Publications
2024
Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.
Kennedy, P. T., Saulters, E. L., Duckworth, A. D., Lim, Y. J., Woolley, J. F., Slupsky, J. R., . . . Dahal, L. N. (2024). Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.. Molecular therapy : the journal of the American Society of Gene Therapy, 32(2), 457-468. doi:10.1016/j.ymthe.2023.11.028
Differential Regulation of the Stimulator of Interferon Genes pathway in Human Papillomavirus positive and negative Head and Neck Cancers.
Saulters, E., Kennedy, P. T., Carter, R. J., Alsufyani, A., Jones, T. M., Woolley, J. F., & Dahal, L. N. (2024). Differential Regulation of the Stimulator of Interferon Genes pathway in Human Papillomavirus positive and negative Head and Neck Cancers.. Cancer research communications. doi:10.1158/2767-9764.crc-23-0299
2023
Neuroblastoma: an ongoing cold front for cancer immunotherapy.
Kennedy, P. T., Zannoupa, D., Son, M. H., Dahal, L. N., & Woolley, J. F. (2023). Neuroblastoma: an ongoing cold front for cancer immunotherapy.. Journal for immunotherapy of cancer, 11(11), e007798. doi:10.1136/jitc-2023-007798
Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity
Data from STINGing Viral Tumors: What We Know from Head and Neck Cancers
Saulters, E., Woolley, J. F., Varadarajan, S., Jones, T. M., & Dahal, L. N. (2023). Data from STINGing Viral Tumors: What We Know from Head and Neck Cancers. doi:10.1158/0008-5472.c.6513438
CD7 receptor expression as a therapeutic target in acute myeloid Leukaemia
Griffin, J., Healy, F., Slupsky, J., & Woolley, J. (2023). CD7 receptor expression as a therapeutic target in acute myeloid Leukaemia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 201 (pp. 32). Retrieved from https://www.webofscience.com/
NRAS contributes to drug-resistant acute myeloid leukaemia
Healy, F. M., Marensi, V., Woolley, J. F., & MacEwan, D. J. (2023). NRAS contributes to drug-resistant acute myeloid leukaemia. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 180 (pp. 492). Retrieved from https://www.webofscience.com/
NRAS mutations contribute to drug resistance in acute myeloid Leukaemia
Healy, F., Marensi, V., Woolley, J. F., & MacEwan, D. J. (2023). NRAS mutations contribute to drug resistance in acute myeloid Leukaemia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 201 (pp. 32-33). Retrieved from https://www.webofscience.com/
Prostaglandin G/H synthase signalling promotes poor outcome and chemoresistance in acute myeloid leukaemia
Alshammari, A., Alsufyani, A., Healy, F., Marensi, V., Griffin, J., & Woolley, J. (2023). Prostaglandin G/H synthase signalling promotes poor outcome and chemoresistance in acute myeloid leukaemia. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 201 (pp. 119). Retrieved from https://www.webofscience.com/
2022
A 5-microRNA signature derived from core binding factor-AML is predictive in adult and childhood AML.
Gabra, M. M., Chow, J. T. -S., Kim, T., Son, M. H., Arruda, A., Woolley, J. F., . . . Salmena, L. (2022). A 5-microRNA signature derived from core binding factor-AML is predictive in adult and childhood AML.. Leukemia research, 123, 106968. doi:10.1016/j.leukres.2022.106968
Identifying the INPP4B-lysosome signaling axis as a putative target in acute myeloid leukemia
Chen, K., Woolley, J. F., Lee, D. K. C., Melo, C. M. P., Saffi, G. T., He, A., . . . Salmena, L. (2022). Identifying the INPP4B-lysosome signaling axis as a putative target in acute myeloid leukemia. In EUROPEAN JOURNAL OF CANCER Vol. 174 (pp. S106). Retrieved from https://www.webofscience.com/
Development of a bispecific Antibody–Drug Conjugate targeting CD7 and CD33 to treat Acute Myeloid Leukaemia
P408: NRAS MUTATIONS ARE INVOLVED IN ACUTE MYELOID LEUKAEMIA DRUG RESISTANCE
Healy, F., Marensi, V., Woolley, J., & MacEwan, D. (n.d.). P408: NRAS MUTATIONS ARE INVOLVED IN ACUTE MYELOID LEUKAEMIA DRUG RESISTANCE. HemaSphere, 6, 308-309. doi:10.1097/01.hs9.0000844520.69163.7a
The importance of Ras in drug resistance in cancer
Healy, F. M., Prior, I. A., & MacEwan, D. J. (2022). The importance of Ras in drug resistance in cancer. BRITISH JOURNAL OF PHARMACOLOGY, 179(12), 2844-2867. doi:10.1111/bph.15420
Worked to the bone: antibody-based conditioning as the future of transplant biology
Griffin, J. M., Healy, F. M., Dahal, L. N., Floisand, Y., & Woolley, J. F. (2022). Worked to the bone: antibody-based conditioning as the future of transplant biology. JOURNAL OF HEMATOLOGY & ONCOLOGY, 15(1). doi:10.1186/s13045-022-01284-6
2021
Abstract P175: Investigating inositol polyphosphate-4-phosphatase, type II (INPP4B) signaling and role in acute myeloid leukemia
Chen, K., Genc, G. E., Woolley, J. F., Lee, D. K. C., Botelho, R. J., & Salmena, L. (2021). Abstract P175: Investigating inositol polyphosphate-4-phosphatase, type II (INPP4B) signaling and role in acute myeloid leukemia. Molecular Cancer Therapeutics, 20(12_Supplement), P175. doi:10.1158/1535-7163.targ-21-p175
DNA Damage/Repair Management in Cancers
Alhmoud, J. F., Woolley, J. F., Al Moustafa, A. -E., & Mallei, M. I. (2021). DNA Damage/Repair Management in Cancers. In Advances in Medical Biochemistry, Genomics, Physiology, and Pathology (pp. 309-339). Jenny Stanford Publishing. doi:10.1201/9781003180449-12
Recent Progress in Interferon Therapy for Myeloid Malignancies
Healy, F. M., Dahal, L. N., Jones, J. R. E., Floisand, Y., & Woolley, J. F. (2021). Recent Progress in Interferon Therapy for Myeloid Malignancies. FRONTIERS IN ONCOLOGY, 11. doi:10.3389/fonc.2021.769628
STINGing Viral Tumors: What We Know from Head and Neck Cancers
Saulters, E., Woolley, J. F., Varadarajan, S., Jones, T. M., & Dahal, L. N. (2021). STINGing Viral Tumors: What We Know from Head and Neck Cancers. CANCER RESEARCH, 81(15), 3945-3952. doi:10.1158/0008-5472.CAN-21-0785
Old Dog, New Trick: Type I IFN-Based Treatment for Acute Myeloid Leukemia
Alsufyani, A., Alanazi, R., Woolley, J. F., & Dahal, L. N. (2021). Old Dog, New Trick: Type I IFN-Based Treatment for Acute Myeloid Leukemia. MOLECULAR CANCER RESEARCH, 19(5), 753-756. doi:10.1158/1541-7786.MCR-20-0871
INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis
NRAS Mutations in Acute Myeloid Leukaemia Confer Increased Leukaemogenic Potential and Contribute to Drug Resistance
Healy, F., Marensi, V., Woolley, J. F., & MacEwan, D. J. (2021). NRAS Mutations in Acute Myeloid Leukaemia Confer Increased Leukaemogenic Potential and Contribute to Drug Resistance. BRITISH JOURNAL OF PHARMACOLOGY, 180, 1161-1162. doi:10.1111/bph.15420
NRAS mutations arise in resistance to FLT3 inhibitors in acute myeloid leukaemia
Healy, F., Marensi, V., Maerken, M., Anyfantis, G., Woolley, J., & MacEwan, D. (2021). NRAS mutations arise in resistance to FLT3 inhibitors in acute myeloid leukaemia. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 4949-4950). Retrieved from https://www.webofscience.com/
2020
DNA Damage/Repair Management in Cancers
Alhmoud, J. F., Woolley, J. F., Moustafa, A. -E. A., & Malki, M. I. (n.d.). DNA Damage/Repair Management in Cancers. Cancers, 12(4), 1050. doi:10.3390/cancers12041050
2018
SubID, a non-median dichotomization tool for heterogeneous populations, reveals the pan-cancer significance of INPP4B and its regulation by EVI1 in AML.
Dzneladze, I., Woolley, J. F., Rossell, C., Han, Y., Rashid, A., Jain, M., . . . Salmena, L. (2018). SubID, a non-median dichotomization tool for heterogeneous populations, reveals the pan-cancer significance of INPP4B and its regulation by EVI1 in AML.. PloS one, 13(2), e0191510. doi:10.1371/journal.pone.0191510
2016
A Novel Role for INPP4B in Haematopoiesis and Leukemia
Woolley, J. F., Son, M. H., Dzneladze, I., He, R., Mangialardi, E., Gabra, M., . . . Salmena, L. (2016). A Novel Role for INPP4B in Haematopoiesis and Leukemia. In BLOOD Vol. 128. doi:10.1182/blood.V128.22.1720.1720
CSF1R Is Associated with Poor Overall Survival in AML and Mediates Supportive Interactions Between AML and Stromal Cells in the AML Microenvironment
Rashid, A., Dzneladze, I., He, R., Woolley, J. F., Jain, M. D., & Minden, M. D. (2016). CSF1R Is Associated with Poor Overall Survival in AML and Mediates Supportive Interactions Between AML and Stromal Cells in the AML Microenvironment. In BLOOD Vol. 128. doi:10.1182/blood.V128.22.2666.2666
INPP4B is a Biomarker of Poor Prognosis in AML Which is Associated with EVI1 Overexpression and a LSC Signature
Dzneladze, I., Woolley, J. F., Han, Y., Sharobim, M., Rashid, A., Jain, M. D., . . . Salmena, L. (2016). INPP4B is a Biomarker of Poor Prognosis in AML Which is Associated with EVI1 Overexpression and a LSC Signature. In BLOOD Vol. 128. doi:10.1182/blood.V128.22.3929.3929
Measurement of PTEN by Flow Cytometry
Woolley, J. F., & Salmena, L. (2016). Measurement of PTEN by Flow Cytometry. PTEN: METHODS AND PROTOCOLS, 39-51. doi:10.1007/978-1-4939-3299-3_4
2015
Phosphoinositide signaling in cancer: INPP4B Akt(s) out
Woolley, J. F., Dzneladze, I., & Salmena, L. (2015). Phosphoinositide signaling in cancer: INPP4B Akt(s) out. TRENDS IN MOLECULAR MEDICINE, 21(9), 530-532. doi:10.1016/j.molmed.2015.06.006
INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia
Dzneladze, I., He, R., Woolley, J. F., Son, M. H., Sharobim, M. H., Greenberg, S. A., . . . Salmena, L. (2015). INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia. Leukemia, 29(7), 1485-1495. doi:10.1038/leu.2015.51
NADPH Oxidase-generated Hydrogen Peroxide Induces DNA Damage in Mutant FLT3-expressing Leukemia Cells
Stanicka, J., Russell, E. G., Woolley, J. F., & Cotter, T. G. (2015). NADPH Oxidase-generated Hydrogen Peroxide Induces DNA Damage in Mutant FLT3-expressing Leukemia Cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 290(15), 9348-9361. doi:10.1074/jbc.M113.510495
2013
Redox-Regulated Growth Factor Survival Signaling
Woolley, J. F., Corcoran, A., Groeger, G., Landry, W. D., & Cotter, T. G. (2013). Redox-Regulated Growth Factor Survival Signaling. ANTIOXIDANTS & REDOX SIGNALING, 19(15), 1815-U187. doi:10.1089/ars.2012.5028
Recent advances in reactive oxygen species measurement in biological systems
Woolley, J. F., Stanicka, J., & Cotter, T. G. (2013). Recent advances in reactive oxygen species measurement in biological systems. TRENDS IN BIOCHEMICAL SCIENCES, 38(11), 556-565. doi:10.1016/j.tibs.2013.08.009
Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox
Landry, W. D., Woolley, J. F., & Cotter, T. G. (2013). Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox. LEUKEMIA RESEARCH, 37(2), 183-189. doi:10.1016/j.leukres.2012.11.003
2012
H<sub>2</sub>O<sub>2</sub> Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling
Woolley, J. F., Naughton, R., Stanicka, J., Gough, D. R., Bhatt, L., Dickinson, B. C., . . . Cotter, T. G. (2012). H<sub>2</sub>O<sub>2</sub> Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling. PLOS ONE, 7(7). doi:10.1371/journal.pone.0034050
TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1
O'Leary, D. P., Bhatt, L., Woolley, J. F., Gough, D. R., Wang, J. H., Cotter, T. G., & Redmond, H. P. (2012). TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1. PLOS ONE, 7(10). doi:10.1371/journal.pone.0044176
2009
The Isolation and Identification of a Secreted Biomarker Associated With Cell Stress in Serum-Free CHO Cell Culture
Woolley, J. F., & Al-Rubeai, M. (2009). The Isolation and Identification of a Secreted Biomarker Associated With Cell Stress in Serum-Free CHO Cell Culture. BIOTECHNOLOGY AND BIOENGINEERING, 104(3), 590-600. doi:10.1002/bit.22408
The application of SELDI-TOF mass spectrometry to mammalian cell culture
Woolley, J. F., & Al-Rubeai, M. (2009). The application of SELDI-TOF mass spectrometry to mammalian cell culture. BIOTECHNOLOGY ADVANCES, 27(2), 177-184. doi:10.1016/j.biotechadv.2008.10.007