Publications
2024
What is the carbon footprint of academic clinical trials? A study of hotspots in 10 trials.
Griffiths, J., Adshead, F., Al-Shahi Salman, R., Anderson, C., Bedson, E., Bliss, J., . . . Williamson, P. R. (2024). What is the carbon footprint of academic clinical trials? A study of hotspots in 10 trials.. BMJ open, 14(10), e088600. doi:10.1136/bmjopen-2024-088600
Seizure control via pH manipulation: a phase II double-blind randomised controlled trial of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (Carbogen for Status Epilepticus in Children Trial (CRESCENT)).
Forsyth, R., Allen, M., Bedson, E., Downes, A., Gough, C., Hartshorn, S., . . . Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) collaborative. (2024). Seizure control via pH manipulation: a phase II double-blind randomised controlled trial of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (Carbogen for Status Epilepticus in Children Trial (CRESCENT)).. Trials, 25(1), 349. doi:10.1186/s13063-024-08188-5
2023
Rationale and design of a randomised trial of trientine in patients with hypertrophic cardiomyopathy
Farrant, J., Dodd, S., Vaughan, C., Reid, A., Schmitt, M., Garratt, C., . . . TEMPEST, I. (2023). Rationale and design of a randomised trial of trientine in patients with hypertrophic cardiomyopathy. HEART, 109(15), 1175-1182. doi:10.1136/heartjnl-2022-322271
2022
Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop
Rosala-Hallas, A., Jones, A. P., Williamson, P. R., Bedson, E., Compton, V., Fernandes, R. M., . . . McNamara, P. S. (2022). Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop. BMJ Open, 12(3), e052943. doi:10.1136/bmjopen-2021-052943
2021
Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial
Lewis, G. A., Dodd, S., Clayton, D., Bedson, E., Eccleson, H., Schelbert, E. B., . . . Miller, C. A. (2021). Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial. NATURE MEDICINE, 27(8), 1477-+. doi:10.1038/s41591-021-01452-0
Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation
Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., . . . Williamson, P. R. (2021). Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation. LANCET RHEUMATOLOGY, 3(5), E347-E356. doi:10.1016/S2665-9913(21)00036-9
Protocol for an open-label feasibility study for a randomised controlled trial of vitamin D supplementation in Crohn's Disease patients with vitamin D deficiency: D-CODE Feasiblity study
Fletcher, J., Bedson, E., Brown, M., Hewison, M., Swift, A., & Cooper, S. C. (2021). Protocol for an open-label feasibility study for a randomised controlled trial of vitamin D supplementation in Crohn's Disease patients with vitamin D deficiency: D-CODE Feasiblity study. PILOT AND FEASIBILITY STUDIES, 7(1). doi:10.1186/s40814-021-00813-3
Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT.
Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., . . . Williamson, P. R. (2021). Microdiscectomy compared with transforaminal epidural steroid injection for persistent radicular pain caused by prolapsed intervertebral disc: the NERVES RCT.. Health Technology Assessment, 25(24), 1-86. doi:10.3310/hta25240
Surgical microdiscectomy vs steroid nerve root injection for sciatica up to 1yr; the nerves trial
Wilby, M., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., . . . Williamson, P. (2021). Surgical microdiscectomy vs steroid nerve root injection for sciatica up to 1yr; the nerves trial. Brain and Spine, 1, 100013. doi:10.1016/j.bas.2021.100013
2020
National survey of feasibility of NIV trials for management of children with bronchiolitis.
Rosala-Hallas, A., Jones, A. P., Bedson, E., Compton, V., Fernandes, R. M., Lacy, D., . . . McNamara, P. S. (2020). National survey of feasibility of NIV trials for management of children with bronchiolitis.. BMJ Paediatrics Open, 4(1), e000780. doi:10.1136/bmjpo-2020-000780
2019
Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial
Rowe, F. J., Hepworth, L. R., Conroy, E. J., Rainford, N. E. A., Bedson, E., Drummond, A., . . . Sackley, C. (2019). Visual Function Questionnaire as an outcome measure for homonymous hemianopia: subscales and supplementary questions, analysis from the VISION trial. Eye, 33(9), 1485-1493. doi:10.1038/s41433-019-0441-z
Pirfenidone in Heart Failure with Preserved Ejection Fraction-Rationale and Design of the PIROUETTE Trial
Lewis, G. A., Schelbert, E. B., Naish, J. H., Bedson, E., Dodd, S., Eccleson, H., . . . Miller, C. A. (2019). Pirfenidone in Heart Failure with Preserved Ejection Fraction-Rationale and Design of the PIROUETTE Trial. CARDIOVASCULAR DRUGS AND THERAPY, 33(4), 461-470. doi:10.1007/s10557-019-06876-y
Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation
Blair, J. C., Mckay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . Investigators, S. C. I. P. I. (2019). Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation. BMJ: British Medical Journal, 365. doi:10.1136/bmj.l1226
Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation.
Blair, J. C., McKay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . SCIPI investigators. (2019). Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation.. BMJ (Clinical research ed.), 365, l1226. doi:10.1136/bmj.l1226
2018
Non-invasive ventilation for the management of children with bronchiolitis (NOVEMBR): a feasibility study and core outcome set development protocol
van Miert, C., Fernandes, R. M., Eccleson, H., Bedson, E., Lane, S., Peak, M., . . . McNamara, P. S. (2018). Non-invasive ventilation for the management of children with bronchiolitis (NOVEMBR): a feasibility study and core outcome set development protocol. TRIALS, 19. doi:10.1186/s13063-018-2969-9
Nerve root block versus surgery (NERVES) for the treatment of radicular pain secondary to a prolapsed intervertebral disc herniation: study protocol for a multi-centre randomised controlled trial
Wilby, M. J., Hopkins, C., Bedson, E., Howlin, S., Burnside, G., Conroy, E. J., . . . Williamson, P. (2018). Nerve root block versus surgery (NERVES) for the treatment of radicular pain secondary to a prolapsed intervertebral disc herniation: study protocol for a multi-centre randomised controlled trial. TRIALS, 19. doi:10.1186/s13063-018-2677-5
Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT
Blair, J., McKay, A., Ridyard, C., Thornborough, K., Bedson, E., Peak, M., . . . Gamble, C. (2018). Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT. Health Technology Assessment, 22(42). doi:10.3310/hta22420
2017
Choice of outcome measures for the VISION pilot trial of interventions for hemianopia
Rowe, F. J., Conroy, E. J., Bedson, E., Cwiklinski, E., Drummond, A., Garcia-Finana, M., . . . Sackley, C. (2017). Choice of outcome measures for the VISION pilot trial of interventions for hemianopia. ACTA NEUROLOGICA SCANDINAVICA, 136(5), 551-553. doi:10.1111/ane.12772
A pilot randomized controlled trial comparing effectiveness of prism glasses, visual search training and standard care in hemianopia
Rowe, F. J., Conroy, E. J., Bedson, E., Cwiklinski, E., Drummond, A., García-Fiñana, M., . . . Sackley, C. (2017). A pilot randomized controlled trial comparing effectiveness of prism glasses, visual search training and standard care in hemianopia. Acta Neurologica Scandinavica, 136(4), 310-321. doi:10.1111/ane.12725
Protocol for an online randomised controlled trial to evaluate the clinical and cost-effectiveness of a peer-supported self-management intervention for relatives of people with psychosis or bipolar disorder: Relatives Education And Coping Toolkit (REACT)
Lobban, F., Robinson, H., Appelbe, D., Barraclough, J., Bedson, E., Collinge, L., . . . Jones, S. (2017). Protocol for an online randomised controlled trial to evaluate the clinical and cost-effectiveness of a peer-supported self-management intervention for relatives of people with psychosis or bipolar disorder: Relatives Education And Coping Toolkit (REACT). BMJ OPEN, 7(7). doi:10.1136/bmjopen-2017-016965
2016
A Randomised Controlled Trial of Treatment for Post-Stroke Homonymous Hemianopia: Screening and Recruitment
Rowe, F. J., Conroy, E. J., Barton, P. G., Bedson, E., Cwiklinski, E., Dodridge, C., . . . Shipman, T. (2016). A Randomised Controlled Trial of Treatment for Post-Stroke Homonymous Hemianopia: Screening and Recruitment. NEURO-OPHTHALMOLOGY, 40(1), 1-7. doi:10.3109/01658107.2015.1126288
2015
Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections
Blair, J., Gregory, J. W., Hughes, D., Ridyard, C. H., Gamble, C., Mckay, A., . . . Peak, M. (2015). Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections. TRIALS, 16. doi:10.1186/s13063-015-0658-5
2014
Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.
Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., . . . Williams, N. (2014). Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.. Health Technology Assessment, 18(48). doi:10.3310/hta18480
A randomised controlled trial to compare the clinical and cost-effectiveness of prism glasses, visual search training and standard care in patients with hemianopia following stroke: a protocol
Rowe, F. J., Barton, P. G., Bedson, E., Breen, R., Conroy, E. J., Cwiklinski, E., . . . Shipman, T. (2014). A randomised controlled trial to compare the clinical and cost-effectiveness of prism glasses, visual search training and standard care in patients with hemianopia following stroke: a protocol. BMJ OPEN, 4(7). doi:10.1136/bmjopen-2014-005885
2013
Involving service users in trials: developing a standard operating procedure.
Evans, B. A., Bedson, E., Bell, P., Hutchings, H., Lowes, L., Rea, D., . . . West Wales Organisation for Rigorous Trials in Health (WWORTH). (2013). Involving service users in trials: developing a standard operating procedure.. Trials, 14, 219. doi:10.1186/1745-6215-14-219
2012
Enhancing rigour in the validation of patient reported outcome measures (PROMs): bridging linguistic and psychometric testing.
Roberts, G., Roberts, S., Tranter, R., Whitaker, R., Bedson, E., Tranter, S., . . . Sylvestre, Y. (2012). Enhancing rigour in the validation of patient reported outcome measures (PROMs): bridging linguistic and psychometric testing.. Health and quality of life outcomes, 10, 64. doi:10.1186/1477-7525-10-64
2011
Including service users in trials and rigorous studies in health and social care: developing a standard operating procedure for researchers
Evans, B. A., Bedson, E., Bell, P., Hutchings, H., Lowes, L., Rea, D., . . . Russell, I. (2011). Including service users in trials and rigorous studies in health and social care: developing a standard operating procedure for researchers. Trials, 12(S1). doi:10.1186/1745-6215-12-s1-a83
2010
Half-baked? B vitamins and depression.
Roberts, S. H., Bedson, E., & Tranter, R. (2010). Half-baked? B vitamins and depression.. The American journal of clinical nutrition, 92(2), 269-270. doi:10.3945/ajcn.2010.29977
2009
Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008)
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008). BMC PSYCHIATRY, 9. doi:10.1186/1471-244X-9-14
Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC Psychiatry, 9(1). doi:10.1186/1471-244x-9-14
Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial
Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC psychiatry, 9, 14.
2007
Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial
Roberts, S. H., Bedson, E., Hughes, D., Lloyd, K., Moat, S., Pirmohamed, M., . . . Russell, I. (2007). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC PSYCHIATRY, 7. doi:10.1186/1471-244X-7-65
2006
Emergency psychiatric assessments: effects of accessing clinical records on outcome
Roberts, S. H., Woodall, A. A., Bedson, E., & Menkes, D. B. (2006). Emergency psychiatric assessments: effects of accessing clinical records on outcome. Journal of Psychiatric Intensive Care, 2(02), 97. doi:10.1017/s1742646407000350
2002
Hemispheric asymmetry for global and local processing: language is less important than one might think.
Bedson, E., & Turnbull, O. H. (2002). Hemispheric asymmetry for global and local processing: language is less important than one might think.. Brain and cognition, 48(2-3), 272-277.