Publications
2024
Review article: the role of epigenetics as an underlying regulator of the immune responses in Parkinson’s disease
Georgoula, M., Ntavaroukas, P., Campbell, B. J., & Papoutsopoulou, S. (2024). Review article: the role of epigenetics as an underlying regulator of the immune responses in Parkinson’s disease. Epigenetics Reports, 2(1), 1-14. doi:10.1080/28361512.2024.2401340
A Novel Quinoline Inhibitor of the Canonical NF-κB Transcription Factor Pathway
Ntavaroukas, P., Michail, K., Tsiakalidou, R., Stampouloglou, E., Tsiggene, K., Komiotis, D., . . . Papoutsopoulou, S. (n.d.). A Novel Quinoline Inhibitor of the Canonical NF-κB Transcription Factor Pathway. Biology, 13(11), 910. doi:10.3390/biology13110910
Erythropoietin Reduces Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Bleomycin-Induced Idiopathic Pulmonary Fibrosis.
Tsavlis, D., Domvri, K., Porpodis, K., Papoutsopoulou, S., Anestakis, D., Tzoumaka, A., . . . Spandou, E. (2024). Erythropoietin Reduces Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Bleomycin-Induced Idiopathic Pulmonary Fibrosis.. Journal of personalized medicine, 14(9), 972. doi:10.3390/jpm14090972
Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson's Disease.
Saponjic, J., Mejías, R., Nikolovski, N., Dragic, M., Canak, A., Papoutsopoulou, S., . . . Marino, F. (2024). Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson's Disease.. International journal of molecular sciences, 25(8), 4330. doi:10.3390/ijms25084330
Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls.
Georgoula, M., Ntavaroukas, P., Androutsopoulou, A., Xiromerisiou, G., Kalala, F., Speletas, M., . . . Papoutsopoulou, S. (2024). Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls.. International journal of molecular sciences, 25(3), 1791. doi:10.3390/ijms25031791
2023
Parkinson's Disease, It Takes Guts: The Correlation between Intestinal Microbiome and Cytokine Network with Neurodegeneration
Xiromerisiou, G., Marogianni, C., Androutsopoulou, A., Ntavaroukas, P., Mysiris, D., & Papoutsopoulou, S. (2023). Parkinson's Disease, It Takes Guts: The Correlation between Intestinal Microbiome and Cytokine Network with Neurodegeneration. BIOLOGY-BASEL, 12(1). doi:10.3390/biology12010093
2022
Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson's Disease Severity
Xiromerisiou, G., Marogianni, C., Lampropoulos, I. C., Dardiotis, E., Speletas, M., Ntavaroukas, P., . . . Papoutsopoulou, S. (2023). Peripheral Inflammatory Markers TNF-α and CCL2 Revisited: Association with Parkinson's Disease Severity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(1). doi:10.3390/ijms24010264
Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa
Papoutsopoulou, S., Tang, J., Elramli, A. H., Williams, J. M., Gupta, N., Ikuomola, F. I., . . . Pritchard, D. M. (2022). Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa. American Journal of Physiology: Gastrointestinal and Liver Physiology, 323(4), G306-G317. doi:10.1152/ajpgi.00037.2022
Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo.
Papoutsopoulou, S., Pollock, L., Williams, J. M., Abdul-Mahdi, M. M. L. F., Dobbash, R., Duckworth, C. A., & Campbell, B. J. (2022). Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo.. Biology, 11(10), 1377. doi:10.3390/biology11101377
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis
Mysiris, D. S., Vavougios, G. D., Karamichali, E., Papoutsopoulou, S., Stavrou, V. T., Papayianni, E., . . . Xiromerisiou, G. (2022). Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(17). doi:10.3390/ijms23179739
THE IMPACT OF ALTERNATIVE (NON-CANONICAL) NF-κB PATHWAY INHIBITION IN PREVENTING INTESTINAL BARRIER DYSFUNCTION IN IBD
Tang, J., Papoutsopoulou, S., Mackay, S., Paul, A., Duckworth, C., & Pritchard, M. (2022). THE IMPACT OF ALTERNATIVE (NON-CANONICAL) NF-κB PATHWAY INHIBITION IN PREVENTING INTESTINAL BARRIER DYSFUNCTION IN IBD. In GUT Vol. 71 (pp. A140). doi:10.1136/gutjnl-2022-BSG.258
Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses
Papoutsopoulou, S., Morris, L., Bayliff, A., Mair, T., England, H., Stagi, M., . . . Campbell, B. J. (2022). Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses. BIOMEDICINES, 10(4). doi:10.3390/biomedicines10040757
TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages
Blair, L., Pattison, M. J., Chakravarty, P., Papoutsopoulou, S., Bakiri, L., Wagner, E. F., . . . Ley, S. C. (2022). TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages. JOURNAL OF IMMUNOLOGY, 208(4), 941-954. doi:10.4049/jimmunol.2100213
2021
Soluble Non-Starch Polysaccharides From Plantain (<i>Musa x paradisiaca</i> L.) Diminish Epithelial Impact of <i>Clostridioides difficile</i>
Simpson, H. L., Roberts, C. L., Thompson, L. M., Leiper, C. R., Gittens, N., Trotter, E., . . . Campbell, B. J. (2021). Soluble Non-Starch Polysaccharides From Plantain (<i>Musa x paradisiaca</i> L.) Diminish Epithelial Impact of <i>Clostridioides difficile</i>. FRONTIERS IN PHARMACOLOGY, 12. doi:10.3389/fphar.2021.766293
Epigenetic Modifications of the Nuclear Factor Kappa B Signalling Pathway and its Impact on Inflammatory Bowel Disease
Papoutsopoulou, S., & Campbell, B. J. (2021). Epigenetic Modifications of the Nuclear Factor Kappa B Signalling Pathway and its Impact on Inflammatory Bowel Disease. CURRENT PHARMACEUTICAL DESIGN, 27(35), 3702-3713. doi:10.2174/1381612827666210218141847
Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals
Papoutsopoulou, S., Pollock, L., Walker, C., Tench, W., Samad, S. S., Bergey, F., . . . Campbell, B. J. (2021). Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.690817
IKKα AS A POTENTIAL THERAPEUTIC TARGET FOR THE PREVENTION OF INFLAMMATORY BOWEL DISEASE
Tang, J., Papoutsopoulou, S., Paul, A., MacKay, P. S., Duckworth, C., & Pritchard, M. (2021). IKKα AS A POTENTIAL THERAPEUTIC TARGET FOR THE PREVENTION OF INFLAMMATORY BOWEL DISEASE. In GUT Vol. 70 (pp. A126-A127). doi:10.1136/gutjnl-2020-bsgcampus.236
2020
Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes
Harman, N., Williamson, P., Sanz-Moreno, A., Papoutsopoulou, S., Lloyd, K. A., Ameen-Ali, K. E., & Macleod, M. (2020). Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes. Journal of Translational Medicine. doi:10.1186/s12967-020-02649-6
Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
Lloyd, K., Papoutsopoulou, S., Smith, E., Stegmaier, P., Bergey, F., Morris, L., . . . Burkitt, M. D. (2020). Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease. DISEASE MODELS & MECHANISMS, 13(11). doi:10.1242/dmm.044040
First person - Katie Lloyd and Stamatia Papoutsopoulou
Lloyd, K., & Papoutsopoulou, S. (2020). First person - Katie Lloyd and Stamatia Papoutsopoulou. DISEASE MODELS & MECHANISMS, 13(11). doi:10.1242/dmm.047506
The Generation of an Engineered Interleukin-10 Protein With Improved Stability and Biological Function.
Minshawi, F., Lanvermann, S., McKenzie, E., Jeffery, R., Couper, K., Papoutsopoulou, S., . . . Muller, W. (2020). The Generation of an Engineered Interleukin-10 Protein With Improved Stability and Biological Function.. Frontiers in Immunology, 11, 1794. doi:10.3389/fimmu.2020.01794
Review article: impact of cigarette smoking on intestinal inflammation-direct and indirect mechanisms
Papoutsopoulou, S., Satsangi, J., Campbell, B. J., & Probert, C. S. (2020). Review article: impact of cigarette smoking on intestinal inflammation-direct and indirect mechanisms. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 51(12), 1268-1285. doi:10.1111/apt.15774
Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors
Lloyd, K. A., Parsons, B. N., Burkitt, M. D., Moore, A. R., Papoutsopoulou, S., Boyce, M., . . . Pritchard, D. M. (2020). Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 10(1), 113-132. doi:10.1016/j.jcmgh.2020.01.010
2019
Macrophage-Specific NF-kappa B Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients
Papoutsopoulou, S., Burkitt, M. D., Bergey, F., England, H., Hough, R., Schmidt, L., . . . Probert, C. S. (2019). Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.02168
Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patients
Papoutsopoulou, S., Burkitt, M., Bergey, F., England, H., Hough, R., Schmidt, L., . . . Probert, C. (2019). Macrophage-specific NF-κB activation dynamics can segregate inflammatory bowel disease patients. doi:10.1101/535096
Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.
Minshawi, F., White, M. R. H., Muller, W., Humphreys, N., Jackson, D., Campbell, B. J., . . . Papoutsopoulou, S. (2019). Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.. Scientific reports, 9. doi:10.1038/s41598-018-36969-x
Using systems medicine to identify a therapeutic agent with potential for repurposing in Inflammatory Bowel Disease
MOUSE - Mapping OUtcomes measured in pre-clinical Studies against randomised phase 3/4 Effectiveness trials. Do core outcome sets developed for phase3/4 effectiveness trials translate to pre-clinical research?
Harman, N. L., Sanz-Moreno, A., Ameen-Ali, K. E., Papoutsopoulou, S., Lloyd, K., Garcia-Finana, M., . . . Williamson, P. R. (2019). MOUSE - Mapping OUtcomes measured in pre-clinical Studies against randomised phase 3/4 Effectiveness trials. Do core outcome sets developed for phase3/4 effectiveness trials translate to pre-clinical research?. In TRIALS Vol. 20. Retrieved from https://www.webofscience.com/
2018
IDENTIFICATION OF A NOVEL THERAPEUTIC AGENT FOR TREATING IBD GUIDED BY SYSTEMS MEDICINE
Burkitt, M., Lloyd, K., Papoutsopoulou, S., Smith, E., Stegmaier, P., Pritchard, D. M., . . . Probert, C. (2018). IDENTIFICATION OF A NOVEL THERAPEUTIC AGENT FOR TREATING IBD GUIDED BY SYSTEMS MEDICINE. In GUT Vol. 67 (pp. A52). doi:10.1136/gutjnl-2018-BSGAbstracts.104
2017
DOP049 Inflammatory dyskinesis: defects of NF-κB dynamic behaviour as a new potential biomarker for personalized medicine in inflammatory bowel disease.
Sellge, G., Papoutsopoulou, S., Verdier, J., Trautwein, C., Bergey, F., Burkitt, M., . . . Probert, C. (2017). DOP049 Inflammatory dyskinesis: defects of NF-κB dynamic behaviour as a new potential biomarker for personalized medicine in inflammatory bowel disease.. In Journal of Crohn's & colitis Vol. 11 (pp. S55-S56).
Inflammatory dyskinesis: defects of NF-κB dynamic behaviour as a new potential biomarker for personalized medicine in inflammatory bowel disease
Sellge, G., Papoutsopoulou, S., Verdier, J., Trautwein, C., Bergey, F., Burkitt, M., . . . Probert, C. (2017). Inflammatory dyskinesis: defects of NF-κB dynamic behaviour as a new potential biomarker for personalized medicine in inflammatory bowel disease. In JOURNAL OF CROHNS & COLITIS Vol. 11 (pp. S55-S56). Retrieved from https://www.webofscience.com/
2016
TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control T<sub>H</sub>2-Mediated Immunopathology
Kannan, Y., Perez-Lloret, J., Li, Y., Entwistle, L. J., Khoury, H., Papoutsopoulou, S., . . . Wilson, M. S. (2016). TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control T<sub>H</sub>2-Mediated Immunopathology. PLOS PATHOGENS, 12(8). doi:10.1371/journal.ppat.1005783
2014
IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen
Jacque, E., Schweighoffer, E., Visekruna, A., Papoutsopoulou, S., Janzen, J., Zillwood, R., . . . Ley, S. C. (2014). IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. JOURNAL OF EXPERIMENTAL MEDICINE, 211(10), 2085-2101. doi:10.1084/jem.20132019
2012
Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105
Yang, H. -T., Papoutsopoulou, S., Belich, M., Brender, C., Janzen, J., Gantke, T., . . . Ley, S. C. (2012). Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105. MOLECULAR AND CELLULAR BIOLOGY, 32(17), 3438-3451. doi:10.1128/MCB.00564-12
2011
NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages through TPL-2-Dependent ERK Activation
Yang, H. -T., Wang, Y., Zhao, X., Demissie, E., Papoutsopoulou, S., Mambole, A., . . . Horwitz, B. H. (2011). NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages through TPL-2-Dependent ERK Activation. JOURNAL OF IMMUNOLOGY, 186(4), 1989-1996. doi:10.4049/jimmunol.1001003
2009
TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells
Kaiser, F., Cook, D., Papoutsopoulou, S., Rajsbaum, R., Wu, X., Yang, H. -T., . . . O'Garra, A. (2009). TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells. JOURNAL OF EXPERIMENTAL MEDICINE, 206(9), 1863-1871. doi:10.1084/jem.20091059
Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation
Sriskantharajah, S., Belich, M. P., Papoutsopoulou, S., Janzen, J., Tybulewicz, V., Seddon, B., & Ley, S. C. (2009). Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation. NATURE IMMUNOLOGY, 10(1), 38-47. doi:10.1038/ni.1685
2008
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNFα in LPS-stimulated macrophages
Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., . . . Cohen, P. (2008). TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNFα in LPS-stimulated macrophages. JOURNAL OF CELL SCIENCE, 121(2), 149-154. doi:10.1242/jcs.018671
2007
Neuroprotective effect of long-term MgSO<sub>4</sub> administration after cerebral hypoxia-ischemia in newborn rats is related to the severity of brain damage
Spandou, E., Soubasi, V., Papoutsopoulou, S., Augoustides-Savvopoulou, P., Loizidis, T., Pazaiti, A., . . . Guiba-Tziampiri, O. (2007). Neuroprotective effect of long-term MgSO<sub>4</sub> administration after cerebral hypoxia-ischemia in newborn rats is related to the severity of brain damage. REPRODUCTIVE SCIENCES, 14(7), 667-677. doi:10.1177/1933719107305864
2006
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses
Papoutsopoulou, S., Symons, A., Tharmalingham, T., Belich, M. P., Kaiser, F., Kioussis, D., . . . Ley, S. C. (2006). ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. NATURE IMMUNOLOGY, 7(6), 606-615. doi:10.1038/ni1334
2004
Hypoxia-ischemia affects erythropoietin and erythropoietin receptor expression pattern in the neonatal rat brain
Spandou, E., Papoutsopoulou, S., Soubasi, V., Karkavelas, G., Simeonidou, C., Kremenopoulos, G., & Guiba-Tziampiri, O. (2004). Hypoxia-ischemia affects erythropoietin and erythropoietin receptor expression pattern in the neonatal rat brain. BRAIN RESEARCH, 1021(2), 167-172. doi:10.1016/j.brainres.2004.06.057
Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia
Spandou, E., Soubasi, V., Papoutsopoulou, S., Karkavelas, G., Simeonidou, C., Kaiki-Astara, A., & Guiba-Tziampiri, O. (2004). Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia. NEUROSCIENCE LETTERS, 366(1), 24-28. doi:10.1016/j.neulet.2004.05.032
2002
The effect of erythropoietin treatment on neonatal hypoxic ischemic brain injury in the rat
Spandou, E., Papoutsopoulou, S., Karkavelas, G., Simeonidou, C., Soubasi, V., Kaikí-Astara, A., . . . Guiba-Tziampiri, O. (2002). The effect of erythropoietin treatment on neonatal hypoxic ischemic brain injury in the rat. In PEDIATRIC RESEARCH Vol. 52 (pp. 820). Retrieved from https://www.webofscience.com/
2000
Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300
Papoutsopoulou, S., & Janknecht, R. (2000). Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300. MOLECULAR AND CELLULAR BIOLOGY, 20(19), 7300-7310. doi:10.1128/MCB.20.19.7300-7310.2000
1999
SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.
Papoutsopoulou, S., Nikolakaki, E., Chalepakis, G., Kruft, V., Chevaillier, P., & Giannakouros, T. (1999). SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.. Nucleic acids research, 27(14), 2972-2980. doi:10.1093/nar/27.14.2972
SRPK1 and LBR protein kinases show identical substrate specificities.
Papoutsopoulou, S., Nikolakaki, E., & Giannakouros, T. (1999). SRPK1 and LBR protein kinases show identical substrate specificities.. Biochemical and biophysical research communications, 255(3), 602-607. doi:10.1006/bbrc.1999.0249
1997
Phosphomannose isomerase of Xanthomonas campestris: a zinc activated enzyme.
Papoutsopoulou, S. V., & Kyriakidis, D. A. (1997). Phosphomannose isomerase of Xanthomonas campestris: a zinc activated enzyme.. Molecular and cellular biochemistry, 177(1-2), 183-191. doi:10.1023/a:1006825825681
1994
Genetic construction of Xanthomonas campestris and xanthan gum production from whey
Papoutsopoulou, S. V., Ekateriniadou, L. V., & Kyriakidis, D. A. (1994). Genetic construction of Xanthomonas campestris and xanthan gum production from whey. Biotechnology Letters, 16(12), 1235-1240. doi:10.1007/bf00149624
High production of xanthan gum by a strain ofXanthomonas campestris conjugated withLactococcus lactis
Ekateriniadou, L. V., Papoutsopoulou, S. V., & Kyriakidis, D. A. (1994). High production of xanthan gum by a strain ofXanthomonas campestris conjugated withLactococcus lactis. Biotechnology Letters, 16(5), 517-522. doi:10.1007/bf01023336