Research outputs
Selected research outputs
- 'Queer in Microbiology': a Microbiology Society members' endeavour for creating a safe and inclusive environment for LGBTQIA+ microbiologists. (Journal article - 2024)
- Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19. (Journal article - 2024)
- Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway (Journal article - 2022)
- Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19 (Journal article - 2022)
- Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial (Journal article - 2022)
- Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19. (Journal article - 2022)
- Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS. (Journal article - 2021)
- SARS-CoV-2 one year on: evidence for ongoing viral adaptation (Journal article - 2021)
- Tissue-Specific Immunopathology in Fatal COVID-19 (Journal article - 2021)
- Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism (Journal article - 2020)
2025
Limited evidence of the effectiveness of antiviral drugs to prevent brain infection by SARS-COV-2 in the K18-hACE2 murine model
De Neck, S., Schläpfer, J., Penrice-Randal, R., Parul, S., Bentley, E. G., Kirby, A., . . . Kipar, A. (2025). Limited evidence of the effectiveness of antiviral drugs to prevent brain infection by SARS-COV-2 in the K18-hACE2 murine model. Journal of Comparative Pathology, 220, 107. doi:10.1016/j.jcpa.2025.03.186
The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19.
Penrice-Randal, R., Bentley, E. G., Sharma, P., Kirby, A., Donovan-Banfield, I., Kipar, A., . . . Stewart, J. P. (2025). The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19.. Microbiology spectrum, 13(5), e0182924. doi:10.1128/spectrum.01829-24
SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection
2024
Circulating inflammatory cytokines predict severity disease in hospitalized COVID-19 patients: A prospective multicenter study of the European DRAGON consortium.
Polese, B., Ernst, M., Henket, M., Ernst, B., Winandy, M., Njock, M. -S., . . . Guiot, J. (2024). Circulating inflammatory cytokines predict severity disease in hospitalized COVID-19 patients: A prospective multicenter study of the European DRAGON consortium.. Journal of infection and public health, 17(12), 102589. doi:10.1016/j.jiph.2024.102589
Can self-testing be enhanced to hasten safe return of healthcare workers in pandemics? Random order, open label trial using two manufacturers' SARS-CoV-2 lateral flow devices concurrently and nested viral culture study.
Zhang, X., Cheyne, C. P., Jones, C., Humann, M., Leeming, G., Smith, C., . . . Buchan, I. E. (2024). Can self-testing be enhanced to hasten safe return of healthcare workers in pandemics? Random order, open label trial using two manufacturers' SARS-CoV-2 lateral flow devices concurrently and nested viral culture study.. BMC infectious diseases, 24(1), 1276. doi:10.1186/s12879-024-10155-z
Queer- and trans-inclusive faculty hiring-A call for change.
Weissman, J. L., Chappell, C. R., Francesco Rodrigues de Oliveira, B., Evans, N., Fagre, A. C., Forsythe, D., . . . Advancing Queer and Trans Equity in Science (AQTES) Consortium. (2024). Queer- and trans-inclusive faculty hiring-A call for change.. PLoS biology, 22(11), e3002919. doi:10.1371/journal.pbio.3002919
SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.
Goldswain, H., Penrice-Randal, R., Donovan-Banfield, I., Duffy, C. W., Dong, X., Randle, N., . . . Emmett, S. R. (2024). SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.. Genome medicine, 16(1), 89. doi:10.1186/s13073-024-01360-1
'Queer in Microbiology': a Microbiology Society members' endeavour for creating a safe and inclusive environment for LGBTQIA+ microbiologists.
de Oliveira, B. F. R., Donovan-Banfield, I., Penrice-Randal, R., Casey, R., & Gonçalves-Carneiro, D. (2024). 'Queer in Microbiology': a Microbiology Society members' endeavour for creating a safe and inclusive environment for LGBTQIA+ microbiologists.. Microbiology (Reading, England), 170(6). doi:10.1099/mic.0.001468
Emerging Variants of Canine Enteric Coronavirus Associated with Outbreaks of Gastroenteric Disease.
Cunningham-Oakes, E., Pilgrim, J., Darby, A. C., Appleton, C., Jewell, C., Rowlingson, B., . . . Radford, A. D. (2024). Emerging Variants of Canine Enteric Coronavirus Associated with Outbreaks of Gastroenteric Disease.. Emerging infectious diseases, 30(6), 1240-1244. doi:10.3201/eid3006.231184
The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.
Fernández, J. J., Marín, A., Rosales, R., Penrice-Randal, R., Mlcochova, P., Alvarez, Y., . . . Fernández, N. (2024). The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.. Biochimica et biophysica acta. Molecular basis of disease, 1870(5), 167193. doi:10.1016/j.bbadis.2024.167193
Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.
Clark, J. J., Penrice-Randal, R., Sharma, P., Dong, X., Pennington, S. H., Marriott, A. E., . . . Stewart, J. P. (2024). Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.. Viruses, 16(6), 863. doi:10.3390/v16060863
Precision medicine for pandemics: stratification of COVID-19 molecular phenotypes defined by topological analysis of global blood gene expression
2023
Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M. G., . . . Hiscox, J. A. (2023). Enrichment of SARS-CoV-2 sequence from nasopharyngeal swabs whilst identifying the nasal microbiome. Journal of Clinical Virology, 105620. doi:10.1016/j.jcv.2023.105620
The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections
De Neck, S., Penrice-Randal, R., Clark, J. J., Sharma, P., Bentley, E. G., Kirby, A., . . . Kipar, A. (2023). The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections. Viruses, 15(8), 1637. doi:10.3390/v15081637
Enrichment of Sars-Cov-2 and Seasonal Coronavirus Sequence from Nasopharyngeal Swabs Whilst Maintaining the Background Context of the Microbiome
Alrezaihi, A., Penrice-Randal, R., Dong, X., Prince, T., Randle, N., Semple, M., . . . Hiscox, J. (2023). Enrichment of Sars-Cov-2 and Seasonal Coronavirus Sequence from Nasopharyngeal Swabs Whilst Maintaining the Background Context of the Microbiome. doi:10.2139/ssrn.4484216
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
2022
Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial
Donovan-Banfield, I., Penrice-Randal, R., Goldswain, H., Rzeszutek, A. M., Pilgrim, J., Bullock, K., . . . Fletcher, T. (2022). Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34839-9
New Cell Lines Derived from Laboratory Colony Triatoma infestans and Rhodnius prolixus, Vectors of Trypanosoma cruzi, Do Not Harbour Triatoma Virus
Penrice-Randal, R., Hartley, C., Beliavskaia, A., Dong, X., Brandner-Garrod, L., Whitten, M., & Bell-Sakyi, L. (2022). New Cell Lines Derived from Laboratory Colony Triatoma infestans and Rhodnius prolixus, Vectors of Trypanosoma cruzi, Do Not Harbour Triatoma Virus. INSECTS, 13(10). doi:10.3390/insects13100906
Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19.
Penrice-Randal, R., Dong, X., Shapanis, A. G., Gardner, A., Harding, N., Legebeke, J., . . . Baralle, D. (2022). Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19.. Frontiers in immunology, 13, 988685. doi:10.3389/fimmu.2022.988685
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages
Prince, T., Dong, X., Penrice-Randal, R., Randle, N., Hartley, C., Goldswain, H., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages. MSPHERE, 7(3). doi:10.1128/msphere.00913-21
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Donovan-Banfield, I., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers. GIGASCIENCE, 11. doi:10.1093/gigascience/giac045
Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19
Legebeke, J., Lord, J., Penrice-Randal, R., Vallejo, A. F., Poole, S., Brendish, N. J., . . . Baralle, D. (2022). Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.853265
Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway
Zhou, J., Peacock, T. P., Brown, J. C., Goldhill, D. H., Elrefaey, A. M. E., Penrice-Randal, R., . . . Barclay, W. S. (2022). Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 110344. doi:10.1016/j.celrep.2022.110344
Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.
Zhou, J., Peacock, T., Brown, J., Goldhill, D., Elrefaey, A., Penrice-Randal, R., . . . Barclay, W. (2021). Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.. doi:10.21203/rs.3.rs-829214/v1
Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19
Russell, C. D., Valanciute, A., Gachanja, N. N., Stephen, J., Penrice-Randal, R., Armstrong, S. D., . . . Lucas, C. D. (2022). Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 66(2), 196-205. doi:10.1165/rcmb.2021-0358OC
2021
Antiviral activity of Molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and implications for the therapeutic window and resistance
Understanding severe coronavirus disease in humans from the analysis of clinical samples with RNA sequencing
Penrice-Randal, R. (2021, November 12). Understanding severe coronavirus disease in humans from the analysis of clinical samples with RNA sequencing.
Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS.
Aljabr, W., Alruwaili, M., Penrice-Randal, R., Alrezaihi, A., Harrison, A. J., Ryan, Y., . . . Hiscox, J. A. (2021). Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS.. mSphere, e0021921. doi:10.1128/msphere.00219-21
SARS-CoV-2 one year on: evidence for ongoing viral adaptation
Peacock, T. P., Penrice-Randal, R., Hiscox, J. A., & Barclay, W. S. (2021). SARS-CoV-2 one year on: evidence for ongoing viral adaptation. JOURNAL OF GENERAL VIROLOGY, 102(4). doi:10.1099/jgv.0.001584
Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Salguero, J., . . . Hiscox, J. (2021). Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans. doi:10.1101/2021.03.03.433753
Tissue-Specific Immunopathology in Fatal COVID-19
Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., . . . Lucas, C. D. (2021). Tissue-Specific Immunopathology in Fatal COVID-19. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 203(2), 192-201. doi:10.1164/rccm.202008-3265OC
2020
Amplicon and metagenomic analysis of MERS-CoV and the microbiome in patients with severe Middle East respiratory syndrome (MERS)
Aljabr, W., Alruwaili, M., Penrice-Randal, R., Alrezaihi, A., Harrison, A. J., Ryan, Y., . . . Hiscox, J. (2020). Amplicon and metagenomic analysis of MERS-CoV and the microbiome in patients with severe Middle East respiratory syndrome (MERS). doi:10.1101/2020.11.28.400671
Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19
Clark, J., Penrice-Randal, R., Sharma, P., Kipar, A., Dong, X., Pennington, S., . . . Stewart, J. (2020). Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19. doi:10.1101/2020.10.13.334532
Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism
Moore, S. C., Penrice-Randal, R., Alruwaili, M., Randle, N., Armstrong, S., Hartley, C., . . . Hiscox, J. A. (2020). Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism. VIRUSES-BASEL, 12(10). doi:10.3390/v12101164
Tissue-specific tolerance in fatal Covid-19
Dorward, D., Russell, C., Um, I. H., Elshani, M., Armstrong, S., Penrice-Randal, R., . . . Lucas, C. (2020). Tissue-specific tolerance in fatal Covid-19. doi:10.1101/2020.07.02.20145003
An integrated national scale SARS-CoV-2 genomic surveillance network
Darby, A. (2020). An integrated national scale SARS-CoV-2 genomic surveillance network. The Lancet Microbe. doi:10.1016/s2666-5247(20)30054-9
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., . . . ISARIC4C investigators. (2020). Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.. BMJ (Clinical research ed.), 369. doi:10.1136/bmj.m1985
Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
Moore, S., Penrice-Randal, R., Alruwaili, M., Dong, X., Pullan, S., Carter, D., . . . Hiscox, J. (2020). Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19. doi:10.1101/2020.03.05.20032011
Undated
Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes
Russell, C. D., Valanciute, A., Gachanja, N. N., Stephen, J., Penrice-Randal, R., Armstrong, S. D., . . . Lucas, C. D. (n.d.). Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes.