED INTESTINAL EPITHELIAL APOPTOSIS IN NF-kappa B1-NULL AND NF-kappa B2-NULL MICE (Journal article)
Hanedi, A., Burkitt, M. D., Duckworth, C. A., Dimaline, R., Caamano, J. H., & Pritchard, D. M. (2012). ALTERED TRAIL, CASPASE12, BAK AND FAS-L EXPRESSIONS ARE ASSOCIATED WITH INCREASED SUSCEPTIBILITY TO RADIATION INDUCED INTESTINAL EPITHELIAL APOPTOSIS IN NF-kappa B1-NULL AND NF-kappa B2-NULL MICE. GUT, 61, A8-A9. doi:10.1136/gutjnl-2012-302514a.19DOI: 10.1136/gutjnl-2012-302514a.19
LIPOPOLYSACCHARIDE INDUCES SMALL INTESTINAL EPITHELIAL CELL APOPTOSIS AND SHEDDING WHICH IS REGULATED BY NF kappa B SIGNALLING (Journal article)
Williams, J. M., Duckworth, C. A., Campbell, B. J., & Pritchard, D. M. (2012). LIPOPOLYSACCHARIDE INDUCES SMALL INTESTINAL EPITHELIAL CELL APOPTOSIS AND SHEDDING WHICH IS REGULATED BY NF kappa B SIGNALLING. GUT, 61, A342. doi:10.1136/gutjnl-2012-302514d.111DOI: 10.1136/gutjnl-2012-302514d.111
NF-kappa B2 DELETION PROTECTS MURINE COLON AGAINST DSS-INDUCED COLITIS AND THIS IS ASSOCIATED WITH REDUCED EXPRESSION OF TNF-alpha AND IL14 (Journal article)
Hanedi, A., Burkitt, M. D., Duckworth, C. A., Dimaline, R., Caamano, J. H., & Pritchard, D. M. (2012). NF-kappa B2 DELETION PROTECTS MURINE COLON AGAINST DSS-INDUCED COLITIS AND THIS IS ASSOCIATED WITH REDUCED EXPRESSION OF TNF-alpha AND IL14. GUT, 61, A165-A166. doi:10.1136/gutjnl-2012-302514b.224DOI: 10.1136/gutjnl-2012-302514b.224
2011
CLASSICAL AND ALTERNATIVE PATHWAY NF-KB SIGNALLING REGULATE GASTRIC EPITHELIAL RESPONSES TO GAMMA-IRRADIATION (Journal article)
Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J. H., & Pritchard, D. M. (2011). CLASSICAL AND ALTERNATIVE PATHWAY NF-KB SIGNALLING REGULATE GASTRIC EPITHELIAL RESPONSES TO GAMMA-IRRADIATION. GUT, 60, A9. doi:10.1136/gut.2011.239301.17DOI: 10.1136/gut.2011.239301.17
NF-KB1 AND NF-KB2 REGULATE SUSCEPTIBILITY TO DNA DAMAGE INDUCED INTESTINAL EPITHELIAL APOPTOSIS IN VIVO (Conference Paper)
Hanedi, A., Duckworth, C. A., Burkitt, M. D., Caamano, J. H., & Pritchard, D. M. (2011). NF-KB1 AND NF-KB2 REGULATE SUSCEPTIBILITY TO DNA DAMAGE INDUCED INTESTINAL EPITHELIAL APOPTOSIS IN VIVO. In GUT Vol. 60. doi:10.1136/gut.2011.239301.39DOI: 10.1136/gut.2011.239301.39
Analysis of Epithelial Cell Shedding and Gaps in the Intestinal Epithelium (Journal article)
Duckworth, C. A., & Watson, A. J. (2011). Analysis of Epithelial Cell Shedding and Gaps in the Intestinal Epithelium. PERMEABILITY BARRIER: METHODS AND PROTOCOLS, 763, 105-114. doi:10.1007/978-1-61779-191-8_7DOI: 10.1007/978-1-61779-191-8_7
Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter fells Infection In Vivo (Journal article)
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., & Pritchard, D. M. (2011). Bak Deficiency Alters Gastric Epithelial Homeostasis and Modulates the Consequences of Helicobacter fells Infection In Vivo. GASTROENTEROLOGY, 140(5), S824. Retrieved from https://www.webofscience.com/
CD24 Co-Localises With DCAMKL-1 in the Intestine and Regulates Epithelial Apoptosis and Crypt Regeneration Following Damage Inducing Stimuli (Journal article)
Duckworth, C. A., Clyde, D., & Pritchard, D. M. (2011). CD24 Co-Localises With DCAMKL-1 in the Intestine and Regulates Epithelial Apoptosis and Crypt Regeneration Following Damage Inducing Stimuli. GASTROENTEROLOGY, 140(5), S6. Retrieved from https://www.webofscience.com/
Classical and Alternative Pathway Nuclear Factor-kappa B Signalling Regulate Gastric Epithelial Responses to gamma-Irradiation (Journal article)
Burkitt, M. D., Duckworth, C. A., Varro, A., Caamano, J., & Pritchard, D. M. (2011). Classical and Alternative Pathway Nuclear Factor-kappa B Signalling Regulate Gastric Epithelial Responses to gamma-Irradiation. GASTROENTEROLOGY, 140(5), S823. Retrieved from https://www.webofscience.com/
Deletion of Bak Leads to Expansion of the Stem Cell Niche in Murine Colonic Crypts (Journal article)
Duckworth, C. A., Stezhka, T., & Pritchard, D. M. (2011). Deletion of Bak Leads to Expansion of the Stem Cell Niche in Murine Colonic Crypts. GASTROENTEROLOGY, 140(5), S39-S40. Retrieved from https://www.webofscience.com/
Epithelial Cell Shedding is Followed by Leakage of Circulatory Components and is Modulated by Luminal Osmolarity (Journal article)
Duckworth, C. A., Moussata, D., Kiesslich, R., & Watson, A. J. (2011). Epithelial Cell Shedding is Followed by Leakage of Circulatory Components and is Modulated by Luminal Osmolarity. GASTROENTEROLOGY, 140(5), S63. Retrieved from https://www.webofscience.com/
NF-κB1 and NF-κB2 regulate susceptibility to DNA damage induced intestinal epithelial apopotosis in vivo (Journal article)
Hanedi, A., Duckworth, C. A., Burkitt, M. D., Caamano, J. H., & Pritchard, D. M. (2011). NF-κB1 and NF-κB2 regulate susceptibility to DNA damage induced intestinal epithelial apopotosis in vivo. Gut, 60, A9.
Progastrin stimulates colonic myofibroblast proliferation in vitro and its transgenic over-expression increases colonic myofibroblast abundance in vivo (Journal article)
Clyde, D., Duckworth, C. A., Varro, A., Wang, T. C., & Pritchard, D. M. (2011). Progastrin stimulates colonic myofibroblast proliferation in vitro and its transgenic over-expression increases colonic myofibroblast abundance in vivo. Gastroenterology, 140(5), S106.
The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding (Journal article)
Marchiando, A. M., Shen, L., Graham, W. V., Edelblum, K. L., Duckworth, C. A., Guan, Y., . . . Watson, A. J. M. (2011). The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding. GASTROENTEROLOGY, 140(4), 1208-+. doi:10.1053/j.gastro.2011.01.004DOI: 10.1053/j.gastro.2011.01.004
Understanding gene-environment interactions in a mouse model of Crohn's disease (Journal article)
Duckworth, C. A. (2011). Understanding gene-environment interactions in a mouse model of Crohn's disease. DISEASE MODELS & MECHANISMS, 4(1), 7-8. doi:10.1242/dmm.007120DOI: 10.1242/dmm.007120
2010
Gut microbiota control gut permeability through GLP-2. (Journal article)
Watson, A. J. M., & Duckworth, C. A. (2010). Gut microbiota control gut permeability through GLP-2.. Gastroenterology, 138(2), 779-781. doi:10.1053/j.gastro.2009.12.017DOI: 10.1053/j.gastro.2009.12.017
2009
Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function (Journal article)
Watson, A. J. M., Duckworth, C. A., Guan, Y., & Montrose, M. H. (2009). Mechanisms of Epithelial Cell Shedding in the Mammalian Intestine and Maintenance of Barrier Function. MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS, 1165, 135-142. doi:10.1111/j.1749-6632.2009.04027.xDOI: 10.1111/j.1749-6632.2009.04027.x
Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of Bak-Null Mice (Journal article)
Duckworth, C. A., & Pritchard, D. M. (2009). Suppression of Apoptosis, Crypt Hyperplasia, and Altered Differentiation in the Colonic Epithelia of Bak-Null Mice. GASTROENTEROLOGY, 136(3), 943-952. doi:10.1053/j.gastro.2008.11.036DOI: 10.1053/j.gastro.2008.11.036
2008
Genetic regulation of intestinal epithelial homeostasis in health and following injury (Thesis / Dissertation)
Duckworth, C. A. (2008). Genetic regulation of intestinal epithelial homeostasis in health and following injury. (PhD Thesis, The University of Liverpool).
2007
Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2 (Journal article)
Przemeck, S. M. C., Duckworth, C. A., & Pritchard, D. M. (2007). Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 292(2), G620-G627. doi:10.1152/ajpgi.00391.2006DOI: 10.1152/ajpgi.00391.2006
Bak-null mice demonstrate suppression of epithelial apoptosis, crypt hyperplasia and altered differentiation in the colon, and are more susceptible to colonic carcinogenesis (Journal article)
Duckworth, C. A., & Pritchard, D. M. (2007). Bak-null mice demonstrate suppression of epithelial apoptosis, crypt hyperplasia and altered differentiation in the colon, and are more susceptible to colonic carcinogenesis. GASTROENTEROLOGY, 132(4), A154. Retrieved from https://www.webofscience.com/
2006
Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo (Journal article)
Przemeck, S., Duckworth, C. A., Varro, A., Pritchard, D., & Pritchard, M. (2006). Gastrin and members of the bcl-2 family regulate gastric epithelial apoptosis in vivo. GUT, 55, A61. Retrieved from https://www.webofscience.com/
Gastrin increases murine intestinal crypt regeneration following injury (Journal article)
Ottewell, P. D., Duckworth, C. A., Varro, A., Dimaline, R., Wang, T. C., Watson, A. J. M., . . . Pritchard, D. M. (2006). Gastrin increases murine intestinal crypt regeneration following injury. GASTROENTEROLOGY, 130(4), 1169-1180. doi:10.1053/j.gastro.2005.12.033DOI: 10.1053/j.gastro.2005.12.033
Suppression of colonic epithelial apoptosis and crypt hyperplasia occurs in bak-null mice (Journal article)
Duckworth, C. A., & Pritchard, D. M. (2006). Suppression of colonic epithelial apoptosis and crypt hyperplasia occurs in bak-null mice. GUT, 55, A9. Retrieved from https://www.webofscience.com/
2005
Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice. (Journal article)
Duckworth, C. A., Ottewell, P. D., Varro, A., Dimaline, R., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced intestinal mucositis in mice.. GASTROENTEROLOGY, 128(4), A203. Retrieved from https://www.webofscience.com/
Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice (Journal article)
Duckworth, C. A., Ottewell, P. D., Dimaline, R., Varro, A., & Pritchard, D. M. (2005). Hypergastrinaemia reduces the severity of dextran sulphate sodium induced colitis and 5-fluorouracil induced mucositis in mice. GUT, 54, A98. Retrieved from https://www.webofscience.com/
