Publications
Selected publications
- A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes (Preprint - 2023)
- Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial (Journal article - 2022)
- Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial (Journal article - 2022)
- Direct RNA sequencing of Respiratory Syncytial Virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance (Preprint - 2021)
2025
Characterising the genomic stability of nucleoside analogue-treated SARS-CoV-2.
Donovan-Banfield, I. (2025, April 10). Characterising the genomic stability of nucleoside analogue-treated SARS-CoV-2.. (University of Liverpool).
The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19.
Penrice-Randal, R., Bentley, E. G., Sharma, P., Kirby, A., Donovan-Banfield, I., Kipar, A., . . . Stewart, J. P. (2025). The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19.. Microbiology spectrum, e0182924. doi:10.1128/spectrum.01829-24
Using minor variant genomes and machine learning to study the genome biology of SARS-CoV-2 over time.
Dong, X., Matthews, D. A., Gallo, G., Darby, A., Donovan-Banfield, I., Goldswain, H., . . . Hiscox, J. A. (2025). Using minor variant genomes and machine learning to study the genome biology of SARS-CoV-2 over time.. Nucleic acids research, 53(4), gkaf077. doi:10.1093/nar/gkaf077
Building an inclusive culture at scientific meetings: foundations for future progress.
Maringer, K., Cunningham-Oakes, E., Lane, F., Jones, K. L., Rodrigues de Oliveira, B. F., Baba-Dikwa, A., . . . Khan, C. M. A. (2025). Building an inclusive culture at scientific meetings: foundations for future progress.. Microbiology (Reading, England), 171(2). doi:10.1099/mic.0.001527
2024
SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.
Goldswain, H., Penrice-Randal, R., Donovan-Banfield, I., Duffy, C. W., Dong, X., Randle, N., . . . Emmett, S. R. (2024). SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.. Genome medicine, 16(1), 89. doi:10.1186/s13073-024-01360-1
'Queer in Microbiology': a Microbiology Society members' endeavour for creating a safe and inclusive environment for LGBTQIA+ microbiologists.
de Oliveira, B. F. R., Donovan-Banfield, I., Penrice-Randal, R., Casey, R., & Gonçalves-Carneiro, D. (2024). 'Queer in Microbiology': a Microbiology Society members' endeavour for creating a safe and inclusive environment for LGBTQIA+ microbiologists.. Microbiology (Reading, England), 170(6). doi:10.1099/mic.0.001468
2023
A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes.
Sanderson, T., Hisner, R., Donovan-Banfield, I., Hartman, H., Løchen, A., Peacock, T. P., & Ruis, C. (2023). A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes.. Nature, 623(7987), 594-600. doi:10.1038/s41586-023-06649-6
Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated<i>in vivo</i>
Genome evolution of dengue virus serotype 1 under selection by <i>Wolbachia pipientis</i> in <i>Aedes aegypti</i> mosquitoes.
Thi Hue Kien, D., Edenborough, K., da Silva Goncalves, D., Thuy Vi, T., Casagrande, E., Thi Le Duyen, H., . . . Simmons, C. (2023). Genome evolution of dengue virus serotype 1 under selection by <i>Wolbachia pipientis</i> in <i>Aedes aegypti</i> mosquitoes.. Virus evolution, 9(1), vead016. doi:10.1093/ve/vead016
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
2022
Tracking outbreak dynamics using within-host variation
Donovan-Banfield, I., & Cunningham-Oakes, E. (2022). Tracking outbreak dynamics using within-host variation. NATURE MICROBIOLOGY, 7(12), 1947-1948. doi:10.1038/s41564-022-01274-x
Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial
Donovan-Banfield, I., Penrice-Randal, R., Goldswain, H., Rzeszutek, A. M., Pilgrim, J., Bullock, K., . . . Fletcher, T. (2022). Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34839-9
Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance.
Donovan-Banfield, I., Milligan, R., Hall, S., Gao, T., Murphy, E., Li, J., . . . Matthews, D. A. (2022). Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance.. PloS one, 17(11), e0276697. doi:10.1371/journal.pone.0276697
Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial
Khoo, S. H., FitzGerald, R., Saunders, G., Middleton, C., Ahmad, S., Edwards, C. J., . . . Vyas, A. (2022). Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. The Lancet Infectious Diseases. doi:10.1016/s1473-3099(22)00644-2
A Randomised -Controlled Phase 2 trial of Molnupiravir in Unvaccinated and Vaccinated Individuals with Early SARS-CoV-2
Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers
Dong, X., Penrice-Randal, R., Goldswain, H., Prince, T., Randle, N., Donovan-Banfield, I., . . . Hiscox, J. A. (2022). Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers. GIGASCIENCE, 11. doi:10.1093/gigascience/giac045
Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway
Zhou, J., Peacock, T. P., Brown, J. C., Goldhill, D. H., Elrefaey, A. M. E., Penrice-Randal, R., . . . Barclay, W. S. (2022). Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 110344. doi:10.1016/j.celrep.2022.110344
Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.
Zhou, J., Peacock, T., Brown, J., Goldhill, D., Elrefaey, A., Penrice-Randal, R., . . . Barclay, W. (2021). Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.. doi:10.21203/rs.3.rs-829214/v1
2021
Direct RNA sequencing of Respiratory Syncytial Virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance
Antiviral activity of Molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and implications for the therapeutic window and resistance
Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS.
Aljabr, W., Alruwaili, M., Penrice-Randal, R., Alrezaihi, A., Harrison, A. J., Ryan, Y., . . . Hiscox, J. A. (2021). Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS.. mSphere, e0021921. doi:10.1128/msphere.00219-21
2020
Amplicon and metagenomic analysis of MERS-CoV and the microbiome in patients with severe Middle East respiratory syndrome (MERS)
Aljabr, W., Alruwaili, M., Penrice-Randal, R., Alrezaihi, A., Harrison, A. J., Ryan, Y., . . . Hiscox, J. (2020). Amplicon and metagenomic analysis of MERS-CoV and the microbiome in patients with severe Middle East respiratory syndrome (MERS). doi:10.1101/2020.11.28.400671
Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution
Donovan-Banfield, I., Turnell, A. S., Hiscox, J. A., Leppard, K. N., & Matthews, D. A. (2020). Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution. COMMUNICATIONS BIOLOGY, 3(1). doi:10.1038/s42003-020-0849-9
2016
Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells
Ho, C. M. K., Donovan-Banfield, I. Z., Tan, L., Zhang, T., Gray, N. S., & Strang, B. L. (2016). Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells. PLOS ONE, 11(3). doi:10.1371/journal.pone.0150339