Publications
2022
Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach
Mone, F., Gupta, J. K., Phelan, M. M., Meher, S., Lian, L. Y., Francis, B., . . . Navaratnam, K. (2022). Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach. PLATELETS, 33(6), 911-917. doi:10.1080/09537104.2021.2007872
Development of chimeric forms of the matrix metalloproteinase 2 collagen binding domain as artificial membrane binding proteins for targeting stem cells to cartilage lesions in osteoarthritic joints
Dabbadie, A., Salerno, A., Perriman, A., Lian, L. -Y., & Hollander, A. P. (2022). Development of chimeric forms of the matrix metalloproteinase 2 collagen binding domain as artificial membrane binding proteins for targeting stem cells to cartilage lesions in osteoarthritic joints. BIOMATERIALS, 285. doi:10.1016/j.biomaterials.2022.121547
Co-Administration of Adjuvanted Recombinant <i>Ov</i>-103 and <i>Ov</i>-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine <i>Onchocerca ochengi</i> Infection Model of Human Onchocerciasis
Luu, L., Bah, G. S., Okah-Nnane, N. H., Hartley, C. S., Glover, A. F., Walsh, T. R., . . . Graham-Brown, J. (2022). Co-Administration of Adjuvanted Recombinant <i>Ov</i>-103 and <i>Ov</i>-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine <i>Onchocerca ochengi</i> Infection Model of Human Onchocerciasis. VACCINES, 10(6). doi:10.3390/vaccines10060861
CPVT-associated calmodulin variants N531 and A102V dysregulate Ca<SUP>2+</SUP> signalling via different mechanisms
Prakash, O., Held, M., McCormick, L. F., Gupta, N., Lian, L. -Y., Antonyuk, S., . . . Helassa, N. (2022). CPVT-associated calmodulin variants N531 and A102V dysregulate Ca<SUP>2+</SUP> signalling via different mechanisms. JOURNAL OF CELL SCIENCE, 135(2). doi:10.1242/jcs.258796
2021
Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach
Gupta, J. K., Care, A., Goodfellow, L., Alfirevic, Z., Lian, L. -Y., Mueller-Myhsok, B., . . . Phelan, M. M. (2021). Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach. BIOSCIENCE REPORTS, 41(9). doi:10.1042/BSR20210759
Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation
Hegedüs, Z., Hóbor, F., Shoemark, D. K., Celis, S., Lian, L. -Y., Trinh, C. H., . . . Wilson, A. J. (n.d.). Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation. Chemical Science, 12(6), 2286-2293. doi:10.1039/d0sc05694d
2020
Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics
Torpey, J., Madine, J., Wood, A., & Lian, L. -Y. (2020). Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-66200-9
Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure
Sindrewicz, P., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2020). Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 523(2), 336-341. doi:10.1016/j.bbrc.2019.12.054
2019
Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions
Sindrewicz, P., Li, X., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2019). Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-47658-8
2018
1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints
Anderson, J., Chokesuwattanaskul, S., Phelan, M., Welting, T., Lian, L. Y., Peffers, M., & Wright, H. L. (2018). 1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints. Journal of Proteome Research, 17(11), 3780-3790. doi:10.1021/acs.jproteome.8b00455
Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.
Zhan, B., Arumugam, S., Kennedy, M. W., Tricoche, N., Lian, L. -Y., Asojo, O. A., . . . Klei, T. R. (2018). Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.. PLoS neglected tropical diseases, 12(10), e0006772. doi:10.1371/journal.pntd.0006772
Characterisation of <i>Anopheles gambiae</i> heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction
Spencer, C. S., Yunta, C., de Lima, G. P. G., Hemmings, K., Lian, L. -Y., Lycett, G., & Paine, M. J. (2018). Characterisation of <i>Anopheles gambiae</i> heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 98, 25-33. doi:10.1016/j.ibmb.2018.04.010
2017
Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia
Helassa, N., Antonyuk, S. V., Lian, L. -Y., Haynes, L. P., & Burgoyne, R. D. (2017). Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Human molecular genetics, 26(13), 2426-2435. doi:10.1093/hmg/ddx133
Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor.
Humbert, M. V., Awanye, A. M., Lian, L. -Y., Derrick, J. P., & Christodoulides, M. (2017). Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor.. PLoS pathogens, 13(6). doi:10.1371/journal.ppat.1006448
2016
Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch
Patel, P., Prescott, G. R., Burgoyne, R. D., Lian, L. -Y., & Morgan, A. (2016). Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch. STRUCTURE, 24(8), 1380-1386. doi:10.1016/j.str.2016.06.009
Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis
Shore, E. R., Awais, M., Kershaw, N. M., Gibson, R. R., Pandalanen, S., Latawiec, D., . . . Sutton, R. (2016). Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis. JOURNAL OF MEDICINAL CHEMISTRY, 59(06), 2596-2611. doi:10.1021/acs.jmedchem.5b01801
NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes
Margaret Phelan, M., & Lian, L. -Y. (2016). NMR Metabolomics: A Comparison of the Suitability of Various Commonly used National Health Service Blood Collection Tubes. Current Metabolomics, 4(1), 78-81. doi:10.2174/2213235x03666151006220726
Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis
Sindrewicz, P., Lian, L. -Y., & Yu, L. -G. (2016). Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis. FRONTIERS IN ONCOLOGY, 6. doi:10.3389/fonc.2016.00079
2015
Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409
Neuronal Calcium Sensor-1 binds the D2 dopamine receptor and G-protein-coupled receptor kinase 1 (GRK1) peptides using different modes of interactions
Pandalaneni, S., Karuppiah, V., Saleem, M., Haynes, L., Burgoyne, B., Mayans, O., . . . Lian, L. -Y. (2015). Neuronal Calcium Sensor-1 binds the D2 dopamine receptor andG-protein-coupled receptor kinase 1 (GRK1) peptides using different modes of interactions. The Journal of Biological Chemistry, 290(30), 18744-18756. doi:10.1074/jbc.M114.627059
Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions
Bach, A., Pedersen, S. W., Dorr, L. A., Vallon, G., Ripoche, I., Ducki, S., & Lian, L. -Y. (2015). Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Scientific reports, 5. doi:10.1038/srep12157
Small Molecule Inhibitors of Cyclophilin D to Protect Mitochondrial Function as a Possible Treatment for Acute Pancreatitis
Awais, M., Shore, E., Gibson, R., Javed, M. A., Wen, L., Latawiec, D., . . . Sutton, R. (2015). Small Molecule Inhibitors of Cyclophilin D to Protect Mitochondrial Function as a Possible Treatment for Acute Pancreatitis. PANCREAS, 44(8), 1360. Retrieved from https://www.webofscience.com/
2014
The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin
Phelan, M. M., McLean, L., Armstrong, S. D., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin. PLoS One, 9(10). doi:10.1371/journal.pone.0108415
Demonstration of Binding of Neuronal Calcium Sensor-1 to the Ca<sub>v</sub>2.1 P/Q-Type Calcium Channel
Lian, L. -Y., Pandalaneni, S. R., Todd, P. A. C., Martin, V. M., Burgoyne, R. D., & Haynes, L. P. (2014). Demonstration of Binding of Neuronal Calcium Sensor-1 to the Ca<sub>v</sub>2.1 P/Q-Type Calcium Channel. BIOCHEMISTRY, 53(38), 6052-6062. doi:10.1021/bi500568v
Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling
Phelan, M. M., McLean, L., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2014). Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 866-872. doi:10.1042/BST20140082
Trifluoroibuprofen Inhibits α-Methylacyl Coenzyme A Racemase (AMACR/P504S), Reduces Cancer Cell Proliferation and Inhibits <i>in vivo</i> Tumor Growth in Aggressive Prostate Cancer Models
Festuccia, C., Gravina, G. L., Mancini, A., Muzi, P., Di Cesare, E., Kirk, R., . . . Carnell, A. J. (2014). Trifluoroibuprofen Inhibits α-Methylacyl Coenzyme A Racemase (AMACR/P504S), Reduces Cancer Cell Proliferation and Inhibits <i>in vivo</i> Tumor Growth in Aggressive Prostate Cancer Models. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 14(7), 1031-1041. doi:10.2174/1871520614666140327152607
2013
A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.
Shammas, C., Neocleous, V., Phelan, M. M., Lian, L. -Y., Skordis, N., & Phylactou, L. A. (2013). A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.. Metabolism: clinical and experimental, 62(11), 1535-1542. doi:10.1016/j.metabol.2013.06.007
Structure-based design of PDZ ligands as inhibitors of 5-HT(2A) receptor/PSD-95 PDZ1 domain interaction possessing anti-hyperalgesic activity.
Vogrig, A., Dorr, L., Bouzidi, N., Boucherle, B., Wattiez, A. -S., Cassier, E., . . . Ducki, S. (2013). Structure-based design of PDZ ligands as inhibitors of 5-HT(2A) receptor/PSD-95 PDZ1 domain interaction possessing anti-hyperalgesic activity.. ACS chemical biology, 8(10), 2209-2216. doi:10.1021/cb400308u
Inhibition of Human α-Methylacyl CoA Racemase (AMACR): a Target for Prostate Cancer
Carnell, A. J., Kirk, R., Smith, M., McKenna, S., Lian, L. -Y., & Gibson, R. (2013). Inhibition of Human α-Methylacyl CoA Racemase (AMACR): a Target for Prostate Cancer. CHEMMEDCHEM, 8(10), 1643-1647. doi:10.1002/cmdc.201300179
Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents.
Bouzidi, N., Deokar, H., Vogrig, A., Boucherle, B., Ripoche, I., Abrunhosa-Thomas, I., . . . Ducki, S. (2013). Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents.. Bioorganic & medicinal chemistry letters, 23(9), 2624-2627. doi:10.1016/j.bmcl.2013.02.100
NMR studies of weak protein-protein interactions.
Lian, L. -Y. (2013). NMR studies of weak protein-protein interactions.. Progress in nuclear magnetic resonance spectroscopy, 71, 59-72. doi:10.1016/j.pnmrs.2012.11.002
Metastasis-Promoting Anterior Gradient 2 Protein Has a Dimeric Thioredoxin Fold Structure and a Role in Cell Adhesion
Patel, P., Clarke, C., Barraclough, D. L., Jowitt, T. A., Rudland, P. S., Barraclough, R., & Lian, L. -Y. (2013). Metastasis-Promoting Anterior Gradient 2 Protein Has a Dimeric Thioredoxin Fold Structure and a Role in Cell Adhesion. JOURNAL OF MOLECULAR BIOLOGY, 425(5), 929-943. doi:10.1016/j.jmb.2012.12.009
Cooperative Catalysis through Noncovalent Interactions
Tang, W., Johnston, S., Iggo, J. A., Berry, N. G., Phelan, M., Lian, L., . . . Xiao, J. (2013). Cooperative Catalysis through Noncovalent Interactions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(6), 1668-1672. doi:10.1002/anie.201208774
Development of Small Molecule Inhibitors of Cyclophilin D for Treatment of Severe Acute Pancreatitis
Awais, M., Javed, M. A., Wen, L., Gibson, R., Shore, E., Kershaw, N., . . . Sutton, R. (2013). Development of Small Molecule Inhibitors of Cyclophilin D for Treatment of Severe Acute Pancreatitis. PANCREAS, 42(8), 1338. Retrieved from https://www.webofscience.com/
2012
Solution NMR Structure of the Ca<SUP>2+</SUP>-bound N-terminal Domain of CaBP7 <i>A REGULATOR OF GOLGI TRAFFICKING</i>
McCue, H. V., Patel, P., Herbert, A. P., Lian, L. -Y., Burgoyne, R. D., & Haynes, L. P. (2012). Solution NMR Structure of the Ca<SUP>2+</SUP>-bound N-terminal Domain of CaBP7 <i>A REGULATOR OF GOLGI TRAFFICKING</i>. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(45). doi:10.1074/jbc.M112.402289
Structure and assembly of a trans-periplasmic channel for type IV pili in Neisseria meningitidis.
Berry, J. -L., Phelan, M. M., Collins, R. F., Adomavicius, T., Tønjum, T., Frye, S. A., . . . Derrick, J. P. (2012). Structure and assembly of a trans-periplasmic channel for type IV pili in Neisseria meningitidis.. PLoS pathogens, 8(9), e1002923. doi:10.1371/journal.ppat.1002923
NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast
Herbert, A. P., Riesen, M., Bloxam, L., Kosmidou, E., Wareing, B. M., Johnson, J. R., . . . Morgan, A. (2012). NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast. PLOS ONE, 7(7). doi:10.1371/journal.pone.0041975
Splice variant <i>PRKC</i>-ζ-<i><sub>PrC</sub></i> is a novel biomarker of human prostate cancer
Yao, S., Ireland, S. J., Bee, A., Beesley, C., Forootan, S. S., Dodson, A., . . . Foster, C. S. (2012). Splice variant <i>PRKC</i>-ζ-<i><sub>PrC</sub></i> is a novel biomarker of human prostate cancer. BRITISH JOURNAL OF CANCER, 107(2), 388-399. doi:10.1038/bjc.2012.162
Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies.
Elliott, V. L., Edge, G. T., Phelan, M. M., Lian, L. -Y., Webster, R., Finn, R. F., . . . Kitteringham, N. R. (2012). Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies.. Molecular pharmaceutics, 9(5), 1291-1301. doi:10.1021/mp200587m
Asymmetric Mode of Ca<SUP>2+</SUP>-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling
Elliott, P. R., Irvine, A. F., Jung, H. S., Tozawa, K., Pastok, M. W., Picone, R., . . . Barsukov, I. L. (2012). Asymmetric Mode of Ca<SUP>2+</SUP>-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling. STRUCTURE, 20(4), 654-666. doi:10.1016/j.str.2012.02.002
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.
Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2012). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic acids research, 40(7), 3232-3244. doi:10.1093/nar/gkr1164
Conformational characterization of synapse-associated protein 97 by nuclear magnetic resonance and small-angle X-ray scattering shows compact and elongated forms.
Tully, M. D., Grossmann, J. G., Phelan, M., Pandelaneni, S., Leyland, M., & Lian, L. -Y. (2012). Conformational characterization of synapse-associated protein 97 by nuclear magnetic resonance and small-angle X-ray scattering shows compact and elongated forms.. Biochemistry, 51(4), 899-908. doi:10.1021/bi201178v
Solution NMR Structure of the Ca2+-Bound N-Terminal Domain of Calcium Binding Protein 7 (CaBP7): A regulator of Golgi trafficking
McCue, H. V., Patel, P., Herbert, A. P., Lian, L. -Y., Burgoyne, R. D., & Haynes, L. P. (2012). Solution NMR Structure of the Ca2+-Bound N-Terminal Domain of Calcium Binding Protein 7 (CaBP7): A regulator of Golgi trafficking. J.Biol. Chem., 45 DOI.
2011
Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1
Lian, L. -Y., Pandalaneni, S. R., Patel, P., McCue, H. V., Haynes, L. P., & Burgoyne, R. D. (2011). Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1. PLOS ONE, 6(11). doi:10.1371/journal.pone.0027779
Cytochrome P450 6M2 from the malaria vector <i>Anopheles gambiae</i> metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed
Stevenson, B. J., Bibby, J., Pignatelli, P., Muangnoicharoen, S., O'Neill, P. M., Lian, L. -Y., . . . Paine, M. J. I. (2011). Cytochrome P450 6M2 from the malaria vector <i>Anopheles gambiae</i> metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 41(7), 492-502. doi:10.1016/j.ibmb.2011.02.003
Biochemical Comparison of <i>Anopheles gambiae</i> and Human NADPH P450 Reductases Reveals Different 2′-5′-ADP and FMN Binding Traits
Lian, L. -Y., Widdowson, P., McLaughlin, L. A., & Paine, M. J. I. (2011). Biochemical Comparison of <i>Anopheles gambiae</i> and Human NADPH P450 Reductases Reveals Different 2′-5′-ADP and FMN Binding Traits. PLOS ONE, 6(5). doi:10.1371/journal.pone.0020574
NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95.
Vogrig, A., Boucherle, B., Deokar, H., Thomas, I., Ripoche, I., Lian, L. -Y., & Ducki, S. (2011). NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95.. Bioorganic & medicinal chemistry letters, 21(11), 3349-3353. doi:10.1016/j.bmcl.2011.04.011
The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing
Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The (1)H, (13)C and (15)N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing. BIOMOLECULAR NMR ASSIGNMENTS, 5, 7-10.
The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.
Clayton, J. C., Phelan, M., Goult, B. T., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2011). The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.. Biomolecular NMR assignments, 5(1), 7-10. doi:10.1007/s12104-010-9254-5
Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1
Lian, L. Y., Pandalaneni, S. R., Patel, P., McCue, H. V., Haynes, L. P., & Burgoyne, R. D. (2011). Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1. PLoS ONE, 6(11), e27779. doi:10.1371/journal.pone.0027779PONE-D-11-17757
Protein NMR Spectroscopy: Practical Techniques and Applications
Roberts, G., & Lian, L. -Y. (Eds.) (2011). Protein NMR Spectroscopy: Practical Techniques and Applications. New Jersey: Wiley-Blackwell.
Protein NMR Spectroscopy: Principal Techniques and Applications
Lian, L. Y., & Roberts, G. C. K. (2011). Protein NMR Spectroscopy: Principal Techniques and Applications. L. Y. Lian, & G. C. K. Roberts (Eds.), London: Chichester.
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.
Phelan, M. M., Goult, B. T., Clayton, J. C., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2011). The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.. Nucleic Acids Research.
2010
1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein.
Phelan, M. M., McLean, L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2010). 1H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein.. Biomolecular NMR assignments, 4(2), 239-241. doi:10.1007/s12104-010-9253-6
Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010)
Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010). DRUG METABOLISM AND DISPOSITION, 38(7), 1259. doi:10.1124/dmd.38.7.1259
Structural and Functional Deficits in a Neuronal Calcium Sensor-1 Mutant Identified in a Case of Autistic Spectrum Disorder
Handley, M. T. W., Lian, L. -Y., Haynes, L. P., & Burgoyne, R. D. (2010). Structural and Functional Deficits in a Neuronal Calcium Sensor-1 Mutant Identified in a Case of Autistic Spectrum Disorder. PLOS ONE, 5(5). doi:10.1371/journal.pone.0010534
PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.
Yao, S., Bee, A., Brewer, D., Dodson, A., Beesley, C., Ke, Y., . . . Foster, C. S. (2010). PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.. Genes & cancer, 1(5), 444-464. doi:10.1177/1947601910376079
(1)H, (15)N and (13)C resonance assignment of darcin, a mouse major urinary protein
Phelan, M. M., McLean, L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. Y. (2010). (1)H, (15)N and (13)C resonance assignment of darcin, a mouse major urinary protein. BIOMOLECULAR NMR ASSIGNMENTS, 4, 239-241.
H-1, N-15 and C-13 resonance assignment of darcin, a mouse major urinary protein
Phelan, M. M., McLean, L. L., Simpson, D. M., Hurst, J. L., Beynon, R. J., & Lian, L. -Y. (2010). H-1, N-15 and C-13 resonance assignment of darcin, a mouse major urinary protein. BIOMOLECULAR NMR ASSIGNMENTS, 4, 239-241.
Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries
Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38(1), 122-132. doi:10.1124/dmd.109.028688
Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries
Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38, 122-132.
2009
Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite.
Lian, L. -Y., Al-Helal, M., Roslaini, A. M., Fisher, N., Bray, P. G., Ward, S. A., & Biagini, G. A. (2009). Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite.. Malaria journal, 8, 38. doi:10.1186/1475-2875-8-38
Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in <i>Caenorhabditis elegans</i>
Johnson, J. R., Ferdek, P., Lian, L. -Y., Barclay, J. W., Burgoyne, R. D., & Morgan, A. (2009). Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in <i>Caenorhabditis elegans</i>. BIOCHEMICAL JOURNAL, 418, 73-80. doi:10.1042/BJ20081956
Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine
Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. Y., Gardner, I., Chaponda, M., . . . Park, B. K. (2009). Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(2), 276-277. Retrieved from https://www.webofscience.com/
2008
S-nitrosylation of syntaxin 1 at Cys<SUP>145</SUP> is a regulatory switch controlling Munc18-1 binding
Palmer, Z. J., Duncan, R. R., Johnson, J. R., Lian, L. -Y., Mello, L. V., Booth, D., . . . Morgan, A. (2008). S-nitrosylation of syntaxin 1 at Cys<SUP>145</SUP> is a regulatory switch controlling Munc18-1 binding. BIOCHEMICAL JOURNAL, 413, 479-491. doi:10.1042/BJ20080069
Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.
Hautbergue, G. M., Hung, M. -L., Golovanov, A. P., Lian, L. -Y., & Wilson, S. A. (2008). Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.. Proceedings of the National Academy of Sciences of the United States of America, 105(13), 5154-5159. doi:10.1073/pnas.0709167105
Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues
Jack, E. R., Madine, J., Lian, L. -Y., & Middleton, D. A. (2008). Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues. MOLECULAR MEMBRANE BIOLOGY, 25(1), 14-22. doi:10.1080/09687680701494007
2007
Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1
Goult, B. T., Rapley, J. D., Dart, C., Kitmitto, A., Grossmann, J. G., Leyland, M. L., & Lian, L. -Y. (2007). Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1. BIOCHEMISTRY, 46(49), 14117-14128. doi:10.1021/bi701257z
Detection and biochemical characterisation of a novel polymorphism in the human <i>GSTP1</i> gene
Kitteringham, N. R., Palmer, L., Owen, A., Lian, L. -Y., Jenkins, R., Dowdall, S., . . . Goldring, C. E. (2007). Detection and biochemical characterisation of a novel polymorphism in the human <i>GSTP1</i> gene. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1240-1247. doi:10.1016/j.bbagen.2007.05.001
Apo calmodulin binding to the L-type voltage-gated calcium channel Cav1.2 IQ peptide.
Lian, L. -Y., Myatt, D., & Kitmitto, A. (2007). Apo calmodulin binding to the L-type voltage-gated calcium channel Cav1.2 IQ peptide.. Biochemical and biophysical research communications, 353(3), 565-570. doi:10.1016/j.bbrc.2006.12.070
Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression.
Kedzierska, B., Lian, L. -Y., & Hayes, F. (2007). Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression.. Nucleic acids research, 35(1), 325-339. doi:10.1093/nar/gkl1028
2006
The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold.
Golovanov, A. P., Balasingham, S., Tzitzilonis, C., Goult, B. T., Lian, L. -Y., Homberset, H., . . . Derrick, J. P. (2006). The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold.. Journal of molecular biology, 364(2), 186-195. doi:10.1016/j.jmb.2006.08.078
Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.
Hargous, Y., Hautbergue, G. M., Tintaru, A. M., Skrisovska, L., Golovanov, A. P., Stevenin, J., . . . Allain, F. H. -T. (2006). Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.. The EMBO journal, 25(21), 5126-5137. doi:10.1038/sj.emboj.7601385
The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA.
Golovanov, A. P., Hautbergue, G. M., Tintaru, A. M., Lian, L. -Y., & Wilson, S. A. (2006). The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA.. RNA (New York, N.Y.), 12(11), 1933-1948. doi:10.1261/rna.212106
Assignment of 1H, 13C, and 15N resonances for the REF2-I (1-155) mRNA export factor
Golovanov, A. P., Hautbergue, G. M., Wilson, S. A., & Lian, L. Y. (2006). Assignment of 1H, 13C, and 15N resonances for the REF2-I (1-155) mRNA export factor. J. Biom. NMR., in press.
2005
Distinct domains of small Tims involved in subunit interaction and substrate recognition.
Vergnolle, M. A. S., Baud, C., Golovanov, A. P., Alcock, F., Luciano, P., Lian, L. -Y., & Tokatlidis, K. (2005). Distinct domains of small Tims involved in subunit interaction and substrate recognition.. Journal of molecular biology, 351(4), 839-849. doi:10.1016/j.jmb.2005.06.010
The unstructured N-terminal tail of ParG modulates assembly of a quaternary nucleoprotein complex in transcription repression.
Carmelo, E., Barillà, D., Golovanov, A. P., Lian, L. -Y., Derome, A., & Hayes, F. (2005). The unstructured N-terminal tail of ParG modulates assembly of a quaternary nucleoprotein complex in transcription repression.. The Journal of biological chemistry, 280(31), 28683-28691. doi:10.1074/jbc.m501173200
2004
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.
Papagrigoriou, E., Gingras, A. R., Barsukov, I. L., Bate, N., Fillingham, I. J., Patel, B., . . . Emsley, J. (2004). Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.. The EMBO journal, 23(15), 2942-2951. doi:10.1038/sj.emboj.7600285
A simple method for improving protein solubility and long-term stability.
Golovanov, A. P., Hautbergue, G. M., Wilson, S. A., & Lian, L. -Y. (2004). A simple method for improving protein solubility and long-term stability.. Journal of the American Chemical Society, 126(29), 8933-8939. doi:10.1021/ja049297h
Kinetic and structural characterization of a product complex of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Escherichia coli.
Garçon, A., Bermingham, A., Lian, L. -Y., & Derrick, J. P. (2004). Kinetic and structural characterization of a product complex of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Escherichia coli.. The Biochemical journal, 380(Pt 3), 867-873. doi:10.1042/bj20031850
Solution structure of the two-iron rubredoxin of Pseudomonas oleovorans determined by NMR spectroscopy and solution X-ray scattering and interactions with rubredoxin reductase.
Perry, A., Tambyrajah, W., Grossmann, J. G., Lian, L. -Y., & Scrutton, N. S. (2004). Solution structure of the two-iron rubredoxin of Pseudomonas oleovorans determined by NMR spectroscopy and solution X-ray scattering and interactions with rubredoxin reductase.. Biochemistry, 43(11), 3167-3182. doi:10.1021/bi035817u
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.
Day, C. L., Puthalakath, H., Skea, G., Strasser, A., Barsukov, I., Lian, L. -Y., . . . Hinds, M. G. (2004). Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.. The Biochemical journal, 377(Pt 3), 597-605. doi:10.1042/bj20031251
2003
ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure.
Golovanov, A. P., Barillà, D., Golovanova, M., Hayes, F., & Lian, L. -Y. (2003). ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure.. Molecular microbiology, 50(4), 1141-1153. doi:10.1046/j.1365-2958.2003.03750.x
Real-time chemical-shift scaling in high-resolution NMR spectroscopy.
Morris, G. A., Jerome, N. P., & Lian, L. -Y. (2003). Real-time chemical-shift scaling in high-resolution NMR spectroscopy.. Angewandte Chemie (International ed. in English), 42(7), 823-825. doi:10.1002/anie.200390220
2001
Role of the conserved phenylalanine 181 of NADPH-cytochrome p450 oxidoreductase in FMN binding and catalytic activity
Paine, M. J. I., Ayivor, S., Munro, A., Tsan, P., Lian, L. Y., Roberts, G. C. K., & Wolf, C. R. (2001). Role of the conserved phenylalanine 181 of NADPH-cytochrome p450 oxidoreductase in FMN binding and catalytic activity. BIOCHEMISTRY, 40(45), 13439-13447. doi:10.1021/bi011147l
Labelling approaches for protein structural studies by solution-state and solid-state NMR
Lian, L. -Y., & Middleton, D. A. (2001). Labelling approaches for protein structural studies by solution-state and solid-state NMR. Progress in Nuclear Magnetic Resonance Spectroscopy, 39(3), 171-190. doi:10.1016/s0079-6565(01)00034-6
Labelling approaches for protein structural studies by solution state and solid state NMR
Lian, L. Y., & Middleton, D. A. (2001). Labelling approaches for protein structural studies by solution state and solid state NMR. Progress in Nuclear Magentic Resonance Spectroscopy, 39(3), 171-190.
1999
Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 Å resolution
Zhao, Q., Modi, S., Smith, G., Paine, M., McDonagh, P. D., Wolf, C. R., . . . Driessen, H. P. C. (1999). Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 Å resolution. PROTEIN SCIENCE, 8(2), 298-306. Retrieved from https://www.webofscience.com/
1997
Active site models of human cytochrome P450s based on NMR relaxation measurements
Modi, S., Paine, M. J., Oliver, C. F., Smith, G., Sutcliffe, M. J., Gilhartr, D. E., . . . Roberts, G. C. K. (1997). Active site models of human cytochrome P450s based on NMR relaxation measurements. FASEB Journal, 11(9).
Genetic structional and functional analysis of cytochrome P450s in the CYP2D gene family
Wolf, C. R., Modi, S., Lian, L. Y., Paine, M., Smith, G., & Roberts, G. C. K. (1997). Genetic structional and functional analysis of cytochrome P450s in the CYP2D gene family. FASEB Journal, 11(9).
H-1,N-15 and C-13 NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase
Barsukov, I., Modi, S., Lian, L. Y., Sze, K. H., Paine, M. J. I., Wolf, C. R., & Roberts, G. C. K. (1997). H-1,N-15 and C-13 NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase. JOURNAL OF BIOMOLECULAR NMR, 10(1), 63-75. doi:10.1023/A:1018313830207
1996
A model for human cytochrome P-450 2D6 based on homology modeling and NMR studies of substrate binding
Modi, S., Paine, M. J., Sutcliffe, M. J., Lian, L. Y., Primrose, W. U., Wolf, C. R., & Roberts, G. C. K. (1996). A model for human cytochrome P-450 2D6 based on homology modeling and NMR studies of substrate binding. BIOCHEMISTRY, 35(14), 4540-4550. doi:10.1021/bi952742o
Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase
Zhao, Q., Smith, G., Modi, S., Paine, M., Wolf, R. C., Tew, D., . . . Driessen, H. P. C. (1996). Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase. JOURNAL OF STRUCTURAL BIOLOGY, 116(2), 320-325. doi:10.1006/jsbi.1996.0048
1995
STRUCTURAL STUDIES ON FMN DOMAIN OF CYTOCHROME-P450 REDUCTASE
MODI, S., LIAN, L. Y., ROBERTS, G. C. K., SMITH, G. C. M., PAINE, M., & WOLF, C. R. (1995). STRUCTURAL STUDIES ON FMN DOMAIN OF CYTOCHROME-P450 REDUCTASE. BIOCHEMICAL SOCIETY TRANSACTIONS, 23(3), S476. doi:10.1042/bst023476s