Em P Ana Alfirevic MD, PhD
Professor Pharmacology & Therapeutics
- Work email Ana.Alfirevic@liverpool.ac.uk
Publications
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2021
Maternal selenium levels and whole genome screen in recurrent spontaneous preterm birth population: A nested case control study (Journal article)
Care, A. G., Gupta, J. K., Goodfellow, L., Zhang, G., Monangi, N., Belling, E., . . . Alfirevic, Z. (2021). Maternal selenium levels and whole genome screen in recurrent spontaneous preterm birth population: A nested case control study. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 265, 203-211. doi:10.1016/j.ejogrb.2021.08.015
Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach (Journal article)
Gupta, J. K., Care, A., Goodfellow, L., Alfirevic, Z., Lian, L. -Y., Mueller-Myhsok, B., . . . Phelan, M. M. (2021). Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach. BIOSCIENCE REPORTS, 41(9). doi:10.1042/BSR20210759
The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review (Journal article)
Jones, S. W., Ball, A. L., Chadwick, A. E., & Alfirevic, A. (n.d.). The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review. Frontiers in Genetics, 12. doi:10.3389/fgene.2021.698825
Plasma long-chain omega-3 fatty acid status and risk of recurrent early spontaneous preterm birth: a prospective observational study (Journal article)
Goodfellow, L., Care, A., Harrold, J., Sharp, A., Ivandic, J., Poljak, B., . . . Alfirevic, Z. (2021). Plasma long-chain omega-3 fatty acid status and risk of recurrent early spontaneous preterm birth: a prospective observational study. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 100(8), 1401-1411. doi:10.1111/aogs.14147
Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study (Journal article)
Goodfellow, L., Verwijs, M. C., Care, A., Sharp, A., Ivandic, J., Poljak, B., . . . van de Wijgert, J. H. H. M. (2021). Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. doi:10.1111/1471-0528.16816
Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01 (Journal article)
Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084
Assessing measures of aspirin adherence in pregnancy: Secondary analysis of the TEST randomized controlled trial (Journal article)
Mone, F., Mulcahy, C., Navaratnam, K., Phelan, M. M., Breathnach, F., Alfirevic, A., & McAuliffe, F. M. (2021). Assessing measures of aspirin adherence in pregnancy: Secondary analysis of the TEST randomized controlled trial. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 259, 222-223. doi:10.1016/j.ejogrb.2020.11.058
Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers (Journal article)
Ball, A. L., Bloch, K. M., Rainbow, L., Liu, X., Kenny, J., Lyon, J. J., . . . Chadwick, A. E. (n.d.). Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers. Archives of Toxicology. doi:10.1007/s00204-021-02988-3
An assessment of drug-induced rhabdomyolysis cases within the US Food and Drug Administration Adverse Event Reporting System (Conference Paper)
Bin Dayel, F., Alfirevic, A., Turner, R., & Chadwick, A. (2021). An assessment of drug-induced rhabdomyolysis cases within the US Food and Drug Administration Adverse Event Reporting System. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 87 (pp. 1617-1618). Retrieved from http://gateway.webofknowledge.com/
Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study (Journal article)
Goodfellow, L., Verwijs, M. C., Care, A., Sharp, A., Ivandic, J., Poljak, B., . . . van de Wijgert, J. H. H. M. (n.d.). Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study. doi:10.1101/2021.01.14.21249680
Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex (Journal article)
Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., . . . Dickens, D. (2021). Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. MOLECULAR PHARMACEUTICS, 18(1), 113-123. doi:10.1021/acs.molpharmaceut.0c00727
Identification of early pregnancy metabolomic biomarkers of women at high-risk of preterm birth using NMR and mGWAS (Conference Paper)
Gupta, J., Care, A., Goodfellow, L., Alfirevic, Z., Lian, L. -Y., Muller-Myhsok, B., . . . Phelan, M. (2021). Identification of early pregnancy metabolomic biomarkers of women at high-risk of preterm birth using NMR and mGWAS. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 432-433). Retrieved from http://gateway.webofknowledge.com/
Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex (Conference Paper)
Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M., Snodgrass, R., . . . Dickens, D. (2021). Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 463). Retrieved from http://gateway.webofknowledge.com/
2020
Examining the uptake of predictive BRCA testing in the UK; findings and implications (Journal article)
Martin, A., Downing, J., Collins, B., Godman, B., Alfirevic, A., Greenhalgh, L., & Pirmohamed, M. (2020). Examining the uptake of predictive BRCA testing in the UK; findings and implications. European Journal of Human Genetics, 2020. doi:10.1038/s41431-020-00783-9
Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment (Journal article)
Rasmussen, E. R., Hallberg, P., Baranova, E. V., Eriksson, N., Karawajczyk, M., Johansson, C., . . . Wadelius, M. (2020). Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment. PHARMACOGENOMICS JOURNAL, 20(6), 770-783. doi:10.1038/s41397-020-0165-2
Characterization of Clozapine-Responsive Human T Cells (Journal article)
Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646
Safety perspectives on presently considered drugs for the treatment of COVID-19 (Journal article)
Penman, S. L., Kiy, R. T., Jensen, R. L., Beoku-Betts, C., Alfirevic, A., Back, D., . . . Chadwick, A. E. (n.d.). Safety perspectives on presently considered drugs for the treatment of COVID-19. British Journal of Pharmacology. doi:10.1111/bph.15204
The longitudinal NIHR ARC North West Coast Household Health Survey: Exploring health inequalities in disadvantaged communities (Journal article)
Giebel, C., McIntyre, J., Alfirevic, A., Corcoran, R., Daras, K., Downing, J., . . . Barr, B. (2020). The longitudinal NIHR ARC North West Coast Household Health Survey: Exploring health inequalities in disadvantaged communities. BMC Public Health, 20. doi:10.1186/s12889-020-09346-5
Pharmacogenetics and statin-related myopathy: what do we know? (Journal article)
Turner, R. M., Radman, I., Bozina, N., & Alfirevic, A. (2020). Pharmacogenetics and statin-related myopathy: what do we know?. PHARMACOGENOMICS, 21(12), 821-825. doi:10.2217/pgs-2020-0041
Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker–Induced Angioedema (Journal article)
Maroteau, C., Siddiqui, M. K., Veluchamy, A., Carr, F., White, M., Cassidy, A. J., . . . PREDICTION-ADR. (2020). Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker–Induced Angioedema. CLINICAL PHARMACOLOGY & THERAPEUTICS. doi:10.1002/cpt.1927
The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier (Conference Paper)
Patel, W., Smith, M., Snodgrass, R., Pirmohamed, M., Alfirevic, A., & Dickens, D. (2020). The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 177 (pp. 2621-2622). Retrieved from http://gateway.webofknowledge.com/
Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study (Journal article)
Alfirevic, A., Downing, J., Daras, K., Comerford, T., Pirmohamed, M., & Barr, B. (2020). Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study. BMJ Open, 10(5). doi:10.1136/bmjopen-2019-033357
Genetic associations with clozapine-induced myocarditis in patients with schizophrenia (Journal article)
Lacaze, P., Ronaldson, K. J., Zhang, E. J., Alfirevic, A., Shah, H., Newman, L., . . . Pirmohamed, M. (2020). Genetic associations with clozapine-induced myocarditis in patients with schizophrenia. TRANSLATIONAL PSYCHIATRY, 10(1). doi:10.1038/s41398-020-0722-0
Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools (Journal article)
Gonzalez-Galarza, F. F., McCabe, A., Santos, E. J. M. D., Jones, J., Takeshita, L., Ortega-Rivera, N. D., . . . Jones, A. R. (n.d.). Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools. Nucleic Acids Research. doi:10.1093/nar/gkz1029
2019
Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink (Journal article)
Carr, D. (2019). Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink. Clinical Pharmacology and Therapeutics, 106(6), 1353-1361. doi:10.1002/cpt.1557
TRENDS AND UPTAKE OF PREDICTIVE BRCA TESTING (Conference Paper)
Martin, A., Pedra, G., Downing, J., Godman, B., Alfirevic, A., Greenhalgh, K. L., & Pirmohamed, M. (2019). TRENDS AND UPTAKE OF PREDICTIVE BRCA TESTING. In VALUE IN HEALTH Vol. 22 (pp. S428). Retrieved from http://gateway.webofknowledge.com/
Trends in BRCA testing and socioeconomic deprivation (Journal article)
Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (2019). Trends in BRCA testing and socioeconomic deprivation. EUROPEAN JOURNAL OF HUMAN GENETICS, 27(9), 1351-1360. doi:10.1038/s41431-019-0424-3
Public involvement in the dissemination of the North West Coast Household Health Survey: Experiences and lessons of co-producing research together (Journal article)
Giebel, C., Hassan, S., McIntyre, J. C., Corcoran, R., Barr, B., Gabbay, M., . . . Alfirevic, A. (2019). Public involvement in the dissemination of the North West Coast Household Health Survey: Experiences and lessons of co-producing research together. HEALTH EXPECTATIONS, 22(4), 643-649. doi:10.1111/hex.12940
Genetic testing for prevention of severe drug-induced skin rash. (Journal article)
Alfirevic, A., Pirmohamed, M., Marinovic, B., Harcourt-Smith, L., Jorgensen, A. L., & Cooper, T. E. (2019). Genetic testing for prevention of severe drug-induced skin rash.. The Cochrane Database of Systematic Reviews, 7, CD010891. doi:10.1002/14651858.cd010891.pub2
Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. (Journal article)
Floyd, J. S., Bloch, K. M., Brody, J. A., Maroteau, C., Siddiqui, M. K., Gregory, R., . . . PREDICTION-ADR Consortium and EUDRAGENE. (2019). Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.. PLoS One, 14(6). doi:10.1371/journal.pone.0218115
Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions. (Journal article)
Nicoletti, P., Barrett, S., McEvoy, L., Daly, A. K., Aithal, G., Lucena, M. I., . . . Pirmohamed, M. (2019). Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.. Clinical pharmacology and therapeutics, 106(5), 1028-1036. doi:10.1002/cpt.1493
Trends in BRCA testing over time and socioeconomic deprivation (Journal article)
Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (n.d.). Trends in BRCA testing over time and socioeconomic deprivation. European Journal of Human Genetics. doi:10.1038/s41431-019-0424-3
Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study (Journal article)
Jorgensen, A. L., Prince, C., Fitzgerald, G., Hanson, A., Downing, J., Reynolds, J., . . . Pirmohamed, M. (2019). Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study. BMC Medicine, 17. doi:10.1186/s12916-019-1308-7
Aspirin nonresponsiveness in pregnant women at high risk of pre-eclampsia (Conference Paper)
Navaratnam, K., Agarwal, U., Alfirevic, A., & Alfirevic, Z. (2019). Aspirin nonresponsiveness in pregnant women at high risk of pre-eclampsia. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 126 (pp. 4). Retrieved from http://gateway.webofknowledge.com/
What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England (Journal article)
Giebel, C., McIntyre, J. C., Daras, K., Gabbay, M., Downing, J., Pirmohamed, M., . . . Barr, B. (2019). What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England. BMJ Open, 9(1). doi:10.1136/bmjopen-2018-022820
Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics (Journal article)
Fitzgerald, G., Prince, C., Downing, J., Reynolds, J., Zhang, J. E., Hanson, A., . . . Pirmohamed, M. (2019). Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics. PHARMACOGENOMICS, 20(8), 599-608. doi:10.2217/pgs-2019-0021
2018
Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies (Journal article)
Martin, A. P., Downing, J., Cochrane, M., Collins, B., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 130, 92-107. doi:10.1016/j.critrevonc.2018.07.012
TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES (Conference Paper)
Martin, A. P., Downing, J., Collins, B., Cochrane, M., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES. In VALUE IN HEALTH Vol. 21 (pp. S43). doi:10.1016/j.jval.2018.04.248
Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures (Conference Paper)
Mone, F., Phelan, M., Alfirevic, A., & McAuliffe, F. M. (2018). Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 66). Retrieved from http://gateway.webofknowledge.com/
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity (Journal article)
Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030
Genetic factors and response to low dose aspirin in pregnancy (Conference Paper)
Alfirevic, A., Navaratnam, K., Alfirevic, Z., & Zhang, E. (2018). Genetic factors and response to low dose aspirin in pregnancy. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 104-105). Retrieved from http://gateway.webofknowledge.com/
The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017) (Journal article)
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019
Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia (Journal article)
Navaratnam, K., Alfirevic, A., Jorgensen, A., & Alfirevic, Z. (2018). Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 221, 144-150. doi:10.1016/j.ejogrb.2017.12.052
2017
A common missense variant of LILRB5 is associated with statin intolerance and myalgia (Journal article)
Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). A common missense variant of LILRB5 is associated with statin intolerance and myalgia. EUROPEAN HEART JOURNAL, 38(48), 3569-3U31. doi:10.1093/eurheartj/ehx467
HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study (Journal article)
Bluett, J., Owen, S. -A., Massey, J., Alfirevic, A., Pirmohamed, M., Plant, D., . . . Consortium, P. S. (2017). HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study. ANNALS OF THE RHEUMATIC DISEASES, 76(12). doi:10.1136/annrheumdis-2017-211512
How important is aspirin adherence when evaluating effectiveness of low-dose aspirin? (Journal article)
Navaratnam, K., Alfirevic, Z., Pirmohamed, M., & Alfirevic, A. (2017). How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 219, 1-9. doi:10.1016/j.ejogrb.2017.10.004
An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review (Journal article)
Martin, A., Downing, J., Maden, M., Fleeman, N., Alfirevic, A., Haycox, A., & Pirmohamed, M. (2017). An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review. PHARMACOGENOMICS, 18(16), 1541-1550. doi:10.2217/pgs-2017-0076
Whole exome sequencing in individuals with statin-induced myopathy (Conference Paper)
Bloch, K. M., Carr, D., Pirmohamed, M., Morris, A., Maroteau, C., Eriksson, N., . . . Alfirevic, A. (2017). Whole exome sequencing in individuals with statin-induced myopathy. In DRUG SAFETY Vol. 40 (pp. 1026). Retrieved from http://gateway.webofknowledge.com/
Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout (Journal article)
Plumpton, C. O., Alfirevic, A., Pirmohamed, M., & Hughes, D. A. (2017). Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. Rheumatology (Oxford, England), 56(10), 1729-1739. doi:10.1093/rheumatology/kex253
Patient ethnicity and the risk of immune-mediated adverse drug reactions (Journal article)
Alfirevic, A. (2017). Patient ethnicity and the risk of immune-mediated adverse drug reactions. PHARMACOGENOMICS, 18(15), 1375-1378. doi:10.2217/pgs-2017-0124
Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon susceptibility to hepatotoxicity (Conference Paper)
Ball, A., Alfirevic, A., Lyon, J., & Chadwick, A. (2017). Generation of a novel, personalised in vitro model to assess the impact of mitochondrial DNA variation upon susceptibility to hepatotoxicity. In DRUG SAFETY Vol. 40 (pp. 1024-1025). Retrieved from http://gateway.webofknowledge.com/
Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt - 1)/PlGF ratio, comparison of predictive accuracy for preeclampsia, and relation to uterine artery Doppler and response to aspirin (Journal article)
Navaratnam, K., Abreu, P., Clarke, H., Jorgensen, A., Alfirevic, A., & Alfirevic, Z. (2017). Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt - 1)/PlGF ratio, comparison of predictive accuracy for preeclampsia, and relation to uterine artery Doppler and response to aspirin. The Journal of Maternal-Fetal and Neonatal Medicine, 32(2), 179-187. doi:10.1080/14767058.2017.1373760
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors (Journal article)
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. doi:10.4049/jimmunol.1602029
CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia (Journal article)
Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia. CIRCULATION-CARDIOVASCULAR GENETICS, 10(4). doi:10.1161/CIRCGENETICS.117.001737
Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response (Journal article)
Zhang, J. E., Klein, K., Jorgensen, A. L., Francis, B., Alfirevic, A., Bourgeois, S., . . . Pirmohamed, M. (2017). Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00323
EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES (Conference Paper)
Martin, A. P., Haycox, A., Downing, J., Alfirevic, A., & Pirmohamed, M. (2016). EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES. In VALUE IN HEALTH Vol. 19 (pp. A266). doi:10.1016/j.jval.2016.03.771
Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population (Journal article)
Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L., Morris, A., Cornejo Castro, E. M., . . . Pirmohamed, M. (2017). Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population. Journal of Antimicrobial Chemotherapy, 72(4), 1152-1162. doi:10.1093/jac/dkw545
Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity (Journal article)
Ghattaoraya, G. S., Middleton, D., Santos, E. J. M., Dickson, R., Jones, A. R., & Alfirevic, A. (2017). Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 44(01), 7-26. doi:10.1111/iji.12304
New Approaches to Investigate Drug-Induced Hypersensitivity (Journal article)
Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333
Genomics of Adverse Drug Reactions (Journal article)
Alfirevic, A., & Pirmohamed, M. (2017). Genomics of Adverse Drug Reactions. TRENDS IN PHARMACOLOGICAL SCIENCES, 38(1), 100-109. doi:10.1016/j.tips.2016.11.003
2016
Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity (Journal article)
Faulkner, L., Gibson, A., Sullivan, A., Tailor, A., Usui, T., Alfirevic, A., . . . Park, B. K. (2016). Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. TOXICOLOGICAL SCIENCES, 154(2), 416-429. doi:10.1093/toxsci/kfw177
Semi-systematic review of definitions and diagnostic tests for aspirin resistance: an opportunity to stratify prevention of placental disease (Conference Paper)
Navaratnam, K., Alfirevic, A., & Alfirevic, Z. (2016). Semi-systematic review of definitions and diagnostic tests for aspirin resistance: an opportunity to stratify prevention of placental disease. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 123 (pp. E10-E11). Retrieved from http://gateway.webofknowledge.com/
Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared to its parent compound, flutamide in HepG2 cells (Journal article)
Ball, A. L., Kamalian, L., Alfirevic, A., Chadwick, A. E., & Lyon, J. J. (2016). Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared to its parent compound, flutamide in HepG2 cells. Toxicological Sciences, 153(02), 341-351. doi:10.1093/toxsci/kfw126
Low dose aspirin and pregnancy: how important is aspirin resistance? (Journal article)
Navaratnam, K., Alfirevic, A., & Alfirevic, Z. (2016). Low dose aspirin and pregnancy: how important is aspirin resistance?. BJOG: an International Journal of Obstetrics and Gynaecology, 123(9), 1481-1487. doi:10.1111/1471-0528.13914
Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia (Journal article)
Legge, S. E., Hamshere, M. L., Ripke, S., Pardinas, A. F., Goldstein, J. I., Rees, E., . . . Walters, J. T. R. (2017). Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Molecular Psychiatry, 22(10), 1502-1508. doi:10.1038/mp.2016.97
Pharmacogenetics and Pharmacogenomics (Chapter)
Alfirevic, A., & Pirmohamed, M. (2016). Pharmacogenetics and Pharmacogenomics. In Medical and Health Genomics (pp. 121-137). Elsevier. doi:10.1016/b978-0-12-420196-5.00010-1
A web resource for mining HLA associations with adverse drug reactions: HLA-ADR. (Journal article)
Ghattaoraya, G. S., Dundar, Y., González-Galarza, F. F., Maia, M. H. T., Santos, E. J. M., da Silva, A. L. S., . . . Jones, A. R. (2016). A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.. Database : the journal of biological databases and curation, 2016. doi:10.1093/database/baw069
2015
Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses (Conference Paper)
Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from http://gateway.webofknowledge.com/
HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis (Journal article)
Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546
Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review (Journal article)
Yip, V. L. M., Alfirevic, A., & Pirmohamed, M. (2015). Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 48(2-3), 165-175. doi:10.1007/s12016-014-8418-y
Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry (Journal article)
Alfirevic, A., Durocher, J., Elati, A., Leon, W., Dickens, D., Raedisch, S., . . . Winikoff, B. (2015). Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry. PHARMACOGENOMICS, 16(9), 919-928. doi:10.2217/pgs.15.53
Cost-effectiveness of screening for HLA -A *31:01 prior to initiation of carbamazepine in epilepsy (Journal article)
Plumpton, C. O., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost-effectiveness of screening for HLA -A *31:01 prior to initiation of carbamazepine in epilepsy. EPILEPSIA, 56(04), 556-563. doi:10.1111/epi.12937
Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Conference Paper)
O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from http://gateway.webofknowledge.com/
Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Journal article)
O'Hara, A., Burkitt, M., Carr, D., Alfirevic, A., Moore, A., Murugesan, S., . . . Pritchard, M. (2015). Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy.
HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis. (Journal article)
Cornejo Castro, E. M., Carr, D., Jorgensen, A., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.. Pharmacogenetics and genomics, 25(04), 186-198. doi:10.1097/FPC.0000000000000124
2014
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. (Journal article)
González-Galarza, F. F., Takeshita, L. Y. C., Santos, E. J. M., Kempson, F., Maia, M. H. T., Silva, A. L. S. D., . . . Middleton, D. (2014). Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.. Nucleic Acids Research, 43(D1), D784-D788. doi:10.1093/nar/gku1166
Phenotype Standardization for Statin-Induced Myotoxicity (Journal article)
Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., . . . Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 470-476. doi:10.1038/clpt.2014.121
Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System (Journal article)
Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q. -Y., . . . Palmer, C. N. A. (2014). Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 477-481. doi:10.1038/clpt.2014.138
Pathway Analysis of Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes (Journal article)
Capece, A., Vasieva, O., Meher, S., Alfirevic, Z., & Alfirevic, A. (2014). Pathway Analysis of Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes. PloS One, 9(9). doi:10.1371/journal.pone.0108578
GATM gene variants and statin myopathy risk (Journal article)
Carr, D., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014). GATM gene variants and statin myopathy risk. Nature, 513(7518). doi:10.1038/nature13628
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles (Journal article)
Goldstein, J. I., Jarskog, L. F., Hilliard, C., Alfirevic, A., Duncan, L., Fourches, D., . . . Sullivan, P. F. (2014). Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. Nature Communications, 5. doi:10.1038/ncomms5757
Is the Interleukin 8 Promoter Polymorphism rs4073/–251T >A Associated With Clostridium difficile Infection? (Journal article)
Miyajima, F., Swale, A., Zhang, E., Alfirevic, A., Little, M., Beeching, N., . . . Pirmohamed, M. (2014). Is the Interleukin 8 Promoter Polymorphism rs4073/–251T >A Associated With Clostridium difficile Infection?. Clinical Infectious Disease, 58(12), e148-e151. doi:10.1093/cid/ciu152
Pharmacogenomics: Current State-of-the-Art (Journal article)
Carr, D. F., Alfirevic, A., & Pirmohamed, M. (2014). Pharmacogenomics: Current State-of-the-Art. GENES, 5(2), 430-443. doi:10.3390/genes5020430
HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient (Journal article)
Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460w
Pharmacogenetics of antiepileptic drug-induced hypersensitivity (Journal article)
Bloch, K. M., Sills, G. J., Pirmohamed, M., & Alfirevic, A. (2014). Pharmacogenetics of antiepileptic drug-induced hypersensitivity. PHARMACOGENOMICS, 15(6), 857-868. doi:10.2217/PGS.14.65
2013
Genetic testing for prevention of severe drug-induced skin rash (Journal article)
Alfirevic, A., Pirmohamed, M., Marinovic, B., Jorgensen, A. L., & Harcourt-Smith, L. (n.d.). Genetic testing for prevention of severe drug-induced skin rash. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd010891
Safety pharmacology - Current and emerging concepts (Journal article)
Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039
A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material (Journal article)
Bediaga, N. G., Davies, M. P. A., Acha-Sagredo, A., Hyde, R., Raji, O. Y., Page, R., . . . Liloglou, T. (2013). A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material. BRITISH JOURNAL OF CANCER, 109(9), 2404-2411. doi:10.1038/bjc.2013.623
ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein (Journal article)
Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein. PHARMACOGENETICS AND GENOMICS, 23(6), 314-323. doi:10.1097/FPC.0b013e328360d10c
A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp (Journal article)
Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLOS ONE, 8(5). doi:10.1371/journal.pone.0064854
T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)
Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p
Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population (Journal article)
Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021
Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity" (Journal article)
Yip, V. L. M., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity". CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(5), 387. doi:10.1038/clpt.2013.5
Response to "HLA allelic variants and carbamazepine-induced hypersensitivity". (Journal article)
Yip, V., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".. Clinical Pharmacology and Therapeutics, 93(5), 387.
Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)
Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077
A multi-system approach assessing the interaction of anticonvulsants with P-gp. (Journal article)
Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A multi-system approach assessing the interaction of anticonvulsants with P-gp.. PloS One, 8(5), e64854.
Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)
Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045
The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK (Journal article)
Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73
2012
HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review (Journal article)
Yip, V. L., Marson, A. G., Jorgensen, A. L., Pirmohamed, M., & Alfirevic, A. (2012). HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 757-765. doi:10.1038/clpt.2012.189
HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review. (Journal article)
Yip, V., Marson, T., Jorgensen, A., Pirmohamed, M., & Alfirevic, A. (2012). HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.. Clinical Pharmacology and Therapeutics, 92(6), 757-765.
Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity (Journal article)
Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146
Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility (Journal article)
Alfirevic, A., & Pirmohamed, M. (2012). Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(3), 376-380. doi:10.1038/clpt.2012.107
In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers (Journal article)
Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350
Lamotrigine is a substrate for OCT1 in brain endothelial cells (Journal article)
Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B., . . . Pirmohamed, M. (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. BIOCHEMICAL PHARMACOLOGY, 83(6), 805-814. doi:10.1016/j.bcp.2011.12.032
5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands (Journal article)
Fox, J. C., Daly, A., Cascorbi, I., Alfirevic, A., Linden, H., & Maitland-van der Zee, A. H. (2012). 5th Anniversary meeting of the European Research Network Pharmacogenetics/Pharmacogenomics. 8-9 December 2011, Utrecht, The Netherlands. Pharmacogenomics, 13(7), 747-749.
HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)
Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.
Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal (Journal article)
Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. BRITISH JOURNAL OF DERMATOLOGY, 166(1), 12-14. doi:10.1111/j.1365-2133.2011.10760.x
Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. (Journal article)
Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal.. British Journal of Dermatology, 166(1), 12-14.
2011
HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans (Journal article)
McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans. NEW ENGLAND JOURNAL OF MEDICINE, 364(12), 1134-1143. doi:10.1056/NEJMoa1013297
Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine. (Journal article)
Carr, D. F., & Alfirevic, A. (2011). Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine.. Pharmacogenomics, 12(3), 315-317. doi:10.2217/pgs.10.217
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans (Journal article)
McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med, 364(12), 1134-1143.
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors (Journal article)
Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. PHARMACOGENETICS AND GENOMICS, 21(5), 297-302. doi:10.1097/FPC.0b013e3283441b95
Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing (Journal article)
Wadelius, M., & Alfirevic, A. (2011). Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing. Genome Medicine, 3(12), 78.
Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics (Journal article)
Becquemont, L., Alfirevic, A., Amstutz, U., Brauch, H., Jacqz-Aigrain, E., Laurent-Puig, P., . . . Daly, A. K. (2011). Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics. Pharmacogenomics, 12(1), 113-124.
2010
Drug Induced Hypersensitivity and the HLA Complex (Journal article)
Alfirevic, A., & Pirmohamed, M. (2010). Drug Induced Hypersensitivity and the HLA Complex. Pharmaceuticals (Basel, Switzerland), 4(1), 69-90.
Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future (Journal article)
Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. PHARMACOGENOMICS, 11(4), 497-499. doi:10.2217/PGS.10.12
Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients (Journal article)
Adetunji, O. R., Blair, J. C., Javadpour, M., Alfirevic, A., Pirmohamed, M., & MacFarlane, I. A. (2010). Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients. CLINICAL ENDOCRINOLOGY, 72(3), 422-423. doi:10.1111/j.1365-2265.2009.03638.x
Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy (Journal article)
Amara, A. B., Sharma, A., Alexander, J. L., Alfirevic, A., Mohiuddin, A., Pirmohamed, M., . . . Rustom, R. (2010). Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy. TRANSPLANTATION, 89(1), 104-114. doi:10.1097/TP.0b013e3181bf13d9
Pharmacogenetics in reproductive and perinatal medicine (Journal article)
Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. PHARMACOGENOMICS, 11(1), 65-79. doi:10.2217/PGS.09.153
Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. (Journal article)
Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.. Pharmacogenomics, 11(4), 497-499.
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. (Journal article)
Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2010). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.. Pharmacogenetics and Genomics, 21(5), 297-302.
Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice. (Journal article)
Maitland-van der Zee, A. H., & Alfirevic, A. (2010). Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice.. Genome Medicine, 2(9), 69.
Pharmacogenetics in reproductive and perinatal medicine (Journal article)
Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. Pharmacogenomics, 11(1), 65-79.
2009
The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy (Journal article)
Adetunji, O. R., MacFarlane, I. A., Javadpour, M., Alfirevic, A., Pirmohamed, M., & Blair, J. C. (2009). The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 161(4), 541-546. doi:10.1530/EJE-09-0405
Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)
Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review (Journal article)
Carr, D. F., Whiteley, G., Alfirevic, A., Pirmohamed, M., & Team, F. S. (2009). Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. PHARMACOGENOMICS JOURNAL, 9(5), 291-305. doi:10.1038/tpj.2009.29
TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole (Journal article)
Alfirevic, A., Vilar, F. J., Alsbou, M., Jawaid, A., Thomson, W., Ollier, W. E. R., . . . Pirmohamed, M. (2009). TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. PHARMACOGENOMICS, 10(4), 531-540. doi:10.2217/PGS.09.6
Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)
Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. Pharmacogenetics and Genomics, 10, 781-789.
2008
Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective (Journal article)
Alfirevic, A., & Pirmohamed, M. (2008). Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective. Journal of Applied Therapeutic Research, 6(3), 3-8.
Pharmacogenetics and pharmacogenomics: adverse drug reactions. (Journal article)
Jorgensen, A., & Alfirevic, A. (2008). Pharmacogenetics and pharmacogenomics: adverse drug reactions.. Pharmacogenomics, 9(10), 1397-1401. doi:10.2217/14622416.9.10.1397
Adverse drug reactions and pharmacogenomics: recent advances (Journal article)
Alfirevic, A., & Pirmohamed, M. (2008). Adverse drug reactions and pharmacogenomics: recent advances. PERSONALIZED MEDICINE, 5(1), 11-23. doi:10.2217/17410541.5.1.11
2007
Tacrine-induced liver damage: an analysis of 19 candidate genes (Journal article)
Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Jawaid, A., Sherwood, J., . . . Pirmohamed, M. (2007). Tacrine-induced liver damage: an analysis of 19 candidate genes. PHARMACOGENETICS AND GENOMICS, 17(12), 1091-1100. doi:10.1097/FPC.0b013e3282f1f12b
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity (Journal article)
Carr, D. F., Alfirevic, A., Tugwood, J. D., Barratt, B. J., Sherwood, J., Smith, J., . . . Park, B. K. (2007). Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 17(11), 961-972. doi:10.1097/FPC.0b013e3282f00919
Pharmacogenetics of adverse drug reactions: a pharmacovigilance perspective. (Journal article)
Alfirevic, A., & Pirmohamed, M. (2007). Pharmacogenetics of adverse drug reactions: a pharmacovigilance perspective.. Pharmacovigilance Review, 1(3), 22-25.
2006
HLA-B locus in Caucasian patients with carbamazepine hypersensitivity (Journal article)
Alfirevic, A., Jorgensen, A. L., Williamson, P. R., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2006). HLA-B locus in Caucasian patients with carbamazepine hypersensitivity. PHARMACOGENOMICS, 7(6), 813-818. doi:10.2217/14622416.7.6.813
The 2nd International Drug Hypersensitivity Meeting (Journal article)
Alfirevic, A., & Naisbitt, D. J. (2006). The 2nd International Drug Hypersensitivity Meeting. Expert Opinion on Drug Safety, 5(5), 729-734. doi:10.1517/14740338.5.5.729
Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster (Journal article)
Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2006). Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. PHARMACOGENETICS AND GENOMICS, 16(4), 287-296. doi:10.1097/01.fpc.0000189800.88596.7a
Pharmacogenetics of Adverse Drug Reactions (Chapter)
Alfirevic, A., Park, B. K., & Pirmohamed, M. (2006). Pharmacogenetics of Adverse Drug Reactions. In I. Hall, & M. Pirmohamed (Eds.), Textbook of Pharmacogenetics (pp. in press). New York: Marcel Dekker.
2005
Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster (Journal article)
Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2005). Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster. TOXICOLOGY, 213(3), 264-265. Retrieved from http://gateway.webofknowledge.com/
Molecular aspects of carbamazepine-induced hypersensitivity reactions (Thesis / Dissertation)
Alfirevic, A. (2005). Molecular aspects of carbamazepine-induced hypersensitivity reactions. (PhD Thesis, The University of Liverpool).
2004
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity (Journal article)
Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. PHARMACOGENETICS, 14(6), 335-342. doi:10.1097/00008571-200406000-00002
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. (Journal article)
Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.. Pharmacogenetics, 14(6), 335-342. doi:10.1097/00008571-200406000-00002
2003
Erratum (Journal article)
Erratum (2003). British Journal of Clinical Pharmacology, 55(4), 417. doi:10.1046/j.1365-2125.2003.01815.x
Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity (Journal article)
Alfirevic, A., Stalford, A. C., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2003). Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(2), 158-165. doi:10.1046/j.1365-2125.2003.01754.x
2002
TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy (Journal article)
Maher, B., Alfirevic, A., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2002). TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS, 16(15), 2013-2018. doi:10.1097/00002030-200210180-00005
2000
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity (Journal article)
Pirmohamed, M., Alfirevic, A., Vilar, J., Stalford, A., Wilkins, E. G. L., Sim, E., & Park, B. K. (2000). Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity. PHARMACOGENETICS, 10(8), 705-713. doi:10.1097/00008571-200011000-00005
1989
Correlation between bone scans and serum levels of osteocalcin, prostate-specific antigen, and prostatic acid phosphatase in monitoring patients with disseminated cancer of the prostate (Journal article)
Tarle, M., Kovacic, K., & Strelkov-Alfirevic, A. (1989). Correlation between bone scans and serum levels of osteocalcin, prostate-specific antigen, and prostatic acid phosphatase in monitoring patients with disseminated cancer of the prostate. The Prostate, 15(3), 211-219. doi:10.1002/pros.2990150302