Research outputs
2025
Abstract P3-12-24: PREMO CNS: PREsentation, Management and Outcomes of patients with CNS disease secondary to breast cancer in England
Bhogal, T., Tharmaratnam, K., Cheyne, C., Leeming, G., Garcia-Finana, M., & Palmieri, C. (2025). Abstract P3-12-24: PREMO CNS: PREsentation, Management and Outcomes of patients with CNS disease secondary to breast cancer in England. Clinical Cancer Research, 31(12_Supplement). doi:10.1158/1557-3265.sabcs24-p3-12-24
Elevated serum interferon-α2 associates with activity and flare risk in juvenile-onset systemic lupus erythematosus.
Natoli, V., Crow, Y. J., Hunt, D. P. J., Tharmaratnam, K., Jorgensen, A. L., Beresford, M. W., . . . Smith, E. M. D. (2025). Elevated serum interferon-α2 associates with activity and flare risk in juvenile-onset systemic lupus erythematosus.. Rheumatology (Oxford, England), 64(6), 3938-3946. doi:10.1093/rheumatology/keae643
P297 The presence of oral bacterial pathobionts and their volatile organic compound markers in the stool of colorectal cancer patients
Slater, R., Frau, A., Ijaz, U. Z., Green, K., Tharmaratnam, K., Lofthouse, M., . . . Probert, C. (2025). P297 The presence of oral bacterial pathobionts and their volatile organic compound markers in the stool of colorectal cancer patients. In Posters (pp. A270.2-A271). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2025-bsg.430
P298 A volatile organic compound, clinical variable and faecal immunochemical test model for the detection of malignant and pre-malignant colorectal neoplasia
Slater, R., Tharmaratnam, K., Green, K., Frau, A., Lofthouse, M., Hold, G., . . . Probert, C. (2025). P298 A volatile organic compound, clinical variable and faecal immunochemical test model for the detection of malignant and pre-malignant colorectal neoplasia. In Posters (pp. A271). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2025-bsg.431
Validation of childhood lupus specific targets: ensuring accurate assessment of disease control in younger, lighter paediatric patients.
Sarker, C., Jorgensen, A. L., Tharmaratnam, K., Al-Abadi, E., Armon, K., Bailey, K., . . . Smith, E. M. D. (2025). Validation of childhood lupus specific targets: ensuring accurate assessment of disease control in younger, lighter paediatric patients.. Rheumatology (Oxford, England), 64(6), 3587-3597. doi:10.1093/rheumatology/keaf057
16 Can we "smell" something important?
Cornford, P., Dawson, J., Yassaie, O., Lazarowicz, H., Tharmaratnam, K., Garyia-Finana, M., & Probert, C. (2025). 16 Can we "smell" something important?. European Urology Open Science, 71, S18. doi:10.1016/s2666-1683(25)00019-9
Cognitive domains affected post-COVID-19; a systematic review and meta-analysis.
Fanshawe, J. B., Sargent, B. F., Badenoch, J. B., Saini, A., Watson, C. J., Pokrovskaya, A., . . . Leek, C. E. (2025). Cognitive domains affected post-COVID-19; a systematic review and meta-analysis.. European journal of neurology, 32(1), e16181. doi:10.1111/ene.16181
Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction.
Wood, G. K., Sargent, B. F., Ahmad, Z. -U. -A., Tharmaratnam, K., Dunai, C., Egbe, F. N., . . . Leek, E. C. (2024). Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction.. Nature medicine. doi:10.1038/s41591-024-03309-8
2024
Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain
Dunai, C., Hetherington, C., Boardman, S. A., Clark, J. J., Sharma, P., Subramaniam, K., . . . Michael, B. D. (2024). Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain. Frontiers in Immunology, 15. doi:10.3389/fimmu.2024.1440324
Gas Chromatography-Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn's from Ulcerative Colitis, in Children.
Slater, R., Tharmaratnam, K., Belnour, S., Auth, M. K. -H., Muhammed, R., Spray, C., . . . Probert, C. (2024). Gas Chromatography-Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn's from Ulcerative Colitis, in Children.. Sensors (Basel, Switzerland), 24(15), 5079. doi:10.3390/s24155079
Faecal volatile organic compounds differ according to inflammatory bowel disease sub-type, severity, and response to treatment in paediatric patients.
Belnour, S., Slater, R., Tharmaratnam, K., Karl-Heinz Auth, M., Muhammed, R., Spray, C., . . . Allen, S. (2024). Faecal volatile organic compounds differ according to inflammatory bowel disease sub-type, severity, and response to treatment in paediatric patients.. United European gastroenterology journal, 12(6), 780-792. doi:10.1002/ueg2.12603
P109 Faecal volatile organic compound detection using a gas chromatography sensor to diagnose inflammatory bowel disease in a paediatric inception cohort
Slater, R., Tharmaratnam, K., Belnour, S., Auth, M., Muhammed, R., Spray, C., . . . Probert, C. (2024). P109 Faecal volatile organic compound detection using a gas chromatography sensor to diagnose inflammatory bowel disease in a paediatric inception cohort. In Poster Presentations (pp. A116.1-A116). BMJ Publishing Group Ltd and British Society of Gastroenterology. doi:10.1136/gutjnl-2024-bsg.191
Diagnostic markers of acute encephalitis syndrome and COVID-associated multisystem inflammatory syndrome in children from Southern India.
Damodar, T., Dunai, C., Prabhu, N., Jose, M., Akhila, L., Kinhal, U. V., . . . Mani, R. S. (2024). Diagnostic markers of acute encephalitis syndrome and COVID-associated multisystem inflammatory syndrome in children from Southern India.. Journal of medical virology, 96(5), e29666. doi:10.1002/jmv.29666
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 15(1), 2918. doi:10.1038/s41467-024-47320-6
Lower than expected? Establishing a PSA density threshold
Dawson, J., Yassaie, O., Tharmaratnam, K., Garcia-Finana, M., Probert, C., Lazarowicz, H. P., & Cornford, P. A. (2024). Lower than expected? Establishing a PSA density threshold. European Urology, 85, S1689. doi:10.1016/s0302-2838(24)01294-6
COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region
Burnside, G., Cheyne, C. P., Leeming, G., Humann, M., Darby, A., Green, M. A., . . . Buchan, I. E. (2024). COVID-19 risk-mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region. Journal of the Royal Society of Medicine. doi:10.1177/01410768231182389
2023
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4
Clinical predictors of encephalitis in UK adults-A multi-centre prospective observational cohort study.
Defres, S., Tharmaratnam, K., Michael, B. D., Ellul, M., Davies, N. W. S., Easton, A., . . . Solomon, T. (2023). Clinical predictors of encephalitis in UK adults-A multi-centre prospective observational cohort study.. PloS one, 18(8), e0282645. doi:10.1371/journal.pone.0282645
Scientific Business Abstracts
Siew, K., Patel, V., Zimmermann, J., Vaughan, M., Cheshire, C., Kubik, A., . . . Leek, C. (2023). Scientific Business Abstracts. QJM: An International Journal of Medicine. doi:10.1093/qjmed/hcad072
A Novel Filter and Embedded Feature Selection Methods applied to High Dimensional Metabolomics Data in Enhancing Colorectal Cancer Classification
2022
Phase I/II Clinical Trials of Donor-Derived Purified Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft Versus Host Disease
Soares, M. V., Gomez, V. E., Azevedo, R. I., Pereira, P. N. G., Velazquez, T. C., Garcia-Calderon, C. B., . . . Lacerda, J. F. (2022). Phase I/II Clinical Trials of Donor-Derived Purified Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft Versus Host Disease. In BLOOD Vol. 140. doi:10.1182/blood-2022-163394
Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts
Wood, G. K., Babar, R., Ellul, M. A., Thomas, R. H., Van Den Tooren, H., Easton, A., . . . Michael, B. D. (2022). Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts. BMJ Neurology Open, 4(2), e000323. doi:10.1136/bmjno-2022-000323
Attainment of low disease activity and remission targets reduces the risk of severe flare and new damage in childhood lupus
Smith, E. M. D., Tharmaratnam, K., Al-Abadi, E., Armon, K., Bailey, K., Brennan, M., . . . Beresford, M. W. (2021). Attainment of low disease activity and remission targets reduces the risk of severe flare and new damage in childhood lupus. Rheumatology. doi:10.1093/rheumatology/keab915
2021
THE UTILITY OF ESTABLISHED PROGNOSTIC SCORES IN COVID-19 HOSPITAL ADMISSIONS: A COLLABORATIVE TRAINEE-LED, MULTI-CENTRE PROSPECTIVE EVALUATION OF CURB-65, NEWS2, AND QSOFA
Frost, F., Bradley, P., Tharmaratnam, K., & Wootton, D. (2021). THE UTILITY OF ESTABLISHED PROGNOSTIC SCORES IN COVID-19 HOSPITAL ADMISSIONS: A COLLABORATIVE TRAINEE-LED, MULTI-CENTRE PROSPECTIVE EVALUATION OF CURB-65, NEWS2, AND QSOFA. In THORAX Vol. 76 (pp. A57-A58). doi:10.1136/thorax-2020-BTSabstracts.100
2020
The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA
Bradley, P., Frost, F., Tharmaratnam, K., & Wootton, D. G. (2020). The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA. BMJ Open Respiratory Research, 7(1). doi:10.1101/2020.07.15.20154815
Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA
Bradley, P., Frost, F., Tharmaratnam, K., & Wootton, D. G. (2020). Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA. BMJ OPEN RESPIRATORY RESEARCH, 7(1). doi:10.1136/bmjresp-2020-000729
Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study.
Harris, L., Griem, J., Gummery, A., Marsh, L., Defres, S., Bhojak, M., . . . ENCEPH UK study group. (2020). Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study.. PloS one, 15(3), e0230436. doi:10.1371/journal.pone.0230436
2018
Cancer risk and survival in <i>path</i>_<i>MMR</i> carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
Moller, P., Seppala, T. T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., . . . Capella, G. (2018). Cancer risk and survival in <i>path</i>_<i>MMR</i> carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. GUT, 67(7), 1306-1316. doi:10.1136/gutjnl-2017-314057
Identification of predicted individual treatment effects in randomized clinical trials
Lamont, A., Lyons, M. D., Jaki, T., Stuart, E., Feaster, D. J., Tharmaratnam, K., . . . Van Horn, M. L. (2018). Identification of predicted individual treatment effects in randomized clinical trials. STATISTICAL METHODS IN MEDICAL RESEARCH, 27(1), 142-157. doi:10.1177/0962280215623981
2017
Colorectal cancer incidence in <i>path_MLH1</i> carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report
Seppala, T., Pylvanainen, K., Evans, D. G., Jarvinen, H., Renkonen-Sinisalo, L., Bernstein, I., . . . Moller, P. (2017). Colorectal cancer incidence in <i>path_MLH1</i> carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report. HEREDITARY CANCER IN CLINICAL PRACTICE, 15. doi:10.1186/s13053-017-0078-5
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database
Moller, P., Seppala, T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., . . . Capella, G. (2017). Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database. GUT, 66(9), 1657-1664. doi:10.1136/gutjnl-2016-311403
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database
Moller, P., Seppala, T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., . . . Moslein, G. (2017). Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database. GUT, 66(3), 464-472. doi:10.1136/gutjnl-2015-309675
Point and interval estimation for predicting individual patients treatment effect based on randomized clinical trial data
Tharmaratnam, K., & Jaki, T. (2017). Point and interval estimation for predicting individual patients treatment effect based on randomized clinical trial data. In TRIALS Vol. 18. Retrieved from https://www.webofscience.com/
2016
Tilting the lasso by knowledge-based post-processing
Tharmaratnam, K., Sperrin, M., Jaki, T., Reppe, S., & Frigessi, A. (2016). Tilting the lasso by knowledge-based post-processing. BMC BIOINFORMATICS, 17. doi:10.1186/s12859-016-1210-7
Intensive breast screening in <i>BRCA2</i> mutation carriers is associated with reduced breast cancer specific and all cause mortality
Evans, D. G., Harkness, E. F., Howell, A., Wilson, M., Hurley, E., Holmen, M. M., . . . Moller, P. (2016). Intensive breast screening in <i>BRCA2</i> mutation carriers is associated with reduced breast cancer specific and all cause mortality. HEREDITARY CANCER IN CLINICAL PRACTICE, 14. doi:10.1186/s13053-016-0048-3
2015
Tumour characteristics and survival in familial breast cancer prospectively diagnosed by annual mammography
Moller, P., Tharmaratnam, K., Howell, A., Stavrinos, P., Sampson, S., Wallace, A., . . . Evans, D. G. (2015). Tumour characteristics and survival in familial breast cancer prospectively diagnosed by annual mammography. BREAST CANCER RESEARCH AND TREATMENT, 152(1), 87-94. doi:10.1007/s10549-015-3448-6
Ten modifiers of <i>BRCA1</i> penetrance validated in a Norwegian series
Heramb, C., Ekstrom, P. O., Tharmaratnam, K., Hovig, E., Moller, P., & Maehle, L. (2015). Ten modifiers of <i>BRCA1</i> penetrance validated in a Norwegian series. HEREDITARY CANCER IN CLINICAL PRACTICE, 13. doi:10.1186/s13053-015-0035-0
Regression
Glad, I. K., & Tharmaratnam, K. (2015). Regression. In Encyclopedia of Applied and Computational Mathematics (pp. 1225-1233). Springer Berlin Heidelberg. doi:10.1007/978-3-540-70529-1_420
2014
MRI screening of women with hereditary predisposition to breast cancer: diagnostic performance and survival analysis
Tharmaratnam, K., Hagen, A. I., & Moller, P. (2014). MRI screening of women with hereditary predisposition to breast cancer: diagnostic performance and survival analysis. BREAST CANCER RESEARCH AND TREATMENT, 148(3), 687-688. doi:10.1007/s10549-014-3178-1
2013
Monotone Splines Lasso
Monotone splines lasso
Bergersen, L. C., Tharmaratnam, K., & Glad, I. K. (2014). Monotone splines lasso. COMPUTATIONAL STATISTICS & DATA ANALYSIS, 77, 336-351. doi:10.1016/j.csda.2014.03.013
A comparison of robust versions of the AIC based on M-, S- and MM-estimators
Tharmaratnam, K., & Claeskens, G. (2013). A comparison of robust versions of the AIC based on M-, S- and MM-estimators. Statistics, 47(1), 216-235. doi:10.1080/02331888.2011.568120
2011
S-Estimation and a Robust Conditional Akaike Information Criterion for Linear Mixed Models
Tharmaratnam, K., & Claeskens, G. (2011). S-Estimation and a Robust Conditional Akaike Information Criterion for Linear Mixed Models.
2010
S-Estimation for Penalized Regression Splines
Tharmaratnam, K., Claeskens, G., Croux, C., & Salibián-Barrera, M. (2010). S-Estimation for Penalized Regression Splines. Journal of Computational and Graphical Statistics, 19(3), 609-625. doi:10.1198/jcgs.2010.08149