2023
Parmar, A., Lakshminarayanan, R., Iyer, A., Goh, E. T. L., To, T. Y., Yam, J. K. H., . . . Singh, I. (2023). Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms.. European journal of medicinal chemistry, 261, 115853. doi:10.1016/j.ejmech.2023.115853DOI: 10.1016/j.ejmech.2023.115853
Wang, X., van Beekveld, R. A. M., Xu, Y., Parmar, A., Das, S., Singh, I., & Breukink, E. (2023). Analyzing mechanisms of action of antimicrobial peptides on bacterial membranes requires multiple complimentary assays and different bacterial strains.. Biochimica et biophysica acta. Biomembranes, 184160. doi:10.1016/j.bbamem.2023.184160DOI: 10.1016/j.bbamem.2023.184160
2020
Shukla, R., Medeiros-Silva, J., Parmar, A., Vermeulen, B. J. A., Das, S., Paioni, A. L., . . . Weingarth, M. (2020). Mode of action of teixobactins in cellular membranes. Nature Communications, 11(1). doi:10.1038/s41467-020-16600-2DOI: 10.1038/s41467-020-16600-2
2018
Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant <i>Staphylococcus Aureus</i> (MRSA) (Journal article)
Malkawi, R., Iyer, A., Parmar, A., Lloyd, D. G., Goh, E. T. L., Taylor, E. J., . . . Singh, I. (2018). Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant <i>Staphylococcus Aureus</i> (MRSA). PHARMACEUTICS, 10(4). doi:10.3390/pharmaceutics10040183DOI: 10.3390/pharmaceutics10040183
Design and Syntheses of Highly Potent Teixobactin Analogues against <i>Staphylococcus</i> <i>aureus</i>, Methicillin-Resistant <i>Staphylococcus</i> <i>aureus</i> (MRSA), and Vancomycin-Resistant Enterococci (VRE) <i>in Vitro</i> and <i>in Vivo</i> (Journal article)
Parmar, A., Lakshminarayanan, R., Iyer, A., Mayandi, V., Goh, E. T. L., Lloyd, D. G., . . . Singh, I. (2018). Design and Syntheses of Highly Potent Teixobactin Analogues against <i>Staphylococcus</i> <i>aureus</i>, Methicillin-Resistant <i>Staphylococcus</i> <i>aureus</i> (MRSA), and Vancomycin-Resistant Enterococci (VRE) <i>in Vitro</i> and <i>in Vivo</i>. JOURNAL OF MEDICINAL CHEMISTRY, 61(5), 2009-2017. doi:10.1021/acs.jmedchem.7b01634DOI: 10.1021/acs.jmedchem.7b01634
2017
Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding (Journal article)
Parmar, A., Iyer, A., Prior, S. H., Lloyd, D. G., Goh, E. T. L., Vincent, C. S., . . . Singh, I. (2017). Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. CHEMICAL SCIENCE, 8(12), 8183-8192. doi:10.1039/c7sc03241bDOI: 10.1039/c7sc03241b
Syntheses of potent teixobactin analogues against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) through the replacement of L-<i>allo</i>-enduracididine with its isosteres (Journal article)
Parmar, A., Iyer, A., Lloyd, D. G., Vincent, C. S., Prior, S. H., Madder, A., . . . Singh, I. (2017). Syntheses of potent teixobactin analogues against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) through the replacement of L-<i>allo</i>-enduracididine with its isosteres. CHEMICAL COMMUNICATIONS, 53(55), 7788-7791. doi:10.1039/c7cc04021kDOI: 10.1039/c7cc04021k
Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities (Journal article)
Parmar, A., Prior, S. H., Iyer, A., Vincent, C. S., Van Lysebetten, D., Breukink, E., . . . Singh, I. (2017). Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities. CHEMICAL COMMUNICATIONS, 53(12), 2016-2019. doi:10.1039/c6cc09490bDOI: 10.1039/c6cc09490b
2016
Efficient total syntheses and biological activities of two teixobactin analogues (Journal article)
Parmar, A., Iyer, A., Vincent, C. S., Van Lysebetten, D., Prior, S. H., Madder, A., . . . Singh, I. (2016). Efficient total syntheses and biological activities of two teixobactin analogues. CHEMICAL COMMUNICATIONS, 52(36), 6060-6063. doi:10.1039/c5cc10249aDOI: 10.1039/c5cc10249a
