Publications
Selected publications
- MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival. (Journal article - 2014)
- Synthesis of a Targeted Library of Heparan Sulfate Hexa‐ to Dodecasaccharides as Inhibitors of β‐Secretase: Potential Therapeutics for Alzheimer’s Disease (Journal article - 2013)
- Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation. (Journal article - 2012)
- Generating heparan sulfate saccharide libraries for glycomics applications (Journal article - 2010)
- Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry. (Journal article - 2017)
2023
Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells.
Pagani, I., Ottoboni, L., Panina-Bordignon, P., Martino, G., Poli, G., Taylor, S., . . . Vicenzi, E. (2023). Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells.. Pharmaceuticals (Basel, Switzerland), 16(10), 1385. doi:10.3390/ph16101385
High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts
Maciej-Hulme, M. L., Leprince, A. C. N., Lavin, A., Guimond, S. E., Turnbull, J. E., Pelletier, J., . . . Skidmore, M. A. (2023). High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. ANALYTICAL METHODS, 15(11), 1461-1469. doi:10.1039/d2ay01803a
Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans
Parafioriti, M., Ni, M., Petitou, M., Mycroft-West, C. J., Rudd, T. R., Gandhi, N. S., . . . Elli, S. (2023). Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans. CHEMISTRY-A EUROPEAN JOURNAL, 29(1). doi:10.1002/chem.202202599
2022
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
Guimond, S. E., Mycroft-West, C. J., Gandhi, N. S., Tree, J. A., Le, T. T., Spalluto, C. M., . . . Turnbull, J. E. (2022). Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction. ACS Central Science. doi:10.1021/acscentsci.1c01293
2021
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
Karlsson, R., Chopra, P., Joshi, A., Yang, Z., Vakhrushev, S. Y., Clausen, T. M., . . . Miller, R. L. (2021). Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates. SCIENCE ADVANCES, 7(52). doi:10.1126/sciadv.abl6026
Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats
Li, K. -P., Yu, Y., Yuan, M., Zhang, C. -M., Rong, X. -L., Turnbull, J. E., & Guo, J. (2021). Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2021. doi:10.1155/2021/6617586
Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations
Tree, J. A., Turnbull, J. E., Buttigieg, K. R., Elmore, M. J., Coombes, N., Hogwood, J., . . . Carroll, M. W. (2021). Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. BRITISH JOURNAL OF PHARMACOLOGY, 178(3), 626-635. doi:10.1111/bph.15304
The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models
2020
Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin
Mycroft-West, C. J., Su, D., Pagani, I., Rudd, T. R., Elli, S., Gandhi, N. S., . . . Skidmore, M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. THROMBOSIS AND HAEMOSTASIS, 120(12), 1700-1715. doi:10.1055/s-0040-1721319
Cryogenic Infrared Spectroscopy Reveals Structural Modularity in the Vibrational Fingerprints of Heparan Sulfate Diastereomers
Lettow, M., Grabarics, M., Greis, K., Mucha, E., Thomas, D. A., Chopra, P., . . . Pagel, K. (2020). Cryogenic Infrared Spectroscopy Reveals Structural Modularity in the Vibrational Fingerprints of Heparan Sulfate Diastereomers. ANALYTICAL CHEMISTRY, 92(15), 10228-10232. doi:10.1021/acs.analchem.0c02048
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction
Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain
Mycroft-West, C., Su, D., Li, Y., Guimond, S., Rudd, T., Elli, S., . . . Skidmore, M. (2020). Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain. doi:10.1101/2020.04.29.068767
SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins
Mycroft-West, C., Su, D., Li, Y., Guimond, S., Rudd, T., Elli, S., . . . Skidmore, M. (2020). SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. doi:10.1101/2020.04.29.068486
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin
Mycroft-West, C., Su, D., Pagani, I., Rudd, T., Elli, S., Guimond, S., . . . Skidmore, M. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin. doi:10.1101/2020.04.28.066761
Better growth-factor binding aids tissue repair.
Lord, M., Whitelock, J., & Turnbull, J. E. (2020). Better growth-factor binding aids tissue repair.. Nature biomedical engineering, 4(4), 368-369. doi:10.1038/s41551-020-0548-3
Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides.
Miller, R. L., Guimond, S. E., Schwörer, R., Zubkova, O. V., Tyler, P. C., Xu, Y., . . . Pagel, K. (2020). Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides.. Nature communications, 11. doi:10.1038/s41467-020-15284-y
Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure
Sindrewicz, P., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2020). Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 523(2), 336-341. doi:10.1016/j.bbrc.2019.12.054
The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
Mycroft-West, C., Su, D., Elli, S., Li, Y., Guimond, S., Miller, G., . . . Skidmore, M. (2020). The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding. doi:10.1101/2020.02.29.971093
2019
Omics Insights into Metabolic Stress and Resilience of Rats in Response to Short-term Fructose Overfeeding.
Li, K. -P., Yuan, M., He, Z. -R., Wu, Q., Zhang, C. -M., Lei, Z. -L., . . . Guo, J. (2019). Omics Insights into Metabolic Stress and Resilience of Rats in Response to Short-term Fructose Overfeeding.. Molecular nutrition & food research, e1900773. doi:10.1002/mnfr.201900773
Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions
Sindrewicz, P., Li, X., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2019). Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-47658-8
Low sulfated heparins target multiple proteins for central nervous system repair.
Barnett, S. C., Mcanney, G., Mcgrath, M., Bavington, C., & Turnbull, J. (2019). Low sulfated heparins target multiple proteins for central nervous system repair.. In GLIA Vol. 67 (pp. E652). Retrieved from http://gateway.webofknowledge.com/
Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage.
Chanalaris, A., Clarke, H., Guimond, S. E., Vincent, T. L., Turnbull, J. E., & Troeberg, L. (2019). Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage.. The American journal of pathology, 189(3), 632-647. doi:10.1016/j.ajpath.2018.11.011
By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans.
Taylor, S. L., Hogwood, J., Guo, W., Yates, E. A., & Turnbull, J. E. (2019). By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans.. Scientific reports, 9(1), 2679. doi:10.1038/s41598-019-39093-6
Low sulfated heparins target multiple proteins for central nervous system repair
McCanney, G. A., McGrath, M. A., Otto, T. D., Burchmore, R., Yates, E. A., Bavington, C. D., . . . Barnett, S. C. (2019). Low sulfated heparins target multiple proteins for central nervous system repair. GLIA, 67(4), 668-687. doi:10.1002/glia.23562
2018
Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy
Zubkova, O. V., Ahmed, Y. A., Guimond, S. E., Noble, S. -L., Miller, J. H., Smith, R. A. A., . . . Turnbull, J. E. (2018). Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy. ACS Chemical Biology, 13(12), 3236-3242. doi:10.1021/acschembio.8b00909
Enhancing the glycosciences toolkit: new GAGs in the lineup.
Turnbull, J. E. (2018). Enhancing the glycosciences toolkit: new GAGs in the lineup.. Nature methods, 15(11), 867-868. doi:10.1038/s41592-018-0190-0
The Satellite Cell Niche Regulates the Balance between Myoblast Differentiation and Self-Renewal via p53
Flamini, V., Ghadiali, R., Antczak, P., Rothwell, A., Turnbull, J., & Pisconti, A. (2018). The Satellite Cell Niche Regulates the Balance between Myoblast Differentiation and Self-Renewal via p53. Stem Cell Reports, 10(3), 970-983. doi:10.1016/j.stemcr.2018.01.007
2017
Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry.
Miller, R. L., Guimond, S. E., Prescott, M., Turnbull, J. E., & Karlsson, N. (2017). Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry.. ANALYTICAL CHEMISTRY, 89(17), 8942-8950. doi:10.1021/acs.analchem.7b01417
How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans
Cartmell, A., Lowe, E. C., Basle, A., Firbank, S. J., Ndeh, D. A., Murray, H., . . . Bolam, D. N. (2017). How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proceedings of the National Academy of Sciences of the United States of America, 114(27), 7037-7042. doi:10.1073/pnas.1704367114
Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling
Ghadiali, R. S., Guimond, S. E., Turnbull, J. E., & Pisconti, A. (2017). Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling. Matrix biology : journal of the International Society for Matrix Biology, 59, 54-68. doi:10.1016/j.matbio.2016.07.007
Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins
Gray, C. J., Sanchez-Ruiz, A., Sardzikova, I., Ahmed, Y. A., Miller, R. L., Reyes Martinez, J. E., . . . Flitsch, S. L. (2017). Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins. ANALYTICAL CHEMISTRY, 89(8), 4444-4451. doi:10.1021/acs.analchem.6b04122
Sulfatase‐mediated manipulation of the astrocyte‐Schwann cell interface
O'Neill, P., Lindsay, S. L., Pantiru, A., Guimond, S. E., Fagoe, N., Verhaagen, J., . . . Barnett, S. C. (2017). Sulfatase‐mediated manipulation of the astrocyte‐Schwann cell interface. Glia, 65(1), 19-33. doi:10.1002/glia.23047
2016
Enrichment of Two Isomeric Heparin Oligosaccharides Exhibiting Different Affinities toward Monocyte Chemoattractant Protein-1
Miller, R. L., Dykstra, A. B., Wei, W., Holsclaw, C., Turnbull, J. E., & Leary, J. A. (2016). Enrichment of Two Isomeric Heparin Oligosaccharides Exhibiting Different Affinities toward Monocyte Chemoattractant Protein-1. ANALYTICAL CHEMISTRY, 88(23), 11551-11558. doi:10.1021/acs.analchem.6b02803
Heparin Isomeric Oligosaccharide Separation Using Volatile Salt Strong Anion Exchange Chromatography
Miller, R. L., Guimond, S. E., Shivkumar, M., Blocksidge, J., Austin, J. A., Leary, J. A., & Turnbull, J. E. (2016). Heparin Isomeric Oligosaccharide Separation Using Volatile Salt Strong Anion Exchange Chromatography. Analytical Chemistry, 88(23), 11542-11550. doi:10.1021/acs.analchem.6b02801
Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity
Ahmed, Y. A., Yates, E. A., Moss, D. J., Loeven, M. A., Hussain, S. -A., Hohenester, E., . . . Powell, A. K. (2016). Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity. Molecular Biosystems, 12(10), 3166-3175. doi:10.1039/c6mb00432f
Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell Responses.
Puvirajesinghe, T. M., & Turnbull, J. E. (2016). Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell Responses.. Microarrays (Basel, Switzerland), 5(1), E3. doi:10.3390/microarrays5010003
2015
Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions.
Kalus, I., Rohn, S., Puvirajesinghe, T. M., Guimond, S. E., Eyckerman-Kölln, P. J., Ten Dam, G., . . . Dierks, T. (2015). Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions.. PloS one, 10(10), e0139853. doi:10.1371/journal.pone.0139853
Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409
2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.
Chan, W. K., Chan, W. K., Howe, K., Clegg, J. M., Guimond, S. E., Price, D. J., . . . Pratt, T. (2015). 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.. PloS one, 10(6), e0130147. doi:10.1371/journal.pone.0130147
Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding
Solari, V., Rudd, T. R., Guimond, S. E., Powell, A. K., Turnbull, J. E., & Yates, E. A. (2015). Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. ORGANIC & BIOMOLECULAR CHEMISTRY, 13(21), 6066-6072. doi:10.1039/c5ob00564g
Composition, sequencing and ion mobility mass spectrometry of heparan sulfate-like octasaccharide isomers differing in glucuronic and iduronic acid content
Miller, R. L., Wei, W., Schwoerer, R., Zubkova, O. V., Tyler, P. C., Turnbull, J. E., & Leary, J. A. (2015). Composition, sequencing and ion mobility mass spectrometry of heparan sulfate-like octasaccharide isomers differing in glucuronic and iduronic acid content. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 21(3), 245-254. doi:10.1255/ejms.1337
Single-entity heparan sulfate glycomimetic clusters for therapeutic applications.
Tyler, P. C., Guimond, S. E., Turnbull, J. E., & Zubkova, O. V. (2015). Single-entity heparan sulfate glycomimetic clusters for therapeutic applications.. Angewandte Chemie (International ed. in English), 54(9), 2718-2723. doi:10.1002/anie.201410251
Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation
Theodoraki, A., Hu, Y., Poopalasundaram, S., Oosterhof, A., Guimond, S. E., Disterer, P., . . . Bouloux, P. -M. (2015). Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 399(C), 296-310. doi:10.1016/j.mce.2014.09.011
2014
MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival.
Solari, V., Borriello, L., Turcatel, G., Shimada, H., Sposto, R., Esteban Fernandz, G., . . . DeClerck, Y. A. (2014). MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival.. Cancer Research, 74(21), 5999-6009. doi:10.1158/0008-5472.CAN-13-2513
Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media
Bromfield, S. M., Posocco, P., Chan, C. W., Calderon, M., Guimond, S. E., Turnbull, J. E., . . . Smith, D. K. (2014). Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media. Chemical Science, 5(4), 1484. doi:10.1039/c4sc00298a
Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.
Clegg, J. M., Conway, C. D., Howe, K. M., Price, D. J., Mason, J. O., Turnbull, J. E., . . . Pratt, T. (2014). Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(6), 2389-2401. doi:10.1523/jneurosci.3157-13.2014
Chemical biology of heparan sulfates: from insights to applications in therapeutics and tissue regeneration
Turnbull, J. E. (2014). Chemical biology of heparan sulfates: from insights to applications in therapeutics and tissue regeneration. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 7. Retrieved from https://www.webofscience.com/
Stem cell plasticity and tumorigenesis: regulatory roles of heparan sulphate in the cancer stem cell niche
Baty, R., Pisconti, A., & Turnbull, J. (2014). Stem cell plasticity and tumorigenesis: regulatory roles of heparan sulphate in the cancer stem cell niche. In FEBS JOURNAL Vol. 281 (pp. 781). Retrieved from https://www.webofscience.com/
2013
Synthesis of a Targeted Library of Heparan Sulfate Hexa‐ to Dodecasaccharides as Inhibitors of β‐Secretase: Potential Therapeutics for Alzheimer’s Disease
Schwörer, R., Zubkova, O. V., Turnbull, J. E., & Tyler, P. C. (2013). Synthesis of a Targeted Library of Heparan Sulfate Hexa‐ to Dodecasaccharides as Inhibitors of β‐Secretase: Potential Therapeutics for Alzheimer’s Disease. Chemistry – A European Journal, 19(21), 6817-6823. doi:10.1002/chem.201204519
Compositions for enhancing neural cell transplants
Turnbull, J. (2013). Compositions for enhancing neural cell transplants.
2012
Glycomics approaches for the bioassay and structural analysis of heparin/heparan sulphates.
Puvirajesinghe, T. M., & Turnbull, J. E. (2012). Glycomics approaches for the bioassay and structural analysis of heparin/heparan sulphates.. Metabolites, 2(4), 1060-1089. doi:10.3390/metabo2041060
Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation.
Higginson, J. R., Thompson, S. M., Santos-Silva, A., Guimond, S. E., Turnbull, J. E., & Barnett, S. C. (2012). Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(45), 15902-15912. doi:10.1523/jneurosci.6340-11.2012
Array-Based Functional Screening of Heparin Glycans
Puvirajesinghe, T. M., Ahmed, Y. A., Powell, A. K., Fernig, D. G., Guimond, S. E., & Turnbull, J. E. (2012). Array-Based Functional Screening of Heparin Glycans. CHEMISTRY & BIOLOGY, 19(5), 553-558. doi:10.1016/j.chembiol.2012.03.011
Array-based Functional Screening of Heparin Glycans
Puvirajesinghe, T. M., Ahmed, Y. A., Powell, A. K., Fernig, D. G., Guimond, S. E., & Turnbull., J. E. (2012). Array-based Functional Screening of Heparin Glycans. Chemistry and Biology, 19, 553-558.
Compositions for enhancing neural cell transplants
Turnbull, J. (2012). Compositions for enhancing neural cell transplants.
2011
Chemistry. Getting the farm out of pharma for heparin production.
Turnbull, J. E. (2011). Chemistry. Getting the farm out of pharma for heparin production.. Science (New York, N.Y.), 334(6055), 462-463. doi:10.1126/science.1211605
Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation?
Thompson, S. M., Connell, M. G., van Kuppevelt, T. H., Xu, R., Turnbull, J. E., Losty, P. D., . . . Jesudason, E. C. (2011). Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation?. BMC developmental biology, 11, 38. doi:10.1186/1471-213x-11-38
The emerging role of extracellular matrix in signalling
Kim, S., Turnbull, J. E., & Guimond, S. E. (2011). The emerging role of extracellular matrix in signalling. Journal of Endocrinology, 209(135-15).
2010
The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.
Smits, N. C., Kurup, S., Rops, A. L., ten Dam, G. B., Massuger, L. F., Hafmans, T., . . . van Kuppevelt, T. H. (2010). The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.. The Journal of biological chemistry, 285(52), 41143-41151. doi:10.1074/jbc.m110.153791
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships
Rudd, T. R., Uniewicz, K. A., Ori, A., Guimond, S. E., Skidmore, M. A., Gaudesi, D., . . . Yates, E. A. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(23), 5390-5397. doi:10.1039/c0ob00246a
Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection
Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection. NATURE PROTOCOLS, 5(12), 1983-1992. doi:10.1038/nprot.2010.145
Heparan sulfate glycomics: towards systems biology strategies.
Turnbull, J. E. (2010). Heparan sulfate glycomics: towards systems biology strategies.. Biochemical Society transactions, 38(5), 1356-1360. doi:10.1042/bst0381356
Determining the anti-coagulant-independent anti-cancer effects of heparin
Solari, V., Jesudason, E. C., Turnbull, J. E., & Yates, E. A. (2010). Determining the anti-coagulant-independent anti-cancer effects of heparin. BRITISH JOURNAL OF CANCER, 103(4), 593-594. doi:10.1038/sj.bjc.6605808
Generating heparan sulfate saccharide libraries for glycomics applications
Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics applications. Nature Protocols, 5(5), 821-833. doi:10.1038/nprot.2010.17
Generating heparan sulfate saccharide libraries for glycomics applications
Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics applications. NATURE PROTOCOLS, 5(5), 821-833. doi:10.1038/nprot.2010.17
Heparan Sulfate in Lung Morphogenesis: The Elephant in the Room
Thompson, S. M., Jesudason, E. C., Turnbull, J. E., & Fernig, D. G. (2010). Heparan Sulfate in Lung Morphogenesis: The Elephant in the Room. BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 90(1), 32-44. doi:10.1002/bdrc.20169
An expression system for screening of proteins for glycan and protein interactions.
Otto, D. M. E., Campanero-Rhodes, M. A., Karamanska, R., Powell, A. K., Bovin, N., Turnbull, J. E., . . . Crocker., P. R. (2010). An expression system for screening of proteins for glycan and protein interactions.. Analytical Biochemistry, 411, 261-270.
Carbohydrate composition analysis of heparin and heparan sulphate derived polymers
Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Carbohydrate composition analysis of heparin and heparan sulphate derived polymers. Nature Protocols.
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships
Rudd, T. R., Uniewicz, K. A., Ori, A., Guimond, S. E., Skidmore, M. A., Gaudesi, D., . . . Yates, E. A. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. Organic & Biomolecular Chemistry, 8(23), 5390. doi:10.1039/c0ob00246a
Glycomics Profiling of Heparan Sulfate Structure and Activity.
Turnbull, J. E., Miller, R., Ahmed, Y., Puvirajesinghe, T., & Guimond, S. (2010). Glycomics Profiling of Heparan Sulfate Structure and Activity.. Unknown Journal, 480, 65-85.
Glycomics Profiling of Heparan Sulfate Structure and Activity. Method in Enzymology
Turnbull, J. E., Miller, R., Ahmed, Y. A., Puvirajesinghe, T., & Guimond, S. E. (2010). Glycomics Profiling of Heparan Sulfate Structure and Activity. Method in Enzymology. Methods in Enzymology.
Glycomics: Technologies Taming a Frontier Omics Field
Turnbull, J. E., & Sasisekharan, R. (2010). Glycomics: Technologies Taming a Frontier Omics Field. Unknown Journal, 14, 4.
2009
Heparan Sulfate Phage Display Antibodies Identify Distinct Epitopes with Complex Binding Characteristics <i>INSIGHTS INTO PROTEIN BINDING SPECIFICITIES</i>
Thompson, S. M., Fernig, D. G., Jesudason, E. C., Losty, P. D., van de Westerlo, E. M. A., van Kuppevelt, T. H., & Turnbull, J. E. (2009). Heparan Sulfate Phage Display Antibodies Identify Distinct Epitopes with Complex Binding Characteristics <i>INSIGHTS INTO PROTEIN BINDING SPECIFICITIES</i>. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(51), 35621-35631. doi:10.1074/jbc.M109.009712
Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies
Arungundram, S., Al-Mafraji, K., Asong, J., Leach, F. E., Amster, I. J., Venot, A., . . . Boons, G. -J. (2009). Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies. Journal of the American Chemical Society, 131(47), 17394-17405. doi:10.1021/ja907358k
Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.
Arungundram, S., Al-Mafraji, K., Asong, J., Leach, F. E., Amster, I. J., Venot, A., . . . Boons, G. -J. (2009). Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.. Journal of the American Chemical Society, 131(47), 17394-17405. doi:10.1021/ja907358k
Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations.
Skidmore, M., Atrih, A., Yates, E., & Turnbull, J. E. (2009). Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations.. Methods in molecular biology (Clifton, N.J.), 534, 157-169. doi:10.1007/978-1-59745-022-5_12
Chemometric analysis for comparison of heparan sulphate oligosaccharides.
Puvirajesinghe, T. M., Guimond, S. E., Turnbull, J. E., & Guenneau, S. (2009). Chemometric analysis for comparison of heparan sulphate oligosaccharides.. Journal of the Royal Society, Interface, 6(40), 997-1004. doi:10.1098/rsif.2008.0483
The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
Rudd, T. R., Skidmore, M. A., Guimond, S. E., Holman, J., Turnbull, J. E., Lauder, R. M., . . . Yates, E. A. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. THROMBOSIS AND HAEMOSTASIS, 102(5), 874-878. doi:10.1160/TH08-12-0797
Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.
Hu, Y., Guimond, S. E., Travers, P., Cadman, S., Hohenester, E., Turnbull, J. E., . . . Bouloux, P. -M. (2009). Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.. The Journal of biological chemistry, 284(43), 29905-29920. doi:10.1074/jbc.m109.049155
Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues <i>TOWARD GLYCOMICS PROFILING</i>
Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M. A., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues <i>TOWARD GLYCOMICS PROFILING</i>. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(38), 25714-25722. doi:10.1074/jbc.M109.032755
Cations Modulate Polysaccharide Structure To Determine FGF-FGFR Signaling: A Comparison of Signaling and Inhibitory Polysaccharide Interactions with FGF-1 in Solution
Guimond, S. E., Rudd, T. R., Skidmore, M. A., Ori, A., Gaudesi, D., Cosentino, C., . . . Yates, E. A. (2009). Cations Modulate Polysaccharide Structure To Determine FGF-FGFR Signaling: A Comparison of Signaling and Inhibitory Polysaccharide Interactions with FGF-1 in Solution. BIOCHEMISTRY, 48(22), 4772-4779. doi:10.1021/bi802318z
Fabrication of Carbohydrate Surfaces by Using Nonderivatised Oligosaccharides, and their Application to Measuring the Assembly of Sugar-Protein Complexes
Popplewell, J. F., Swann, M. J., Ahmed, Y., Turnbull, J. E., & Fernig, D. G. (2009). Fabrication of Carbohydrate Surfaces by Using Nonderivatised Oligosaccharides, and their Application to Measuring the Assembly of Sugar-Protein Complexes. CHEMBIOCHEM, 10(7), 1218-1226. doi:10.1002/cbic.200800696
Heparan sulphate saccharide microarrays for high-throughput interrogation of protein binding interactions
Powell, A., Zhi, Z., & Turnbull, J. E. (2009). Heparan sulphate saccharide microarrays for high-throughput interrogation of protein binding interactions. Methods in Molecular Biology, 534, 313=329.
Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.
Hu, Y., Guimond, S. E., Travers, P., Cadman, S., Hohenester, E., Turnbull, J. E., . . . Bouloux, P. M. (2009). Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.. J Biol Chem, 284(29905-).
Plasma Polymer surface chemical gradients used to investigate the geometric control of mouse embryonic stem cell pluripotency
Wells., Turnbull., & al, E. (2009). Plasma Polymer surface chemical gradients used to investigate the geometric control of mouse embryonic stem cell pluripotency. Biomaterials, 30, 1066-1070.
Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling
Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M. A., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling. Journal of Biological Chemistry.
Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: towards glycomics profiling.
Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: towards glycomics profiling.. J Biol Chem, 284, 25714-25722.
The potential for circular dichroism as an additional facile and sensitive method of monitoring low molecular weight heparins and heparinoids.
Rudd, T., Skidmore, M., Guimond, S., Holman, J., Turnbull, J. E., Lauder, R., . . . Yates, E. A. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low molecular weight heparins and heparinoids.. Thrombosis and Haemostasis, 102, 874-878.
2008
Software Tool for the Structural Determination of Glycosaminoglycans by Mass Spectrometry
Tissot, B., Ceroni, A., Powell, A. K., Morris, H. R., Yates, E. A., Turnbull, J. E., . . . Haslam, S. M. (2008). Software Tool for the Structural Determination of Glycosaminoglycans by Mass Spectrometry. ANALYTICAL CHEMISTRY, 80(23), 9204-9212. doi:10.1021/ac8013753
Extracellular regulation of developmental cell signaling by XtSulf1.
Freeman, S. D., Moore, W. M., Guiral, E. C., Holme, A. D., Turnbull, J. E., & Pownall, M. E. (2008). Extracellular regulation of developmental cell signaling by XtSulf1.. Developmental biology, 320(2), 436-445. doi:10.1016/j.ydbio.2008.05.554
Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques
Rudd, T. R., Skidmore, M. A., Guimond, S. E., Guerrini, M., Cosentino, C., Edge, R., . . . Yates, E. A. (2008). Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques. CARBOHYDRATE RESEARCH, 343(12), 2184-2193. doi:10.1016/j.carres.2007.12.019
A versatile gold surface approach for fabrication and interrogation of glycoarrays.
Zhi, Z. -L., Laurent, N., Powell, A. K., Karamanska, R., Fais, M., Voglmeir, J., . . . Turnbull, J. E. (2008). A versatile gold surface approach for fabrication and interrogation of glycoarrays.. Chembiochem : a European journal of chemical biology, 9(10), 1568-1575. doi:10.1002/cbic.200700788
Extracellular regulation of developmental cell signaling by XtSulf1
freeman, S. D., Moore, W. M., Guiral, E. C., Holme, A. D., Turnbull, J. E., & Pownall, M. E. (2008). Extracellular regulation of developmental cell signaling by XtSulf1. Developmental Biology, 320(2), 436-445.
The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation
Skidmore, M. A., Guimond, S. E., Rudd, T. R., Fernig, D. G., Turnbull, J. E., & Yates, E. A. (2008). The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation. CONNECTIVE TISSUE RESEARCH, 49(3-4), 140-144. doi:10.1080/03008200802148595
Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation
Patel, V. N., Likar, K. M., Zisman-Rozen, S., Cowherd, S. N., Lassiter, K. S., Sher, I., . . . Hoffman, M. P. (2008). Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(14), 9308-9317. doi:10.1074/jbc.M709995200
Disruption of rosetting in <i>Plasmodium falciparum</i> malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities
Skidmore, M. A., Dumax-Vorzet, A. F., Guimond, S. E., Rudd, T. R., Edwards, E. A., Turnbull, J. E., . . . Yates, E. A. (2008). Disruption of rosetting in <i>Plasmodium falciparum</i> malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities. JOURNAL OF MEDICINAL CHEMISTRY, 51(5), 1453-1458. doi:10.1021/jm701337t
Engineered heparins:: Novel β-secretase inhibitors as potential Alzheimer's disease therapeutics
Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2008). Engineered heparins:: Novel β-secretase inhibitors as potential Alzheimer's disease therapeutics. NEURODEGENERATIVE DISEASES, 5(3-4), 197-199. doi:10.1159/000113701
2007
Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.
Rudd, T. R., Guimond, S. E., Skidmore, M. A., Duchesne, L., Guerrini, M., Torri, G., . . . Yates, E. A. (2007). Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.. Glycobiology, 17(9), 983-993. doi:10.1093/glycob/cwm062
Towards GAG glycomics: Analysis of highly sulfated heparins by MALDI-TOF mass spectrometry
Tissot, B., Gasiunas, N., Powell, A. K., Ahmed, Y., Zhi, Z. -L., Haslam, S. M., . . . Dell, A. (2007). Towards GAG glycomics: Analysis of highly sulfated heparins by MALDI-TOF mass spectrometry. Glycobiology, 17(9), 972-982. doi:10.1093/glycob/cwm072
Novel 'phage display antibodies identify distinct heparan sulfate domains in developing mammalian lung
Thompson, S. M., Connell, M. G., Fernig, D. G., Ten Dam, G. B., van Kuppevelt, T. H., Turnbull, J. E., . . . Losty, P. D. (2007). Novel 'phage display antibodies identify distinct heparan sulfate domains in developing mammalian lung. PEDIATRIC SURGERY INTERNATIONAL, 23(5), 411-417. doi:10.1007/s00383-006-1864-8
Emerging glycomics technologies.
Turnbull, J. E., & Field, R. A. (2007). Emerging glycomics technologies.. Nature chemical biology, 3(2), 74-77. doi:10.1038/nchembio0207-74
Novel 'phage display antibodies identify distinct heparan sulphate domains in developing mammalian lung.
Thompson, S., Connell, M. G., Fernig, D. G., Ten Dam, G. B., Van Kuppevelt, T. H., Turnbull, J. E., . . . Losty, P. D. (2007). Novel 'phage display antibodies identify distinct heparan sulphate domains in developing mammalian lung.. Paediatric Surgery International, 23(411-41).
Sequencing Heparan Sulphate Saccharides
Turnbull, J. E. (2007). Sequencing Heparan Sulphate Saccharides. In J. Walker, & J. Walker (Eds.), Protein Protocols Handbook (pp. in press). Cambridge: Humana Press.
Site-specific interactions of copper (II) ions with heparin revealed with complementary
Rudd, T. R., Skidmore, M. A., Guimond, S. E., Guerrini, M., Cosentino, C., Edge, R., . . . Yates, E. A. (2007). Site-specific interactions of copper (II) ions with heparin revealed with complementary. Carbohydrate Research. Retrieved from doi:10.1016/j.carres.2007.12.0
2006
A molecular mechanism for the heparan sulfate dependence of Slit-Robo signaling
Hussain, S. -A., Piper, M., Fukuhara, N., Strochlic, L., Cho, G., Howitt, J. A., . . . Hohenester, E. (2006). A molecular mechanism for the heparan sulfate dependence of Slit-Robo signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(51), 39693-39698. doi:10.1074/jbc.M609384200
High sensitivity separation and detection of heparan sulfate disaccharides
Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Atrih, A., Yates, E. A., & Turnbull, J. E. (2006). High sensitivity separation and detection of heparan sulfate disaccharides. JOURNAL OF CHROMATOGRAPHY A, 1135(1), 52-56. doi:10.1016/j.chroma.2006.09.064
Heparin derivatives as inhibitors of BACE-1, the Alzheimer's β-secretase, with reduced activity against factor Xa and other proteases
Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2006). Heparin derivatives as inhibitors of BACE-1, the Alzheimer's β-secretase, with reduced activity against factor Xa and other proteases. JOURNAL OF MEDICINAL CHEMISTRY, 49(20), 6129-6132. doi:10.1021/jm051221o
Synthetic sugars enhance the functional glycomics toolkit.
Turnbull, J. E., & Linhardt, R. J. (2006). Synthetic sugars enhance the functional glycomics toolkit.. Nature chemical biology, 2(9), 449-450. doi:10.1038/nchembio0906-449
Engineered bio-active polysaccharides from heparin
Guimond, S. E., Turnbull, J. E., & Yates, E. A. (2006). Engineered bio-active polysaccharides from heparin. MACROMOLECULAR BIOSCIENCE, 6(8), 681-686. doi:10.1002/mabi.200600042
Fabrication of carbohydrate microarrays on gold surfaces: direct attachment of nonderivatized oligosaccharides to hydrazide-modified self-assembled monolayers.
Zhi, Z. -L., Powell, A. K., & Turnbull, J. E. (2006). Fabrication of carbohydrate microarrays on gold surfaces: direct attachment of nonderivatized oligosaccharides to hydrazide-modified self-assembled monolayers.. Analytical chemistry, 78(14), 4786-4793. doi:10.1021/ac060084f
Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex.
Leadbeater, W. E., Gonzalez, A. -M., Logaras, N., Berry, M., Turnbull, J. E., & Logan, A. (2006). Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex.. Journal of neurochemistry, 96(4), 1189-1200. doi:10.1111/j.1471-4159.2005.03632.x
2005
Novel heparan sulphate analogues:: inhibition of β-secretase cleavage of amyloid precursor protein
Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues:: inhibition of β-secretase cleavage of amyloid precursor protein. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 1116-1118. doi:10.1042/BST0331116
Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.
Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.. In Biochemical Society transactions Vol. 33 (pp. 1116-1118). doi:10.1042/bst20051116
Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2
West, D. C., Rees, C. G., Duchesne, L., Patey, S. J., Terry, C. J., Turnbull, J. E., . . . Fernig, D. G. (2005). Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(14), 13457-13464. doi:10.1074/jbc.M410924200
Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.
Kinnunen, T., Huang, Z., Townsend, J., Gatdula, M. M., Brown, J. R., Esko, J. D., & Turnbull, J. E. (2005). Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.. Proceedings of the National Academy of Sciences of the United States of America, 102(5), 1507-1512. doi:10.1073/pnas.0401591102
A synthetic glycosaminoglycan mimetic (RGTA) modifies natural glycosaminoglycan species during myogenesis.
Barbosa, I., Morin, C., Garcia, S., Duchesnay, A., Oudghir, M., Jenniskens, G., . . . Papy-Garcia, D. (2005). A synthetic glycosaminoglycan mimetic (RGTA) modifies natural glycosaminoglycan species during myogenesis.. Journal of cell science, 118(Pt 1), 253-264. doi:10.1242/jcs.01607
Functions of heparan sulfate proteoglycans and the Kallman syndrome protein KAL-1 in Caenorhabditis elegans embryogenesis
Hudson, M. L., Kinnunen, T., Turnbull, J. E., & Chisholm, A. D. (2005). Functions of heparan sulfate proteoglycans and the Kallman syndrome protein KAL-1 in Caenorhabditis elegans embryogenesis. Glycobiology, 15(11), 1189-1190.
Heparan Sulphate-Growth Factor Interactions in Development and Disease
Guimond, S. E., & Turnbull, J. E. (2005). Heparan Sulphate-Growth Factor Interactions in Development and Disease. Trends in Glycoscience and Glycotechnology, 17(98), 241-253. doi:10.4052/tigg.17.241
Heparan sulphate-growth factor interactions in development and disease
Guimond, S. E., & Turnbull, J. E. (2005). Heparan sulphate-growth factor interactions in development and disease. Trends In Glycoscience And Glycotechnology, 17(98), 241-253.
Separation & sequencing of heparin and HS saccharides.
Skidmore, M. A., & Turnbull, J. E. (2005). Separation & sequencing of heparin and HS saccharides.. Chemistry and Biology of Heparin and Heparan Sulphate.
Separation and Sequencing of Heparin and Heparan Sulfate Saccharides
Skidmore, M. A., & Turnbull, J. E. (2005). Separation and Sequencing of Heparin and Heparan Sulfate Saccharides. In H. G. Garg, R. J. Linhardt, & C. A. Hales (Eds.), Chemistry and Biology of Heparin and Heparan sulfate (pp. 1). New York: Elsevier.
2004
Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces
Skidmore, M. A., Patey, S. J., Thanh, N. T. K., Fernig, D. G., Turnbull, J. E., & Yates, E. A. (2004). Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces. CHEMICAL COMMUNICATIONS, (23), 2700-2701. doi:10.1039/b411726c
Anosmin-1 Modulates Fibroblast Growth Factor Receptor 1 Signaling in Human Gonadotropin-Releasing Hormone Olfactory Neuroblasts through a Heparan Sulfate-Dependent Mechanism
González-Martínez, D., Kim, S. -H., Hu, Y., Guimond, S., Schofield, J., Winyard, P., . . . Bouloux, P. -M. (2004). Anosmin-1 Modulates Fibroblast Growth Factor Receptor 1 Signaling in Human Gonadotropin-Releasing Hormone Olfactory Neuroblasts through a Heparan Sulfate-Dependent Mechanism. The Journal of Neuroscience, 24(46), 10384-10392. doi:10.1523/jneurosci.3400-04.2004
Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.
González-Martínez, D., Kim, S. -H., Hu, Y., Guimond, S., Schofield, J., Winyard, P., . . . Bouloux, P. -M. (2004). Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(46), 10384-10392. doi:10.1523/jneurosci.3400-04.2004
Proteoglycans make the grade-ient.
Guimond, S., & Turnbull, J. E. (2004). Proteoglycans make the grade-ient.. Molecular cell, 16(2), 159-160. doi:10.1016/j.molcel.2004.10.008
Highly diverse heparan sulfate analogue libraries: a novel resource for bioactivity screening of proteins
Guimond, S. E., Patey, S. J., Yates, E. A., & Turnbull, J. E. (2004). Highly diverse heparan sulfate analogue libraries: a novel resource for bioactivity screening of proteins. International Journal of Experimental Pathology, 85(4). doi:10.1111/j.0959-9673.2004.0390w.x
Role of heparan sulfate in embryoid body formation
Drummond, K. J., Yates, E. A., Murray, P. A., & Turnbull, J. E. (2004). Role of heparan sulfate in embryoid body formation. International Journal of Experimental Pathology, 85(4). doi:10.1111/j.0959-9673.2004.0390t.x
Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and epxerimental approaches
Powell, A. K., Yates, E. A., Fernig, D. G., & Turnbull, J. E. (2004). Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and epxerimental approaches. GLYCOBIOLOGY, 14(4), 17R-30R. doi:10.1093/glycob/cwh051
Saccharide Libraries and Arrays
Turnbull, J., Yates, E., & Powell, A. (2004). Saccharide Libraries and Arrays.
Highly Diverse Heparan Sulfate Analogue Libraries: Providing Access to Expanded Areas of Sequence Space for Bioactivity Screening
Yates, E. A., Guimond, S. E., & Turnbull, J. E. (2004). Highly Diverse Heparan Sulfate Analogue Libraries: Providing Access to Expanded Areas of Sequence Space for Bioactivity Screening. Journal of Medicinal Chemistry, 47(1), 277-280. doi:10.1021/jm0309755
Highly diverse heparan sulfate analogue libraries: Providing access to expanded areas of sequence space for bioactivity screening
Yates, E. A., Guimond, S. E., & Turnbull, J. E. (2004). Highly diverse heparan sulfate analogue libraries: Providing access to expanded areas of sequence space for bioactivity screening. JOURNAL OF MEDICINAL CHEMISTRY, 47(1), 277-280. doi:10.1021/jm0309755
Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces.
Yates, E. A., Jones, M. O., Clarke, C., Powell, A. K., Johnson, S. R., Porch, A., . . . Turnbull, J. E. (2004). Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces.. Journal Of Materials Chemistry, 13, 2061-2063.
Proteoglycans make the grade-ient
Guimond, S., & Turnbull, J. E. (2004). Proteoglycans make the grade-ient. Molecular Cell, 16(2), 159-160.
Soluble syndecan-1 modulates myeloma growth but not through FGF signalling
Lovell, R. A., Guimond, S. E., Turnbull, J. E., Moss, P. A. H., & Pratt, G. (2004). Soluble syndecan-1 modulates myeloma growth but not through FGF signalling. British Journal Of Haematology, 125, 9.
2003
Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
Scholefield, Z., Yates, E. A., Wayne, G., Amour, A., McDowell, W., & Turnbull, J. E. (2003). Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase. JOURNAL OF CELL BIOLOGY, 163(1), 97-107. doi:10.1083/jcb.200303059
Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces
Yates, E. A., Jones, M. O., Clarke, C. E., Powell, A. K., Johnson, S. R., Porch, A., . . . Turnbull, J. E. (2003). Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces. JOURNAL OF MATERIALS CHEMISTRY, 13(9), 2061-2063. doi:10.1039/b305248f
Structural determinants of heparan sulphate modulation of GDNF signalling
Davies, J. A., Yates, E. A., & Turnbull, J. E. (2003). Structural determinants of heparan sulphate modulation of GDNF signalling. GROWTH FACTORS, 21(3-4), 109-119. doi:10.1080/08977190310001621005
Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development
Ford‐Perriss, M., Turner, K., Guimond, S., Apedaile, A., Haubeck, H., Turnbull, J., & Murphy, M. (2003). Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Developmental Dynamics, 227(2), 170-184. doi:10.1002/dvdy.10298
Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development.
Ford-Perriss, M., Turner, K., Guimond, S., Apedaile, A., Haubeck, H. -D., Turnbull, J., & Murphy, M. (2003). Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development.. Developmental dynamics : an official publication of the American Association of Anatomists, 227(2), 170-184. doi:10.1002/dvdy.10298
Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans.
Turnbull, J., Drummond, K., Huang, Z., Kinnunen, T., Ford-Perriss, M., Murphy, M., & Guimond, S. (2003). Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans.. In Biochemical Society transactions Vol. 31 (pp. 343-348). doi:10.1042/bst0310343
Heparan sulfate sulfotransferase expression in mice and C. elegans.
Turnbull, J. E., Drummond, K. J., Huang, Z. B., Kinnunen, T., Murphy, M., Ford-Perriss, M., & Guimond, S. (2003). Heparan sulfate sulfotransferase expression in mice and C. elegans.. Biochemical Society Transactions, 31, 343-348.
2002
Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling
Ford-Perriss, M., Guimond, S. E., Greferath, U., Kita, M., Grobe, K., Habuchi, H., . . . Turnbull, J. E. (2002). Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology, 12(11), 721-727. doi:10.1093/glycob/cwf072
Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.
Ford-Perriss, M., Guimond, S. E., Greferath, U., Kita, M., Grobe, K., Habuchi, H., . . . Turnbull, J. E. (2002). Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.. Glycobiology, 12(11), 721-727. doi:10.1093/glycob/cwf072
Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate - Implications for dynamic assembly of a ternary signaling complex
Powell, A. K., Fernig, D. G., & Turnbull, J. E. (2002). Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate - Implications for dynamic assembly of a ternary signaling complex. JOURNAL OF BIOLOGICAL CHEMISTRY, 277(32), 28554-28563. doi:10.1074/jbc.M111754200
Identification of the heparan sulfate binding sites in the cellular prion protein.
Warner, R. G., Hundt, C., Weiss, S., & Turnbull, J. E. (2002). Identification of the heparan sulfate binding sites in the cellular prion protein.. The Journal of biological chemistry, 277(21), 18421-18430. doi:10.1074/jbc.m110406200
Sequencing Heparan Sulphate Saccharides. In: Protein Protocols Handbook.
Turnbull, J. E. (2002). Sequencing Heparan Sulphate Saccharides. In: Protein Protocols Handbook.. Unknown Journal, 893-904.
Specific Heparan Sulfate Structures involved in Retinal Axon Targeting.
Irie, A., Yates, E. A., Turnbull, J. E., & Holt, C. E. (2002). Specific Heparan Sulfate Structures involved in Retinal Axon Targeting.. Development, 129(1), 61-70.
Specific heparan sulfate structures involved in retinal axon targeting
Irie, A., Yates, E. A., Turnbull, J. E., & Holt, C. E. (2002). Specific heparan sulfate structures involved in retinal axon targeting. DEVELOPMENT, 129(1), 61-70. Retrieved from https://www.webofscience.com/
2001
A rise from obscurity — proteoglycans in focus
Turnbull, J. (2001). A rise from obscurity — proteoglycans in focus. Nature Cell Biology, 3(9), E214. doi:10.1038/ncb0901-e214
Dynamic biosynthesis of heparan sulphate sequences in developing mouse brain: a potential regulatory mechanism during development.
Guimond, S., Turner, K., Kita, M., Ford-Perriss, M., & Turnbull, J. (2001). Dynamic biosynthesis of heparan sulphate sequences in developing mouse brain: a potential regulatory mechanism during development.. In Biochemical Society transactions Vol. 29 (pp. 177-181). doi:10.1042/0300-5127:0290177
Heparan sulfate: decoding a dynamic multifunctional cell regulator.
Turnbull, J., Powell, A., & Guimond, S. (2001). Heparan sulfate: decoding a dynamic multifunctional cell regulator.. Trends in cell biology, 11(2), 75-82. doi:10.1016/s0962-8924(00)01897-3
Infectivity of Chlamydia trachomatis serovar LGV but not E is dependent on host cell heparan sulfate.
Taraktchoglou, M., Pacey, A. A., Turnbull, J. E., & Eley, A. (2001). Infectivity of Chlamydia trachomatis serovar LGV but not E is dependent on host cell heparan sulfate.. Infection and immunity, 69(2), 968-976. doi:10.1128/iai.69.2.968-976.2001
Analytical and preparative anion-exchange HPLC of GAG saccharides. In: Proteoglycan Protocols.
Turnbull, J. E. (2001). Analytical and preparative anion-exchange HPLC of GAG saccharides. In: Proteoglycan Protocols.. Meth. Mol. Biol., 171, 141-148.
Dynamic Biosynthesis of Heparan Sulphate Sequences in Developing Mouse brain: a potential regulatory mechanism during development.
Guimond, S. E., Ford-Perriss, M., & Turnbull, J. E. (2001). Dynamic Biosynthesis of Heparan Sulphate Sequences in Developing Mouse brain: a potential regulatory mechanism during development.. Biochemical Society Transactions, 29, 177-181.
Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label
Drummond, K. J., Yates, E. A., & Turnbull, J. E. (2001). Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label. PROTEOMICS, 1(2), 304-310. doi:3.0.co;2-b">10.1002/1615-9861(200102)1:2<304::aid-prot304>3.0.co;2-b
Heparan sulfate: decoding a dynamic multifunctional cell regulator
Turnbull, J., Powell, A., & Guimond, S. (2001). Heparan sulfate: decoding a dynamic multifunctional cell regulator. Unknown Journal, 11(2), 75-82.
Integral Glycan Sequencing ofClycosaminoglycan Saccharides. In: Proteoglycan Protocols.
Turnbull, J. E. (2001). Integral Glycan Sequencing ofClycosaminoglycan Saccharides. In: Proteoglycan Protocols.. Meth. Mol. Biol., 171, 129-140.
1999
Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides.
Guimond, S. E., & Turnbull, J. E. (1999). Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides.. Current biology : CB, 9(22), 1343-1346. doi:10.1016/s0960-9822(00)80060-3
1997
Corrections: Heparin sulphate in breast cancer cells (Biochemical Society Transactions (1996) 24,3 (355S))
Rahmoune, H., Turnbull, J. E., Gallagher, J. T., Rudland, P. S., & Fernig, D. G. (1997). Corrections: Heparin sulphate in breast cancer cells (Biochemical Society Transactions (1996) 24,3 (355S)). Biochemical Society Transactions, 25(4), 1299.
1996
Heparan sulphate in breast cancer cells
Rahmoune, H., Turnbull, J. E., Gallagher, J. T., Rudland, P. S., & Fernig, D. G. (1996). Heparan sulphate in breast cancer cells. In BIOCHEMICAL SOCIETY TRANSACTIONS Vol. 24 (pp. S355). doi:10.1042/bst024355s
1992
IDENTIFICATION OF THE BASIC FIBROBLAST GROWTH-FACTOR BINDING SEQUENCE IN FIBROBLAST HEPARAN-SULFATE
TURNBULL, J. E., FERNIG, D. G., KE, Y. Q., WILKINSON, M. C., & GALLAGHER, J. T. (1992). IDENTIFICATION OF THE BASIC FIBROBLAST GROWTH-FACTOR BINDING SEQUENCE IN FIBROBLAST HEPARAN-SULFATE. JOURNAL OF BIOLOGICAL CHEMISTRY, 267(15), 10337-10341. Retrieved from https://www.webofscience.com/